AU2014352843B2 - Compositions and methods for treating pulmonary hypertension - Google Patents

Compositions and methods for treating pulmonary hypertension Download PDF

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Publication number
AU2014352843B2
AU2014352843B2 AU2014352843A AU2014352843A AU2014352843B2 AU 2014352843 B2 AU2014352843 B2 AU 2014352843B2 AU 2014352843 A AU2014352843 A AU 2014352843A AU 2014352843 A AU2014352843 A AU 2014352843A AU 2014352843 B2 AU2014352843 B2 AU 2014352843B2
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AU
Australia
Prior art keywords
tgf
subject
ligand trap
ligand
soluble recombinant
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AU2014352843A
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AU2014352843A1 (en
Inventor
Roselyne CASTONGUAY
Asya Grinberg
Ravindra Kumar
Dianne S. Sako
Rita Steeves
Paul Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Acceleron Pharma Inc
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Brigham and Womens Hospital Inc
Acceleron Pharma Inc
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Application filed by Brigham and Womens Hospital Inc, Acceleron Pharma Inc filed Critical Brigham and Womens Hospital Inc
Publication of AU2014352843A1 publication Critical patent/AU2014352843A1/en
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Publication of AU2014352843B2 publication Critical patent/AU2014352843B2/en
Priority to AU2020203110A priority Critical patent/AU2020203110A1/en
Priority to AU2023263573A priority patent/AU2023263573A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2014352843A 2013-11-21 2014-11-21 Compositions and methods for treating pulmonary hypertension Active AU2014352843B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020203110A AU2020203110A1 (en) 2013-11-21 2020-05-12 Compositions and methods for treating pulmonary hypertension
AU2023263573A AU2023263573A1 (en) 2013-11-21 2023-11-12 Compositions and methods for treating pulmonary hypertension

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361907260P 2013-11-21 2013-11-21
US61/907,260 2013-11-21
PCT/US2014/066776 WO2015077540A2 (en) 2013-11-21 2014-11-21 Compositions and methods for treating pulmonary hypertension

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020203110A Division AU2020203110A1 (en) 2013-11-21 2020-05-12 Compositions and methods for treating pulmonary hypertension

Publications (2)

Publication Number Publication Date
AU2014352843A1 AU2014352843A1 (en) 2016-06-16
AU2014352843B2 true AU2014352843B2 (en) 2020-03-05

Family

ID=53180397

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2014352843A Active AU2014352843B2 (en) 2013-11-21 2014-11-21 Compositions and methods for treating pulmonary hypertension
AU2020203110A Abandoned AU2020203110A1 (en) 2013-11-21 2020-05-12 Compositions and methods for treating pulmonary hypertension
AU2023263573A Pending AU2023263573A1 (en) 2013-11-21 2023-11-12 Compositions and methods for treating pulmonary hypertension

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2020203110A Abandoned AU2020203110A1 (en) 2013-11-21 2020-05-12 Compositions and methods for treating pulmonary hypertension
AU2023263573A Pending AU2023263573A1 (en) 2013-11-21 2023-11-12 Compositions and methods for treating pulmonary hypertension

Country Status (9)

Country Link
US (3) US10682392B2 (enExample)
EP (4) EP4417255A3 (enExample)
JP (4) JP6640083B2 (enExample)
CN (2) CN105934249A (enExample)
AU (3) AU2014352843B2 (enExample)
CA (1) CA2931309C (enExample)
DK (2) DK3071215T3 (enExample)
ES (2) ES2778201T3 (enExample)
WO (1) WO2015077540A2 (enExample)

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JP6955443B2 (ja) * 2014-08-01 2021-10-27 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． 肺動脈性肺高血圧症の処置に関する方法および組成物
CN116327952A (zh) 2015-08-04 2023-06-27 阿塞勒隆制药公司 用于治疗骨髓增生性病症的方法
CA2996996A1 (en) * 2015-08-31 2017-03-09 National Research Council Of Canada Tgf-.beta.-receptor ectodomain fusion molecules and uses thereof
CN116531490A (zh) 2016-07-15 2023-08-04 阿塞勒隆制药公司 用于治疗肺高血压的组合物和方法
AU2017336546C1 (en) * 2016-09-27 2025-05-29 Epicentrx, Inc. Immunomodulatory fusion proteins
JP7231553B2 (ja) 2017-03-02 2023-03-01 ナショナル リサーチ カウンシル オブ カナダ Ｔｇｆ－ｂ－受容体外部ドメイン融合分子及びその使用
BR112019023071A2 (pt) 2017-05-04 2020-06-09 Acceleron Pharma Inc proteínas de fusão do receptor tgf-beta do tipo ii e uso das mesmas
AU2018264455B2 (en) 2017-05-12 2024-12-12 Jiangsu Hengrui Medicine Co., Ltd. Fusion protein containing TGF-beta receptor and medicinal uses thereof
KR102757384B1 (ko) 2017-09-27 2025-01-20 에피센트알엑스, 인코포레이티드 면역조절 융합 단백질
TWI823906B (zh) 2018-03-09 2023-12-01 美商艾吉納斯公司 抗-cd73 抗體及其使用方法
US11168138B2 (en) 2018-03-26 2021-11-09 Altor Bioscience, Llc Anti-PDL1, IL-15 and TGF-beta receptor combination molecules
TWI829799B (zh) 2018-11-09 2024-01-21 大陸商江蘇恆瑞醫藥股份有限公司 一種TGF-β受體融合蛋白醫藥組成物及其用途
CN112239507A (zh) * 2019-07-17 2021-01-19 鸿运华宁（杭州）生物医药有限公司 ETA抗体与TGF-β Trap的融合蛋白质，以及其药物组合物和应用
US20220362333A1 (en) * 2019-07-26 2022-11-17 Board Of Trustees Of Michigan State University Methods Of Preventing Or Treating Fatty Degeneration Of Skeletal Muscle
US20210061871A1 (en) * 2019-08-29 2021-03-04 Nantbio, Inc. Modified N-810 and Methods Therefor
TW202128763A (zh) * 2019-11-12 2021-08-01 大陸商江蘇恆瑞醫藥股份有限公司 含有ＴＧＦ－β受體的融合蛋白及其醫藥用途
EP4142769A4 (en) 2020-04-28 2024-05-15 Acceleron Pharma Inc. ACTRII PROTEINS AND USE IN THE TREATMENT OF POSTCAPILLARY PULMONARY HYPERTENSION
US20250152670A1 (en) * 2022-04-28 2025-05-15 Wenzhou Prarucom Bio-Chemical Technology Co. Method for alleviating pulmonary fibrosis using epidermal growth factor

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Also Published As

Publication number Publication date
EP3685848B1 (en) 2021-09-15
US10682392B2 (en) 2020-06-16
JP7474729B2 (ja) 2024-04-25
US20200323955A1 (en) 2020-10-15
US11951156B2 (en) 2024-04-09
JP2020073528A (ja) 2020-05-14
JP6952100B2 (ja) 2021-10-20
EP4417255A3 (en) 2024-10-23
EP4005585B1 (en) 2024-03-27
WO2015077540A3 (en) 2015-11-19
ES2778201T3 (es) 2020-08-10
WO2015077540A2 (en) 2015-05-28
US20240366720A1 (en) 2024-11-07
EP3685848A1 (en) 2020-07-29
CN105934249A (zh) 2016-09-07
EP4005585A1 (en) 2022-06-01
DK3071215T3 (da) 2020-03-23
AU2023263573A1 (en) 2023-11-30
ES2902533T3 (es) 2022-03-28
US20160287664A1 (en) 2016-10-06
EP3071215A2 (en) 2016-09-28
EP3071215B1 (en) 2020-01-08
EP3071215A4 (en) 2017-08-23
JP2024096891A (ja) 2024-07-17
AU2020203110A1 (en) 2020-06-11
EP4417255A2 (en) 2024-08-21
JP6640083B2 (ja) 2020-02-05
JP2021193139A (ja) 2021-12-23
CA2931309A1 (en) 2015-05-28
AU2014352843A1 (en) 2016-06-16
CN120919282A (zh) 2025-11-11
DK3685848T3 (da) 2021-12-13
JP2017501977A (ja) 2017-01-19
CA2931309C (en) 2022-06-21

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