JP6640083B2 - 肺高血圧症を治療するための組成物および方法 - Google Patents

肺高血圧症を治療するための組成物および方法 Download PDF

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JP6640083B2
JP6640083B2 JP2016533067A JP2016533067A JP6640083B2 JP 6640083 B2 JP6640083 B2 JP 6640083B2 JP 2016533067 A JP2016533067 A JP 2016533067A JP 2016533067 A JP2016533067 A JP 2016533067A JP 6640083 B2 JP6640083 B2 JP 6640083B2
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JP2017501977A5 (enExample
JP2017501977A (ja
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ポール ユ
ポール ユ
アシャ グリンバーグ
アシャ グリンバーグ
ダイアン エス． サコ
ダイアン エス． サコ
ローズライン キャストングアイ
ローズライン キャストングアイ
リタ スティーブス
リタ スティーブス
ラヴィンドラ クマー
ラヴィンドラ クマー
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Brigham and Womens Hospital Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016533067A 2013-11-21 2014-11-21 肺高血圧症を治療するための組成物および方法 Active JP6640083B2 (ja)

Priority Applications (1)

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JP2019233811A JP6952100B2 (ja) 2013-11-21 2019-12-25 肺高血圧症を治療するための組成物および方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361907260P 2013-11-21 2013-11-21
US61/907,260 2013-11-21
PCT/US2014/066776 WO2015077540A2 (en) 2013-11-21 2014-11-21 Compositions and methods for treating pulmonary hypertension

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JP2017501977A JP2017501977A (ja) 2017-01-19
JP2017501977A5 JP2017501977A5 (enExample) 2018-04-05
JP6640083B2 true JP6640083B2 (ja) 2020-02-05

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JP2019233811A Active JP6952100B2 (ja) 2013-11-21 2019-12-25 肺高血圧症を治療するための組成物および方法
JP2021156343A Active JP7474729B2 (ja) 2013-11-21 2021-09-27 肺高血圧症を治療するための組成物および方法
JP2024065676A Pending JP2024096891A (ja) 2013-11-21 2024-04-15 肺高血圧症を治療するための組成物および方法

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JP2021156343A Active JP7474729B2 (ja) 2013-11-21 2021-09-27 肺高血圧症を治療するための組成物および方法
JP2024065676A Pending JP2024096891A (ja) 2013-11-21 2024-04-15 肺高血圧症を治療するための組成物および方法

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US (3) US10682392B2 (enExample)
EP (4) EP3071215B1 (enExample)
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CN (2) CN105934249A (enExample)
AU (3) AU2014352843B2 (enExample)
CA (1) CA2931309C (enExample)
DK (2) DK3071215T3 (enExample)
ES (2) ES2778201T3 (enExample)
WO (1) WO2015077540A2 (enExample)

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EP3685848A1 (en) 2020-07-29
AU2020203110A1 (en) 2020-06-11
EP3685848B1 (en) 2021-09-15
EP3071215A4 (en) 2017-08-23
CA2931309C (en) 2022-06-21
CA2931309A1 (en) 2015-05-28
AU2014352843A1 (en) 2016-06-16
AU2023263573A1 (en) 2023-11-30
EP3071215B1 (en) 2020-01-08
WO2015077540A3 (en) 2015-11-19
US20200323955A1 (en) 2020-10-15
CN120919282A (zh) 2025-11-11
US10682392B2 (en) 2020-06-16
JP6952100B2 (ja) 2021-10-20
AU2014352843B2 (en) 2020-03-05
JP2021193139A (ja) 2021-12-23
JP2017501977A (ja) 2017-01-19
US11951156B2 (en) 2024-04-09
WO2015077540A2 (en) 2015-05-28
EP4005585A1 (en) 2022-06-01
EP4417255A3 (en) 2024-10-23
US20160287664A1 (en) 2016-10-06
EP4417255A2 (en) 2024-08-21
JP2020073528A (ja) 2020-05-14
JP2024096891A (ja) 2024-07-17
EP4005585B1 (en) 2024-03-27
CN105934249A (zh) 2016-09-07
EP3071215A2 (en) 2016-09-28
ES2778201T3 (es) 2020-08-10
DK3071215T3 (da) 2020-03-23
ES2902533T3 (es) 2022-03-28
JP7474729B2 (ja) 2024-04-25
DK3685848T3 (da) 2021-12-13
US20240366720A1 (en) 2024-11-07

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