JP2017501972A5 - - Google Patents
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- JP2017501972A5 JP2017501972A5 JP2016529444A JP2016529444A JP2017501972A5 JP 2017501972 A5 JP2017501972 A5 JP 2017501972A5 JP 2016529444 A JP2016529444 A JP 2016529444A JP 2016529444 A JP2016529444 A JP 2016529444A JP 2017501972 A5 JP2017501972 A5 JP 2017501972A5
- Authority
- JP
- Japan
- Prior art keywords
- less
- poly
- composition
- active ingredient
- fatty acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 18
- 235000014113 dietary fatty acids Nutrition 0.000 claims 13
- 239000000194 fatty acid Substances 0.000 claims 13
- 229930195729 fatty acid Natural products 0.000 claims 13
- 239000004480 active ingredient Substances 0.000 claims 10
- 150000004665 fatty acids Chemical class 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 229920000642 polymer Polymers 0.000 claims 7
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 7
- 150000003626 triacylglycerols Chemical class 0.000 claims 6
- -1 DOO triglyceride compound Chemical class 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 238000013268 sustained release Methods 0.000 claims 5
- 239000012730 sustained-release form Substances 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 4
- PJHKBYALYHRYSK-UHFFFAOYSA-N triheptanoin Chemical compound CCCCCCC(=O)OCC(OC(=O)CCCCCC)COC(=O)CCCCCC PJHKBYALYHRYSK-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 239000011343 solid material Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 229940078561 triheptanoin Drugs 0.000 claims 3
- 102000002666 Carnitine O-palmitoyltransferase Human genes 0.000 claims 2
- 108010018424 Carnitine O-palmitoyltransferase Proteins 0.000 claims 2
- 101710088194 Dehydrogenase Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 2
- 239000005977 Ethylene Substances 0.000 claims 2
- 108091006296 SLC2A1 Proteins 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229920002301 cellulose acetate Polymers 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229920003176 water-insoluble polymer Polymers 0.000 claims 2
- 102000003925 1,4-alpha-Glucan Branching Enzyme Human genes 0.000 claims 1
- 108090000344 1,4-alpha-Glucan Branching Enzyme Proteins 0.000 claims 1
- OZCMOJQQLBXBKI-UHFFFAOYSA-N 1-ethenoxy-2-methylpropane Chemical compound CC(C)COC=C OZCMOJQQLBXBKI-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 208000021873 Adult polyglucosan body disease Diseases 0.000 claims 1
- 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 claims 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000013658 Carnitine Acyltransferases Human genes 0.000 claims 1
- 108010051527 Carnitine Acyltransferases Proteins 0.000 claims 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 1
- 229920008347 Cellulose acetate propionate Polymers 0.000 claims 1
- DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 claims 1
- 229920002284 Cellulose triacetate Polymers 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical group CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 102100024295 Maltase-glucoamylase Human genes 0.000 claims 1
- 206010058799 Mitochondrial encephalomyopathy Diseases 0.000 claims 1
- 102000001105 Phosphofructokinases Human genes 0.000 claims 1
- 108010069341 Phosphofructokinases Proteins 0.000 claims 1
- 108010064071 Phosphorylase Kinase Proteins 0.000 claims 1
- 102000009097 Phosphorylases Human genes 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920001305 Poly(isodecyl(meth)acrylate) Polymers 0.000 claims 1
- 229920002319 Poly(methyl acrylate) Polymers 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims 1
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 108010028144 alpha-Glucosidases Proteins 0.000 claims 1
- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 claims 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 1
- 229920006218 cellulose propionate Polymers 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- ZSDBFLMJVAGKOU-UHFFFAOYSA-N glycerol phenylbutyrate Chemical compound C=1C=CC=CC=1CCCC(=O)OCC(OC(=O)CCCC=1C=CC=CC=1)COC(=O)CCCC1=CC=CC=C1 ZSDBFLMJVAGKOU-UHFFFAOYSA-N 0.000 claims 1
- 229960002815 glycerol phenylbutyrate Drugs 0.000 claims 1
- 208000007345 glycogen storage disease Diseases 0.000 claims 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 1
- IWVKTOUOPHGZRX-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-N 0.000 claims 1
- IQSHMXAZFHORGY-UHFFFAOYSA-N methyl prop-2-enoate;2-methylprop-2-enoic acid Chemical group COC(=O)C=C.CC(=C)C(O)=O IQSHMXAZFHORGY-UHFFFAOYSA-N 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
- 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 claims 1
- 229920001483 poly(ethyl methacrylate) polymer Polymers 0.000 claims 1
- 229920000212 poly(isobutyl acrylate) Polymers 0.000 claims 1
- 229920000205 poly(isobutyl methacrylate) Polymers 0.000 claims 1
- 229920000196 poly(lauryl methacrylate) Polymers 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 229920000184 poly(octadecyl acrylate) Polymers 0.000 claims 1
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
- 229920000129 polyhexylmethacrylate Polymers 0.000 claims 1
- 229920000197 polyisopropyl acrylate Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 229920000182 polyphenyl methacrylate Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 229960004274 stearic acid Drugs 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904369P | 2013-11-14 | 2013-11-14 | |
| US61/904,369 | 2013-11-14 | ||
| PCT/US2014/065693 WO2015073816A1 (en) | 2013-11-14 | 2014-11-14 | Solid compositions of triglycerides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020041943A Division JP2020111585A (ja) | 2013-11-14 | 2020-03-11 | トリグリセリドの固体組成物及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017501972A JP2017501972A (ja) | 2017-01-19 |
| JP2017501972A5 true JP2017501972A5 (https=) | 2017-10-19 |
Family
ID=53058066
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016529444A Pending JP2017501972A (ja) | 2013-11-14 | 2014-11-14 | トリグリセリドの固体組成物及びその使用 |
| JP2020041943A Pending JP2020111585A (ja) | 2013-11-14 | 2020-03-11 | トリグリセリドの固体組成物及びその使用 |
| JP2022080251A Pending JP2022107017A (ja) | 2013-11-14 | 2022-05-16 | トリグリセリドの固体組成物及びその使用 |
| JP2024106876A Pending JP2024129109A (ja) | 2013-11-14 | 2024-07-02 | トリグリセリドの固体組成物及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020041943A Pending JP2020111585A (ja) | 2013-11-14 | 2020-03-11 | トリグリセリドの固体組成物及びその使用 |
| JP2022080251A Pending JP2022107017A (ja) | 2013-11-14 | 2022-05-16 | トリグリセリドの固体組成物及びその使用 |
| JP2024106876A Pending JP2024129109A (ja) | 2013-11-14 | 2024-07-02 | トリグリセリドの固体組成物及びその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US20160243071A1 (https=) |
| EP (2) | EP3782610A1 (https=) |
| JP (4) | JP2017501972A (https=) |
| KR (1) | KR102291310B1 (https=) |
| CN (2) | CN113181158A (https=) |
| AR (2) | AR099353A1 (https=) |
| AU (1) | AU2014348470B2 (https=) |
| CA (2) | CA2929688C (https=) |
| CL (1) | CL2016001130A1 (https=) |
| ES (1) | ES2833294T3 (https=) |
| IL (1) | IL245588B (https=) |
| MX (2) | MX383005B (https=) |
| MY (1) | MY177028A (https=) |
| PE (1) | PE20161024A1 (https=) |
| PH (1) | PH12016500821A1 (https=) |
| RU (1) | RU2016123169A (https=) |
| TW (1) | TWI640327B (https=) |
| WO (1) | WO2015073816A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI640327B (zh) | 2013-11-14 | 2018-11-11 | 美商奧崔基尼克斯製藥公司 | 三酸甘油酯之固體組合物及其用途 |
| US20190076383A1 (en) * | 2017-09-08 | 2019-03-14 | Horizon Therapeutics, Llc | Methods for treating urea cycle disorders |
| US12419852B2 (en) | 2018-08-27 | 2025-09-23 | Exerkine Corporation | Method for treating lysosomal storage disease |
| US11583542B2 (en) | 2019-12-16 | 2023-02-21 | Amylyx Pharmaceuticals, Inc. | Compositions of bile acids and phenylbutyrate compounds |
| CN113476408A (zh) * | 2021-07-23 | 2021-10-08 | 兆科药业（广州）有限公司 | 一种苯丁酸甘油酯颗粒剂及其制备方法与应用 |
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| EP2838522B1 (en) * | 2012-04-16 | 2024-02-21 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Phenylbutyrate for the treatment of medium-chain acyl-coa dehydrogenase deficiency |
| ES2728727T3 (es) | 2012-12-13 | 2019-10-28 | Baylor Res Institute At Dallas | Triheptanoína para el tratamiento de la deficiencia del transportador de glucosa 1 |
| EP3027180B1 (en) | 2013-07-31 | 2021-07-07 | The Children's Hospital of Philadelphia | Compositions and methods of the treatment of fatty acid metabolism disorders |
| TWI640327B (zh) | 2013-11-14 | 2018-11-11 | 美商奧崔基尼克斯製藥公司 | 三酸甘油酯之固體組合物及其用途 |
| US11844775B2 (en) | 2018-07-11 | 2023-12-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Method of treating fatty acid oxidation disorders using Omega3/Omega6 unsaturated or branched chain fatty acids |
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