RU2016123169A - Твердые композиции триглицеридов и их применение - Google Patents
Твердые композиции триглицеридов и их применение Download PDFInfo
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- RU2016123169A RU2016123169A RU2016123169A RU2016123169A RU2016123169A RU 2016123169 A RU2016123169 A RU 2016123169A RU 2016123169 A RU2016123169 A RU 2016123169A RU 2016123169 A RU2016123169 A RU 2016123169A RU 2016123169 A RU2016123169 A RU 2016123169A
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- 239000007787 solid Substances 0.000 title claims 22
- 239000000203 mixture Substances 0.000 title claims 10
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 title claims 3
- 239000008247 solid mixture Substances 0.000 claims 51
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 20
- 239000013543 active substance Substances 0.000 claims 17
- 235000014113 dietary fatty acids Nutrition 0.000 claims 16
- 229930195729 fatty acid Natural products 0.000 claims 16
- 239000000194 fatty acid Substances 0.000 claims 16
- 150000004665 fatty acids Chemical class 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 150000003626 triacylglycerols Chemical class 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 229920000642 polymer Polymers 0.000 claims 11
- PJHKBYALYHRYSK-UHFFFAOYSA-N triheptanoin Chemical compound CCCCCCC(=O)OCC(OC(=O)CCCCCC)COC(=O)CCCCCC PJHKBYALYHRYSK-UHFFFAOYSA-N 0.000 claims 11
- 229940078561 triheptanoin Drugs 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 7
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 6
- 239000005977 Ethylene Substances 0.000 claims 6
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- 229920003176 water-insoluble polymer Polymers 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 229920002301 cellulose acetate Polymers 0.000 claims 5
- 238000013268 sustained release Methods 0.000 claims 5
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 150000007513 acids Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 230000003111 delayed effect Effects 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 102000003925 1,4-alpha-Glucan Branching Enzyme Human genes 0.000 claims 2
- 108090000344 1,4-alpha-Glucan Branching Enzyme Proteins 0.000 claims 2
- OZCMOJQQLBXBKI-UHFFFAOYSA-N 1-ethenoxy-2-methylpropane Chemical compound CC(C)COC=C OZCMOJQQLBXBKI-UHFFFAOYSA-N 0.000 claims 2
- 229910018072 Al 2 O 3 Inorganic materials 0.000 claims 2
- 102000002666 Carnitine O-palmitoyltransferase Human genes 0.000 claims 2
- 108010018424 Carnitine O-palmitoyltransferase Proteins 0.000 claims 2
- 229920008347 Cellulose acetate propionate Polymers 0.000 claims 2
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- 229920002284 Cellulose triacetate Polymers 0.000 claims 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical group CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- 229920002527 Glycogen Polymers 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 229920001305 Poly(isodecyl(meth)acrylate) Polymers 0.000 claims 2
- 229920002319 Poly(methyl acrylate) Polymers 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 2
- 229910004298 SiO 2 Inorganic materials 0.000 claims 2
- 229910010413 TiO 2 Inorganic materials 0.000 claims 2
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 2
- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
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- ZSDBFLMJVAGKOU-UHFFFAOYSA-N glycerol phenylbutyrate Chemical compound C=1C=CC=CC=1CCCC(=O)OCC(OC(=O)CCCC=1C=CC=CC=1)COC(=O)CCCC1=CC=CC=C1 ZSDBFLMJVAGKOU-UHFFFAOYSA-N 0.000 claims 2
- 229960002815 glycerol phenylbutyrate Drugs 0.000 claims 2
- 229940096919 glycogen Drugs 0.000 claims 2
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- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 2
- 229920000184 poly(octadecyl acrylate) Polymers 0.000 claims 2
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- 239000005020 polyethylene terephthalate Substances 0.000 claims 2
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- 229920000197 polyisopropyl acrylate Polymers 0.000 claims 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims 2
- 229920000182 polyphenyl methacrylate Polymers 0.000 claims 2
- 229920001155 polypropylene Polymers 0.000 claims 2
- -1 polypropylene methyl acetate Polymers 0.000 claims 2
- 239000004814 polyurethane Substances 0.000 claims 2
- 229920002635 polyurethane Polymers 0.000 claims 2
- 239000011118 polyvinyl acetate Substances 0.000 claims 2
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- 239000004800 polyvinyl chloride Substances 0.000 claims 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000010457 zeolite Substances 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 claims 1
- UIERETOOQGIECD-UHFFFAOYSA-N Angelic acid Natural products CC=C(C)C(O)=O UIERETOOQGIECD-UHFFFAOYSA-N 0.000 claims 1
- 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102000018711 Facilitative Glucose Transport Proteins Human genes 0.000 claims 1
- 229920001503 Glucan Polymers 0.000 claims 1
- 108091052347 Glucose transporter family Proteins 0.000 claims 1
- 102100029492 Glycogen phosphorylase, muscle form Human genes 0.000 claims 1
- 208000028547 Inborn Urea Cycle disease Diseases 0.000 claims 1
- 102100024295 Maltase-glucoamylase Human genes 0.000 claims 1
- 201000002169 Mitochondrial myopathy Diseases 0.000 claims 1
- 108010049717 Muscle Form Glycogen Phosphorylase Proteins 0.000 claims 1
- 102000001105 Phosphofructokinases Human genes 0.000 claims 1
- 108010069341 Phosphofructokinases Proteins 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 108010028144 alpha-Glucosidases Proteins 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
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- 235000013305 food Nutrition 0.000 claims 1
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 1
- 150000001261 hydroxy acids Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 208000023692 inborn mitochondrial myopathy Diseases 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000030954 urea cycle disease Diseases 0.000 claims 1
- 150000004669 very long chain fatty acids Chemical class 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Botany (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fats And Perfumes (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904369P | 2013-11-14 | 2013-11-14 | |
| US61/904,369 | 2013-11-14 | ||
| PCT/US2014/065693 WO2015073816A1 (en) | 2013-11-14 | 2014-11-14 | Solid compositions of triglycerides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2016123169A true RU2016123169A (ru) | 2017-12-19 |
Family
ID=53058066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016123169A RU2016123169A (ru) | 2013-11-14 | 2014-11-14 | Твердые композиции триглицеридов и их применение |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US20160243071A1 (https=) |
| EP (2) | EP3782610A1 (https=) |
| JP (4) | JP2017501972A (https=) |
| KR (1) | KR102291310B1 (https=) |
| CN (2) | CN105764497A (https=) |
| AR (2) | AR099353A1 (https=) |
| AU (1) | AU2014348470B2 (https=) |
| CA (2) | CA2929688C (https=) |
| CL (1) | CL2016001130A1 (https=) |
| ES (1) | ES2833294T3 (https=) |
| IL (1) | IL245588B (https=) |
| MX (2) | MX383005B (https=) |
| MY (1) | MY177028A (https=) |
| PE (1) | PE20161024A1 (https=) |
| PH (1) | PH12016500821A1 (https=) |
| RU (1) | RU2016123169A (https=) |
| TW (1) | TWI640327B (https=) |
| WO (1) | WO2015073816A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105764497A (zh) * | 2013-11-14 | 2016-07-13 | 奥特吉尼克斯制药公司 | 三酸甘油酯的固体组合物及其用途 |
| US20190076383A1 (en) * | 2017-09-08 | 2019-03-14 | Horizon Therapeutics, Llc | Methods for treating urea cycle disorders |
| CA3110724A1 (en) | 2018-08-27 | 2020-03-05 | Exerkine Corporation | Method for treating lysosomal storage disease |
| US11583542B2 (en) | 2019-12-16 | 2023-02-21 | Amylyx Pharmaceuticals, Inc. | Compositions of bile acids and phenylbutyrate compounds |
| CN113476408A (zh) * | 2021-07-23 | 2021-10-08 | 兆科药业（广州）有限公司 | 一种苯丁酸甘油酯颗粒剂及其制备方法与应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3337596A (en) | 1965-02-18 | 1967-08-22 | Procter & Gamble | Synthesis of mixed glycerides |
| JPS5215834A (en) | 1975-07-12 | 1977-02-05 | Ajinomoto Kk | Method of producing food composition |
| US4753963A (en) | 1985-09-26 | 1988-06-28 | The Procter & Gamble Company | Nutritional fat suitable for enteral and parenteral products |
| JPH07102106B2 (ja) | 1987-06-10 | 1995-11-08 | 日清製粉株式会社 | 経口，経管栄養食の製造法 |
| KR100318295B1 (ko) | 1989-07-05 | 2002-11-16 | 가부시키가이샤 저펜에너지 | 냉각윤활제 |
| EP0421581A1 (en) | 1989-10-03 | 1991-04-10 | Warner-Lambert Company | Chewable spray dried spheroidal microcapsules and wax coated microcapsules and methods for preparing same |
| JPH0692848A (ja) | 1992-09-11 | 1994-04-05 | Sagami Chem Res Center | 糖尿病治療用乳剤 |
| JPH06145688A (ja) | 1992-11-10 | 1994-05-27 | Nippon San Sekiyu Kk | 冷凍機用潤滑油組成物 |
| JP2800610B2 (ja) * | 1992-12-15 | 1998-09-21 | 不二製油株式会社 | 水中油型乳化物の製造法 |
| JP3522843B2 (ja) * | 1994-07-29 | 2004-04-26 | 昭和産業株式会社 | リポ製剤 |
| US5746933A (en) | 1994-11-07 | 1998-05-05 | Nippon Oil Co., Ltd. | Lubricating oil and composition for refrigerating machine, and refrigerating machine |
| DE69612755T2 (de) * | 1995-02-07 | 2001-08-23 | Brusilow Enterprises, Llc | Triglyceride und ethylester von phenylalkansäuren und phenylalkensäuren zur behandlung verschiedener erkrankungen |
| US5698210A (en) | 1995-03-17 | 1997-12-16 | Lee County Mosquito Control District | Controlled delivery compositions and processes for treating organisms in a column of water or on land |
| JPH08311480A (ja) * | 1995-05-18 | 1996-11-26 | D H Ee Kodo Seisei Chushutsu Gijutsu Kenkyu Kumiai | 高純度トリアシルグリセロールからなる油脂の製造方法及び高度不飽和脂肪酸含有油脂組成物 |
| JP3391798B2 (ja) | 1995-09-25 | 2003-03-31 | 花王株式会社 | エステル化合物及び潤滑油組成物 |
| US5908631A (en) * | 1997-02-27 | 1999-06-01 | L'oreal S.A. | Monohydric alcohol-free composition for topical use comprising solubilized ethylcellulose |
| US5885616A (en) | 1997-08-18 | 1999-03-23 | Impax Pharmaceuticals, Inc. | Sustained release drug delivery system suitable for oral administration |
| US6278006B1 (en) | 1999-01-19 | 2001-08-21 | Cargill, Incorporated | Transesterified oils |
| WO2000045649A1 (en) * | 1999-02-05 | 2000-08-10 | Baylor University Medical Center | Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid |
| US20030162833A1 (en) | 2001-08-01 | 2003-08-28 | Roe Charles R. | Fatty acid treatment for cardiac patients |
| DE60130083T2 (de) | 2000-10-16 | 2008-05-15 | Nof Corp. | Herstellung von Estern für die Verwendung als Basisschmieröl |
| JP4282289B2 (ja) | 2002-08-29 | 2009-06-17 | 株式会社ジャパンエナジー | 流体軸受用潤滑油及びそれを用いた流体軸受 |
| AU2003261928A1 (en) | 2002-09-05 | 2004-03-29 | The Nisshin Oillio Group, Ltd. | Agents, foods and drinks controlling lipid metabolism |
| US8399515B2 (en) * | 2003-05-20 | 2013-03-19 | Baylor Research Institute | Five and fifteen carbon fatty acids for treating metabolic disorders and as nutritional supplements |
| US20050058673A1 (en) * | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| WO2005120484A1 (ja) | 2004-06-09 | 2005-12-22 | Kurume University | グレリンの生理学的機能のレギュレーター |
| US7141114B2 (en) * | 2004-06-30 | 2006-11-28 | Rec Silicon Inc | Process for producing a crystalline silicon ingot |
| EP1773317A4 (en) | 2004-07-02 | 2012-10-03 | Baylor Res Inst | METHOD OF TREATING OVERLOADING DISEASE DUE TO ACCUMULATION OF GLYCOGENES OR POLYSACCHARIDES |
| WO2006099325A2 (en) | 2005-03-10 | 2006-09-21 | 3M Innovative Properties Company | Methods of treating ear infections |
| BRPI0608691A2 (pt) * | 2005-03-10 | 2010-12-07 | 3M Innovative Properties Company | composição antimicrobiana, e, métodos para matar ou inativar microorganismos em tecido da mucosa de um mamìfero, para tratar uma lesão ou ferimento infectado, para descolonização de microorganismos, para proporcionar eficácia antimicrobiana residual sobre uma superfìcie e para tratar uma condição |
| FR2894822B1 (fr) | 2005-12-20 | 2011-11-18 | Pf Medicament | Composition pharmaceutique contenant des acides gras omega-3 |
| EP1991208A2 (en) | 2006-02-10 | 2008-11-19 | SportsCom Danmark ApS | Coated tablets, their methods of preparation, and related uses |
| JP5099808B2 (ja) | 2006-05-29 | 2012-12-19 | 独立行政法人農業・食品産業技術総合研究機構 | 脂質代謝改善用組成物 |
| CN101730475A (zh) | 2007-05-08 | 2010-06-09 | 帝斯曼知识产权资产管理有限公司 | 体重维持和机体组成 |
| JP5296366B2 (ja) * | 2007-10-29 | 2013-09-25 | 日清オイリオグループ株式会社 | 医薬品用持久力向上剤および持久力向上用医薬品 |
| CA2719246A1 (en) | 2008-03-26 | 2009-10-01 | Taro Pharmaceuticals North America, Inc. | Stabilizing lipid compositions for oral pharmaceutical agents |
| WO2009134460A1 (en) | 2008-04-29 | 2009-11-05 | Hyperion Therapeutics | Methods of treatment using ammonia-scavenging drugs |
| ES2695534T3 (es) | 2008-08-29 | 2019-01-08 | Horizon Therapeutics Llc | Métodos de tratamiento usando fármacos de captación de amoniaco |
| KR20120129898A (ko) | 2009-12-30 | 2012-11-28 | 베일러 리서치 인스티튜트 | 알츠하이머 질환 및 노화 뇌를 위한 보충대사 치료요법 |
| JP2013528648A (ja) * | 2010-06-14 | 2013-07-11 | ベイラー リサーチ インスティテュート | 成人ポリグルコサン小体病（ａｐｂｄ）を処置するためのトリヘプタノイン食 |
| US8932646B2 (en) | 2010-06-18 | 2015-01-13 | Bausch & Lomb Incorporated | Peroxide contact lens care solution |
| CN101919453B (zh) * | 2010-08-16 | 2013-04-10 | 苏州市佳禾食品工业有限公司 | 中碳链脂肪酸粉末油脂及其制备方法 |
| JP5820256B2 (ja) | 2011-02-10 | 2015-11-24 | 株式会社ファンケル | 自己乳化製剤 |
| WO2013012699A2 (en) | 2011-07-15 | 2013-01-24 | 3M Innovative Properties Company | Polyurethane based coating compositions |
| EP3263102A1 (en) | 2011-09-30 | 2018-01-03 | Horizon Therapeutics, LLC | Methods of therapeutic monitoring of nitrogen scavenging drugs |
| JP6080269B2 (ja) | 2012-02-15 | 2017-02-15 | 日清オイリオグループ株式会社 | 飼料用組成物、飼料、及び飼料の製造方法 |
| TWI572352B (zh) * | 2012-03-01 | 2017-03-01 | 波麥堤克藥學Ｓｍｔ有限公司 | 用於製備具中鏈長度之脂肪酸的三酸甘油酯之方法 |
| EP2838522B1 (en) * | 2012-04-16 | 2024-02-21 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Phenylbutyrate for the treatment of medium-chain acyl-coa dehydrogenase deficiency |
| CA2894456C (en) | 2012-12-13 | 2022-06-28 | Baylor Research Institute | Triheptanoin for the treatment of glucose transporter 1 deficiency |
| AU2014296415B2 (en) | 2013-07-31 | 2019-11-21 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of fatty acid metabolism disorders |
| CN105764497A (zh) | 2013-11-14 | 2016-07-13 | 奥特吉尼克斯制药公司 | 三酸甘油酯的固体组合物及其用途 |
| WO2020014428A1 (en) | 2018-07-11 | 2020-01-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Method of treating fatty acid oxidation disorders using omega3/omega6 unsaturated or branched chain fatty acids |
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