JP2017105750A5 - - Google Patents
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- JP2017105750A5 JP2017105750A5 JP2016135602A JP2016135602A JP2017105750A5 JP 2017105750 A5 JP2017105750 A5 JP 2017105750A5 JP 2016135602 A JP2016135602 A JP 2016135602A JP 2016135602 A JP2016135602 A JP 2016135602A JP 2017105750 A5 JP2017105750 A5 JP 2017105750A5
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- JP
- Japan
- Prior art keywords
- substituted
- substituent group
- group
- alkyl
- carbocyclic
- Prior art date
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- 125000001424 substituent group Chemical group 0.000 claims 59
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000002837 carbocyclic group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- -1 carbocyclic alkyl Chemical group 0.000 claims 3
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005195 alkyl amino carbonyloxy group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000004437 phosphorous atom Chemical group 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 claims 1
- 125000005103 alkyl silyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 0 C[C@](COCC1)([N-]N(C=C2)C3=C(*)C2=O)N1C3=O Chemical compound C[C@](COCC1)([N-]N(C=C2)C3=C(*)C2=O)N1C3=O 0.000 description 6
- ACXQROFICZTSKE-UHFFFAOYSA-N Fc1ccc(Cc2ccccc2SC2)c2c1 Chemical compound Fc1ccc(Cc2ccccc2SC2)c2c1 ACXQROFICZTSKE-UHFFFAOYSA-N 0.000 description 5
- SZVMKELHQQKXDC-CUJSYCCXSA-N C[C@@H](COC[C@H]1N([C@@H]2c3ccccc3SCc3cc(F)ccc23)N(C=CC2=O)C3=C2O)N1C3=O Chemical compound C[C@@H](COC[C@H]1N([C@@H]2c3ccccc3SCc3cc(F)ccc23)N(C=CC2=O)C3=C2O)N1C3=O SZVMKELHQQKXDC-CUJSYCCXSA-N 0.000 description 1
- KEAPVRQCXJSAQQ-YADHBBJMSA-N OC(C(C=C1)=O)=C(C(N2[C@H]3CCCC2)=O)N1N3[C@@H]1c(cccc2)c2SCc2cc(F)ccc12 Chemical compound OC(C(C=C1)=O)=C(C(N2[C@H]3CCCC2)=O)N1N3[C@@H]1c(cccc2)c2SCc2cc(F)ccc12 KEAPVRQCXJSAQQ-YADHBBJMSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015090909 | 2015-04-28 | ||
| JP2015090909 | 2015-04-28 | ||
| JP2015236844 | 2015-12-03 | ||
| JP2015236844 | 2015-12-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535247A Division JP5971830B1 (ja) | 2015-04-28 | 2016-04-27 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075767A Division JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017105750A JP2017105750A (ja) | 2017-06-15 |
| JP2017105750A5 true JP2017105750A5 (OSRAM) | 2019-04-25 |
| JP6697209B2 JP6697209B2 (ja) | 2020-05-20 |
Family
ID=57199167
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016135602A Active JP6697209B2 (ja) | 2015-04-28 | 2016-07-08 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
| JP2020075767A Withdrawn JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075767A Withdrawn JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Country Status (36)
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX394421B (es) * | 2015-04-28 | 2025-03-24 | Shionogi & Co | Derivados de piridona policiclica sustituida y profarmaco de los mismos |
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| KR20190018469A (ko) * | 2016-08-10 | 2019-02-22 | 시오노기세야쿠 가부시키가이샤 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
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| WO2019070059A1 (ja) * | 2017-10-06 | 2019-04-11 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体の立体選択的な製造方法 |
| EP3670502A4 (en) * | 2017-10-11 | 2021-01-20 | Daikin Industries, Ltd. | PROCESS FOR THE PRODUCTION OF CYCLIC CARBONATE WITH AN UNSATURATED GROUP, AND NEW CYCLIC CARBONATE |
| TWI795462B (zh) | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
| AU2019210414B2 (en) | 2018-01-17 | 2021-04-01 | Jiangxi Caishi Pharmaceutical Technology Co., Ltd. | Pyridone derivative, composition thereof and application thereof as anti-influenza drug |
| CN109503625A (zh) * | 2018-01-19 | 2019-03-22 | 赵蕾 | 一种多环吡啶酮化合物及其药物组合和用途 |
| US10596171B2 (en) * | 2018-01-22 | 2020-03-24 | Taigen Biotechnology Co., Ltd. | Cap-dependent endonuclease inhibitors |
| CN108440564B (zh) * | 2018-04-11 | 2019-08-06 | 安帝康（无锡）生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
| JP6590436B1 (ja) * | 2018-04-24 | 2019-10-16 | 塩野義製薬株式会社 | 安定性に優れた固形製剤 |
| CA3098006A1 (en) | 2018-04-24 | 2019-10-31 | Shionogi & Co., Ltd. | Solid dosage form having excellent stability |
| CN109956956B (zh) * | 2018-05-15 | 2020-07-07 | 广东东阳光药业有限公司 | 一种并环吡啶酮化合物的制备方法 |
| JP7307412B2 (ja) | 2018-06-27 | 2023-07-12 | 国立大学法人北海道大学 | 多環性カルバモイルピリドン誘導体を含有するアレナウイルス増殖阻害剤 |
| WO2020015669A1 (zh) * | 2018-07-17 | 2020-01-23 | 南京明德新药研发有限公司 | 抗流感病毒三并环衍生物 |
| CN110317211B (zh) * | 2018-07-27 | 2022-05-13 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的多环性吡啶酮化合物及其前药 |
| CN110872247A (zh) * | 2018-08-29 | 2020-03-10 | 上海复星星泰医药科技有限公司 | Xofluza含硫杂环化合物、其中间体及制备方法 |
| ES2937837T3 (es) * | 2018-09-10 | 2023-03-31 | Cocrystal Pharma Inc | Inhibidores de piridopirazina y piridotriazina de la replicación del virus de la gripe |
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| WO2020078401A1 (en) * | 2018-10-17 | 2020-04-23 | Sunshine Lake Pharma Co., Ltd. | Influenza virus replication inhibitor and uses thereof |
| JP2022514645A (ja) * | 2018-12-20 | 2022-02-14 | アイミューン セラピューティクス，インコーポレイテッド | ピーナツ経口免疫療法において投与が欠落した場合の投与スケジュール |
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| US20210069204A1 (en) * | 2019-08-13 | 2021-03-11 | F. Hoffmann-La Roche Ag | Dosage of baloxavir marboxil for pediatric patients |
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| CN115947737B (zh) * | 2022-01-26 | 2023-11-28 | 南京赛弗斯医药科技有限公司 | 一种含硒化合物及其用途 |
| CN117343079B (zh) * | 2022-07-05 | 2024-08-20 | 山东如至生物医药科技有限公司 | 一种新型抗流感病毒化合物及其药物组合物和用途 |
| CN117003766B (zh) * | 2022-10-08 | 2024-02-02 | 石家庄迪斯凯威医药科技有限公司 | 一种抗流感病毒衍生物及其用途 |
| WO2024109707A1 (zh) * | 2022-11-21 | 2024-05-30 | 合肥医工医药股份有限公司 | 稠环吡啶酮衍生物及其制备方法和用途 |
| CN116284046B (zh) * | 2023-02-22 | 2025-11-11 | 山东新华制药股份有限公司 | 巴洛沙韦衍生物及其制备方法和应用 |
| WO2024213129A1 (zh) * | 2023-04-14 | 2024-10-17 | 南京卡文迪许生物工程技术有限公司 | 一种酰乙酯多环化合物及其药物组合物和用途 |
| WO2025073819A2 (en) | 2023-10-05 | 2025-04-10 | F. Hoffmann-La Roche Ag | Process for manufacturing baloxavir marboxil |
| WO2025152855A1 (zh) * | 2024-01-16 | 2025-07-24 | 上海翊石医药科技有限公司 | 用于治疗流感的化合物及其制备方法 |
| CN118561867B (zh) * | 2024-05-27 | 2025-04-18 | 安徽贝克制药股份有限公司 | 一种帽状依赖性核酸内切酶抑制剂及其制备方法和其应用 |
| CN119841849B (zh) * | 2024-09-26 | 2025-08-15 | 浙江大学 | 一种吡啶酮类化合物、合成方法及其应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
| US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
| AU2003211381B9 (en) * | 2002-02-19 | 2009-07-30 | Ono Pharmaceutical Co., Ltd. | Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| US7291733B2 (en) * | 2003-10-10 | 2007-11-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted tricyclic heterocycles and their uses |
| WO2006066414A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
| PL3372281T3 (pl) * | 2005-04-28 | 2021-12-27 | Viiv Healthcare Company | Policykliczne pochodne karbamoilopirydonu o aktywności inhibitorowej wobec integrazy HIV |
| BRPI0617842A2 (pt) | 2005-10-27 | 2011-08-09 | Shionogi & Co | composto ou um sal farmaceuticamente aceitável ou um solvato do mesmo, e, composição farmacêutica |
| TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| PL2444400T3 (pl) | 2009-06-15 | 2018-08-31 | Shionogi & Co., Ltd. | Podstawiona policykliczna pochodna karbamoilopirydonowa |
| JP5766690B2 (ja) * | 2010-04-12 | 2015-08-19 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
| US8987441B2 (en) | 2010-09-24 | 2015-03-24 | Shionogi & Co., Ltd. | Substituted polycyclic carbamoyl pyridone derivative prodrug |
| US8278541B2 (en) * | 2011-01-12 | 2012-10-02 | Trick Percussion Products, Inc. | Drum pedal with optical sensor |
| US8859290B2 (en) | 2011-07-22 | 2014-10-14 | Rutgers, The State University Of New Jersey | Inhibitors of influenza endonuclease activity and tools for their discovery |
| RU2014113230A (ru) * | 2011-10-12 | 2015-11-20 | Шионоги Энд Ко., Лтд. | Полициклическое производное пиридона, обладающее ингибирующей активностью в отношении интегразы |
| US20130102600A1 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| US20130102601A1 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| US20130317021A1 (en) | 2012-05-23 | 2013-11-28 | Savira Pharmaceuticals Gmbh | Heterocyclic pyrimidine carbonic acid derivatives which are useful in the treatment, amelioration or prevention of a viral disease |
| JP2015517555A (ja) | 2012-05-23 | 2015-06-22 | ザヴィラ ファーマシューティカルズ ゲーエムベーハー | ７−オキソ−チアゾロピリジン炭酸誘導体及びウイルス性疾患の治療、改善又は予防におけるその使用 |
| BR112015002516A2 (pt) | 2012-08-06 | 2017-07-04 | European Molecular Biology Laboratory | derivados de ácido carbônico di-hidroxipirimidina e seu uso no tratamento, melhora ou prevenção de doença viral. |
| US9573938B2 (en) | 2012-09-11 | 2017-02-21 | Rutgers, The State University Of New Jersey | Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones |
| US9701638B2 (en) | 2012-11-09 | 2017-07-11 | Rutgers, The State University Of New Jersey | Therapeutic hydroxyquinolones |
| SI3067358T1 (sl) * | 2012-12-21 | 2019-12-31 | Gilead Sciences, Inc. | Policiklične spojine karbamoilpiridona in njihova farmacevtska uporaba |
| KR20150103672A (ko) | 2013-01-08 | 2015-09-11 | 사피라 파르마슈티칼즈 게엠베하 | 나프티리디논 유도체 및 바이러스성 질환의 치료, 개선 또는 예방에서의 이의 용도 |
| HK1211286A1 (en) | 2013-01-08 | 2016-05-20 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| RU2015125570A (ru) | 2013-01-08 | 2017-02-10 | Савира Фармасьютикалз Гмбх | Пиридоновые производные и их применение в лечении, уменьшении интенсивности симптомов или предотвращении вирусного заболевания |
| HK1225382A1 (zh) | 2013-09-12 | 2017-09-08 | Alios Biopharma, Inc. | 噠嗪酮化合物及其用途 |
| PE20160661A1 (es) | 2013-09-12 | 2016-08-05 | Alios Biopharma Inc | Compuesto de azapiridona y sus usos de los mismos |
| CN104016983B (zh) * | 2013-10-08 | 2018-11-02 | 上海创诺制药有限公司 | 吡咯并三嗪类衍生物及其制法和用途 |
| WO2016005331A1 (en) | 2014-07-07 | 2016-01-14 | F. Hoffmann-La Roche Ag | Pyridopyrazine compounds and their use in the treatment, amelioration or prevention of influenza |
| CN107074880A (zh) | 2014-07-07 | 2017-08-18 | 萨维拉制药有限公司 | 二氢吡啶并吡嗪‑1,8‑二酮和它们在治疗、改善或预防病毒疾病中的用途 |
| MX394421B (es) * | 2015-04-28 | 2025-03-24 | Shionogi & Co | Derivados de piridona policiclica sustituida y profarmaco de los mismos |
| US20170081331A1 (en) | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease |
| WO2017072341A1 (en) | 2015-10-30 | 2017-05-04 | F. Hoffmann-La Roche Ag | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| EP3391888B1 (en) * | 2015-12-15 | 2023-09-27 | Shionogi & Co., Ltd. | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| WO2017109088A1 (en) | 2015-12-23 | 2017-06-29 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| JP6806413B2 (ja) | 2016-02-03 | 2021-01-06 | 塩野義製薬株式会社 | 多環性ピリドン誘導体およびそのプロドラッグ |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| WO2017158151A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
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