|
US3361742A
(en)
|
1964-12-07 |
1968-01-02 |
Hoffmann La Roche |
5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides
|
|
US3523941A
(en)
|
1967-03-06 |
1970-08-11 |
Hoffmann La Roche |
Benzodiazepine compounds and process for their preparation
|
|
US3524849A
(en)
|
1967-10-27 |
1970-08-18 |
Hoffmann La Roche |
Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein
|
|
FR2027356A1
(en)
|
1968-12-30 |
1970-09-25 |
Fujisawa Pharmaceutical Co |
Benzodiazepinone antibiotics
|
|
IL33558A
(en)
|
1968-12-30 |
1973-10-25 |
Fujisawa Pharmaceutical Co |
Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production
|
|
JPS4843755B1
(OSRAM)
|
1969-06-26 |
1973-12-20 |
|
|
|
JPS6053033B2
(ja)
|
1976-12-28 |
1985-11-22 |
財団法人微生物化学研究会 |
新制癌抗生物質マゼスラマイシン及びその製造方法
|
|
JPS585916B2
(ja)
|
1977-12-27 |
1983-02-02 |
株式会社ミドリ十字 |
新規ベンゾジアゼピン系化合物
|
|
JPS5615289A
(en)
|
1979-07-17 |
1981-02-14 |
Green Cross Corp:The |
Novel benzodiazepinnbased compound 3
|
|
JPS57131791A
(en)
|
1980-12-31 |
1982-08-14 |
Fujisawa Pharmaceut Co Ltd |
Benzodiazepine derivative and its preparation
|
|
CA1173441A
(en)
|
1981-02-27 |
1984-08-28 |
Hoffmann-La Roche Limited |
Imidazodiazepines
|
|
CA1184175A
(en)
|
1981-02-27 |
1985-03-19 |
Walter Hunkeler |
Imidazodiazepines
|
|
CA1185602A
(en)
|
1981-02-27 |
1985-04-16 |
Emilio Kyburz |
Imidazodiazepines
|
|
JPS58180487A
(ja)
|
1982-04-16 |
1983-10-21 |
Kyowa Hakko Kogyo Co Ltd |
抗生物質dc−81およびその製造法
|
|
US4427588A
(en)
|
1982-11-08 |
1984-01-24 |
Bristol-Myers Company |
Process for conversion of oxotomaymycin to tomaymycin
|
|
US4427587A
(en)
|
1982-11-10 |
1984-01-24 |
Bristol-Myers Company |
Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
|
|
JPS59152329A
(ja)
|
1983-02-17 |
1984-08-31 |
Green Cross Corp:The |
局所障害抑制剤
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
FR2586683B1
(fr)
|
1985-08-29 |
1988-07-01 |
Centre Nat Rech Scient |
Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments
|
|
US5583024A
(en)
|
1985-12-02 |
1996-12-10 |
The Regents Of The University Of California |
Recombinant expression of Coleoptera luciferase
|
|
JP2660201B2
(ja)
|
1988-08-05 |
1997-10-08 |
塩野義製薬株式会社 |
新規ピロロ[1,4]ベンゾジアゼピン誘導体および老人性痴呆薬
|
|
FR2676230B1
(fr)
|
1991-05-07 |
1993-08-27 |
Centre Nat Rech Scient |
Nouveaux derives de pyrrolo [1,4]-benzodiazepines, leur procede de preparation et medicaments les contenant.
|
|
GB9205051D0
(en)
|
1992-03-09 |
1992-04-22 |
Cancer Res Campaign Tech |
Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
|
|
FR2696176B1
(fr)
|
1992-09-28 |
1994-11-10 |
Synthelabo |
Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
GB9316162D0
(en)
|
1993-08-04 |
1993-09-22 |
Zeneca Ltd |
Fungicides
|
|
WO1995024382A1
(en)
*
|
1994-03-10 |
1995-09-14 |
G.D. Searle & Co. |
L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
|
|
JPH08336393A
(ja)
|
1995-04-13 |
1996-12-24 |
Mitsubishi Chem Corp |
光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
|
|
JP4568429B2
(ja)
|
1998-07-08 |
2010-10-27 |
イー インク コーポレイション |
マイクロカプセル化された電気泳動デバイスにおいて改良されたカラーを得る方法
|
|
GB9818732D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collection of compounds
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
DK1413582T3
(da)
|
1998-08-27 |
2006-07-17 |
Spirogen Ltd |
Dimere pyrrolobenzodiazepiner
|
|
GB9818730D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
US6909006B1
(en)
|
1999-08-27 |
2005-06-21 |
Spirogen Limited |
Cyclopropylindole derivatives
|
|
EP1320522B8
(en)
|
2000-09-19 |
2006-02-01 |
Moses Lee |
Compositions and methods of the use thereof achiral analogues of cc-1065 and the duocarmycins
|
|
US6362331B1
(en)
|
2001-03-30 |
2002-03-26 |
Council Of Scientific And Industrial Research |
Process for the preparation of antitumor agents
|
|
EP1401850A1
(en)
|
2001-06-20 |
2004-03-31 |
Nuevolution A/S |
Nucleoside derivatives for library preparation
|
|
US6660856B2
(en)
|
2002-03-08 |
2003-12-09 |
Kaohsiung Medical University |
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
|
|
SI2357006T1
(sl)
|
2002-07-31 |
2016-01-29 |
Seattle Genetics, Inc. |
Konjugati zdravil in njihova uporaba za zdravljenje raka, avtoimunske bolezni ali infekcijske bolezni
|
|
US20040138269A1
(en)
|
2002-10-11 |
2004-07-15 |
Sugen, Inc. |
Substituted pyrroles as kinase inhibitors
|
|
GB0226593D0
(en)
|
2002-11-14 |
2002-12-24 |
Consultants Ltd |
Compounds
|
|
EP1608664B1
(en)
|
2003-03-31 |
2009-01-28 |
Council of Scientific and Industrial Research |
Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines as potential antitumour agents and process thereof
|
|
GB0321295D0
(en)
|
2003-09-11 |
2003-10-15 |
Spirogen Ltd |
Synthesis of protected pyrrolobenzodiazepines
|
|
GB0416511D0
(en)
|
2003-10-22 |
2004-08-25 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
ATE516288T1
(de)
|
2003-10-22 |
2011-07-15 |
Us Gov Health & Human Serv |
Pyrrolobenzodiazepinderivate, zusammensetzungen, die diese enthalten, und damit in zusammenhang stehende verfahren
|
|
BR122018071808B8
(pt)
|
2003-11-06 |
2020-06-30 |
Seattle Genetics Inc |
conjugado
|
|
WO2005079479A2
(en)
|
2004-02-17 |
2005-09-01 |
Absalus, Inc. |
Super-humanized antibodies against respiratory syncytial virus
|
|
AU2005216251B2
(en)
|
2004-02-23 |
2011-03-10 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
GB0404578D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0404574D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Amino acids
|
|
GB0404577D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
ES2398975T3
(es)
|
2004-03-01 |
2013-03-25 |
Spirogen Sàrl |
Derivados de 11-hidroxi-5H-pirrolo[2,1-c][1,4]benzodiazepin-5-ona como intermedios clave para la preparación de pirrolobenzodiazepinas sustituidas en C2
|
|
DE102004010943A1
(de)
|
2004-03-03 |
2005-09-29 |
Degussa Ag |
Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten
|
|
JP5166861B2
(ja)
|
2004-03-09 |
2013-03-21 |
スピロゲン リミティッド |
ピロロベンゾジアゼピン
|
|
FR2869231B1
(fr)
|
2004-04-27 |
2008-03-14 |
Sod Conseils Rech Applic |
Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine
|
|
GB0410725D0
(en)
|
2004-05-13 |
2004-06-16 |
Spirogen Ltd |
Pyrrolobenzodiazepine therapeutic agents
|
|
CN101065151B
(zh)
|
2004-09-23 |
2014-12-10 |
健泰科生物技术公司 |
半胱氨酸改造的抗体和偶联物
|
|
EP1831418A2
(en)
|
2004-12-24 |
2007-09-12 |
Showa Denko Kabushiki Kaisha |
Production method of thermoelectric semiconductor alloy, thermoelectric conversion module and thermoelectric power generating device
|
|
JP5122441B2
(ja)
|
2005-04-19 |
2013-01-16 |
シアトル ジェネティックス, インコーポレイテッド |
ヒト化抗cd70結合剤およびその使用
|
|
SI1879901T1
(sl)
|
2005-04-21 |
2010-04-30 |
Spirogen Ltd |
Pirolobenzodiazepini
|
|
US20070154906A1
(en)
|
2005-10-05 |
2007-07-05 |
Spirogen Ltd. |
Methods to identify therapeutic candidates
|
|
ATE427949T1
(de)
|
2005-10-05 |
2009-04-15 |
Spirogen Ltd |
4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung
|
|
DK1813614T3
(da)
|
2006-01-25 |
2012-01-23 |
Sanofi Sa |
Cytotoksiske midler, der omfatter nye tomaymycinderivater
|
|
ZA200900545B
(en)
|
2006-07-18 |
2010-03-31 |
Sanofi Aventis |
Antagonist antibody against EPHA2 for the treatment of cancer
|
|
WO2008009079A2
(en)
*
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
Substituted pteridines useful for the treatment and prevention of viral infections
|
|
EP1914242A1
(en)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
WO2008050140A2
(en)
|
2006-10-27 |
2008-05-02 |
Spirogen Limited |
Compounds for treatment of parasitic infection
|
|
CA2699837C
(en)
|
2006-12-01 |
2017-06-13 |
Seattle Genetics, Inc. |
Variant target binding agents and uses thereof
|
|
JP2008291207A
(ja)
*
|
2007-04-27 |
2008-12-04 |
Kyowa Hakko Kirin Co Ltd |
塩基性アミノ酸を有するらせん状ポリマー
|
|
JP5290276B2
(ja)
|
2007-05-08 |
2013-09-18 |
ジェネンテック, インコーポレイテッド |
システイン改変抗muc16抗体および抗体−薬物結合体
|
|
SI2019104T1
(sl)
|
2007-07-19 |
2013-12-31 |
Sanofi |
Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
|
|
GB0716799D0
(en)
|
2007-08-31 |
2007-10-10 |
Univ Kent Canterbury |
Improvements in or relating to radio-labelled peptides
|
|
CN101835803B
(zh)
|
2007-10-19 |
2016-05-25 |
健泰科生物技术公司 |
半胱氨酸改造的抗tenb2抗体和抗体药物偶联物
|
|
GB0722087D0
(en)
|
2007-11-09 |
2007-12-19 |
Spirogen Ltd |
Polyamides
|
|
GB0722088D0
(en)
|
2007-11-09 |
2007-12-19 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
CA2718942A1
(en)
|
2008-03-18 |
2009-09-24 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
GB0813432D0
(en)
|
2008-07-22 |
2008-08-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819095D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819097D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
US20110077365A1
(en)
*
|
2008-12-29 |
2011-03-31 |
Gilbert Yu |
Preparation of organosilicon-containing triazoles
|
|
EP3100745B1
(en)
|
2009-02-05 |
2018-04-18 |
Immunogen, Inc. |
Novel benzodiazepine derivatives
|
|
CN101492494A
(zh)
|
2009-03-05 |
2009-07-29 |
浙江大学 |
整合素配体环肽类似物及其环化方法
|
|
FR2949469A1
(fr)
|
2009-08-25 |
2011-03-04 |
Sanofi Aventis |
Derives anticancereux, leur preparation et leur application en therapeutique
|
|
ES2651690T3
(es)
*
|
2009-09-16 |
2018-01-29 |
Astellas Pharma Inc. |
Compuesto de glicina
|
|
JP2013505944A
(ja)
|
2009-09-24 |
2013-02-21 |
シアトル ジェネティックス, インコーポレイテッド |
Dr5リガンド薬物結合体
|
|
EP2534158B1
(en)
|
2010-02-09 |
2014-01-08 |
Bristol-Myers Squibb Company |
Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
|
|
BR112012026213B1
(pt)
|
2010-04-15 |
2021-12-28 |
Medimmune Limited |
Compostos de pirrolobenzodiazepinas, conjugado das mesmas, composição farmacêutica compreendendo o conjugado e uso do mesmo para o tratamento de uma doença proliferativa
|
|
MX368648B
(es)
|
2010-04-15 |
2019-10-09 |
Seattle Genetics Inc |
Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
|
|
WO2011130615A2
(en)
|
2010-04-15 |
2011-10-20 |
Dr. Reddy's Laboratories Ltd. |
Preparation of lacosamide
|
|
GB201006340D0
(en)
|
2010-04-15 |
2010-06-02 |
Spirogen Ltd |
Synthesis method and intermediates
|
|
NZ602932A
(en)
|
2010-04-15 |
2014-08-29 |
Seattle Genetics Inc |
Targeted pyrrolobenzodiazapine conjugates
|
|
EP2673281B1
(en)
*
|
2011-02-07 |
2016-04-13 |
Rempex Pharmaceuticals, Inc. |
Boron containing polybasic bacterial efflux pump inhibitors and therapeutics uses thereof
|
|
EP2675479B1
(en)
|
2011-02-15 |
2016-01-13 |
Immunogen, Inc. |
Cytotoxic benzodiazepine derivatives
|
|
MX341524B
(es)
*
|
2011-09-20 |
2016-08-24 |
Medimmune Ltd |
Pirrolobenzodiazepinas como compuestos pbd dimericos asimetricos para inclusion en conjugados dirigidos.
|
|
KR101891859B1
(ko)
|
2011-10-14 |
2018-08-24 |
메디뮨 리미티드 |
피롤로벤조디아제핀
|
|
AU2012322613B2
(en)
|
2011-10-14 |
2016-04-21 |
Medimmune Limited |
Pyrrolobenzodiazepines and targeted conjugates
|
|
SG11201401406YA
(en)
|
2011-10-14 |
2014-05-29 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
EA029046B1
(ru)
|
2011-10-14 |
2018-02-28 |
Медимьюн Лимитед |
Пирролобензодиазепины и промежуточные соединения для их получения, способы их синтеза
|
|
EP2751110B1
(en)
|
2011-10-14 |
2017-04-19 |
MedImmune Limited |
Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative and autoimmune diseases
|
|
AU2013221448B2
(en)
*
|
2012-02-16 |
2017-02-23 |
The University Of Toledo |
Xenoantigen-displaying anti-cancer vaccines and method of making
|
|
FR2989085A1
(fr)
*
|
2012-04-05 |
2013-10-11 |
Commissariat Energie Atomique |
Radiotraceurs, procedes de preparation et applications
|
|
AU2013255613B2
(en)
|
2012-04-30 |
2017-06-22 |
Medimmune Limited |
Pyrrolobenzodiazepines
|
|
CN104540827B
(zh)
|
2012-04-30 |
2018-03-23 |
Ucl商业有限公司 |
吡咯并苯并二氮杂卓
|
|
AU2013288930A1
(en)
|
2012-07-09 |
2014-12-04 |
Genentech, Inc. |
Immunoconjugates comprising anti-CD79b antibodies
|
|
SG11201500087VA
(en)
|
2012-07-09 |
2015-02-27 |
Genentech Inc |
Immunoconjugates comprising anti-cd22 antibodies
|
|
KR20150039818A
(ko)
|
2012-08-02 |
2015-04-13 |
제넨테크, 인크. |
항-etbr 항체 및 면역접합체
|
|
SMT201800346T1
(it)
|
2012-10-12 |
2018-09-13 |
Medimmune Ltd |
Coniugati pirrolobenzodiazepina-anticorpo
|
|
HRP20171264T1
(hr)
|
2012-10-12 |
2017-10-20 |
Adc Therapeutics Sa |
Konjugati protutijela anti-her2-pirolobenzodiazepina
|
|
EP2906250B1
(en)
|
2012-10-12 |
2018-05-30 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-anti-psma antibody conjugates
|
|
PT2906298T
(pt)
|
2012-10-12 |
2018-12-28 |
Medimmune Ltd |
Conjugados de pirrolobenzodiazepina-anticorpos
|
|
WO2014057122A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
|
|
WO2014057074A1
(en)
|
2012-10-12 |
2014-04-17 |
Spirogen Sàrl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
ES2713164T3
(es)
|
2012-10-12 |
2019-05-20 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas
|
|
US10695433B2
(en)
|
2012-10-12 |
2020-06-30 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
WO2014057118A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sarl |
Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
|
|
EP2906249B1
(en)
|
2012-10-12 |
2018-06-27 |
MedImmune Limited |
Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
|
|
SI2906253T1
(sl)
|
2012-10-12 |
2018-11-30 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin-protitelo proti PSMA
|
|
JP6307519B2
(ja)
|
2012-12-21 |
2018-04-04 |
メドイミューン・リミテッドMedImmune Limited |
ピロロベンゾジアゼピンおよびその結合体
|
|
CN110627797A
(zh)
|
2012-12-21 |
2019-12-31 |
麦迪穆有限责任公司 |
用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
|
|
ES2731681T3
(es)
|
2013-02-22 |
2019-11-18 |
Abbvie Stemcentrx Llc |
Conjugados de anticuerpo anti-DLL3 y PBD y usos de los mismos
|
|
JP6340019B2
(ja)
|
2013-03-13 |
2018-06-06 |
メドイミューン・リミテッドMedImmune Limited |
ピロロベンゾジアゼピン及びそのコンジュゲート
|
|
AU2014230735B2
(en)
|
2013-03-13 |
2018-03-15 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EP2968596B1
(en)
|
2013-03-13 |
2019-03-06 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2014174111A1
(en)
|
2013-04-26 |
2014-10-30 |
Pierre Fabre Medicament |
Axl antibody-drug conjugate and its use for the treatment of cancer
|
|
US10010624B2
(en)
|
2013-10-11 |
2018-07-03 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
US20160256561A1
(en)
|
2013-10-11 |
2016-09-08 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
EP3054985B1
(en)
|
2013-10-11 |
2018-12-26 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
WO2015052535A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
GB201317981D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
HK1222577A1
(zh)
|
2013-12-16 |
2017-07-07 |
Genentech Inc. |
擬肽化合物及其抗體藥物偶聯物
|
|
GB201406767D0
(en)
|
2014-04-15 |
2014-05-28 |
Cancer Rec Tech Ltd |
Humanized anti-Tn-MUC1 antibodies anf their conjugates
|