JP2016519569A5 - - Google Patents

Download PDF

Info

Publication number
JP2016519569A5
JP2016519569A5 JP2016503199A JP2016503199A JP2016519569A5 JP 2016519569 A5 JP2016519569 A5 JP 2016519569A5 JP 2016503199 A JP2016503199 A JP 2016503199A JP 2016503199 A JP2016503199 A JP 2016503199A JP 2016519569 A5 JP2016519569 A5 JP 2016519569A5
Authority
JP
Japan
Prior art keywords
hrs
fusion polypeptide
therapeutic composition
item
region fusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016503199A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016519569A (ja
JP6397479B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/029699 external-priority patent/WO2014145050A1/en
Publication of JP2016519569A publication Critical patent/JP2016519569A/ja
Publication of JP2016519569A5 publication Critical patent/JP2016519569A5/ja
Application granted granted Critical
Publication of JP6397479B2 publication Critical patent/JP6397479B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016503199A 2013-03-15 2014-03-14 ヒスチジル−tRNAシンテターゼFcコンジュゲート Active JP6397479B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361789011P 2013-03-15 2013-03-15
US61/789,011 2013-03-15
PCT/US2014/029699 WO2014145050A1 (en) 2013-03-15 2014-03-14 Histidyl-trna synthetase-fc conjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018163396A Division JP6687692B2 (ja) 2013-03-15 2018-08-31 ヒスチジル−tRNAシンテターゼFcコンジュゲート

Publications (3)

Publication Number Publication Date
JP2016519569A JP2016519569A (ja) 2016-07-07
JP2016519569A5 true JP2016519569A5 (cg-RX-API-DMAC7.html) 2017-03-23
JP6397479B2 JP6397479B2 (ja) 2018-09-26

Family

ID=50877652

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2016503199A Active JP6397479B2 (ja) 2013-03-15 2014-03-14 ヒスチジル−tRNAシンテターゼFcコンジュゲート
JP2018163396A Active JP6687692B2 (ja) 2013-03-15 2018-08-31 ヒスチジル−tRNAシンテターゼFcコンジュゲート
JP2020066585A Withdrawn JP2020141673A (ja) 2013-03-15 2020-04-02 ヒスチジル−tRNAシンテターゼFcコンジュゲート
JP2022062451A Pending JP2022104983A (ja) 2013-03-15 2022-04-04 ヒスチジル-tRNAシンテターゼFcコンジュゲート
JP2024175280A Pending JP2025004141A (ja) 2013-03-15 2024-10-04 ヒスチジル-tRNAシンテターゼFcコンジュゲート

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2018163396A Active JP6687692B2 (ja) 2013-03-15 2018-08-31 ヒスチジル−tRNAシンテターゼFcコンジュゲート
JP2020066585A Withdrawn JP2020141673A (ja) 2013-03-15 2020-04-02 ヒスチジル−tRNAシンテターゼFcコンジュゲート
JP2022062451A Pending JP2022104983A (ja) 2013-03-15 2022-04-04 ヒスチジル-tRNAシンテターゼFcコンジュゲート
JP2024175280A Pending JP2025004141A (ja) 2013-03-15 2024-10-04 ヒスチジル-tRNAシンテターゼFcコンジュゲート

Country Status (9)

Country Link
US (6) US9587235B2 (cg-RX-API-DMAC7.html)
EP (2) EP3460054B1 (cg-RX-API-DMAC7.html)
JP (5) JP6397479B2 (cg-RX-API-DMAC7.html)
CN (2) CN114717206A (cg-RX-API-DMAC7.html)
AU (1) AU2014233436B2 (cg-RX-API-DMAC7.html)
CA (1) CA2907046C (cg-RX-API-DMAC7.html)
DK (2) DK2970921T3 (cg-RX-API-DMAC7.html)
ES (2) ES2708565T3 (cg-RX-API-DMAC7.html)
WO (1) WO2014145050A1 (cg-RX-API-DMAC7.html)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2403864B1 (en) 2009-02-27 2015-08-12 Atyr Pharma, Inc. Polypeptide structural motifs associated with cell signaling activity
AU2010226726B8 (en) 2009-03-16 2014-08-14 Pangu Biopharma Limited Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
CN103096910A (zh) 2010-04-27 2013-05-08 Atyr医药公司 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2013022982A2 (en) 2011-08-09 2013-02-14 Atyr Pharma, Inc. Pegylated tyrosyl-trna synthetase polypeptides
US9816084B2 (en) 2011-12-06 2017-11-14 Atyr Pharma, Inc. Aspartyl-tRNA synthetases
WO2013086228A1 (en) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Pegylated aspartyl-trna synthetase polypeptides
EP2797959A4 (en) 2011-12-29 2015-08-26 Atyr Pharma Inc ASPARTYL-tRNA synthetase FC CONJUGATES
DK2970921T3 (en) 2013-03-15 2019-01-14 Atyr Pharma Inc Histidyl-tRNA synthetase-Fc conjugates
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CA3176123A1 (en) 2015-05-19 2016-11-24 Yale University Compositions for treating pathological calcification conditions, and methods using same
EA039859B1 (ru) * 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
JP2018537093A (ja) 2015-11-20 2018-12-20 イエール ユニバーシティ 異所性石灰化障害を治療するための組成物およびそれを使用する方法
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
CN109311949B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 储存分离基质的方法
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
US11753438B2 (en) 2016-05-11 2023-09-12 Cytiva Bioprocess R&D Ab Method of cleaning and/or sanitizing a separation matrix
EP3455243B1 (en) 2016-05-11 2021-03-24 Cytiva BioProcess R&D AB Separation matrix
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
TW201825118A (zh) * 2016-11-30 2018-07-16 美商艾堤爾製藥公司 抗-hrs抗體及用於治療癌症之組合療法
WO2018195338A1 (en) * 2017-04-20 2018-10-25 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
WO2019067502A1 (en) 2017-09-27 2019-04-04 Alexion Pharmaceuticals, Inc. METHODS FOR IMPROVING CARDIOVASCULAR FUNCTION AND TREATING CARDIOVASCULAR DISEASE USING RECOMBINANT ECTO-NUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE
CA3099266A1 (en) 2018-05-08 2019-11-14 Yale University Compositions and methods for reducing progression of nephrolithiasis
JP7490925B2 (ja) * 2018-07-26 2024-05-28 エータイアー ファーマ, インコーポレイテッド Nrp2関連疾患を治療するための組成物および方法
CN112930397B (zh) 2018-08-31 2025-05-09 耶鲁大学 Enpp1多肽及其使用方法
BR112021008908A2 (pt) * 2018-11-07 2021-08-17 Daiichi Sankyo Company, Limited método para melhorar a cinética do peptídeo no sangue
CN111458396B (zh) * 2019-01-18 2022-07-08 成都康弘生物科技有限公司 一种蛋白的电荷异质性检测方法
MX2021012197A (es) * 2019-04-05 2022-01-06 Univ Yale Polipeptidos de ectonucleotido pirofosfatasa (enpp1) y metodos de uso de los mismos.
CN110205302B (zh) * 2019-06-24 2021-03-23 扬州大学 一株分泌抗麦考酚酸单克隆抗体的细胞株、其单克隆抗体及其应用
AU2020358854A1 (en) 2019-10-03 2022-05-26 Atyr Pharma, Inc. Compositions and methods comprising anti-NRP2 antibodies
EP4065599A4 (en) * 2019-11-26 2023-11-01 Cedars-Sinai Medical Center COMPOSITIONS AND METHODS FOR TREATING DISEASES AND HEALTH CONDITIONS BY MITOCHONDRIAL OR GENOMIC CIRCULATION DNA DEPLETION
CN111218502B (zh) * 2020-04-23 2020-07-21 圣湘生物科技股份有限公司 提升qPCR检测性能的组合物、反应液、用途及方法
US11788074B2 (en) 2020-06-23 2023-10-17 New England Biolabs, Inc. Vaccinia capping enzyme compositions and methods
ES2936277B2 (es) 2020-07-20 2025-05-19 Enanta Pharm Inc Peptidos funcionalizados como agentes antivirales
CN111826334A (zh) * 2020-07-24 2020-10-27 暨南大学 一种超长大肠杆菌及其制备方法与应用
JP7463910B2 (ja) 2020-08-25 2024-04-09 株式会社Jvcケンウッド ドライブレコーダ、ドライブレコーダの制御方法、及び、撮影制御プログラム
US11384090B2 (en) 2020-11-23 2022-07-12 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11352363B1 (en) 2020-11-23 2022-06-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
CA3202764A1 (en) 2020-11-23 2022-05-27 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US11319325B1 (en) 2021-05-11 2022-05-03 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
US11325916B1 (en) 2021-07-29 2022-05-10 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11339170B1 (en) 2021-07-23 2022-05-24 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US12479854B2 (en) 2021-07-29 2025-11-25 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2023086352A1 (en) 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US11919910B2 (en) 2021-11-12 2024-03-05 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2023086350A1 (en) 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Alkyne-containing antiviral agents
US12145942B2 (en) 2022-04-05 2024-11-19 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2025137268A1 (en) 2023-12-20 2025-06-26 Pacific Biosciences Of California, Inc. Methods and compositions for reducing gc bias

Family Cites Families (284)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
KR830002802B1 (ko) 1978-12-04 1983-12-16 제임스 에프 · 너우톤 박테리아 발효에 의한 다당류 s-60의 제조방법
US4326053A (en) 1978-12-04 1982-04-20 Merck & Co., Inc. Polysaccharide S-60 and bacterial fermentation process for its preparation
JPS5590540A (en) 1978-12-28 1980-07-09 Daihachi Kagaku Kogyosho:Kk Cross-linkable vinyl chloride paste resin composition
US5155214A (en) 1984-03-05 1992-10-13 The Salk Institute For Biological Studies Basic fibroblast growth factor
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
DE3883899T3 (de) 1987-03-18 1999-04-22 Sb2, Inc., Danville, Calif. Geänderte antikörper.
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
US4865841A (en) 1987-10-23 1989-09-12 Imre Corporation Methods and compositions for transient elimination of humoral immune antibodies
US4888354A (en) 1987-12-21 1989-12-19 Theratech, Inc. Skin penetration enhancement using free base and acid addition salt combinations of active agents
US6018026A (en) 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5725871A (en) 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
ATE131872T1 (de) 1989-11-22 1996-01-15 Genentech Inc Latenz assoziierte peptide und deren verwendung
US5716632A (en) * 1989-11-22 1998-02-10 Margolin; Solomon B. Compositions and methods for reparation and prevention of fibrotic lesions
US5556645A (en) 1990-01-12 1996-09-17 Bockman; Richard Methods of enhancing wound healing and tissue repair
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
SE9100142L (sv) 1991-01-17 1992-07-18 Bengt Sandberg En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal
US5981606A (en) 1991-03-01 1999-11-09 Warner-Lambert Company Therapeutic TGF-beta-wound healing compositions and methods for preparing and using same
US5149691A (en) 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
US5756353A (en) 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
DE9115660U1 (de) 1991-12-18 1992-07-30 Aventis Research & Technologies GmbH & Co KG, 65929 Frankfurt L-Phenylalanyl-tRNA-Synthetase mit erweiterter Substratselektivität aus Mikroorganismen
ES2105262T3 (es) 1992-05-18 1997-10-16 Minnesota Mining & Mfg Dispositivo de suministro de farmaco a traves de las mucosas.
US5977079A (en) 1992-08-21 1999-11-02 Alberta Research Council Edmonton Compositions for attenuating antibody- mediated xenograft rejection in human recipients
US5484703A (en) 1993-04-22 1996-01-16 United States Of America Assay using recombinant histidyl-tRNA synthetase
US5665066A (en) 1993-09-03 1997-09-09 Ultradent Products, Inc. Methods and apparatus for mixing and dispensing multi-part compositions
US5641867A (en) 1993-09-29 1997-06-24 The Trustees Of Columbia University In The City Of New York Antibody which specifically binds to endothelial-monocyte activating polypeptide II
US5420109A (en) 1993-11-12 1995-05-30 Houghten Pharmaceuticals, Inc. Cytokine restraining agents
DE69534187T2 (de) 1994-05-13 2005-11-17 Miltenyi Biotec Gmbh Sterile und pyrogenfreie säulen, gekoppelt mit einem protein, zum binden und entfernen von substanzen aus dem blut
US5759833A (en) 1994-05-27 1998-06-02 Cubist Pharmaceuticals, Inc. Human isoleucyl-tRNA synthetase proteins, nucleic acids and tester strains comprising same
US5756327A (en) 1994-09-13 1998-05-26 Cubist Pharmaceuticals, Inc. Recombinant mycobacterial isoleucyl-tRNA synthetase genes, tester strains and assays
US5798240A (en) 1994-09-13 1998-08-25 Cubist Pharmaceuticals, Inc. Recombinant mycobacterial methionyl-tRNA synthetase genes and methods of use therefore
US5801013A (en) 1995-05-26 1998-09-01 Cubist Pharmaceuticals, Inc. Helicobacter aminoacyl-tRNA synthetase proteins, nucleic acids and strains comprising same
CA2212992A1 (en) 1995-06-05 1996-12-12 Human Genome Sciences, Inc. Fibroblast growth factor-14
US6013483A (en) 1995-06-07 2000-01-11 Human Genome Sciences, Inc. DNA encoding endothelial monocyte activating polypeptide III
NZ330887A (en) 1996-01-11 2001-01-26 Corixa Corp Monoclonals and polyclonals antibodies for the diagnosis of breast cancer
EP0785264A1 (en) 1996-01-19 1997-07-23 Smithkline Beecham Plc Lencyl t-RNA synthetase of Staphylococcus aureus
EP1288298A3 (en) 1996-01-19 2003-03-12 Smithkline Beecham Plc TRNA synthetase from Staphylococcus aureus
US5795757A (en) 1997-01-17 1998-08-18 Smithkline Beecham, P.L.C. DNA encoding threonyl tRNA synthetase from staphylococcus aureus
GB9601067D0 (en) 1996-01-19 1996-03-20 Smithkline Beecham Plc Novel compounds
GB9607993D0 (en) 1996-04-18 1996-06-19 Smithkline Beecham Plc Novel compounds
US5795758A (en) 1997-04-18 1998-08-18 Smithkline Beecham Corporation DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae
GB9607991D0 (en) 1996-04-18 1996-06-19 Smithkline Beecham Plc Novel compounds
KR100203919B1 (ko) 1996-10-04 1999-06-15 신동권 수용성 단백질을 생산하는 새로운 발현 플라스미드
US5885815A (en) 1996-11-01 1999-03-23 Cubist Pharmaceuticals, Inc. Candida isoleucyl-tRNA synthetase proteins, nucleic acids and strains comprising same
US5776749A (en) 1997-01-17 1998-07-07 Smithkline Beecham P.L.C. DNA encoding cysteinyl tRNA synthetase from Staphylococcus aureus
AU735444B2 (en) 1997-05-06 2001-07-05 Human Genome Sciences, Inc. (Enterococcus faecalis) polynucleotides and polypeptides
US5858720A (en) 1997-07-23 1999-01-12 Smithkline Beecham Corporation Hiss
US5939298A (en) 1997-07-23 1999-08-17 Smithkline Beecham Corporation DNA encoding phenylalanyl tRNA synthetase alpha sub-unit from chlamydi a trachomatis
US5882892A (en) 1997-07-23 1999-03-16 Smithkline Beecham Corporation Asps
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
EP1037981A1 (en) 1997-12-09 2000-09-27 Children's Medical Center Corporation Soluble inhibitors of vascular endothelial growth factor and use thereof
AU1810499A (en) 1997-12-09 1999-06-28 Children's Medical Center Corporation Antagonists of neuropilin receptor functional and use thereof
CN1292033A (zh) 1998-03-04 2001-04-18 昂尼克斯药物公司 用于遗传物质高通量表达的杆状病毒表达系统和方法
US6428960B1 (en) 1998-03-04 2002-08-06 Onyx Pharmaceuticals, Inc. Selection method for producing recombinant baculovirus
US6255090B1 (en) 1998-07-15 2001-07-03 E. I. Du Pont De Nemours & Company Plant aminoacyl-tRNA synthetase
US6271441B1 (en) 1998-07-21 2001-08-07 E. I. Du Pont De Nemours & Company Plant aminoacyl-tRNA synthetase
US6800286B1 (en) 1998-08-19 2004-10-05 The Regents Of The University Of Colorado Chimeric fibroblast growth factor proteins, nucleic acid molecules, and uses thereof
US6696619B1 (en) 1998-11-05 2004-02-24 Omolayo O. Famodu Plant aminoacyl-tRNA synthetases
WO2000029620A1 (en) 1998-11-13 2000-05-25 Children's Hospital Of Los Angeles Methods of facilitating vascular growth
PL220113B1 (pl) 1999-01-15 2015-08-31 Genentech Inc Wariant macierzystego polipeptydu zawierającego region Fc, polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania receptora Fc gamma (FcγR), polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania noworodkowego receptora Fc (FcRn), kompozycja, wyizolowany kwas nukleinowy, wektor, komórka gospodarza, sposób otrzymywania wariantu polipeptydu, zastosowanie wariantu polipeptydu i sposób otrzymywania wariantu regionu Fc
AU3395900A (en) 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
JP2003518364A (ja) 1999-05-28 2003-06-10 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 乳癌、胃癌および前立腺癌関連抗原ならびにそれらの使用
WO2001007628A2 (en) 1999-07-22 2001-02-01 Incyte Genomics, Inc. Human synthetases
WO2001019999A1 (en) 1999-09-14 2001-03-22 Shanghai Biorigin Gene Development Co. Ltd. A GENE ENCODING A NOVEL THREONYL-tRNA SYNTHETASE, ITS USES AND THE PREPARING METHODS
US6548060B1 (en) 1999-11-18 2003-04-15 Sunghoon Kim Anti-apoptotic use of human glutaminyl-tRNA synthetase with two consecutive pro-apoptotic mediators
US20030165921A1 (en) 2000-02-03 2003-09-04 Tang Y. Tom Novel nucleic acids and polypeptides
AU2001234944A1 (en) 2000-02-03 2001-08-14 Hyseq, Inc. Novel nucleic acids and polypeptides
US20030158400A1 (en) 2000-02-03 2003-08-21 Tang Y. Tom Novel nucleic acids and polypeptides
US20020128187A1 (en) 2000-02-03 2002-09-12 Tang Y. Tom Novel nucleic acids and polypeptides
US20070042392A1 (en) 2000-02-03 2007-02-22 Nuvelo, Inc. Novel nucleic acids and polypeptides
CN1311300A (zh) 2000-03-02 2001-09-05 上海博德基因开发有限公司 一种新的多肽-人苏氨酰-tRNA合成酶14和编码这种多肽的多核苷酸
DE10011482B4 (de) 2000-03-09 2004-06-09 Fresenius Hemocare Gmbh Verfahren zum Herstellen eines Adsorbens zum Absenken der Konzentration von Fibrinogen und/oder Fibrin, Adsorbens und Verwendung des Adsorbens zur Herstellung eines Adsorbers
CN1314486A (zh) 2000-03-17 2001-09-26 上海博德基因开发有限公司 一种新的多肽——人组氨酰-tRNA合成酶85和编码这种多肽的多核苷酸
EP2258834B1 (en) 2000-03-31 2015-09-23 The Scripps Research Institute Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
US7273844B2 (en) 2000-03-31 2007-09-25 The Scripps Research Institute Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
US7144984B2 (en) 2000-03-31 2006-12-05 The Scripps Research Institute Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
CN1322818A (zh) 2000-05-09 2001-11-21 上海博德基因开发有限公司 一种新的多肽——人II类氨酰基-tRNA合成酶10和编码这种多肽的多核苷酸
US20040181830A1 (en) 2001-05-07 2004-09-16 Kovalic David K. Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
AU2001256780A1 (en) 2000-05-18 2001-11-26 Nihon University, School Juridical Person Method for examining ischemic conditions
JP2004510407A (ja) 2000-05-25 2004-04-08 インサイト・ゲノミックス・インコーポレイテッド アミノアシルtRNA合成酵素
AU5114000A (en) 2000-06-14 2001-12-24 Imagene Co., Ltd. P43 anti-tumor therapeutic agent and three dimensional structure of its cytokinedomain
CN1331293A (zh) 2000-06-28 2002-01-16 上海博德基因开发有限公司 一种新的多肽——组氨酸tRNA合成酶11.99和编码这种多肽的多核苷酸
MXPA03000105A (es) 2000-06-28 2004-09-13 Glycofi Inc Metodo para producir glicoproteinas modificadas.
CN1341727A (zh) 2000-09-07 2002-03-27 上海博德基因开发有限公司 一种新的多肽——甲硫氨酰tRNA合成酶35.09和编码这种多肽的多核苷酸
CN1341725A (zh) 2000-09-07 2002-03-27 上海博德基因开发有限公司 一种新的多肽——人苏氨酰-tRNA合成酶48.73和编码这种多肽的多核苷酸
US6812339B1 (en) 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US20070037165A1 (en) 2000-09-08 2007-02-15 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
CN1352242A (zh) 2000-11-02 2002-06-05 上海博德基因开发有限公司 一种新的多肽——人谷氨酰tRNA合成酶12.65和编码这种多肽的多核苷酸
CN1352252A (zh) 2000-11-06 2002-06-05 上海博德基因开发有限公司 一种新的多肽——人II类氨酰基-tRNA合成酶11.77和编码这种多肽的多核苷酸
WO2002044349A2 (en) 2000-11-28 2002-06-06 Mcgill University INCORPORATION AND PRIMING FUNCTION OF tRNALYS IN HIV AND RELATED VIRUSES
PT1355919E (pt) 2000-12-12 2011-03-02 Medimmune Llc Moléculas com semivida longa, composições que as contêm e suas utilizações
WO2002059323A2 (en) 2000-12-15 2002-08-01 Incyte Genomics, Inc. Aminoacyl trna synthetases
AU2002255478A1 (en) 2001-01-10 2002-09-12 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof
AU2002245257A1 (en) 2001-01-12 2002-07-24 Exelixis, Inc. Srebp pathway modulation through targeting hisrs
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US6743619B1 (en) 2001-01-30 2004-06-01 Nuvelo Nucleic acids and polypeptides
WO2002067970A1 (en) 2001-02-23 2002-09-06 The Scripps Research Institute TRYPTOPHANYL-tRNA SYNTHETASE DERIVED POLYPEPTIDES USEFUL FOR THE REGULATION OF ANGIOGENESIS
US6903189B2 (en) 2001-03-21 2005-06-07 The Scripps Research Institute Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
US7083970B2 (en) 2001-04-19 2006-08-01 The Scripps Research Institute Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
US20030215827A1 (en) 2001-05-22 2003-11-20 Henry Yue Aminoacyl trna synthetases
KR100405919B1 (ko) 2001-06-05 2003-11-14 주식회사 이매진 p43의 N-말단 펩타이드를 유효성분으로 하는 면역증강용 약학조성물
US20040018505A1 (en) 2001-06-29 2004-01-29 Lee Ernestine A. Aminoacyl trna synthetases
WO2003009813A2 (en) 2001-07-26 2003-02-06 Novartis Ag Methods of treating neuropilin-mediated diseases
US6900292B2 (en) 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US7785827B2 (en) 2001-09-20 2010-08-31 University Of Houston System Method and composition for leucyl-tRNA synthetases and derivatives thereof that activate and aminoacylate non-leucine amino acid to tRNA adaptor molecules
JP2005532253A (ja) 2001-10-25 2005-10-27 ジェネンテック・インコーポレーテッド 糖タンパク質組成物
US20040048290A1 (en) 2001-12-13 2004-03-11 Lee Ernestine A Aminoacyl trna synthetases
EP1455813B1 (en) 2001-12-18 2015-07-15 mondoBIOTECH AG Interferon gamma in combination with a diagnostic array for use in the improved treatment of idiopathic pulmonary fibrosis
US20040101879A1 (en) 2002-01-11 2004-05-27 Cynthia Seidel-Dugan Srebp pathway modulation through targeting hisrs
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
EP1490113A4 (en) 2002-03-20 2007-05-02 Univ Florida RAAV VECTOR COMPOSITIONS AND METHOD FOR TREATING CHOROIDAL NEOVASCULARIZATION
AU2003236018A1 (en) 2002-04-09 2003-10-20 Kyowa Hakko Kirin Co., Ltd. METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcGamma RECEPTOR IIIa
WO2003094848A2 (en) 2002-05-10 2003-11-20 Incyte Corporation Nucleic acid-associated proteins
WO2003094862A2 (en) 2002-05-13 2003-11-20 Rigel Pharmaceuticals, Inc. tRNA SYNTHASE: MODULATORS OF ANGIOGENESIS
KR100515016B1 (ko) 2002-07-22 2005-09-15 재단법인서울대학교산학협력재단 p43을 유효성분으로 하는 창상 치료용 약학적 조성물
EP1534335B9 (en) 2002-08-14 2016-01-13 Macrogenics, Inc. Fcgammariib-specific antibodies and methods of use thereof
US20090017023A1 (en) 2002-08-14 2009-01-15 Macrogenics, Inc. FcGammaRIIB Specific Antibodies and Methods of Use Thereof
WO2004022736A1 (ja) 2002-08-30 2004-03-18 Japan Science And Technology Corporation 遺伝子のターゲティング破壊法および超耐熱菌ゲノム、ならびにこれらを利用したゲノムチップ
DK1534830T3 (da) 2002-09-06 2011-02-14 Isogenica Ltd In vito-peptid-ekspressionsbibliotek
AU2003289716A1 (en) 2002-09-12 2004-04-30 Incyte Corporation Molecules for diagnostics and therapeutics
WO2004030615A2 (en) 2002-10-02 2004-04-15 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7217798B2 (en) 2003-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of Fc-fusion protein serum half-lives by mutagenesis
WO2004060262A2 (en) 2003-01-07 2004-07-22 Lorantis Limited Modulators of notch signalling for use in immunotherpapy
WO2004063355A2 (en) 2003-01-10 2004-07-29 Protein Design Labs, Inc. Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer
CN1519315A (zh) 2003-01-21 2004-08-11 上海博德基因开发有限公司 一种多肽——人组氨酰-trna合成酶13.09和编码这种多肽的多核苷酸
JP2006517533A (ja) 2003-01-23 2006-07-27 ロランティス リミテッド Notchシグナル伝達経路のアクチベーターを用いる自己免疫疾患の治療
KR100575251B1 (ko) 2003-03-03 2006-05-02 재단법인서울대학교산학협력재단 p38/JTV-1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법
WO2004087875A2 (en) 2003-03-25 2004-10-14 Incyte Corporation Nucleic acid-associated proteins
US20050255144A1 (en) 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
JP2007502861A (ja) 2003-05-01 2007-02-15 レプリダイン・インコーポレーテッド 抗菌方法及び組成物
AU2004247042A1 (en) 2003-06-12 2004-12-23 Eli Lilly And Company Fusion proteins
PT1914314E (pt) 2003-07-07 2010-09-08 Scripps Research Inst Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações
WO2005007870A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
JP2007503838A (ja) * 2003-09-05 2007-03-01 ジーティーシー バイオセラピューティクス, インコーポレイティド トランスジェニック動物の乳汁中での融合タンパク質の産生方法
EP2322569B1 (en) 2003-10-09 2020-08-26 Ambrx, Inc. Polymer derivatives for the selective modification of proteins
ME01775B (me) 2003-11-05 2011-02-28 Glycart Biotechnology Ag Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom
WO2005063815A2 (en) 2003-11-12 2005-07-14 Biogen Idec Ma Inc. Fcϝ receptor-binding polypeptide variants and methods related thereto
EP1682584B1 (en) 2003-11-13 2013-04-17 Hanmi Science Co., Ltd. A pharmaceutical composition comprising an immunoglobulin fc region as a carrier
US20070054278A1 (en) 2003-11-18 2007-03-08 Applera Corporation Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof
AU2004321117B2 (en) 2003-12-18 2010-09-02 The Scripps Research Institute Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
EP1713914A2 (en) 2004-01-28 2006-10-25 Celldex Therapeutics Limited MEDICAL TREATMENT USING AN RNAi AGENT TARGETING A HUMAN NOTCH SIGNALLING PATHWAY MEMBER
WO2005087953A2 (en) 2004-03-05 2005-09-22 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
WO2005113812A2 (en) 2004-04-23 2005-12-01 Invitrogen Corporation Collections of matched biological reagents and methods for identifying matched reagents
KR100599454B1 (ko) 2004-04-27 2006-07-12 재단법인서울대학교산학협력재단 종양 억제자로 작용하는 aim3의 신규 용도
AU2005248351A1 (en) 2004-05-14 2005-12-08 The Regents Of The University Of California Methods for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA
ES2439390T3 (es) 2004-06-04 2014-01-22 The Scripps Research Institute Composiciones y procedimiento para el tratamiento de enfermedades neovasculares
CN102532321B (zh) 2004-06-18 2018-10-12 Ambrx公司 新颖抗原结合多肽和其用途
US7638299B2 (en) 2004-07-21 2009-12-29 Ambrx, Inc. Biosynthetic polypeptides utilizing non-naturally encoded amino acids
US20060079673A1 (en) 2004-08-02 2006-04-13 Paul Glidden Polynucleotides encoding tRNA synthetase fragments and uses thereof
US20060024288A1 (en) 2004-08-02 2006-02-02 Pfizer Inc. tRNA synthetase fragments
US20060078553A1 (en) 2004-10-07 2006-04-13 Paul Glidden Diverse multi-unit complexes including a tRNA synthetase fragment
US8282921B2 (en) 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
CN101001873B (zh) 2004-08-04 2013-03-13 曼璀克生物科技有限责任公司 Fc区变体
CN104447992A (zh) 2004-09-23 2015-03-25 健泰科生物技术公司 半胱氨酸改造的抗体和偶联物
CA2586201A1 (en) 2004-11-03 2006-05-11 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
EP1657232A1 (en) 2004-11-05 2006-05-17 Cellzome Ag Use of S-enantiomers of alpha-sustituted aryl acetic acids for the prevention of Alzheimer's disease
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
BRPI0517837A (pt) 2004-11-12 2008-10-21 Xencor Inc variantes fc com ligação alterada a fcrn
US7459529B2 (en) 2004-11-24 2008-12-02 Seoul National University Industry Foundation AIMP2-DX2 and its uses
US8003780B2 (en) 2004-11-24 2011-08-23 Neomics Co., Ltd. AIMP2-DX2 gene and SiRNA targeting AIMP2-DX2
SG160437A1 (en) 2004-12-22 2010-04-29 Ambrx Inc Modified human growth hormone
EP1836298B1 (en) 2004-12-22 2012-01-18 Ambrx, Inc. COMPOSITIONS OF AMINOACYL-tRNA SYNTHETASE AND USES THEREOF
EP1836316A4 (en) 2004-12-22 2009-07-22 Ambrx Inc PROCESS FOR EXPRESSION AND CLEANING OF RECOMBINANT HUMAN GROWTH HORMONE
CN103520735B (zh) 2004-12-22 2015-11-25 Ambrx公司 包含非天然编码的氨基酸的人生长激素配方
US20100167997A1 (en) 2005-02-01 2010-07-01 Atyr Pharma, Inc. Method for stimulation collagen synthesis and/or kgf expression
US20060275794A1 (en) 2005-03-07 2006-12-07 Invitrogen Corporation Collections of matched biological reagents and methods for identifying matched reagents
KR100689274B1 (ko) 2005-03-30 2007-03-08 김현기 인간 원암 유전자, 이에 의해 코드되는 단백질
EP1888649A2 (en) 2005-05-09 2008-02-20 GlycArt Biotechnology AG Antigen binding molecules having modified fc regions and altered binding to fc receptors
US7842467B1 (en) 2005-05-12 2010-11-30 Celera Corporation Breast disease targets and uses thereof
US20070072175A1 (en) 2005-05-13 2007-03-29 Biogen Idec Ma Inc. Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof
AU2006270057A1 (en) 2005-07-18 2007-01-25 Trustees Of Boston University Method to inhibit proliferation and growth of metastases
US7375188B2 (en) 2005-07-29 2008-05-20 Mallinckrodt Baker, Inc. Vegetarian protein a preparation and methods thereof
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007020075A1 (en) 2005-08-16 2007-02-22 Klinikum Der Universität Regensburg Use of neuropilin-2 antagonists
CN101258164B (zh) 2005-08-16 2013-05-01 韩美科学株式会社 用于大量生产缺失起始甲硫氨酸残基的免疫球蛋白Fc区的方法
ES2408581T3 (es) 2005-08-18 2013-06-21 Ambrx, Inc. Composiciones de ARNt y usos de las mismas
DE102005043321A1 (de) 2005-09-12 2007-03-22 Fresenius Medical Care Deutschland Gmbh Hohlfasermembrantrennvorrichtung
NZ591443A (en) 2005-09-22 2013-04-26 Intermune Inc Granule formation of pirfenidone and pharmaceutically acceptable excipients
US7514229B2 (en) 2005-09-29 2009-04-07 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosing and evaluating treatment of blood disorders
EP1931709B1 (en) 2005-10-03 2016-12-07 Xencor, Inc. Fc variants with optimized fc receptor binding properties
WO2007048122A2 (en) 2005-10-21 2007-04-26 Genzyme Corporation Antibody-based therapeutics with enhanced adcc activity
US20080206246A1 (en) 2006-04-05 2008-08-28 Ravetch Jeffrey V Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
EP1977004B1 (en) 2005-12-02 2014-10-29 The Scripps Research Institute Angiogenic tyrosyl trna synthetase compositions and methods
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
CN101370821B (zh) 2006-01-23 2012-07-18 伊玛吉恩有限公司 新型肽及其用途
MX2008010187A (es) 2006-02-10 2008-10-31 Summit Corp Plc Tratamiento de distrofia muscular de duchenne.
EP1999259B1 (en) 2006-03-03 2014-06-25 California Institute of Technology Site-specific incorporation of amino acids into molecules
WO2007119796A1 (ja) 2006-04-14 2007-10-25 Medical And Biological Laboratories Co., Ltd. エフェクター機能を有するポリペプチド変異体
EP2029620B1 (en) 2006-05-26 2016-05-25 Waikatolink Limited Ob fold domains
WO2008007818A1 (en) 2006-07-13 2008-01-17 Seoul National University Industry Foundation Novel use of aimp1 for controlling glucose level
WO2008016356A2 (en) 2006-08-02 2008-02-07 Genizon Biosciences Genemap of the human genes associated with psoriasis
WO2008021290A2 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
JP5840345B2 (ja) 2006-09-08 2016-01-06 アンブルックス, インコーポレイテッドAmbrx, Inc. 修飾ヒト血漿ポリペプチドまたは修飾ヒトFc足場タンパク質ならびにこれらの利用
CN101528914B (zh) 2006-09-08 2014-12-03 Ambrx公司 通过脊椎动物细胞位点特异性并入非天然氨基酸
EP2407548A1 (en) 2006-10-16 2012-01-18 MedImmune, LLC Molecules with reduced half-lives, compositions and uses thereof
CN101553506B (zh) 2006-11-17 2013-08-07 诺瓦提斯公司 Lingo结合分子及其制药用途
MX2009008270A (es) 2007-02-01 2009-08-12 Imagene Co Ltd Polipeptido novedoso que tiene actividad anti-tumoral.
TW200902544A (en) * 2007-03-13 2009-01-16 Hoffmann La Roche Peptide-complement conjugates
EP2087111A2 (en) 2007-03-19 2009-08-12 Medimmune Limited Polypeptide variants
JP2010525362A (ja) 2007-04-27 2010-07-22 アイマジーン カンパニー リミテッド 免疫調節剤のスクリーニング方法
EP2639316A1 (en) 2007-05-11 2013-09-18 The Johns Hopkins University Biomarkers for melanoma
KR101523788B1 (ko) 2007-05-17 2015-06-26 제넨테크, 인크. 뉴로필린 단편 및 뉴로필린-항체 복합체의 결정 구조
AU2007353778B9 (en) 2007-05-17 2014-04-03 Genentech, Inc. Inhibition of tumor metastasis by anti neuropilin 2 antibodies
CA2687377C (en) 2007-05-30 2013-05-14 Genexine Co., Ltd. Immunoglobulin fusion proteins
JP2009017840A (ja) 2007-07-13 2009-01-29 Japan Agengy For Marine-Earth Science & Technology 外来遺伝子を細胞に安定に保持する方法
CN103992406A (zh) 2007-08-24 2014-08-20 乌利班-马克西姆利安大学 抑制β1-肾上腺素受体抗体的突变双环化受体肽
CA2699916A1 (en) 2007-09-18 2009-08-06 The Jackson Laboratory Antibodies and fc fusion protein modifications with enhanced persistence or pharmacokinetic stability in vivo and methods of use thereof
MX2010004374A (es) 2007-10-31 2010-04-30 Medimmune Llc Armazones proteinicos.
EP2220218A4 (en) 2007-11-02 2010-12-08 Scripps Research Inst GENETICALLY ENCODED BORONATE AMINO ACID
KR101067816B1 (ko) 2007-11-09 2011-09-27 (주)네오믹스 Aimp2-dx2의 억제제를 유효성분으로 포함하는 염증성질환 예방 및 치료용 조성물
JP5585904B2 (ja) 2008-02-08 2014-09-10 独立行政法人理化学研究所 アミノアシルtRNA合成酵素活性を有するポリペプチド及びその利用
MX2010010068A (es) 2008-03-11 2010-10-04 Univ North Carolina Composiciones angiostaticas que comprenden polipeptidos de tirosil-acido ribonucleico de transferencia sintetasa truncado y metodos de uso de las mismas.
CN102123717A (zh) 2008-05-27 2011-07-13 普拉里斯坦有限公司 治疗炎性结肠疾病的方法
US20100092434A1 (en) 2008-06-11 2010-04-15 Atyr Pharma, Inc. Thrombopoietic activity of tyrosyl-trna synthetase polypeptides
CN102159708B (zh) 2008-06-26 2016-08-31 Atyr医药公司 包含具有非常规生物活性的甘氨酰-tRNA合成酶的组合物和方法
CA2734892A1 (en) 2008-08-18 2010-02-25 Seoul National University Industry Foundation Method for controlling cancer metastasis or cancer cell migration by modulating the cellular level of lysyl trna synthetase
FR2935385B1 (fr) 2008-08-27 2013-04-19 Diaclone Induction de l'expression de p53 par neutralisation de la neuropiline-2 pour le traitement des cancers
KR101067817B1 (ko) 2008-10-10 2011-09-27 서울대학교산학협력단 Aimp1 폴리펩티드에 대한 항체를 포함하는 관절염 진단용 조성물
WO2010041913A2 (ko) 2008-10-10 2010-04-15 서울대학교산학협력단 Grs 단백질 또는 이의 단편의 신규한 용도
KR101067815B1 (ko) 2009-02-05 2011-09-27 서울대학교산학협력단 제1형 당뇨병의 신규한 진단 마커
US20120058133A1 (en) 2009-02-19 2012-03-08 President And Fellows Of Harvard College Inhibition of trna synthetases and therapeutic applications thereof
EP2403864B1 (en) 2009-02-27 2015-08-12 Atyr Pharma, Inc. Polypeptide structural motifs associated with cell signaling activity
AU2010226726B8 (en) 2009-03-16 2014-08-14 Pangu Biopharma Limited Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
JP5848236B2 (ja) 2009-03-31 2016-01-27 エータイアー ファーマ, インコーポレイテッド 非標準的な生物活性を有するアスパルチルtRNA合成酵素を含む組成物および方法
KR20120105423A (ko) 2009-09-11 2012-09-25 제넨테크, 인크. 항암제에 반응할 증가된 가능성을 갖는 환자를 확인하는 방법
HRP20160295T1 (hr) 2009-09-21 2016-05-20 Baxalta GmbH Stabilizirana tekuća i liofilizirana formulacija adamts13
CA2775564A1 (en) * 2009-10-09 2011-04-14 New York Blood Center, Inc. Immunopotentiator-linked oligomeric influenza immunogenic compositions
CN106474462A (zh) 2009-12-11 2017-03-08 Atyr 医药公司 用于调节炎症的氨酰tRNA合成酶
US8828395B2 (en) 2009-12-11 2014-09-09 Atyr Pharma, Inc. Antibodies that bind tyrosyl-tRNA synthetases
WO2011072266A2 (en) 2009-12-11 2011-06-16 Atyr Pharma, Inc. Aminoacyl trna synthetases for modulating hematopoiesis
WO2011097031A2 (en) 2010-02-04 2011-08-11 The Scripps Research Institute Monomeric forms of human aminoacyl-trna synthetases having non-canonical biological activities
JP5975886B2 (ja) 2010-03-11 2016-08-23 ヘルス リサーチ インコーポレイテッドHealth Research, Inc. Fc融合タンパク質を含む、免疫応答を増強するための方法および組成物
EP2563380B1 (en) 2010-04-26 2018-05-30 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
AU2011248614B2 (en) 2010-04-27 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
CN103096910A (zh) 2010-04-27 2013-05-08 Atyr医药公司 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2011139853A2 (en) 2010-04-28 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
EP2566516B1 (en) 2010-05-03 2019-07-03 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
US8961961B2 (en) 2010-05-03 2015-02-24 a Tyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
CN103096912A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2011248230B2 (en) 2010-05-03 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases
US9062302B2 (en) 2010-05-04 2015-06-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex
CA2798301C (en) 2010-05-04 2020-09-15 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-trna synthetases
AU2011252990B2 (en) 2010-05-14 2017-04-20 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
AU2011256366C1 (en) 2010-05-17 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
CA2800375C (en) 2010-05-27 2021-03-09 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
US8962560B2 (en) 2010-06-01 2015-02-24 Atyr Pharma Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases
WO2012021247A2 (en) 2010-07-12 2012-02-16 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
AU2011289833C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Histidyl-tRNA synthetases
JP5991973B2 (ja) 2010-07-12 2016-09-14 エータイアー ファーマ, インコーポレイテッド アスパルチルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
CA2812795C (en) 2010-10-06 2021-08-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases
CN118078979A (zh) 2011-04-29 2024-05-28 西莱克塔生物科技公司 用于降低针对治疗性蛋白的免疫应答的致耐受性合成纳米载体
US20160144003A1 (en) 2011-05-19 2016-05-26 The Scripps Research Institute Compositions and methods for treating charcot-marie-tooth diseases and related neuronal diseases
WO2013022982A2 (en) 2011-08-09 2013-02-14 Atyr Pharma, Inc. Pegylated tyrosyl-trna synthetase polypeptides
WO2013036302A1 (en) 2011-09-06 2013-03-14 Selecta Biosciences, Inc. Induced tolerogenic dendritic cells for generating cd8+ regulatory t cells
WO2013086228A1 (en) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Pegylated aspartyl-trna synthetase polypeptides
US9816084B2 (en) 2011-12-06 2017-11-14 Atyr Pharma, Inc. Aspartyl-tRNA synthetases
EP2797959A4 (en) 2011-12-29 2015-08-26 Atyr Pharma Inc ASPARTYL-tRNA synthetase FC CONJUGATES
MX356107B (es) 2012-02-16 2018-05-15 Atyr Pharma Inc Histidil-arnt sintetasas para tratar enfermedades autoinmunes e inflamatorias.
US20140066321A1 (en) * 2012-07-23 2014-03-06 Pangu Biopharma Limited Structures of human histidyl-trna synthetase and methods of use
DK2970921T3 (en) * 2013-03-15 2019-01-14 Atyr Pharma Inc Histidyl-tRNA synthetase-Fc conjugates
KR20150077770A (ko) 2013-12-30 2015-07-08 재단법인 의약바이오컨버젼스연구단 항 hrs 모노클로날 항체 및 이의 용도
AU2015270925A1 (en) 2014-06-02 2016-12-22 Children's Medical Center Corporation Methods and compositions for immunomodulation
EP3233920B1 (en) 2014-12-19 2020-08-26 Alkermes, Inc. Single chain fc fusion proteins
RU2719033C2 (ru) 2015-04-23 2020-04-16 Нантомикс, Ллс Способ получения фармацевтического агента для иммунотерапии рака
US10500203B2 (en) 2015-09-09 2019-12-10 Rush University Medical Center Compositions and methods for treating bone diseases
TW201825118A (zh) 2016-11-30 2018-07-16 美商艾堤爾製藥公司 抗-hrs抗體及用於治療癌症之組合療法
WO2018195338A1 (en) 2017-04-20 2018-10-25 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
WO2019195770A1 (en) 2018-04-06 2019-10-10 Atyr Pharma, Inc. Compositions and methods comprising anti-nrp2 antibodies
JP7490925B2 (ja) 2018-07-26 2024-05-28 エータイアー ファーマ, インコーポレイテッド Nrp2関連疾患を治療するための組成物および方法

Similar Documents

Publication Publication Date Title
JP2016519569A5 (cg-RX-API-DMAC7.html)
TWI648401B (zh) 生長分化因子15(gdf-15)構築體
AU2018247255B2 (en) Single chain fc fusion proteins
JP2015503349A5 (cg-RX-API-DMAC7.html)
JP6746564B2 (ja) Il−23a及びtnf−アルファを標的とする化合物ならびにその使用
HUE035607T2 (en) Targeted therapeutic agents
JP2015523320A (ja) 低減されたエフェクター機能及び延長された半減期を有する分子、組成物、並びにそれらの使用
AU2016288484A1 (en) Interleukin 15 fusion protein for tumor target therapy
CN105593242A (zh) 卷曲螺旋免疫球蛋白融合蛋白及其组合物
JP2019519527A (ja) 操作されたFcコンストラクトに関する組成物及び方法
TW202206462A (zh) 具有經修飾重鏈恆定區之多特異性重鏈抗體
US11034775B2 (en) Cysteine-optimized stradomers
Thomas Dendritic cells as targets or therapeutics in rheumatic autoimmune disease
IL293745A (en) Bifunctional molecules comprising an il-7 variant
CN117412989A (zh) 具有改进的特性的双功能分子的新支架
US20230242606A1 (en) Cxcl9 and variants thereof for immunotherapy of cancer diseases
TW202421649A (zh) 用於治療慢性病毒感染之cd8抗原結合分子之融合體
CA3238005A1 (en) Chimeric antigen receptors
EP4168431A1 (en) Modified cxcl10 for immunotherapy of cancer diseases
CN118076373A (zh) 用于联合疗法的包括生长分化因子-15变体和胰高血糖素样肽-1受体激动剂的组合物
US20250074966A1 (en) Agents and methods for preventing or inhibiting adaptive immune responses associated with multiple sclerosis
CN117229397A (zh) 抗cd40抗体及其用途
WO2024141788A1 (en) Genetically modified stem cells expressing exogenous binding agents and uses thereof
JPWO2022271466A5 (cg-RX-API-DMAC7.html)
CN117209612A (zh) 融合蛋白及其应用