JP2016505251A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016505251A5 JP2016505251A5 JP2015545938A JP2015545938A JP2016505251A5 JP 2016505251 A5 JP2016505251 A5 JP 2016505251A5 JP 2015545938 A JP2015545938 A JP 2015545938A JP 2015545938 A JP2015545938 A JP 2015545938A JP 2016505251 A5 JP2016505251 A5 JP 2016505251A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- protein
- seq
- item
- cleavage site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 46
- 108020001507 fusion proteins Proteins 0.000 claims description 44
- 102000037865 fusion proteins Human genes 0.000 claims description 44
- 102000019298 Lipocalin Human genes 0.000 claims description 30
- 108050006654 Lipocalin Proteins 0.000 claims description 30
- 238000003776 cleavage reaction Methods 0.000 claims description 29
- 230000007017 scission Effects 0.000 claims description 29
- 230000004927 fusion Effects 0.000 claims description 26
- 108010051335 Lipocalin-2 Proteins 0.000 claims description 17
- 102000013519 Lipocalin-2 Human genes 0.000 claims description 17
- 102000004961 Furin Human genes 0.000 claims description 13
- 108090001126 Furin Proteins 0.000 claims description 13
- 210000004027 cell Anatomy 0.000 claims description 13
- 101710190711 Bubble protein Proteins 0.000 claims description 7
- 101800000155 Epiregulin Proteins 0.000 claims description 7
- 102000016776 Midkine Human genes 0.000 claims description 7
- 108010092801 Midkine Proteins 0.000 claims description 7
- 239000003446 ligand Substances 0.000 claims description 7
- 210000004962 mammalian cell Anatomy 0.000 claims description 7
- 244000061456 Solanum tuberosum Species 0.000 claims description 6
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- 239000007858 starting material Substances 0.000 claims description 5
- 102000005367 Carboxypeptidases Human genes 0.000 claims description 4
- 108010006303 Carboxypeptidases Proteins 0.000 claims description 4
- 101500007544 Locusta migratoria Protease inhibitor LCMI-I Proteins 0.000 claims description 4
- 108090000631 Trypsin Proteins 0.000 claims description 4
- 102000004142 Trypsin Human genes 0.000 claims description 4
- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- 108700012359 toxins Proteins 0.000 claims description 4
- 239000012588 trypsin Substances 0.000 claims description 4
- 101001063955 Gallus gallus Extracellular fatty acid-binding protein Proteins 0.000 claims description 3
- 241000286209 Phasianidae Species 0.000 claims description 3
- 108050003126 conotoxin Proteins 0.000 claims description 3
- 230000028327 secretion Effects 0.000 claims description 2
- 102000007134 Epiregulin Human genes 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000000973 chemotherapeutic effect Effects 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 241000723792 Tobacco etch virus Species 0.000 description 14
- 108090000623 proteins and genes Proteins 0.000 description 13
- 238000004458 analytical method Methods 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 11
- 108020001580 protein domains Proteins 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 9
- 102000035195 Peptidases Human genes 0.000 description 8
- 108091005804 Peptidases Proteins 0.000 description 8
- 108010076504 Protein Sorting Signals Proteins 0.000 description 7
- 238000010367 cloning Methods 0.000 description 7
- 241000282414 Homo sapiens Species 0.000 description 6
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 6
- 108010067902 Peptide Library Proteins 0.000 description 6
- 241000894007 species Species 0.000 description 6
- 102400001329 Epiregulin Human genes 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108010029485 Protein Isoforms Proteins 0.000 description 4
- 102000001708 Protein Isoforms Human genes 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 229940122644 Chymotrypsin inhibitor Drugs 0.000 description 3
- 101710137926 Chymotrypsin inhibitor Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 108010093488 His-His-His-His-His-His Proteins 0.000 description 3
- 101001079623 Homo sapiens Heme oxygenase 1 Proteins 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 210000004899 c-terminal region Anatomy 0.000 description 3
- 239000003541 chymotrypsin inhibitor Substances 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 235000014304 histidine Nutrition 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 229910052759 nickel Inorganic materials 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 229940121981 Carboxypeptidase inhibitor Drugs 0.000 description 2
- 101710127041 Carboxypeptidase inhibitor Proteins 0.000 description 2
- 102100028006 Heme oxygenase 1 Human genes 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 101710140999 Metallocarboxypeptidase inhibitor Proteins 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000208125 Nicotiana Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- 239000000589 Siderophore Substances 0.000 description 2
- 108010076818 TEV protease Proteins 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000001086 cytosolic effect Effects 0.000 description 2
- -1 heftoxin Substances 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 230000017854 proteolysis Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000002864 sequence alignment Methods 0.000 description 2
- 238000001542 size-exclusion chromatography Methods 0.000 description 2
- 102100027936 Attractin Human genes 0.000 description 1
- 101710134735 Attractin Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000288950 Callithrix jacchus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010025905 Cystine-Knot Miniproteins Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 241000282574 Gorilla gorilla Species 0.000 description 1
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 description 1
- 101001023833 Homo sapiens Neutrophil gelatinase-associated lipocalin Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 241000283093 Loxodonta africana Species 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- 241001416539 Microcebus murinus Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 101001079625 Mus musculus Heme oxygenase 1 Proteins 0.000 description 1
- 101100370002 Mus musculus Tnfsf14 gene Proteins 0.000 description 1
- 241000283965 Ochotona princeps Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 241000282577 Pan troglodytes Species 0.000 description 1
- 101000865553 Pentadiplandra brazzeana Defensin-like protein Proteins 0.000 description 1
- 241000282871 Procavia capensis Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 241000283293 Tursiops Species 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 229960002964 adalimumab Drugs 0.000 description 1
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 108010002696 circulin Proteins 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 108010088252 hanatoxin Proteins 0.000 description 1
- 150000002411 histidines Chemical class 0.000 description 1
- 102000053305 human HMOX1 Human genes 0.000 description 1
- 102000047202 human LCN2 Human genes 0.000 description 1
- 238000000126 in silico method Methods 0.000 description 1
- 229960000598 infliximab Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 description 1
- 108010011110 polyarginine Proteins 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 102220084139 rs863224800 Human genes 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 229960000575 trastuzumab Drugs 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 108010000137 violacin A Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261735516P | 2012-12-10 | 2012-12-10 | |
| US61/735,516 | 2012-12-10 | ||
| US201361794685P | 2013-03-15 | 2013-03-15 | |
| US61/794,685 | 2013-03-15 | ||
| PCT/US2013/074215 WO2014093403A1 (en) | 2012-12-10 | 2013-12-10 | Lipocalin fusion partners |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016505251A JP2016505251A (ja) | 2016-02-25 |
| JP2016505251A5 true JP2016505251A5 (OSRAM) | 2017-02-02 |
Family
ID=49883268
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545941A Ceased JP2016505826A (ja) | 2012-12-10 | 2013-12-10 | スクリーニングの方法 |
| JP2015545938A Pending JP2016505251A (ja) | 2012-12-10 | 2013-12-10 | リポカリン融合パートナー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545941A Ceased JP2016505826A (ja) | 2012-12-10 | 2013-12-10 | スクリーニングの方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20140179560A1 (OSRAM) |
| EP (2) | EP2928913A1 (OSRAM) |
| JP (2) | JP2016505826A (OSRAM) |
| CN (2) | CN105008393A (OSRAM) |
| AU (2) | AU2013359429A1 (OSRAM) |
| BR (2) | BR112015013515A2 (OSRAM) |
| CA (2) | CA2913029A1 (OSRAM) |
| IL (2) | IL239262A0 (OSRAM) |
| RU (2) | RU2015126651A (OSRAM) |
| SG (2) | SG11201504602VA (OSRAM) |
| WO (2) | WO2014093406A1 (OSRAM) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011142858A2 (en) | 2010-05-11 | 2011-11-17 | Fred Hutchinson Cancer Research Center | Chlorotoxin variants, conjugates, and methods for their use |
| CN108524919A (zh) | 2012-05-17 | 2018-09-14 | 延伸生物科学股份有限公司 | 用于改进的药物递送的载体 |
| US20140179560A1 (en) | 2012-12-10 | 2014-06-26 | Fred Hutchinson Cancer Research Center | Drug discovery methods and platforms |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| KR101576904B1 (ko) * | 2014-07-31 | 2015-12-14 | (주)케어젠 | 파골세포 분화 및 활성 억제능을 갖는 펩타이드 및 이의 용도 |
| WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| FI3298030T3 (fi) * | 2015-05-18 | 2023-02-22 | Pieris Pharmaceuticals Gmbh | Syöpää ehkäisevä fuusiopolypeptidi |
| EP3313427A4 (en) * | 2015-06-26 | 2018-12-26 | Fred Hutchinson Cancer Research Center | Therapeutic peptides and methods of use thereof |
| BR112017027985A2 (pt) * | 2015-06-26 | 2018-08-28 | Hutchinson Fred Cancer Res | peptídeos terapêuticos e métodos de uso dos mesmos |
| CN108135970B (zh) * | 2015-09-09 | 2023-09-01 | 弗莱德哈钦森癌症中心 | 软骨归巢肽 |
| JP7085990B2 (ja) * | 2015-10-13 | 2022-06-17 | シティ・オブ・ホープ | クロロトキシンドメインを含むキメラ抗原レセプター |
| US10815290B2 (en) | 2015-11-10 | 2020-10-27 | Fred Hutchinson Cancer Research Center | NKG2D decoys |
| CN105348392B (zh) * | 2015-11-18 | 2019-08-02 | 北京华金瑞清生物医药技术有限公司 | 一种Nav1.7抑制剂及其改造方法 |
| US12048732B2 (en) | 2016-04-15 | 2024-07-30 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| EP3442555A4 (en) * | 2016-04-15 | 2020-04-01 | Blaze Bioscience, Inc. | METHOD FOR TREATING BREAST CANCER |
| WO2018039283A1 (en) * | 2016-08-22 | 2018-03-01 | Fred Hutchinson Cancer Research Center | Peptides and methods of use thereof |
| ES3015117T3 (en) | 2016-08-29 | 2025-04-29 | Fred Hutchinson Cancer Center | Chelating platform for delivery of radionuclides |
| CN106699866A (zh) * | 2016-12-13 | 2017-05-24 | 山西农业大学 | 一种鸡细胞外脂肪酸结合蛋白、原核表达及其纯化方法 |
| AU2018210157B2 (en) | 2017-01-18 | 2022-10-06 | Fred Hutchinson Cancer Center | Peptide compositions and methods of use thereof for disrupting TEAD interactions |
| EP3595699A4 (en) * | 2017-03-16 | 2020-12-23 | Blaze Bioscience, Inc. | PEPTIDIC CONJUGATES OF CARTILAGE ECOTROPISM AND THEIR METHODS OF USE |
| CA3064436A1 (en) | 2017-06-15 | 2018-12-20 | Blaze Bioscience, Inc. | Renal-homing peptide conjugates and methods of use thereof |
| CN107739410B (zh) * | 2017-10-18 | 2021-07-30 | 南京鼓楼医院 | CD3单链抗体-iRGD融合蛋白、制备及其作为抗肿瘤药物的应用 |
| AU2018388583A1 (en) | 2017-12-19 | 2020-06-11 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| EP3773668A4 (en) * | 2018-03-16 | 2022-10-19 | Blaze Bioscience, Inc. | Truncated cartilage-homing peptides and peptide complexes and methods of use thereof |
| CA3148682A1 (en) * | 2019-12-19 | 2021-06-24 | Alan Cohen | Methods of treating vascular lesions and malformations |
| CN115329965B (zh) * | 2022-08-16 | 2025-08-01 | 北京有竹居网络技术有限公司 | 数据处理方法和电子设备 |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444744A (en) | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
| DE3407582A1 (de) | 1984-03-01 | 1985-09-05 | Dornier System Gmbh, 7990 Friedrichshafen | Schaltungsanordnung fuer einen regelkreis |
| WO1988002117A1 (en) | 1986-09-19 | 1988-03-24 | Scripps Clinic And Research Foundation | Monoclonal paratopic molecule directed to human ganglioside gd2 |
| US5591829A (en) | 1987-05-29 | 1997-01-07 | Matsushita; Shuzo | Antibodies modified with toxic substance |
| US5051364A (en) | 1989-02-16 | 1991-09-24 | The Salk Institute For Biological Studies | Anti-lipocortin-I and anti-lipocortin-II monoclonal antibodies |
| DE3909799A1 (de) | 1989-03-24 | 1990-09-27 | Behringwerke Ag | Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung |
| ATE135373T1 (de) | 1989-09-08 | 1996-03-15 | Univ Johns Hopkins | Modifikationen der struktur des egf-rezeptor-gens in menschlichen glioma |
| US5223253A (en) | 1989-09-28 | 1993-06-29 | American Home Products Corporation | Bovine vaccine compositions and method for preventing trichomonas infections using same |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| GB2250993B (en) | 1990-11-21 | 1995-02-15 | Inst Nat Sante Rech Med | Stromelysin-3 and its application in the diagnosis and treatment of malignant breast cancer |
| US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| MX9205293A (es) | 1991-09-20 | 1993-05-01 | Syntex Sinergen Neuroscience J | Factores neurotrofico derivado del glial |
| US5314992A (en) | 1991-11-25 | 1994-05-24 | Trustees Of Dartmouth College | Lipocortin-1 receptor protein and its uses |
| WO1993023075A1 (en) | 1992-05-14 | 1993-11-25 | Oncologix, Inc. | Treatment of vascular leakage syndrome and collagenase induced disease by administration of matrix metalloproteinase inhibitors |
| AU5838494A (en) | 1993-01-14 | 1994-08-15 | Cancer Research Campaign Technology Limited | Potentiation of temozolomide in human tumour cells |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5688773A (en) | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
| US5985822A (en) | 1994-12-09 | 1999-11-16 | The Scripps Research Institute | Inhibition of glial cell proliferation with N-CAM homophilic peptides |
| US5756340A (en) | 1995-05-08 | 1998-05-26 | The Regents Of The University Of California | Insect control with multiple toxins |
| JP3809502B2 (ja) | 1995-05-30 | 2006-08-16 | 二郎 有川 | ハンタウィルス抗原蛋白質およびモノクローナル抗体 |
| JPH0971599A (ja) | 1995-09-06 | 1997-03-18 | Nippon Seibutsu Kagaku Kenkyusho | 鶏貧血ウイルス(cav)感染鶏血清と高い反応性を示すポリペプチド及びこのポリペプチドに対する抗体、鶏貧血ウイルス感染の診断法及びワクチン |
| US6667156B2 (en) | 1995-12-27 | 2003-12-23 | Uab Research Foundation | Diagnosis and treatment of neuroectodermal tumors |
| US5905027A (en) | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
| WO1997043301A2 (en) * | 1996-05-10 | 1997-11-20 | Novartis Ag | Identification of members of combinatorial libraries by mass spectrometry |
| US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| NZ504938A (en) | 1997-12-05 | 2002-10-25 | Kyogo Itoh | Tumor antigen peptide derivatives capable of binding to HLA-A24 antigen |
| GB9809776D0 (en) * | 1998-05-07 | 1998-07-08 | Nycomed Imaging As | Method |
| US6403625B1 (en) | 1998-08-12 | 2002-06-11 | Daiichi Pure Chemicals Co., Ltd. | Fluorescent labeling reagents |
| US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| ATE253126T1 (de) * | 1998-08-25 | 2003-11-15 | Univ Washington | Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen |
| US6214986B1 (en) | 1998-10-07 | 2001-04-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of bcl-x expression |
| US6629040B1 (en) * | 1999-03-19 | 2003-09-30 | University Of Washington | Isotope distribution encoded tags for protein identification |
| SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| JP2003509034A (ja) | 1999-09-14 | 2003-03-11 | バイオメディカル アフエレーゼ システム ゲーエムベーハー | 生化学活性を有する磁性ナノ粒子、その製造法と使用 |
| AUPQ339899A0 (en) * | 1999-10-13 | 1999-11-04 | University Of Queensland, The | Novel molecules |
| AU4305101A (en) | 1999-11-22 | 2001-06-04 | Research Foundation Of The State University Of New York, The | Magnetic nanoparticles for selective therapy |
| DE10020376A1 (de) | 2000-04-26 | 2001-11-08 | Inst Zelltechnologie E V | Dynamische Marker |
| CA2427858A1 (en) | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| US20020077921A1 (en) | 2000-12-15 | 2002-06-20 | Paul-David Morrison | Method and apparatus for an interactive catalog |
| US20040180846A1 (en) | 2001-03-01 | 2004-09-16 | Ruo-Pan Huang | Connexin enhances chemotherapy-induced apoptiosis in human cancer cells inhibiting tumor cell proliferation |
| WO2003008583A2 (en) | 2001-03-02 | 2003-01-30 | Sagres Discovery | Novel compositions and methods for cancer |
| GB0115581D0 (en) * | 2001-06-26 | 2001-08-15 | Glaxo Group Ltd | Method of mass spectometry |
| US20030021810A1 (en) | 2001-06-26 | 2003-01-30 | Sontheimer Harald W. | Chlorotoxin inhibition of cell invasion, cancer metastasis, angiogenesis and tissue remodeling |
| WO2003029462A1 (en) * | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| US6972326B2 (en) | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
| AU2003207835A1 (en) | 2002-02-04 | 2003-09-02 | Auburn University | Peptides for recognition and targeting of glial cell tumors |
| US20030232013A1 (en) | 2002-02-22 | 2003-12-18 | Gary Sieckman | Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides |
| US20060088899A1 (en) | 2002-05-31 | 2006-04-27 | Alvarez Vernon L | Combination chemotherapy with chlorotoxin |
| WO2003101475A1 (en) | 2002-05-31 | 2003-12-11 | Transmolecular Inc. | Treatment of cell proliferative disorders with chlorotoxin |
| US7563600B2 (en) * | 2002-09-12 | 2009-07-21 | Combimatrix Corporation | Microarray synthesis and assembly of gene-length polynucleotides |
| US7560160B2 (en) | 2002-11-25 | 2009-07-14 | Materials Modification, Inc. | Multifunctional particulate material, fluid, and composition |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| WO2004085618A2 (en) * | 2003-03-21 | 2004-10-07 | Schering Corporation | Method of screening for target ligands |
| CN1791671A (zh) * | 2003-03-21 | 2006-06-21 | 先灵公司 | 靶配体的筛选方法 |
| KR20060031809A (ko) | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
| DE10328251A1 (de) | 2003-06-24 | 2005-01-13 | Toximed Gmbh | Pharmazeutischer Wirkstoff |
| WO2005053611A2 (en) | 2003-11-26 | 2005-06-16 | Transmolecular, Inc. | Treatment of phosphatidylinositol phospholipid disorders |
| ATE428779T1 (de) * | 2003-12-18 | 2009-05-15 | Biomethodes | Verfahren zur ortspezifischen massenmutagenese |
| US20080153746A1 (en) | 2004-04-06 | 2008-06-26 | Transmolecular, Inc. | Diagnosis and Treatment of Myeloid and Lymphoid Cell Cancers |
| JP2007532879A (ja) | 2004-04-06 | 2007-11-15 | トランスモレキュラー, インコーポレイテッド | 骨髄およびリンパ系細胞癌の診断および処置 |
| CA2565701A1 (en) | 2004-05-06 | 2005-11-17 | Jonathan M. Barasch | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
| MX2007000728A (es) | 2004-07-21 | 2007-03-15 | Ambrx Inc | Polipeptidos biosinteticos que utilizan amino acidos no naturalmente codificados. |
| WO2006036928A2 (en) * | 2004-09-27 | 2006-04-06 | Wayne State University | Inhibitors of matrix metalloproteinases to treat neurological disorders |
| GB0422901D0 (en) * | 2004-10-14 | 2004-11-17 | Ares Trading Sa | Lipocalin protein |
| KR100681763B1 (ko) | 2005-02-28 | 2007-02-15 | 재단법인 목암생명공학연구소 | 인간 리포칼린 2를 유효성분으로 포함하는 암 전이 억제용약학적 조성물, 이를 이용한 암 전이 억제 방법 |
| GB0504767D0 (en) * | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
| US20070037232A1 (en) | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
| JP2008535853A (ja) | 2005-04-07 | 2008-09-04 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | 癌関連遺伝子 |
| US20060286089A1 (en) | 2005-04-08 | 2006-12-21 | Xcyte Therapies, Inc. | Compositions and methods for the treatment of burns and sepsis |
| ES2360519T3 (es) | 2005-04-22 | 2011-06-06 | University Of Washington | Conjugado de cianina-clorotoxina y procedimiento para la visualización intraquirúrgica del cáncer. |
| US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| JP4829969B2 (ja) | 2005-08-18 | 2011-12-07 | アンブルックス,インコーポレイテッド | tRNA組成物、およびその使用 |
| EP2147927A3 (en) | 2006-03-31 | 2010-09-01 | Transmolecular, Inc. | Use of 131i-tm-601 for the diagnosis and treatment of gliomas |
| US8106013B2 (en) | 2006-05-19 | 2012-01-31 | Georgia Tech Research Corporation | ABC transporter ligand GATX1 |
| CN101003788A (zh) | 2006-09-21 | 2007-07-25 | 武汉大学 | 一种蝎抗肿瘤转移肽及其制备方法和应用 |
| CN100564517C (zh) | 2006-09-21 | 2009-12-02 | 武汉大学 | 一种蝎抗神经胶质瘤肽及其制备方法和应用 |
| WO2008088422A2 (en) | 2006-10-25 | 2008-07-24 | Amgen Inc. | Toxin peptide therapeutic agents |
| DE602008005596D1 (de) | 2007-06-21 | 2011-04-28 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
| US20090004105A1 (en) | 2007-06-27 | 2009-01-01 | Zhen Cheng | Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin |
| CA2696303A1 (en) | 2007-08-07 | 2009-02-12 | Transmolecular, Inc. | Chlorotoxins as drug carriers |
| WO2009029760A1 (en) | 2007-08-31 | 2009-03-05 | Iosemantics, Llc | Quality assurance tools for use with source code and a semantic model |
| CN101918041A (zh) | 2007-10-12 | 2010-12-15 | 超分子有限公司 | 用于肿瘤诊断和治疗的氯毒素剂的系统性给药 |
| US20090123946A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
| US20090176274A1 (en) | 2007-10-19 | 2009-07-09 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| CA2702590A1 (en) | 2007-10-19 | 2009-04-23 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
| US20090269777A1 (en) | 2007-10-19 | 2009-10-29 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
| US20090124022A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Antibodies that bind to mammalian ngal and uses thereof |
| US20090123970A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
| US20100304413A1 (en) | 2007-11-15 | 2010-12-02 | Lars Otto Uttenthal | Diagnostic use of individual molecular forms of a biomarker |
| AU2009205950C1 (en) | 2008-01-18 | 2015-08-06 | Visen Medical, Inc. | Fluorescent imaging agents |
| WO2009108762A2 (en) | 2008-02-26 | 2009-09-03 | The Penn State Research Foundation | Methods and compositions for treatment of retinoid-responsive conditions |
| US8093060B2 (en) | 2008-02-28 | 2012-01-10 | Canon Kabushiki Kaisha | Multisite phosphorylated peptide (protein) recognizing compound and detection method, imaging method, alzheimer's disease diagnosing method and reagent kit using the same |
| WO2009114776A2 (en) | 2008-03-14 | 2009-09-17 | Visen Medical, Inc. | Integrin targeting agents and methods of using same |
| CA2718854A1 (en) | 2008-03-20 | 2009-09-24 | Transmolecular, Inc. | Inhibition of angiogenesis |
| GB0807831D0 (en) | 2008-04-29 | 2008-06-04 | Cambridge Entpr Ltd | Agents for imaging cell death |
| CN101270158B (zh) | 2008-04-30 | 2010-12-22 | 武汉大学 | 一种靶向抗神经胶质瘤蛋白及制备方法和用途 |
| BRPI0912683A2 (pt) | 2008-05-15 | 2016-01-26 | Transmolecular Inc | tratamento de tumores metastáticos |
| JP2009300110A (ja) | 2008-06-10 | 2009-12-24 | Olympus Corp | 移植細胞の光学的検出方法又はイメージング方法 |
| EP2313430B1 (en) | 2008-06-24 | 2018-05-02 | Technische Universität München | Muteins of hngal and related proteins with affinity for a given target |
| US20100098637A1 (en) | 2008-09-23 | 2010-04-22 | The Regents Of The University Of Michigan | Dye-loaded nanoparticle |
| CN101381405B (zh) | 2008-09-24 | 2011-07-27 | 武汉摩尔生物科技有限公司 | 基因工程肿瘤靶向kct-w1多肽及制备方法和用途 |
| JP2010085108A (ja) | 2008-09-29 | 2010-04-15 | Nano Factory:Kk | 生体光イメージング用プローブ |
| US20100105150A1 (en) | 2008-10-24 | 2010-04-29 | Abbott Laboratories | Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal |
| US20100331650A1 (en) * | 2009-06-25 | 2010-12-30 | Roche Diagnostics Operations, Inc. | Episodic blood glucose monitoring system with an interactive graphical user interface and methods thereof |
| US10191060B2 (en) | 2009-11-09 | 2019-01-29 | University Of Washington | Functionalized chromophoric polymer dots and bioconjugates thereof |
| CN101921769B (zh) | 2010-01-11 | 2012-07-25 | 山西大学 | 一种重组腺病毒及其制备方法和应用 |
| WO2011094671A2 (en) | 2010-01-29 | 2011-08-04 | The Uab Research Foundation | N-terminally conjugated polypeptides for targeted therapy and diagnosis |
| CN106995493B (zh) | 2010-02-04 | 2021-09-24 | 卫材公司 | 氯毒素多肽和结合物及其应用 |
| CN101824084A (zh) | 2010-04-08 | 2010-09-08 | 山西大学 | 靶向性抗胶质瘤蛋白质及其应用 |
| WO2011142858A2 (en) | 2010-05-11 | 2011-11-17 | Fred Hutchinson Cancer Research Center | Chlorotoxin variants, conjugates, and methods for their use |
| CA2808392C (en) * | 2010-08-16 | 2020-03-10 | Pieris Ag | Binding proteins for hepcidin |
| AU2011326164B2 (en) | 2010-11-08 | 2016-05-05 | The Board Of Trustees Of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| EP3511973B1 (en) | 2010-12-28 | 2021-08-04 | Quest Diagnostics Investments LLC | Quantitation of insulin by mass spectrometry |
| SG10201605812YA (en) | 2011-09-07 | 2016-09-29 | Chem Inc X | Methods for tagging dna-encoded libraries |
| US20140179560A1 (en) | 2012-12-10 | 2014-06-26 | Fred Hutchinson Cancer Research Center | Drug discovery methods and platforms |
-
2013
- 2013-12-10 US US14/102,396 patent/US20140179560A1/en not_active Abandoned
- 2013-12-10 BR BR112015013515A patent/BR112015013515A2/pt not_active IP Right Cessation
- 2013-12-10 RU RU2015126651A patent/RU2015126651A/ru not_active Application Discontinuation
- 2013-12-10 JP JP2015545941A patent/JP2016505826A/ja not_active Ceased
- 2013-12-10 RU RU2015126650A patent/RU2015126650A/ru not_active Application Discontinuation
- 2013-12-10 CA CA2913029A patent/CA2913029A1/en not_active Abandoned
- 2013-12-10 CN CN201380072527.9A patent/CN105008393A/zh active Pending
- 2013-12-10 AU AU2013359429A patent/AU2013359429A1/en not_active Abandoned
- 2013-12-10 SG SG11201504602VA patent/SG11201504602VA/en unknown
- 2013-12-10 EP EP13814341.7A patent/EP2928913A1/en not_active Withdrawn
- 2013-12-10 US US14/651,175 patent/US10156559B2/en active Active
- 2013-12-10 SG SG11201504600UA patent/SG11201504600UA/en unknown
- 2013-12-10 AU AU2013359426A patent/AU2013359426A1/en not_active Abandoned
- 2013-12-10 WO PCT/US2013/074218 patent/WO2014093406A1/en not_active Ceased
- 2013-12-10 EP EP13814726.9A patent/EP2928914A1/en not_active Withdrawn
- 2013-12-10 CA CA2913127A patent/CA2913127A1/en not_active Abandoned
- 2013-12-10 CN CN201380072523.0A patent/CN105189540A/zh active Pending
- 2013-12-10 JP JP2015545938A patent/JP2016505251A/ja active Pending
- 2013-12-10 BR BR112015013525A patent/BR112015013525A2/pt not_active IP Right Cessation
- 2013-12-10 US US14/651,172 patent/US20150316536A1/en not_active Abandoned
- 2013-12-10 WO PCT/US2013/074215 patent/WO2014093403A1/en not_active Ceased
-
2015
- 2015-06-07 IL IL239262A patent/IL239262A0/en unknown
- 2015-06-07 IL IL239261A patent/IL239261A0/en unknown
-
2018
- 2018-12-11 US US16/216,625 patent/US20190101528A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016505251A5 (OSRAM) | ||
| Costa et al. | Fusion tags for protein solubility, purification and immunogenicity in Escherichia coli: the novel Fh8 system | |
| KR102064396B1 (ko) | 신규한 면역글로불린-결합 단백질 및 친화도 정제에서의 이의 용도 | |
| EP2495253B1 (en) | Novel immunoglobulin-binding proteins with improved specificity | |
| US10584152B2 (en) | Binding proteins based on di-ubiquitin muteins and methods for generation | |
| JP2019531055A (ja) | アルカリ安定性免疫グロブリン結合タンパク質 | |
| CN102892885B (zh) | IgA结合性肽以及利用其的IgA的纯化 | |
| KR20200035112A (ko) | C-말단 나선형 영역에 시스테인을 갖는 fc 결합 단백질 | |
| JP2020529221A5 (OSRAM) | ||
| US12466857B2 (en) | Triple-helical polypeptides lacking binding affinity for the Fc domain of immunoglobulin and uses thereof | |
| JP7573287B2 (ja) | アフィニティー精製用免疫グロブリン結合タンパク質 | |
| US20200172580A1 (en) | Novel populations of polypeptides having a triple-helical structure | |
| Nogi et al. | Novel affinity tag system using structurally defined antibody‐tag interaction: application to single‐step protein purification | |
| Zhang et al. | Fusion partners as a tool for the expression of difficult proteins in mammalian cells | |
| JP4160864B2 (ja) | 融合蛋白質、その製造方法及びそれを用いた評価方法 | |
| US20240076350A1 (en) | Mhc: peptide complexes | |
| JP2023057069A5 (OSRAM) | ||
| CN114672476A (zh) | 人pcsk9蛋白的优势构象表位及其应用 | |
| JP2022022974A (ja) | 抗SARS-CoV-2抗体を用いた医薬品及び検査キット | |
| WO2012161227A1 (ja) | 核酸構築物、核酸-蛋白質複合体、及びその利用 |