|
BR112013024337A2
(pt)
|
2011-03-23 |
2017-09-26 |
Du Pont |
locus de traço transgênico complexo em uma planta, planta ou semente, método para produzir em uma planta um locus de traço transgênico complexo e construto de expressão
|
|
EP2734621B1
(en)
|
2011-07-22 |
2019-09-04 |
President and Fellows of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
EP3604555B1
(en)
|
2011-10-14 |
2024-12-25 |
President and Fellows of Harvard College |
Sequencing by structure assembly
|
|
WO2014163886A1
(en)
|
2013-03-12 |
2014-10-09 |
President And Fellows Of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
CN104364380B
(zh)
|
2012-04-25 |
2018-10-09 |
瑞泽恩制药公司 |
核酸酶介导的使用大靶向载体的靶向
|
|
EP3597741A1
(en)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetic correction of mutated genes
|
|
PL4289948T3
(pl)
|
2012-05-25 |
2025-06-02 |
The Regents Of The University Of California |
Sposoby i kompozycje do modyfikacji kierowanego na rna docelowego dna i do nakierowanej na rna modulacji transkrypcji
|
|
EP2861737B1
(en)
|
2012-06-19 |
2019-04-17 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
KR20230065381A
(ko)
*
|
2012-07-25 |
2023-05-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유도 dna 결합 단백질 및 게놈 교란 도구 및 이의 적용
|
|
EP2912175B1
(en)
|
2012-10-23 |
2018-08-22 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
CN105142669B
(zh)
|
2012-12-06 |
2018-07-03 |
西格马-奥尔德里奇有限责任公司 |
基于crispr的基因组修饰和调控
|
|
EP3434776A1
(en)
|
2012-12-12 |
2019-01-30 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
CN105121648B
(zh)
*
|
2012-12-12 |
2021-05-07 |
布罗德研究所有限公司 |
用于序列操纵的系统、方法和优化的指导组合物的工程化
|
|
CN105658796B
(zh)
*
|
2012-12-12 |
2021-10-26 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
WO2014093694A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
|
|
PT2898075E
(pt)
|
2012-12-12 |
2016-06-16 |
Harvard College |
Manipulação e otimização de sistemas, métodos e composições de enzima melhorados para manipulação de sequências
|
|
WO2014093655A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
PL2784162T3
(pl)
|
2012-12-12 |
2016-01-29 |
Broad Inst Inc |
Opracowanie systemów, metod oraz zoptymalizowanych kompozycji przewodnikowych do manipulacji sekwencyjnej
|
|
WO2014093622A2
(en)
*
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
US8697359B1
(en)
*
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP4282970A3
(en)
*
|
2012-12-17 |
2024-01-17 |
President and Fellows of Harvard College |
Rna-guided human genome engineering
|
|
KR20170108172A
(ko)
|
2013-03-14 |
2017-09-26 |
카리부 바이오사이언시스 인코포레이티드 |
핵산-표적화 핵산의 조성물 및 방법
|
|
EP2970997A1
(en)
*
|
2013-03-15 |
2016-01-20 |
Regents of the University of Minnesota |
Engineering plant genomes using crispr/cas systems
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
JP2016522679A
(ja)
*
|
2013-04-04 |
2016-08-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
CRISPR/Cas系を用いたゲノム編集の治療的使用
|
|
US20160186208A1
(en)
*
|
2013-04-16 |
2016-06-30 |
Whitehead Institute For Biomedical Research |
Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal
|
|
CA2908697C
(en)
|
2013-04-16 |
2023-12-12 |
Regeneron Pharmaceuticals, Inc. |
Targeted modification of rat genome
|
|
WO2014186686A2
(en)
*
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
|
JP7065564B2
(ja)
*
|
2013-05-29 |
2022-05-12 |
セレクティス |
Cas9ニッカーゼ活性を用いて正確なdna切断をもたらすための方法
|
|
MY197877A
(en)
*
|
2013-06-04 |
2023-07-22 |
Harvard College |
Rna-guided transcriptional regulation
|
|
US20140356956A1
(en)
|
2013-06-04 |
2014-12-04 |
President And Fellows Of Harvard College |
RNA-Guided Transcriptional Regulation
|
|
AU2014279694B2
(en)
|
2013-06-14 |
2020-07-23 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
EP3674411A1
(en)
|
2013-06-17 |
2020-07-01 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
CA2915837A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
KR20240172759A
(ko)
|
2013-06-17 |
2024-12-10 |
더 브로드 인스티튜트, 인코퍼레이티드 |
간의 표적화 및 치료를 위한 CRISPRCas 시스템, 벡터 및 조성물의 전달 및 용도
|
|
EP3597755A1
(en)
|
2013-06-17 |
2020-01-22 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
EP3019595A4
(en)
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
|
WO2015006290A1
(en)
*
|
2013-07-09 |
2015-01-15 |
President And Fellows Of Harvard College |
Multiplex rna-guided genome engineering
|
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
KR102304167B1
(ko)
|
2013-08-16 |
2021-09-24 |
메사추세츠 인스티튜트 오브 테크놀로지 |
세포로의 선택적 물질 전달
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
MX363842B
(es)
|
2013-08-22 |
2019-04-05 |
Du Pont |
Métodos para producir modificaciones genéticas en un genoma vegetal sin incorporar un marcador transgénico seleccionable, y composiciones de éstas.
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
|
EP3418379B1
(en)
|
2013-09-18 |
2020-12-09 |
Kymab Limited |
Methods, cells & organisms
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
|
JP2016536021A
(ja)
|
2013-11-07 |
2016-11-24 |
エディタス・メディシン,インコーポレイテッド |
CRISPR関連方法および支配gRNAのある組成物
|
|
US10787684B2
(en)
*
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
SG10201700961TA
(en)
|
2013-12-11 |
2017-04-27 |
Regeneron Pharma |
Methods and compositions for the targeted modification of a genome
|
|
HUE041331T2
(hu)
|
2013-12-11 |
2019-05-28 |
Regeneron Pharma |
Módszerek és készítmények a genom célzott módosításához
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
CN105899658B
(zh)
|
2013-12-12 |
2020-02-18 |
布罗德研究所有限公司 |
针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
EP3080260B1
(en)
|
2013-12-12 |
2019-03-06 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
EP3653229A1
(en)
|
2013-12-12 |
2020-05-20 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
WO2015089354A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
DE212015000061U1
(de)
|
2014-02-11 |
2017-09-03 |
The Regents Of The University Of Colorado, A Body Corporate |
CRISPR-ermöglichtes Multiplex Genom Engineering
|
|
KR20160130392A
(ko)
|
2014-02-18 |
2016-11-11 |
듀크 유니버시티 |
바이러스 복제의 불활성화를 위한 조성물 및 그의 제조 및 사용 방법
|
|
WO2015131101A1
(en)
|
2014-02-27 |
2015-09-03 |
Monsanto Technology Llc |
Compositions and methods for site directed genomic modification
|
|
EP3957735A1
(en)
|
2014-03-05 |
2022-02-23 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
|
|
SG11201609211VA
(en)
*
|
2014-03-05 |
2016-12-29 |
Nat Univ Corp Univ Kobe |
Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
|
|
ES2745769T3
(es)
|
2014-03-10 |
2020-03-03 |
Editas Medicine Inc |
Procedimientos y composiciones relacionados con CRISPR/CAS para tratar la amaurosis congénita de Leber 10 (LCA10)
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
WO2015148863A2
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
US12460231B2
(en)
|
2014-04-02 |
2025-11-04 |
Editas Medicine, Inc. |
Crispr/CAS-related methods and compositions for treating primary open angle glaucoma
|
|
WO2015155686A2
(en)
|
2014-04-08 |
2015-10-15 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
|
CA2949697A1
(en)
*
|
2014-05-20 |
2015-11-26 |
Regents Of The University Of Minnesota |
Method for editing a genetic sequence
|
|
JP2017516500A
(ja)
*
|
2014-05-28 |
2017-06-22 |
ツールゲン インコーポレイテッドToolgen Incorporated |
標的特異的ヌクレアーゼを用いた標的dnaの敏感な検出方法
|
|
EP3152319A4
(en)
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
HUE049776T2
(hu)
|
2014-06-06 |
2020-10-28 |
Regeneron Pharma |
Módszerek és készítmények egy célzott lókusz módosítására
|
|
CA2951707A1
(en)
*
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
JP6779866B2
(ja)
|
2014-06-13 |
2020-11-04 |
チルドレンズ メディカル センター コーポレイション |
ミトコンドリアを単離するための製品および方法
|
|
MX384887B
(es)
|
2014-06-23 |
2025-03-14 |
Regeneron Pharma |
Ensamblaje de adn mediado por nucleasa.
|
|
WO2015200555A2
(en)
*
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
|
US20150376586A1
(en)
*
|
2014-06-25 |
2015-12-31 |
Caribou Biosciences, Inc. |
RNA Modification to Engineer Cas9 Activity
|
|
EP3161128B1
(en)
|
2014-06-26 |
2018-09-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modifications and methods of use
|
|
WO2016007347A1
(en)
|
2014-07-11 |
2016-01-14 |
E. I. Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
WO2016007839A1
(en)
|
2014-07-11 |
2016-01-14 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
CA2954791C
(en)
*
|
2014-07-14 |
2025-11-18 |
The Regents Of The University Of California |
CRISPR/CAS TRANSCRIPTIONAL MODULATION
|
|
CN112941065A
(zh)
*
|
2014-07-21 |
2021-06-11 |
亿明达股份有限公司 |
使用crispr-cas系统的多核苷酸富集
|
|
CA2956224A1
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US10280402B2
(en)
|
2014-08-06 |
2019-05-07 |
College Of Medicine Pochon Cha University Industry-Academic Cooperation Foundation |
Immune-compatible cells created by nuclease-mediated editing of genes encoding HLA
|
|
WO2016021973A1
(ko)
*
|
2014-08-06 |
2016-02-11 |
주식회사 툴젠 |
캄필로박터 제주니 crispr/cas 시스템 유래 rgen을 이용한 유전체 교정
|
|
CN107429241B
(zh)
|
2014-08-14 |
2025-10-24 |
百奥赛图(北京)医药科技股份有限公司 |
Dna敲入系统
|
|
AU2015308910B2
(en)
*
|
2014-08-27 |
2017-12-07 |
Caribou Biosciences, Inc. |
Methods for increasing Cas9-mediated engineering efficiency
|
|
US10450584B2
(en)
|
2014-08-28 |
2019-10-22 |
North Carolina State University |
Cas9 proteins and guiding features for DNA targeting and genome editing
|
|
US10570418B2
(en)
|
2014-09-02 |
2020-02-25 |
The Regents Of The University Of California |
Methods and compositions for RNA-directed target DNA modification
|
|
CA2956487A1
(en)
|
2014-09-12 |
2016-03-17 |
E. I. Du Pont De Nemours And Company |
Generation of site-specific-integration sites for complex trait loci in corn and soybean, and methods of use
|
|
CN104212836A
(zh)
*
|
2014-09-18 |
2014-12-17 |
东华大学 |
一种在哺乳动物细胞系中敲除mir-505的方法
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
CN107109487B
(zh)
|
2014-10-15 |
2022-03-04 |
赛琪科学股份有限公司 |
自动处理核酸和电泳样品制备的装置、方法和系统
|
|
DK3207124T3
(da)
|
2014-10-15 |
2019-08-12 |
Regeneron Pharma |
Fremgangsmåder og sammensætninger til generering eller bevaring af pluripotente celler
|
|
GB201418965D0
(enExample)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
RU2739794C2
(ru)
|
2014-10-31 |
2020-12-28 |
Массачусетс Инститьют Оф Текнолоджи |
Доставка биомолекул в клетки иммунной системы
|
|
WO2016073433A1
(en)
|
2014-11-06 |
2016-05-12 |
E. I. Du Pont De Nemours And Company |
Peptide-mediated delivery of rna-guided endonuclease into cells
|
|
US12180263B2
(en)
|
2014-11-06 |
2024-12-31 |
President And Fellows Of Harvard College |
Cells lacking B2M surface expression and methods for allogeneic administration of such cells
|
|
US11680268B2
(en)
|
2014-11-07 |
2023-06-20 |
Editas Medicine, Inc. |
Methods for improving CRISPR/Cas-mediated genome-editing
|
|
US11352666B2
(en)
|
2014-11-14 |
2022-06-07 |
Institute For Basic Science |
Method for detecting off-target sites of programmable nucleases in a genome
|
|
CN107109486B
(zh)
*
|
2014-11-14 |
2021-08-13 |
基础科学研究院 |
用于检测基因组中遗传剪刀的脱靶位点的方法
|
|
EP3221457B1
(en)
|
2014-11-21 |
2019-03-20 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
US10900034B2
(en)
|
2014-12-03 |
2021-01-26 |
Agilent Technologies, Inc. |
Guide RNA with chemical modifications
|
|
CN113699116A
(zh)
|
2014-12-10 |
2021-11-26 |
明尼苏达大学董事会 |
用于治疗疾病的遗传修饰的细胞、组织和器官
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
DK3234150T3
(da)
*
|
2014-12-16 |
2025-11-03 |
Danisco Us Inc |
Systemer til svampegenommodificering og fremgangsmåder til anvendelse deraf
|
|
EP3786296A1
(en)
*
|
2014-12-18 |
2021-03-03 |
Integrated Dna Technologies, Inc. |
Crispr-based compositions and methods of use
|
|
JP6840077B2
(ja)
|
2014-12-19 |
2021-03-10 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
単一ステップの複数標的化を通じた標的化された遺伝子修飾のための方法及び組成物
|
|
US10196613B2
(en)
|
2014-12-19 |
2019-02-05 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
US11125739B2
(en)
|
2015-01-12 |
2021-09-21 |
Massachusetts Institute Of Technology |
Gene editing through microfluidic delivery
|
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
|
KR102194612B1
(ko)
*
|
2015-03-16 |
2020-12-23 |
인스티튜트 오브 제네틱스 앤드 디벨롭멘털 바이오롤지, 차이니즈 아카데미 오브 사이언시스 |
비-유전성 물질을 이용한 식물 게놈의 부위-특이적인 변형 방법
|
|
EP3271461A1
(en)
*
|
2015-03-20 |
2018-01-24 |
Danmarks Tekniske Universitet |
Crispr/cas9 based engineering of actinomycetal genomes
|
|
EP3274453B1
(en)
*
|
2015-03-26 |
2021-01-27 |
Editas Medicine, Inc. |
Crispr/cas-mediated gene conversion
|
|
US10450576B2
(en)
|
2015-03-27 |
2019-10-22 |
E I Du Pont De Nemours And Company |
Soybean U6 small nuclear RNA gene promoters and their use in constitutive expression of small RNA genes in plants
|
|
KR102888521B1
(ko)
|
2015-04-06 |
2025-11-19 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
EP4019975A1
(en)
|
2015-04-24 |
2022-06-29 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
CN107921148A
(zh)
|
2015-05-08 |
2018-04-17 |
哈佛学院校长同事会 |
通用供体干细胞和相关方法
|
|
CA2986310A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
KR101785847B1
(ko)
|
2015-05-12 |
2017-10-17 |
연세대학교 산학협력단 |
선형 이중가닥 DNA를 활용한 CRISPR/Cas9 시스템을 이용한 표적 유전체 교정
|
|
EP3095870A1
(en)
|
2015-05-19 |
2016-11-23 |
Kws Saat Se |
Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom
|
|
AU2016270649B2
(en)
|
2015-05-29 |
2022-04-21 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids
|
|
CN108368502B
(zh)
|
2015-06-03 |
2022-03-18 |
内布拉斯加大学董事委员会 |
使用单链dna的dna编辑
|
|
WO2016201047A1
(en)
|
2015-06-09 |
2016-12-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for improving transplantation
|
|
ES2960226T3
(es)
|
2015-06-15 |
2024-03-01 |
Univ North Carolina State |
Métodos y composiciones para la administración eficiente de ácidos nucleicos y antimicrobianos basados en ARN
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
US9790490B2
(en)
*
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
MX392008B
(es)
*
|
2015-06-18 |
2025-03-21 |
Broad Inst Inc |
Mutaciones de la enzima crispr que reducen los efectos fuera del blanco
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US11414657B2
(en)
|
2015-06-29 |
2022-08-16 |
Ionis Pharmaceuticals, Inc. |
Modified CRISPR RNA and modified single CRISPR RNA and uses thereof
|
|
JP6925984B2
(ja)
|
2015-07-09 |
2021-08-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
無核細胞への物質の送達
|
|
US20180208945A1
(en)
*
|
2015-07-28 |
2018-07-26 |
Danisco Us Inc. |
Genome editing systems and methods of use
|
|
IL295616A
(en)
*
|
2015-07-31 |
2022-10-01 |
Us Health |
Adapted cells and treatment methods
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
WO2017027910A1
(en)
|
2015-08-14 |
2017-02-23 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
CN108351350B
(zh)
|
2015-08-25 |
2022-02-18 |
杜克大学 |
使用rna指导型内切核酸酶改善基因组工程特异性的组合物和方法
|
|
US11613759B2
(en)
|
2015-09-04 |
2023-03-28 |
Sqz Biotechnologies Company |
Intracellular delivery of biomolecules to cells comprising a cell wall
|
|
WO2017053312A1
(en)
*
|
2015-09-21 |
2017-03-30 |
The Regents Of The University Of California |
Compositions and methods for target nucleic acid modification
|
|
EP3786294A1
(en)
|
2015-09-24 |
2021-03-03 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
WO2017058751A1
(en)
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
US11149281B2
(en)
*
|
2015-10-06 |
2021-10-19 |
Institute For Basic Science |
Method for producing genome-modified plants from plant protoplasts at high efficiency
|
|
US11970710B2
(en)
|
2015-10-13 |
2024-04-30 |
Duke University |
Genome engineering with Type I CRISPR systems in eukaryotic cells
|
|
US20180282763A1
(en)
*
|
2015-10-20 |
2018-10-04 |
Pioneer Hi-Bred International, Inc. |
Restoring function to a non-functional gene product via guided cas systems and methods of use
|
|
WO2017070598A1
(en)
|
2015-10-23 |
2017-04-27 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
|
EP4434589A3
(en)
|
2015-10-23 |
2025-05-14 |
President and Fellows of Harvard College |
Evolved cas9 proteins for gene editing
|
|
EP3371329B1
(en)
|
2015-11-03 |
2026-03-25 |
President and Fellows of Harvard College |
Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
|
|
KR101885901B1
(ko)
|
2015-11-13 |
2018-08-07 |
기초과학연구원 |
5' 말단의 인산기가 제거된 rna를 포함하는 리보핵산단백질 전달용 조성물
|
|
AU2016357319B2
(en)
*
|
2015-11-20 |
2022-03-10 |
Sage Science, Inc. |
Preparative electrophoretic method for targeted purification of genomic DNA fragments
|
|
CN106811479B
(zh)
*
|
2015-11-30 |
2019-10-25 |
中国农业科学院作物科学研究所 |
利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用
|
|
KR102787119B1
(ko)
|
2015-11-30 |
2025-03-27 |
듀크 유니버시티 |
유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
|
|
WO2017095946A1
(en)
|
2015-11-30 |
2017-06-08 |
Flagship Pioneering, Inc. |
Methods and compositions relating to chondrisomes
|
|
RU2018117360A
(ru)
|
2015-12-04 |
2020-01-09 |
Карибо Биосайенсиз, Инк. |
Сконструированные нуклеиновые кислоты, нацеленные на нуклеиновую кислоту
|
|
CN106845151B
(zh)
*
|
2015-12-07 |
2019-03-26 |
中国农业大学 |
CRISPR-Cas9系统sgRNA作用靶点的筛选方法及装置
|
|
WO2017099494A1
(ko)
*
|
2015-12-08 |
2017-06-15 |
기초과학연구원 |
Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
|
|
WO2017112620A1
(en)
|
2015-12-22 |
2017-06-29 |
North Carolina State University |
Methods and compositions for delivery of crispr based antimicrobials
|
|
MX2018008344A
(es)
|
2016-01-11 |
2018-12-06 |
Univ Leland Stanford Junior |
Proteinas quimericas y metodos para regular la expresion genica.
|
|
JP7012645B2
(ja)
|
2016-01-11 |
2022-01-28 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
キメラタンパク質および免疫治療の方法
|
|
AU2017208086A1
(en)
*
|
2016-01-15 |
2018-08-09 |
The Jackson Laboratory |
Genetically modified non-human mammals by multi-cycle electroporation of Cas9 protein
|
|
FI4272834T3
(fi)
|
2016-01-15 |
2025-12-05 |
Childrens Medical Ct Corp |
Mitokondrioiden ja yhdistettyjen mitokondriaalisten aineiden terapeuttinen käyttö
|
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
US11597924B2
(en)
|
2016-03-25 |
2023-03-07 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
SMT202500211T1
(it)
*
|
2016-03-30 |
2025-07-22 |
Intellia Therapeutics Inc |
Formulazioni di nanoparticelle lipidiche per componenti crispr/cas
|
|
WO2017180694A1
(en)
|
2016-04-13 |
2017-10-19 |
Editas Medicine, Inc. |
Cas9 fusion molecules gene editing systems, and methods of use thereof
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
KR20260004568A
(ko)
|
2016-04-19 |
2026-01-08 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
CA3210120C
(en)
|
2016-04-25 |
2024-04-09 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
|
CN107326046A
(zh)
*
|
2016-04-28 |
2017-11-07 |
上海邦耀生物科技有限公司 |
一种提高外源基因同源重组效率的方法
|
|
CN109475109B
(zh)
|
2016-05-20 |
2021-10-29 |
瑞泽恩制药公司 |
用于使用多个引导rna来破坏免疫耐受性的方法
|
|
MX388294B
(es)
*
|
2016-05-27 |
2025-03-19 |
Aadigen Llc |
Peptidos y nanoparticulas para suministro intracelular de moleculas editoras de genoma.
|
|
KR102811233B1
(ko)
|
2016-06-02 |
2025-05-29 |
시그마-알드리치 컴퍼니., 엘엘씨 |
프로그램가능한 dna 결합 단백질을 사용한, 표적화된 게놈 변형의 개선
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
US20190177710A1
(en)
*
|
2016-06-15 |
2019-06-13 |
Toolgen Incorporated |
Method For Screening Target Specific Nuclease Using Multi-Target System Of On-Target And Off-Target And Use Thereof
|
|
WO2017216771A2
(en)
*
|
2016-06-17 |
2017-12-21 |
Genesis Technologies Limited |
Crispr-cas system, materials and methods
|
|
KR20190019168A
(ko)
*
|
2016-06-17 |
2019-02-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
제vi형 crispr 오솔로그 및 시스템
|
|
EP3472325B1
(en)
*
|
2016-06-20 |
2024-04-03 |
Keygene N.V. |
Method for targeted dna alteration in plant cells
|
|
CN109688820B
(zh)
|
2016-06-24 |
2023-01-10 |
科罗拉多州立大学董事会(法人团体) |
用于生成条形码化组合文库的方法
|
|
CN109963598A
(zh)
*
|
2016-07-05 |
2019-07-02 |
约翰霍普金斯大学 |
用于治疗癌症的基于crispr/cas9的组合物和方法
|
|
KR102319845B1
(ko)
|
2016-07-13 |
2021-11-01 |
디에스엠 아이피 어셋츠 비.브이. |
조류 숙주 세포에 대한 crispr-cas 시스템
|
|
JP7004651B2
(ja)
*
|
2016-07-19 |
2022-02-04 |
株式会社バイオダイナミクス研究所 |
長鎖一本鎖dnaを調製する方法
|
|
EP4275747A3
(en)
|
2016-07-19 |
2024-01-24 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
CN109789185A
(zh)
|
2016-07-28 |
2019-05-21 |
基础科学研究院 |
用于治疗眼部疾病的含cas9蛋白和向导rna的药物组合物
|
|
RU2721125C1
(ru)
|
2016-07-29 |
2020-05-18 |
Регенерон Фармасьютикалз, Инк. |
Мыши, содержащие мутации, вследствие которых экспрессируется укороченный на с-конце фибриллин-1
|
|
CA3032822A1
(en)
|
2016-08-02 |
2018-02-08 |
Editas Medicine, Inc. |
Compositions and methods for treating cep290 associated disease
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
US11661590B2
(en)
|
2016-08-09 |
2023-05-30 |
President And Fellows Of Harvard College |
Programmable CAS9-recombinase fusion proteins and uses thereof
|
|
KR101710026B1
(ko)
|
2016-08-10 |
2017-02-27 |
주식회사 무진메디 |
Cas9 단백질 및 가이드 RNA의 혼성체를 함유하는 나노 리포좀 전달체 조성물
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
KR101856345B1
(ko)
*
|
2016-08-24 |
2018-06-20 |
경상대학교산학협력단 |
CRISPR/Cas9 시스템을 이용하여 APOBEC3H 및 APOBEC3CH 이중-넉아웃 고양이를 제조하는 방법
|
|
GB2569252A
(en)
|
2016-08-31 |
2019-06-12 |
Harvard College |
Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
WO2018064352A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
US11242542B2
(en)
|
2016-10-07 |
2022-02-08 |
Integrated Dna Technologies, Inc. |
S. pyogenes Cas9 mutant genes and polypeptides encoded by same
|
|
CN110462034A
(zh)
|
2016-10-07 |
2019-11-15 |
综合Dna技术公司 |
化脓链球菌cas9突变基因和由其编码的多肽
|
|
KR101997116B1
(ko)
|
2016-10-14 |
2019-07-05 |
연세대학교 산학협력단 |
Kras 유전자에 상보적인 가이드 rna 및 이의 용도
|
|
AU2017342543B2
(en)
|
2016-10-14 |
2024-06-27 |
President And Fellows Of Harvard College |
AAV delivery of nucleobase editors
|
|
EP4338799A3
(en)
|
2016-10-18 |
2024-06-05 |
Regents of the University of Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
WO2018144097A1
(en)
|
2016-11-04 |
2018-08-09 |
Akeagen Llc |
Genetically modified non-human animals and methods for producing heavy chain-only antibodies
|
|
CA3042259A1
(en)
|
2016-11-04 |
2018-05-11 |
Flagship Pioneering Innovations V. Inc. |
Novel plant cells, plants, and seeds
|
|
WO2018088694A2
(ko)
*
|
2016-11-14 |
2018-05-17 |
주식회사 툴젠 |
인위적으로 조작된 sc 기능 조절 시스템
|
|
JP2019535287A
(ja)
|
2016-11-22 |
2019-12-12 |
インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド |
Crispr/cpf1システム及び方法
|
|
WO2018111947A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing enhancement
|
|
KR101748575B1
(ko)
*
|
2016-12-16 |
2017-06-20 |
주식회사 엠젠플러스 |
Ins 유전자 녹아웃 당뇨병 또는 당뇨병 합병증 동물모델 및 이의 제조방법
|
|
WO2018119010A1
(en)
|
2016-12-19 |
2018-06-28 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
KR102117110B1
(ko)
|
2016-12-22 |
2020-05-29 |
주식회사 툴젠 |
Fad2 유전자 조작된 올레인산 강화 식물체 및 이의 제조 방법
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
CN110300802A
(zh)
*
|
2016-12-23 |
2019-10-01 |
基础科学研究院 |
用于动物胚胎碱基编辑的组合物和碱基编辑方法
|
|
JP6994730B2
(ja)
*
|
2016-12-26 |
2022-02-04 |
独立行政法人酒類総合研究所 |
ゲノム編集タンパク質の直接導入による糸状菌ゲノム編集方法
|
|
US11859219B1
(en)
|
2016-12-30 |
2024-01-02 |
Flagship Pioneering Innovations V, Inc. |
Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
|
|
WO2018129368A2
(en)
|
2017-01-06 |
2018-07-12 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
KR102515727B1
(ko)
*
|
2017-01-11 |
2023-03-30 |
주식회사 툴젠 |
중첩된 가이드핵산을 이용한 표적 핵산에 특정 핵산 서열을 삽입하기 위한 조성물 및 방법
|
|
WO2018136758A1
(en)
|
2017-01-23 |
2018-07-26 |
Regeneron Pharmaceuticals, Inc. |
Hsd17b13 variants and uses thereof
|
|
EP3573448A4
(en)
|
2017-01-28 |
2020-09-02 |
Inari Agriculture, Inc. |
NEW PLANT CELLS, PLANTS AND SEEDS
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
EP3594339A4
(en)
*
|
2017-03-06 |
2020-12-30 |
Institute For Basic Science |
COMPOSITION CONTAINING A C2CL ENDONUCLEASE FOR DIELECTRIC CALIBRATION, AND METHOD FOR DIELECTRIC CALIBRATION USING THE SAME
|
|
US11898179B2
(en)
|
2017-03-09 |
2024-02-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
CN110662556A
(zh)
|
2017-03-09 |
2020-01-07 |
哈佛大学的校长及成员们 |
癌症疫苗
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
WO2018176009A1
(en)
|
2017-03-23 |
2018-09-27 |
President And Fellows Of Harvard College |
Nucleobase editors comprising nucleic acid programmable dna binding proteins
|
|
US11867661B2
(en)
|
2017-04-07 |
2024-01-09 |
Sage Science, Inc. |
Systems and methods for detection of genetic structural variation using integrated electrophoretic DNA purification
|
|
US11767512B2
(en)
|
2017-04-13 |
2023-09-26 |
Cellectis |
Sequence specific reagents targeting CCR5 in primary hematopoietic cells
|
|
US11913015B2
(en)
|
2017-04-17 |
2024-02-27 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
|
US12058986B2
(en)
|
2017-04-20 |
2024-08-13 |
Egenesis, Inc. |
Method for generating a genetically modified pig with inactivated porcine endogenous retrovirus (PERV) elements
|
|
EP3615672A1
(en)
|
2017-04-28 |
2020-03-04 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide rna molecules
|
|
JP2020518253A
(ja)
*
|
2017-05-05 |
2020-06-25 |
インスティテュート・オブ・ジェネティクス・アンド・ディヴェロプメンタル・バイオロジー、チャイニーズ・アカデミー・オブ・サイエンシズInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences |
トランスジェニックマーカー配列を使用せず細胞を単離する方法
|
|
WO2018209158A2
(en)
|
2017-05-10 |
2018-11-15 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CN108977442B
(zh)
*
|
2017-06-05 |
2023-01-06 |
广州市锐博生物科技有限公司 |
用于dna编辑的系统及其应用
|
|
FI3635102T3
(fi)
|
2017-06-05 |
2025-10-28 |
Regeneron Pharma |
B4GALT1-variantteja ja niiden käyttöjä
|
|
EP3635104A1
(en)
|
2017-06-09 |
2020-04-15 |
Editas Medicine, Inc. |
Engineered cas9 nucleases
|
|
AU2018285860A1
(en)
|
2017-06-13 |
2020-01-02 |
Flagship Pioneering Innovations V, Inc. |
Compositions comprising curons and uses thereof
|
|
MX2019015188A
(es)
|
2017-06-15 |
2020-08-03 |
Univ California |
Inserciones de adn no virales orientadas.
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
EP3645021A4
(en)
|
2017-06-30 |
2021-04-21 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
|
CN107488710B
(zh)
|
2017-07-14 |
2020-09-22 |
上海吐露港生物科技有限公司 |
一种Cas蛋白的用途及靶标核酸分子的检测方法和试剂盒
|
|
WO2019014564A1
(en)
|
2017-07-14 |
2019-01-17 |
Editas Medicine, Inc. |
SYSTEMS AND METHODS OF TARGETED INTEGRATION AND GENOME EDITING AND DETECTION THEREOF WITH INTEGRATED PRIMING SITES
|
|
WO2019018441A1
(en)
*
|
2017-07-17 |
2019-01-24 |
Massachusetts Institute Of Technology |
ATLAS OF HEAVY AND ILLUMINATED HEAVY BARRIER TISSUE CELLS
|
|
US11732274B2
(en)
|
2017-07-28 |
2023-08-22 |
President And Fellows Of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
|
|
SG11201912235PA
(en)
|
2017-07-31 |
2020-01-30 |
Regeneron Pharma |
Cas-transgenic mouse embryonic stem cells and mice and uses thereof
|
|
EP3585160A2
(en)
|
2017-07-31 |
2020-01-01 |
Regeneron Pharmaceuticals, Inc. |
Crispr reporter non-human animals and uses thereof
|
|
AU2018309714A1
(en)
|
2017-07-31 |
2020-01-30 |
Regeneron Pharmaceuticals, Inc. |
Assessment of CRISPR/Cas-induced recombination with an exogenous donor nucleic acid in vivo
|
|
EP3663310A4
(en)
|
2017-08-04 |
2021-08-11 |
Peking University |
TALE RVD SPECIFICALLY RECOGNIZING A DNA BASE MODIFIED BY METHYLATION AND CORRESPONDING APPLICATION
|
|
US11624077B2
(en)
|
2017-08-08 |
2023-04-11 |
Peking University |
Gene knockout method
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
US11713452B2
(en)
|
2017-09-08 |
2023-08-01 |
University Of North Texas Health Science Center |
Engineered CAS9 variants
|
|
CN111194350A
(zh)
|
2017-09-18 |
2020-05-22 |
博雅辑因(北京)生物科技有限公司 |
一种基因编辑t细胞及其用途
|
|
RU2022103641A
(ru)
*
|
2017-09-28 |
2022-03-18 |
Тулджен Инкорпорейтед |
Искусственная модификация генома для регуляции экспрессии гена
|
|
US11572574B2
(en)
|
2017-09-28 |
2023-02-07 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
|
KR102207352B1
(ko)
*
|
2017-09-29 |
2021-01-26 |
서울대학교산학협력단 |
Klotho 유전자 넉아웃 질환모델 동물 및 이의 용도
|
|
KR20250093420A
(ko)
*
|
2017-09-29 |
2025-06-24 |
인텔리아 테라퓨틱스, 인크. |
게놈 편집을 위한 폴리뉴클레오티드, 조성물 및 방법
|
|
ES2962277T3
(es)
|
2017-09-29 |
2024-03-18 |
Regeneron Pharma |
Roedores que comprenden un locus Ttr humanizado y métodos de uso
|
|
KR20200121782A
(ko)
|
2017-10-16 |
2020-10-26 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
CN109722414A
(zh)
|
2017-10-27 |
2019-05-07 |
博雅辑因(北京)生物科技有限公司 |
一种高效制备成熟红细胞的方法以及用于制备成熟红细胞的培养基
|
|
JP7101419B2
(ja)
|
2017-10-27 |
2022-07-15 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
内因性t細胞受容体の標的置換
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
CN108192956B
(zh)
*
|
2017-11-17 |
2021-06-01 |
东南大学 |
一种基于Cas9核酸酶的DNA检测分析方法及其应用
|
|
WO2019103442A2
(ko)
|
2017-11-21 |
2019-05-31 |
한국생명공학연구원 |
CRISPR/Cpf1 시스템을 이용한 유전체 편집용 조성물 및 이의 용도
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
US20200362366A1
(en)
|
2018-01-12 |
2020-11-19 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
|
US12509492B2
(en)
|
2018-01-19 |
2025-12-30 |
Duke University |
Genome engineering with CRISPR-Cas systems in eukaryotes
|
|
CN111742051A
(zh)
|
2018-01-23 |
2020-10-02 |
基础科学研究院 |
延伸的单向导rna及其用途
|
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
|
WO2019156475A1
(ko)
*
|
2018-02-06 |
2019-08-15 |
주식회사 진씨커 |
돌연변이 세포 유리 유전자 분리 키트 및 이를 이용한 돌연변이 세포 유리 유전자 분리 방법
|
|
KR102086689B1
(ko)
*
|
2018-02-06 |
2020-03-09 |
주식회사 진씨커 |
돌연변이 세포 유리 유전자 분리 키트 및 이를 이용한 돌연변이 세포 유리 유전자 분리 방법
|
|
WO2019165168A1
(en)
|
2018-02-23 |
2019-08-29 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 orthologs
|
|
EP3765614A1
(en)
|
2018-03-14 |
2021-01-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
KR20240038811A
(ko)
|
2018-03-19 |
2024-03-25 |
리제너론 파마슈티칼스 인코포레이티드 |
CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
|
|
CN112334577B
(zh)
|
2018-04-19 |
2023-10-17 |
加利福尼亚大学董事会 |
用于基因编辑的组合物和方法
|
|
WO2019206233A1
(zh)
*
|
2018-04-25 |
2019-10-31 |
中国农业大学 |
一种RNA编辑的CRISPR/Cas效应蛋白及系统
|
|
CN112654710A
(zh)
|
2018-05-16 |
2021-04-13 |
辛瑟高公司 |
用于指导rna设计和使用的方法和系统
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
|
AU2019291918B2
(en)
|
2018-06-29 |
2025-06-12 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
KR102035654B1
(ko)
*
|
2018-07-23 |
2019-10-24 |
대한민국 |
항균 펩타이드를 생산하는 돌연변이 곤충 세포주 또는 이의 제조방법
|
|
US12545910B2
(en)
|
2018-08-31 |
2026-02-10 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US11479762B1
(en)
|
2018-08-31 |
2022-10-25 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US12534743B2
(en)
|
2018-08-31 |
2026-01-27 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
JP7410154B2
(ja)
*
|
2018-09-12 |
2024-01-09 |
インスティチュート フォー ベーシック サイエンス |
遺伝的に変異された細胞の死滅誘導組成物及び該組成物を用いた遺伝的に変異された細胞の死滅誘導方法
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
US12264313B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
WO2020072253A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for screening for variant cells
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
KR102081962B1
(ko)
*
|
2018-10-11 |
2020-02-26 |
충남대학교 산학협력단 |
아밀로이드 전구 단백질 유전자를 절단하기 위한 조성물
|
|
MX2021004278A
(es)
|
2018-10-18 |
2021-09-08 |
Intellia Therapeutics Inc |
Composiciones y metodos para la expresion de transgenes a partir de un locus de albumina.
|
|
BR112021007289A2
(pt)
|
2018-10-18 |
2021-07-27 |
Intellia Therapeutics, Inc. |
composições e métodos para tratar deficiência de alfa-1 antitripsina
|
|
AU2019360269A1
(en)
|
2018-10-18 |
2021-05-27 |
Intellia Therapeutics, Inc. |
Nucleic acid constructs and methods of use
|
|
EP3867380A2
(en)
|
2018-10-18 |
2021-08-25 |
Intellia Therapeutics, Inc. |
Compositions and methods for expressing factor ix
|
|
US20210395784A1
(en)
*
|
2018-10-29 |
2021-12-23 |
China Agricultural University |
Crispr/cas12f enzyme and system
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
JP2022505440A
(ja)
*
|
2018-11-01 |
2022-01-14 |
キージーン ナムローゼ フェンノートシャップ |
植物細胞におけるCRISPR/Casゲノム編集のためのデュアルガイドRNA
|
|
EP3650557B1
(en)
*
|
2018-11-07 |
2021-10-20 |
Justus-Liebig-Universität Gießen |
Method for determination of restriction efficiency of endonucleases mediating double-strand breaks in dna target sequences
|
|
US12365923B2
(en)
|
2018-11-16 |
2025-07-22 |
Osaka University |
Method for producing genome-edited cell
|
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
|
JP7553100B2
(ja)
*
|
2018-12-12 |
2024-09-18 |
国立大学法人九州大学 |
ゲノム編集された細胞の製造方法
|
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
|
US12365888B2
(en)
|
2018-12-14 |
2025-07-22 |
Pioneer Hi-Bred International, Inc. |
CRISPR-Cas systems for genome editing
|
|
US11690362B2
(en)
|
2018-12-20 |
2023-07-04 |
Regeneran Pharmaceuticals, Inc. |
Nuclease-mediated repeat expansion
|
|
WO2020146290A1
(en)
*
|
2019-01-07 |
2020-07-16 |
Crisp-Hr Therapeutics, Inc. |
A non-toxic cas9 enzyme and application thereof
|
|
WO2020154500A1
(en)
|
2019-01-23 |
2020-07-30 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
CN109868275A
(zh)
*
|
2019-03-12 |
2019-06-11 |
中国农业大学 |
CRISPR/Cas9介导的羊FGF5基因敲除和定点整合MTNR1A基因的方法
|
|
SG11202108090XA
(en)
|
2019-03-18 |
2021-08-30 |
Regeneron Pharma |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
|
WO2020190932A1
(en)
|
2019-03-18 |
2020-09-24 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
|
MX2021011426A
(es)
|
2019-03-19 |
2022-03-11 |
Broad Inst Inc |
Metodos y composiciones para editar secuencias de nucleótidos.
|
|
AU2020256225B9
(en)
|
2019-04-03 |
2025-04-10 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for insertion of antibody coding sequences into a safe harbor locus
|
|
US11111504B2
(en)
|
2019-04-04 |
2021-09-07 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
|
WO2020206139A1
(en)
|
2019-04-04 |
2020-10-08 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized coagulation factor 12 locus
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN113785059A
(zh)
|
2019-04-30 |
2021-12-10 |
博雅辑因(北京)生物科技有限公司 |
一种血红蛋白病治疗有效性预测方法
|
|
US11692197B2
(en)
|
2019-05-06 |
2023-07-04 |
Inari Agriculture Technology, Inc. |
Delivery of biological molecules to plant cells
|
|
CN111304180B
(zh)
*
|
2019-06-04 |
2023-05-26 |
山东舜丰生物科技有限公司 |
一种新的dna核酸切割酶及其应用
|
|
EP3801011A1
(en)
|
2019-06-04 |
2021-04-14 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
|
|
AU2020289581B2
(en)
|
2019-06-07 |
2024-11-21 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized albumin locus
|
|
CA3137765A1
(en)
|
2019-06-14 |
2020-12-17 |
Regeneron Pharmaceuticals, Inc. |
Models of tauopathy
|
|
MX2021014861A
(es)
|
2019-06-25 |
2022-06-22 |
Inari Agriculture Tech Inc |
Edicion genomica de reparacion dependiente de homologia mejorada.
|
|
US11746354B2
(en)
|
2019-07-19 |
2023-09-05 |
Inari Agriculture Technology, Inc. |
Homology dependent repair genome editing
|
|
CN115244176A
(zh)
*
|
2019-08-19 |
2022-10-25 |
钟明宏 |
向导rna-cas蛋白复合物的缀合物
|
|
KR20220053671A
(ko)
|
2019-09-04 |
2022-04-29 |
에디진 인크. |
오프 타겟 평가 기반의 유전자 편집 치료의 평가 방법
|
|
CA3153980A1
(en)
|
2019-09-13 |
2021-03-18 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems delivered by lipid nanoparticles
|
|
CA3147643A1
(en)
|
2019-09-23 |
2021-04-01 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (hnf4.alpha.) gene expression
|
|
EP4048807A1
(en)
|
2019-09-23 |
2022-08-31 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein b (apob) gene expression
|
|
CA3153197A1
(en)
|
2019-10-03 |
2021-04-08 |
Ryan T. Gill |
Crispr systems with engineered dual guide nucleic acids
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
AU2020369599A1
(en)
|
2019-10-23 |
2022-05-12 |
Monsanto Technology Llc |
Compositions and methods for RNA-templated editing in plants
|
|
CA3160186A1
(en)
*
|
2019-11-05 |
2021-05-14 |
Pairwise Plants Services, Inc. |
Compositions and methods for rna-encoded dna-replacement of alleles
|
|
AU2020379046B2
(en)
|
2019-11-08 |
2025-03-13 |
Regeneron Pharmaceuticals, Inc. |
CRISPR and AAV strategies for X-linked juvenile retinoschisis therapy
|
|
JP7448120B2
(ja)
*
|
2019-11-14 |
2024-03-12 |
国立研究開発法人農業・食品産業技術総合研究機構 |
プラズマを用いてゲノム編集酵素を植物細胞内に導入する方法
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
WO2021108442A2
(en)
*
|
2019-11-27 |
2021-06-03 |
The Regents Of The University Of California |
Modulators of cas9 polypeptide activity and methods of use thereof
|
|
CN114901813A
(zh)
|
2019-12-30 |
2022-08-12 |
博雅缉因(北京)生物科技有限公司 |
一种靶向t细胞淋巴瘤细胞的通用型car-t及其制备方法和应用
|
|
WO2021136415A1
(zh)
|
2019-12-30 |
2021-07-08 |
博雅辑因(北京)生物科技有限公司 |
一种纯化ucart细胞的方法与应用
|
|
WO2021143714A1
(en)
*
|
2020-01-14 |
2021-07-22 |
Mgi Tech Co., Ltd. |
Rapid multiplexing crispr-based diagnostics using microfluidic compartmentalization
|
|
US20230063739A1
(en)
*
|
2020-01-14 |
2023-03-02 |
Toolgen Incorporated |
Cells having high adaptability under hypoxic conditions, and use thereof
|
|
WO2021145703A1
(ko)
|
2020-01-14 |
2021-07-22 |
주식회사 툴젠 |
알츠하이머 예방 또는 치료용 약학적 조성물 및 이의 용도
|
|
WO2021155063A1
(en)
|
2020-01-29 |
2021-08-05 |
Readcoor, Llc |
Compositions and methods for analyte detection
|
|
WO2021163515A1
(en)
*
|
2020-02-12 |
2021-08-19 |
Temple University - Of The Commonwealth System Of Higher Education |
Crispr-cas9 mediated disruption of alcam gene inhibits adhesion and trans-endothelial migration of myeloid cells
|
|
JP2023515671A
(ja)
|
2020-03-04 |
2023-04-13 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
免疫療法に対する腫瘍細胞の感作のための方法及び組成物
|
|
EP4118207A1
(en)
|
2020-03-11 |
2023-01-18 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
|
WO2021195079A1
(en)
|
2020-03-23 |
2021-09-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
WO2021202938A1
(en)
|
2020-04-03 |
2021-10-07 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
WO2021226558A1
(en)
|
2020-05-08 |
2021-11-11 |
The Broad Institute, Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
CN111690720B
(zh)
*
|
2020-06-16 |
2021-06-15 |
山东舜丰生物科技有限公司 |
利用修饰的单链核酸进行靶核酸检测的方法
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
KR102638799B1
(ko)
*
|
2020-10-08 |
2024-02-22 |
주식회사 진코어 |
CRISPR/Cas12f1(Cas14a1) system 효율화를 위한 engineered guide RNA 및 이의 용도
|
|
WO2022120022A1
(en)
|
2020-12-02 |
2022-06-09 |
Regeneron Pharmaceuticals, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
WO2022124839A1
(ko)
*
|
2020-12-09 |
2022-06-16 |
재단법인 아산사회복지재단 |
온-타겟 활성이 유지되고 오프-타겟 활성이 감소된 가이드 rna 및 이의 용도
|
|
CA3206361A1
(en)
|
2020-12-23 |
2022-06-30 |
Flagship Pioneering Innovations V, Inc. |
In vitro assembly of anellovirus capsids enclosing rna
|
|
CN116848235A
(zh)
|
2020-12-30 |
2023-10-03 |
因特利亚治疗公司 |
工程化t细胞
|
|
KR102285906B1
(ko)
*
|
2021-02-18 |
2021-08-04 |
주식회사 엔에이피 |
수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물
|
|
EP4298212A1
(en)
|
2021-02-25 |
2024-01-03 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing, or modifying genes
|
|
EP4337769A1
(en)
|
2021-05-10 |
2024-03-20 |
SQZ Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
|
KR102616916B1
(ko)
*
|
2021-05-11 |
2023-12-21 |
주식회사 애이마 |
발암성 돌연변이 유전자 검출용 가이드 rna 내지 이의 용도
|
|
WO2022251644A1
(en)
|
2021-05-28 |
2022-12-01 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
EP4419672A2
(en)
|
2021-06-01 |
2024-08-28 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing, or modifying genes
|
|
WO2022256437A1
(en)
|
2021-06-02 |
2022-12-08 |
Lyell Immunopharma, Inc. |
Nr4a3-deficient immune cells and uses thereof
|
|
KR102618072B1
(ko)
|
2021-06-15 |
2023-12-28 |
대한민국 |
작물의 개화조절 관련 유전자 교정용 가이드 rna 및 이의 용도
|
|
EP4370676A2
(en)
|
2021-06-18 |
2024-05-22 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing or modifying human genes
|
|
WO2023283359A2
(en)
|
2021-07-07 |
2023-01-12 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
|
EP4368703A4
(en)
|
2021-07-09 |
2025-07-09 |
Toolgen Inc |
MESENCHYMAL STEM CELL HAVING RESISTANCE TO OXIDATIVE STRESS, PREPARATION METHOD AND USE THEREOF
|
|
WO2023008933A1
(ko)
|
2021-07-29 |
2023-02-02 |
주식회사 툴젠 |
혈액 적합성을 갖는 중간엽 줄기세포, 이의 제조방법 및 용도
|
|
CN113584134B
(zh)
*
|
2021-09-06 |
2024-01-30 |
青岛金斯达生物技术有限公司 |
一种基于CRISPR-Cas9的等温核酸检测系统及其方法和应用
|
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
|
KR20240099259A
(ko)
|
2021-10-14 |
2024-06-28 |
아스널 바이오사이언시스, 인크. |
공동 발현된 shrna 및 논리 게이트 시스템을 갖는 면역 세포
|
|
KR20240082391A
(ko)
|
2021-10-14 |
2024-06-10 |
론자 세일즈 아게 |
세포외 소포 생산을 위한 변형된 생산자 세포
|
|
EP4423271A2
(en)
|
2021-10-28 |
2024-09-04 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-related methods and compositions for knocking out c5
|
|
WO2023077148A1
(en)
|
2021-11-01 |
2023-05-04 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
KR20240117571A
(ko)
|
2021-12-08 |
2024-08-01 |
리제너론 파마슈티칼스 인코포레이티드 |
돌연변이 마이오실린 질환 모델 및 이의 용도
|
|
AU2022420615A1
(en)
|
2021-12-22 |
2024-07-04 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
AU2022417615A1
(en)
|
2021-12-23 |
2024-06-27 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
|
CA3241882A1
(en)
|
2021-12-29 |
2023-07-06 |
Bristol-Myers Squibb Company |
Generation of landing pad cell lines
|
|
WO2023150181A1
(en)
|
2022-02-01 |
2023-08-10 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
JP2025508677A
(ja)
|
2022-02-02 |
2025-04-10 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ポンペ病の処置のための抗TfR:GAA及び抗CD63:GAAの挿入
|
|
US20250388896A1
(en)
|
2022-03-01 |
2025-12-25 |
Celyntra Therapeutics Sa |
Composition and methods for transgene insertion
|
|
JP2025506976A
(ja)
|
2022-03-04 |
2025-03-13 |
ツールゲン インコーポレイテッド |
低免疫原性幹細胞、幹細胞から分化または由来した低免疫原性細胞およびこの製造方法
|
|
CN114410609B
(zh)
*
|
2022-03-29 |
2022-07-12 |
舜丰生物科技(海南)有限公司 |
一种活性提高的Cas蛋白以及应用
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023205844A1
(en)
*
|
2022-04-26 |
2023-11-02 |
Peter Maccallum Cancer Institute |
Nucleic acids and uses thereof
|
|
CN117004604A
(zh)
*
|
2022-04-28 |
2023-11-07 |
南京北恒生物科技有限公司 |
一种ciita基因被敲除的工程化免疫细胞及其用途
|
|
EP4514981A2
(en)
|
2022-04-29 |
2025-03-05 |
Regeneron Pharmaceuticals, Inc. |
Identification of tissue-specific extragenic safe harbors for gene therapy approaches
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
WO2023220603A1
(en)
|
2022-05-09 |
2023-11-16 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
|
WO2023219434A1
(ko)
|
2022-05-13 |
2023-11-16 |
주식회사 툴젠 |
혈액 적합성을 갖는 혈관 내 이식용 세포, 이의 제조방법 및 용도
|
|
CN119947735A
(zh)
|
2022-05-19 |
2025-05-06 |
莱尔免疫制药公司 |
靶向nr4a3的多核苷酸及其用途
|
|
EP4526884A2
(en)
|
2022-05-20 |
2025-03-26 |
Artisan Development Labs, Inc. |
Systems and methods for assessing risk of genome editing events
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
EP4532765A2
(en)
|
2022-05-25 |
2025-04-09 |
Flagship Pioneering Innovations VII, LLC |
Compositions and methods for modulation of immune responses
|
|
CA3254044A1
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
COMPOSITIONS AND MODULATION METHODS OF TUMOR SUPPRESSANTS AND ONCOGENS
|
|
US20250319115A1
(en)
|
2022-05-25 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and Methods for Modulating Cytokines
|
|
EP4533088A2
(en)
|
2022-05-25 |
2025-04-09 |
Flagship Pioneering Innovations VII, LLC |
Compositions and methods for modulating genetic drivers
|
|
US20250320254A1
(en)
|
2022-05-25 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and Methods for Modulating Circulating Factors
|
|
EP4532720A2
(en)
|
2022-05-31 |
2025-04-09 |
Regeneron Pharmaceuticals, Inc. |
Crispr interference therapeutics for c9orf72 repeat expansion disease
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
EP4544051A2
(en)
|
2022-06-24 |
2025-04-30 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
|
|
JP2025525437A
(ja)
|
2022-06-29 |
2025-08-05 |
インテリア セラピューティクス,インコーポレイテッド |
操作されたt細胞
|
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
AU2023314808A1
(en)
|
2022-07-29 |
2025-03-20 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
|
CA3261296A1
(en)
|
2022-08-05 |
2024-02-08 |
Regeneron Pharmaceuticals, Inc. |
TDP-43 VARIANTS RESISTANT TO AGGREGATION
|
|
CN115386597B
(zh)
*
|
2022-09-19 |
2025-04-25 |
国家纳米科学中心 |
一种提高基因载体转染效率和/或转染精度的转染辅助试剂及其应用
|
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
|
WO2024073606A1
(en)
|
2022-09-28 |
2024-04-04 |
Regeneron Pharmaceuticals, Inc. |
Antibody resistant modified receptors to enhance cell-based therapies
|
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
EP4612184A1
(en)
|
2022-11-04 |
2025-09-10 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
|
WO2024107765A2
(en)
|
2022-11-14 |
2024-05-23 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
JP2026503704A
(ja)
|
2023-01-27 |
2026-01-29 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
修飾されたラブドウイルス糖タンパク質およびその使用
|
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
|
WO2024218295A1
(en)
|
2023-04-21 |
2024-10-24 |
Vib Vzw |
Allelic combinations in crops for yield increase
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
|
KR20260026049A
(ko)
|
2023-06-15 |
2026-02-25 |
리제너론 파아마슈티컬스, 인크. |
청력 장애에 대한 유전자 치료
|
|
AU2024309884A1
(en)
|
2023-06-30 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for increasing homology-directed repair
|
|
AU2024317483A1
(en)
|
2023-07-28 |
2026-01-29 |
Regeneron Pharmaceuticals, Inc. |
Anti-tfr:gaa and anti-cd63:gaa insertion for treatment of pompe disease
|
|
AR133384A1
(es)
|
2023-07-28 |
2025-09-24 |
Regeneron Pharma |
Anti-tfr:esfingomielinasa ácida para el tratamiento de la deficiencia de esfingomielinasa ácida
|
|
AU2024315073A1
(en)
|
2023-07-28 |
2026-01-22 |
Regeneron Pharmaceuticals, Inc. |
Use of bgh-sv40l tandem polya to enhance transgene expression during unidirectional gene insertion
|
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
WO2025038164A1
(en)
*
|
2023-08-15 |
2025-02-20 |
University Of Massachusetts |
Nick resection in cancer
|
|
WO2025049524A1
(en)
|
2023-08-28 |
2025-03-06 |
Regeneron Pharmaceuticals, Inc. |
Cxcr4 antibody-resistant modified receptors
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
WO2025056732A1
(en)
|
2023-09-13 |
2025-03-20 |
Medizinische Universität Graz |
Method for providing antigen-reactive lymphocytes
|
|
WO2025076141A1
(en)
|
2023-10-03 |
2025-04-10 |
Inari Agriculture Technology, Inc. |
Viral delivery of grna to the scion
|
|
WO2025137439A2
(en)
|
2023-12-20 |
2025-06-26 |
Intellia Therapeutics, Inc. |
Engineered t cells
|
|
WO2025168705A1
(en)
|
2024-02-08 |
2025-08-14 |
Vib Vzw |
Means and methods for the production of saponins with endosomal escape-enhancing properties
|
|
US20250276092A1
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
|
|
WO2025188676A1
(en)
*
|
2024-03-04 |
2025-09-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genetic engineering of cells for secretion of therapeutic antibodies
|
|
WO2025217398A1
(en)
|
2024-04-10 |
2025-10-16 |
Lyell Immunopharma, Inc. |
Methods for culturing cells with improved culture medium
|
|
WO2025224107A1
(en)
|
2024-04-22 |
2025-10-30 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
WO2025240947A1
(en)
|
2024-05-17 |
2025-11-20 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
|
WO2025259669A1
(en)
|
2024-06-10 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for characterizing modified oligonucleotides
|
|
US20250388890A1
(en)
|
2024-06-20 |
2025-12-25 |
Regeneron Pharmaceuticals, Inc. |
ASS1 Gene Insertion For The Treatment Of Citrullinemia Type I
|
|
US20260043035A1
(en)
|
2024-08-08 |
2026-02-12 |
Invaio Sciences, Inc. |
Nature-derived lipid particles for use in agriculture
|