|
AR085533A1
(es)
|
2011-03-23 |
2013-10-09 |
Pioneer Hi Bred Int |
Metodos de produccion de un locus de rasgos transgenicos complejo
|
|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
EP2766498B1
(en)
|
2011-10-14 |
2019-06-19 |
President and Fellows of Harvard College |
Sequencing by structure assembly
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
US9637739B2
(en)
*
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
ES2683071T3
(es)
|
2012-04-25 |
2018-09-24 |
Regeneron Pharmaceuticals, Inc. |
Direccionamiento mediado por nucleasas con grandes vectores de direccionamiento
|
|
EP2841572B1
(en)
|
2012-04-27 |
2019-06-19 |
Duke University |
Genetic correction of mutated genes
|
|
ES2728782T3
(es)
|
2012-05-25 |
2019-10-28 |
Univ California |
Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN
|
|
US20150225734A1
(en)
|
2012-06-19 |
2015-08-13 |
Regents Of The University Of Minnesota |
Gene targeting in plants using dna viruses
|
|
CN116622704A
(zh)
*
|
2012-07-25 |
2023-08-22 |
布罗德研究所有限公司 |
可诱导的dna结合蛋白和基因组干扰工具及其应用
|
|
EP4397759A3
(en)
*
|
2012-10-23 |
2024-10-09 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
DK3363902T3
(da)
|
2012-12-06 |
2020-01-02 |
Sigma Aldrich Co Llc |
Crispr-baseret genommodifikation og -regulering
|
|
WO2014093694A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
|
|
US8697359B1
(en)
*
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
KR102955556B1
(ko)
*
|
2012-12-12 |
2026-04-22 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
|
|
SG10201707569YA
(en)
|
2012-12-12 |
2017-10-30 |
Broad Inst Inc |
Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
|
|
CN105209621B
(zh)
*
|
2012-12-12 |
2021-05-25 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
EP3064585B1
(en)
|
2012-12-12 |
2020-02-05 |
The Broad Institute, Inc. |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
MX380562B
(es)
*
|
2012-12-12 |
2025-03-12 |
Broad Inst Inc |
Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias.
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
PT2931898E
(pt)
|
2012-12-12 |
2016-06-16 |
Harvard College |
Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais
|
|
IL308158A
(en)
*
|
2012-12-17 |
2023-12-01 |
Harvard College |
Rna-guided human genome engineering
|
|
US10138509B2
(en)
|
2013-03-12 |
2018-11-27 |
President And Fellows Of Harvard College |
Method for generating a three-dimensional nucleic acid containing matrix
|
|
ES2749624T3
(es)
|
2013-03-14 |
2020-03-23 |
Caribou Biosciences Inc |
Composiciones y métodos de ácidos nucleicos dirigidos a ácido nucleico
|
|
JP2016512048A
(ja)
*
|
2013-03-15 |
2016-04-25 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
ＣＲＩＳＰＲ／Ｃａｓシステムを使用した植物ゲノム操作
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
EP4286517A3
(en)
|
2013-04-04 |
2024-03-13 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
DK3456831T3
(da)
|
2013-04-16 |
2021-09-06 |
Regeneron Pharma |
Målrettet modifikation af rottegenom
|
|
WO2014172470A2
(en)
*
|
2013-04-16 |
2014-10-23 |
Whitehead Institute For Biomedical Research |
Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal
|
|
WO2014186686A2
(en)
*
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
|
DK3004349T3
(en)
*
|
2013-05-29 |
2018-06-06 |
Cellectis Sa |
A method for producing precise DNA cleavage using CAS9 nickase activity
|
|
EP3603679B1
(en)
|
2013-06-04 |
2022-08-10 |
President and Fellows of Harvard College |
Rna-guided transcriptional regulation
|
|
US20160145631A1
(en)
|
2013-06-14 |
2016-05-26 |
Cellectis |
Methods for non-transgenic genome editing in plants
|
|
JP6738728B2
(ja)
|
2013-06-17 |
2020-08-19 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
肝臓ターゲティングおよび治療のためのＣＲＩＳＰＲ−Ｃａｓ系、ベクターおよび組成物の送達および使用
|
|
KR20250012194A
(ko)
|
2013-06-17 |
2025-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
WO2014204725A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
ES2777217T3
(es)
|
2013-06-17 |
2020-08-04 |
Broad Inst Inc |
Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
KR20260047646A
(ko)
*
|
2013-07-09 |
2026-04-08 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
멀티플렉스 rna-가이드된 게놈 조작
|
|
JP2016528890A
(ja)
|
2013-07-09 |
2016-09-23 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
ＣＲＩＳＰＲ／Ｃａｓ系を用いるゲノム編集の治療用の使用
|
|
US11306328B2
(en)
|
2013-07-26 |
2022-04-19 |
President And Fellows Of Harvard College |
Genome engineering
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US10124336B2
(en)
|
2013-08-16 |
2018-11-13 |
Massachusetts Institute Of Technology |
Selective delivery of material to cells
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
CN106133138A
(zh)
|
2013-08-22 |
2016-11-16 |
先锋国际良种公司 |
使用引导多核苷酸/cas内切核酸酶系统的基因组修饰及其使用方法
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
ES2681622T3
(es)
|
2013-09-18 |
2018-09-14 |
Kymab Limited |
Métodos, células y organismos
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
|
CN111218447B
(zh)
|
2013-11-07 |
2024-10-11 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
US10787684B2
(en)
*
|
2013-11-19 |
2020-09-29 |
President And Fellows Of Harvard College |
Large gene excision and insertion
|
|
MX388127B
(es)
|
2013-12-11 |
2025-03-19 |
Regeneron Pharma |
Metodos y composiciones para la modificacion dirigida de un genoma.
|
|
EP3460063B1
(en)
|
2013-12-11 |
2024-03-13 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
|
CA2932439A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute, Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
CN105899658B
(zh)
|
2013-12-12 |
2020-02-18 |
布罗德研究所有限公司 |
针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
|
|
CN111206032B
(zh)
|
2013-12-12 |
2024-07-19 |
布罗德研究所有限公司 |
用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
KR20160097338A
(ko)
|
2013-12-12 |
2016-08-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
뉴클레오티드 반복 장애에서의 ｃｒｉｓｐｒ-ｃａｓ 시스템의 조성물 및 방법 및 용도
|
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
LT3105328T
(lt)
|
2014-02-11 |
2020-07-10 |
The Regents Of The University Of Colorado, A Body Corporate |
Daugiakomponentis genomo konstravimas, sudarantis sąlygas crispr
|
|
WO2015126927A2
(en)
|
2014-02-18 |
2015-08-27 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
ES2898460T3
(es)
|
2014-02-27 |
2022-03-07 |
Monsanto Technology Llc |
Composiciones y procedimientos para la modificación genómica dirigida al sitio
|
|
EP3613854A1
(en)
*
|
2014-03-05 |
2020-02-26 |
National University Corporation Kobe University |
Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
|
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
US9938521B2
(en)
|
2014-03-10 |
2018-04-10 |
Editas Medicine, Inc. |
CRISPR/CAS-related methods and compositions for treating leber's congenital amaurosis 10 (LCA10)
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3981876A1
(en)
|
2014-03-26 |
2022-04-13 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
EP3129490A4
(en)
|
2014-04-08 |
2017-10-04 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
|
WO2015179540A1
(en)
*
|
2014-05-20 |
2015-11-26 |
Regents Of The University Of Minnesota |
Method for editing a genetic sequence
|
|
WO2015183026A1
(ko)
*
|
2014-05-28 |
2015-12-03 |
주식회사 툴젠 |
불활성화된 표적 특이적 뉴클레아제를 이용한 표적 dna의 분리 방법
|
|
US9970001B2
(en)
|
2014-06-05 |
2018-05-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for nuclease design
|
|
DK3152312T3
(da)
|
2014-06-06 |
2020-04-06 |
Regeneron Pharma |
Fremgangsmåder og sammensætninger til modifikation af et mållocus
|
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
CA2952121A1
(en)
|
2014-06-13 |
2015-12-17 |
Childrens' Medical Center Corporation |
Products and methods to isolate mitochondria
|
|
US9738897B2
(en)
|
2014-06-23 |
2017-08-22 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated DNA assembly
|
|
WO2015200555A2
(en)
*
|
2014-06-25 |
2015-12-30 |
Caribou Biosciences, Inc. |
Rna modification to engineer cas9 activity
|
|
DK3161128T3
(en)
|
2014-06-26 |
2018-11-05 |
Regeneron Pharma |
METHODS AND COMPOSITIONS FOR TARGETED GENTICAL MODIFICATIONS AND PROCEDURES FOR USE THEREOF
|
|
EP3166391A1
(en)
|
2014-07-11 |
2017-05-17 |
E. I. du Pont de Nemours and Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
WO2016007839A1
(en)
|
2014-07-11 |
2016-01-14 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
EP3169776B1
(en)
*
|
2014-07-14 |
2025-09-03 |
The Regents of The University of California |
Crispr/cas transcriptional modulation
|
|
EP3172321B2
(en)
*
|
2014-07-21 |
2023-01-04 |
Illumina, Inc. |
Polynucleotide enrichment using crispr-cas systems
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
CN106536721B
(zh)
*
|
2014-08-06 |
2020-12-04 |
车医科学大学校产学协力团 |
核酸酶介导的编辑编码hla的基因所产生的免疫相容性细胞
|
|
WO2016021973A1
(ko)
*
|
2014-08-06 |
2016-02-11 |
주식회사 툴젠 |
캄필로박터 제주니 crispr/cas 시스템 유래 rgen을 이용한 유전체 교정
|
|
CN107429241B
(zh)
|
2014-08-14 |
2025-10-24 |
百奥赛图(北京)医药科技股份有限公司 |
Dna敲入系统
|
|
ES2730378T3
(es)
|
2014-08-27 |
2019-11-11 |
Caribou Biosciences Inc |
Procedimientos para incrementar la eficiencia de la modificación mediada por Cas9
|
|
US10450584B2
(en)
|
2014-08-28 |
2019-10-22 |
North Carolina State University |
Cas9 proteins and guiding features for DNA targeting and genome editing
|
|
WO2016036754A1
(en)
|
2014-09-02 |
2016-03-10 |
The Regents Of The University Of California |
Methods and compositions for rna-directed target dna modification
|
|
BR112017003757A2
(pt)
|
2014-09-12 |
2017-12-26 |
Du Pont |
?plantas de milho, partes de planta de milho ou sementes de milho?
|
|
CN104212836A
(zh)
*
|
2014-09-18 |
2014-12-17 |
东华大学 |
一种在哺乳动物细胞系中敲除mir-505的方法
|
|
EP3204496A1
(en)
|
2014-10-10 |
2017-08-16 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
BR112017007770A2
(pt)
|
2014-10-15 |
2018-01-16 |
Regeneron Pharma |
cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc.
|
|
US10131901B2
(en)
|
2014-10-15 |
2018-11-20 |
Sage Science, Inc. |
Apparatuses, methods and systems for automated processing of nucleic acids and electrophoretic sample preparation
|
|
GB201418965D0
(enExample)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
CN122564053A
(zh)
|
2014-10-31 |
2026-08-14 |
麻省理工学院 |
递送生物分子至免疫细胞
|
|
WO2016073955A2
(en)
|
2014-11-06 |
2016-05-12 |
President And Fellows Of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
DK3597740T3
(da)
*
|
2014-11-06 |
2022-06-20 |
Dupont Us Holding Llc |
Peptidmedieret indføring af rna-styret endonuklease i celler
|
|
WO2016073990A2
(en)
*
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
WO2016076672A1
(ko)
*
|
2014-11-14 |
2016-05-19 |
기초과학연구원 |
유전체에서 유전자 가위의 비표적 위치를 검출하는 방법
|
|
US11352666B2
(en)
|
2014-11-14 |
2022-06-07 |
Institute For Basic Science |
Method for detecting off-target sites of programmable nucleases in a genome
|
|
EP3221457B1
(en)
|
2014-11-21 |
2019-03-20 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
CA2969619A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
WO2016094679A1
(en)
|
2014-12-10 |
2016-06-16 |
Regents Of The University Of Minnesota |
Genetically modified cells, tissues, and organs for treating disease
|
|
EP3985115A1
(en)
|
2014-12-12 |
2022-04-20 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
CN107667171A
(zh)
|
2014-12-16 |
2018-02-06 |
丹尼斯科美国公司 |
真菌基因组修饰系统及使用方法
|
|
JP2017538427A
(ja)
*
|
2014-12-18 |
2017-12-28 |
インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド |
Ｃｒｉｓｐｒ系組成物及び使用方法
|
|
MX388784B
(es)
|
2014-12-19 |
2025-03-20 |
Regeneron Pharma |
Métodos y composiciones para la modificación genética dirigida a través de direccionamiento múltiple de una sola etapa.
|
|
WO2016100857A1
(en)
|
2014-12-19 |
2016-06-23 |
Regeneron Pharmaceuticals, Inc. |
Stem cells for modeling type 2 diabetes
|
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
|
AU2016206870B2
(en)
|
2015-01-12 |
2022-02-17 |
Massachusetts Institute Of Technology |
Gene editing through microfluidic delivery
|
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
AR103926A1
(es)
*
|
2015-03-16 |
2017-06-14 |
Inst Genetics & Dev Biolog Cas |
Método para realizar modificaciones sitio dirigidas en el genoma de una planta usando materiales no heredables
|
|
WO2016150855A1
(en)
*
|
2015-03-20 |
2016-09-29 |
Danmarks Tekniske Universitet |
Crispr/cas9 based engineering of actinomycetal genomes
|
|
EP3274453B1
(en)
*
|
2015-03-26 |
2021-01-27 |
Editas Medicine, Inc. |
Crispr/cas-mediated gene conversion
|
|
BR112017017260A2
(pt)
|
2015-03-27 |
2018-04-17 |
Du Pont |
construções de dna, vetor, célula, plantas, semente, método de expressão de rna e método de modificação de local alvo
|
|
CN107787367B
(zh)
|
2015-04-06 |
2021-10-26 |
里兰斯坦福初级大学理事会 |
用于crispr/cas介导的基因调控的化学修饰的引导rna
|
|
GB201506509D0
(en)
|
2015-04-16 |
2015-06-03 |
Univ Wageningen |
Nuclease-mediated genome editing
|
|
EP4019975A1
(en)
|
2015-04-24 |
2022-06-29 |
Editas Medicine, Inc. |
Evaluation of cas9 molecule/guide rna molecule complexes
|
|
EP3294342A4
(en)
|
2015-05-08 |
2018-11-07 |
President and Fellows of Harvard College |
Universal donor stem cells and related methods
|
|
CA2986310A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
KR101785847B1
(ko)
|
2015-05-12 |
2017-10-17 |
연세대학교 산학협력단 |
선형 이중가닥 ＤＮＡ를 활용한 ＣＲＩＳＰＲ／Ｃａｓ９ 시스템을 이용한 표적 유전체 교정
|
|
EP3095870A1
(en)
|
2015-05-19 |
2016-11-23 |
Kws Saat Se |
Methods for the in planta transformation of plants and manufacturing processes and products based and obtainable therefrom
|
|
WO2016196361A1
(en)
|
2015-05-29 |
2016-12-08 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids
|
|
CN108368502B
(zh)
|
2015-06-03 |
2022-03-18 |
内布拉斯加大学董事委员会 |
使用单链dna的dna编辑
|
|
US11911415B2
(en)
|
2015-06-09 |
2024-02-27 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for improving transplantation
|
|
AU2016280002B2
(en)
|
2015-06-15 |
2022-04-14 |
North Carolina State University |
Methods and compositions for efficient delivery of nucleic acids and RNA-based antimicrobials
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US9790490B2
(en)
*
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
US10648020B2
(en)
|
2015-06-18 |
2020-05-12 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
EP3929287A3
(en)
|
2015-06-18 |
2022-04-13 |
The Broad Institute, Inc. |
Crispr enzyme mutations reducing off-target effects
|
|
JP2018519811A
(ja)
|
2015-06-29 |
2018-07-26 |
アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
修飾ｃｒｉｓｐｒ ｒｎａ及び修飾単一ｃｒｉｓｐｒ ｒｎａならびにその使用
|
|
JP6925984B2
(ja)
|
2015-07-09 |
2021-08-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
無核細胞への物質の送達
|
|
US20180208945A1
(en)
*
|
2015-07-28 |
2018-07-26 |
Danisco Us Inc. |
Genome editing systems and methods of use
|
|
EP4339287A3
(en)
|
2015-07-31 |
2024-05-22 |
Regents Of The University Of Minnesota |
Modified cells and methods of therapy
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
EP3334746B1
(en)
|
2015-08-14 |
2021-11-24 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
KR20240132120A
(ko)
*
|
2015-08-25 |
2024-09-02 |
듀크 유니버시티 |
Rna-가이드된 엔도뉴클레아제를 이용하는 게놈 조작에서 특이성을 개선하는 조성물 및 방법
|
|
US11613759B2
(en)
|
2015-09-04 |
2023-03-28 |
Sqz Biotechnologies Company |
Intracellular delivery of biomolecules to cells comprising a cell wall
|
|
US20180237800A1
(en)
*
|
2015-09-21 |
2018-08-23 |
The Regents Of The University Of California |
Compositions and methods for target nucleic acid modification
|
|
CA2999500A1
(en)
|
2015-09-24 |
2017-03-30 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
US11286480B2
(en)
|
2015-09-28 |
2022-03-29 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
CN111961683A
(zh)
|
2015-10-06 |
2020-11-20 |
基础科学研究院 |
用于以高效率从植物原生质体生成基因组工程改造的植物的方法
|
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
BR112018008134A2
(pt)
*
|
2015-10-20 |
2018-11-06 |
Pioneer Hi Bred Int |
método para restaurar a função de um produto gênico não funcional no genoma de uma célula, método para editar uma sequência nucleotídica no genoma de uma célula, planta ou planta de progênie, método para editar uma sequência nucleotídica no genoma de uma célula sem o uso de um molde polinucleotídico de modificação e método para entregar um complexo de rna guia/endonuclease cas numa célula
|
|
EP3350327B1
(en)
|
2015-10-23 |
2018-09-26 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
|
WO2017070632A2
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
CN108474022A
(zh)
|
2015-11-03 |
2018-08-31 |
哈佛学院董事及会员团体 |
用于包含三维核酸的基质容积成像的设备和方法
|
|
KR101885901B1
(ko)
*
|
2015-11-13 |
2018-08-07 |
기초과학연구원 |
5' 말단의 인산기가 제거된 rna를 포함하는 리보핵산단백질 전달용 조성물
|
|
EP3414255B1
(en)
*
|
2015-11-20 |
2021-09-22 |
Washington University |
Preparative electrophoretic method for targeted purification of genomic dna fragments
|
|
CN106811479B
(zh)
*
|
2015-11-30 |
2019-10-25 |
中国农业科学院作物科学研究所 |
利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用
|
|
US20170151287A1
(en)
|
2015-11-30 |
2017-06-01 |
Flagship Ventures Management, Inc. |
Methods and compositions of chondrisomes
|
|
US12214054B2
(en)
|
2015-11-30 |
2025-02-04 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
EP3564371B1
(en)
*
|
2015-12-04 |
2020-05-27 |
Caribou Biosciences, Inc. |
Engineered nucleic-acid targeting nucleic acids
|
|
CN106845151B
(zh)
*
|
2015-12-07 |
2019-03-26 |
中国农业大学 |
CRISPR-Cas9系统sgRNA作用靶点的筛选方法及装置
|
|
WO2017099494A1
(ko)
*
|
2015-12-08 |
2017-06-15 |
기초과학연구원 |
Cpf1을 포함하는 유전체 교정용 조성물 및 그 용도
|
|
WO2017112620A1
(en)
|
2015-12-22 |
2017-06-29 |
North Carolina State University |
Methods and compositions for delivery of crispr based antimicrobials
|
|
WO2017123559A2
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of regulating gene expression
|
|
JP7012645B2
(ja)
|
2016-01-11 |
2022-01-28 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
キメラタンパク質および免疫治療の方法
|
|
CA3011481A1
(en)
*
|
2016-01-15 |
2017-07-20 |
The Jackson Laboratory |
Genetically modified non-human mammals by multi-cycle electroporation of cas9 protein
|
|
ES3057779T3
(en)
|
2016-01-15 |
2026-03-04 |
Childrens Medical Ct Corp |
Therapeutic use of mitochondria and combined mitochondrial agents
|
|
WO2017165826A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
EP3433364A1
(en)
|
2016-03-25 |
2019-01-30 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
ES3030658T3
(en)
*
|
2016-03-30 |
2025-07-01 |
Intellia Therapeutics Inc |
Lipid nanoparticle formulations for crispr/cas components
|
|
EP3443081A4
(en)
|
2016-04-13 |
2019-10-30 |
Duke University |
CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE
|
|
US11236313B2
(en)
|
2016-04-13 |
2022-02-01 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
KR20260004568A
(ko)
|
2016-04-19 |
2026-01-08 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
AU2017257624B2
(en)
|
2016-04-25 |
2023-05-25 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
|
CN107326046A
(zh)
*
|
2016-04-28 |
2017-11-07 |
上海邦耀生物科技有限公司 |
一种提高外源基因同源重组效率的方法
|
|
SG10202102885UA
(en)
|
2016-05-20 |
2021-05-28 |
Regeneron Pharma |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
CA3025523A1
(en)
*
|
2016-05-27 |
2017-11-30 |
Aadigen, Llc |
Peptides and nanoparticles for intracellular delivery of genome-editing molecules
|
|
DK3604527T3
(da)
|
2016-06-02 |
2021-05-31 |
Sigma Aldrich Co Llc |
Anvendelse af programmerbare dna-bindingsproteiner til at forbedre målrettet genommodifikation
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CN109312386B
(zh)
*
|
2016-06-15 |
2022-10-25 |
株式会社图尔金 |
使用中靶靶标和脱靶靶标的多重靶标系统筛选靶特异性核酸酶的方法及其用途
|
|
US20190330603A1
(en)
*
|
2016-06-17 |
2019-10-31 |
Genesis Technologies Limited |
Crispr-cas system, materials and methods
|
|
AU2017283713B2
(en)
|
2016-06-17 |
2021-04-08 |
Massachusetts Institute Of Technology |
Type VI CRISPR orthologs and systems
|
|
ES2981548T3
(es)
*
|
2016-06-20 |
2024-10-09 |
Keygene Nv |
Método para la alteración dirigida del ADN en células vegetales
|
|
CN109688820B
(zh)
|
2016-06-24 |
2023-01-10 |
科罗拉多州立大学董事会（法人团体） |
用于生成条形码化组合文库的方法
|
|
KR20190039115A
(ko)
*
|
2016-07-05 |
2019-04-10 |
더 존스 홉킨스 유니버시티 |
암을 치료하기 위한 crispr/cas9-기반 조성물 및 방법
|
|
WO2018013821A1
(en)
*
|
2016-07-13 |
2018-01-18 |
Dsm Ip Assets B.V. |
A crispr-cas system for an algal host cell
|
|
JP7004651B2
(ja)
*
|
2016-07-19 |
2022-02-04 |
株式会社バイオダイナミクス研究所 |
長鎖一本鎖ｄｎａを調製する方法
|
|
JP7490211B2
(ja)
|
2016-07-19 |
2024-05-27 |
デューク ユニバーシティ |
Ｃｐｆ１に基づくゲノム編集の治療適用
|
|
KR101961332B1
(ko)
|
2016-07-28 |
2019-03-22 |
기초과학연구원 |
Cas9 단백질 및 가이드 RNA를 포함하는 안질환 치료용 약학 조성물
|
|
CN109803530A
(zh)
|
2016-07-29 |
2019-05-24 |
瑞泽恩制药公司 |
包含引起c-截短的原纤维蛋白-1表达的突变的小鼠
|
|
US11566263B2
(en)
|
2016-08-02 |
2023-01-31 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290 associated disease
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
AU2017308889B2
(en)
|
2016-08-09 |
2023-11-09 |
President And Fellows Of Harvard College |
Programmable Cas9-recombinase fusion proteins and uses thereof
|
|
KR101710026B1
(ko)
|
2016-08-10 |
2017-02-27 |
주식회사 무진메디 |
Cas9 단백질 및 가이드 RNA의 혼성체를 함유하는 나노 리포좀 전달체 조성물
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
KR101856345B1
(ko)
*
|
2016-08-24 |
2018-06-20 |
경상대학교산학협력단 |
CRISPR/Cas9 시스템을 이용하여 APOBEC3H 및 APOBEC3CH 이중-넉아웃 고양이를 제조하는 방법
|
|
GB2569252A
(en)
|
2016-08-31 |
2019-06-12 |
Harvard College |
Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
JP2019532644A
(ja)
|
2016-09-30 |
2019-11-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Ｒｎａ誘導型核酸修飾酵素及びその使用方法
|
|
CA3038982A1
(en)
|
2016-09-30 |
2018-04-05 |
The Regents Of The University Of California |
Rna-guided nucleic acid modifying enzymes and methods of use thereof
|
|
US11242542B2
(en)
|
2016-10-07 |
2022-02-08 |
Integrated Dna Technologies, Inc. |
S. pyogenes Cas9 mutant genes and polypeptides encoded by same
|
|
WO2018068053A2
(en)
|
2016-10-07 |
2018-04-12 |
Integrated Dna Technologies, Inc. |
S. pyogenes cas9 mutant genes and polypeptides encoded by same
|
|
KR101997116B1
(ko)
|
2016-10-14 |
2019-07-05 |
연세대학교 산학협력단 |
Kras 유전자에 상보적인 가이드 rna 및 이의 용도
|
|
KR20240007715A
(ko)
|
2016-10-14 |
2024-01-16 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
EP4338799A3
(en)
|
2016-10-18 |
2024-06-05 |
Regents of the University of Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
|
CA3042259A1
(en)
|
2016-11-04 |
2018-05-11 |
Flagship Pioneering Innovations V. Inc. |
Novel plant cells, plants, and seeds
|
|
CN109906030B
(zh)
|
2016-11-04 |
2022-03-18 |
安健基因公司 |
用于产生仅重链抗体的经基因修饰的非人动物和方法
|
|
BR112019009725A2
(pt)
*
|
2016-11-14 |
2019-11-19 |
Toolgen Incorporated |
sistema de controle de função de sc artificialmente manipulado
|
|
CA3044101A1
(en)
|
2016-11-22 |
2018-05-31 |
Integrated Dna Technologies, Inc. |
Crispr/cpf1 systems and methods
|
|
WO2018111947A1
(en)
|
2016-12-12 |
2018-06-21 |
Integrated Dna Technologies, Inc. |
Genome editing enhancement
|
|
KR101748575B1
(ko)
*
|
2016-12-16 |
2017-06-20 |
주식회사 엠젠플러스 |
Ins 유전자 녹아웃 당뇨병 또는 당뇨병 합병증 동물모델 및 이의 제조방법
|
|
EP3555297A1
(en)
|
2016-12-19 |
2019-10-23 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
EA202091316A1
(ru)
|
2016-12-22 |
2020-08-18 |
Тулджин Инкорпорейтид |
Обогащенный олеиновой кислотой растительный организм, имеющий генетически модифицированный fad2, и способ его получения
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
US20200385753A1
(en)
*
|
2016-12-23 |
2020-12-10 |
Institute For Basic Science |
Composition for base editing for animal embryo and base editing method
|
|
JP6994730B2
(ja)
*
|
2016-12-26 |
2022-02-04 |
独立行政法人酒類総合研究所 |
ゲノム編集タンパク質の直接導入による糸状菌ゲノム編集方法
|
|
US11859219B1
(en)
|
2016-12-30 |
2024-01-02 |
Flagship Pioneering Innovations V, Inc. |
Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA
|
|
WO2018129368A2
(en)
|
2017-01-06 |
2018-07-12 |
Editas Medicine, Inc. |
Methods of assessing nuclease cleavage
|
|
KR102515727B1
(ko)
*
|
2017-01-11 |
2023-03-30 |
주식회사 툴젠 |
중첩된 가이드핵산을 이용한 표적 핵산에 특정 핵산 서열을 삽입하기 위한 조성물 및 방법
|
|
CA3049980A1
(en)
|
2017-01-23 |
2018-07-26 |
Regeneron Pharmaceuticals, Inc. |
Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof
|
|
WO2018140899A1
(en)
|
2017-01-28 |
2018-08-02 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018164457A1
(ko)
*
|
2017-03-06 |
2018-09-13 |
기초과학연구원 |
C2cL 엔도뉴클레아제를 포함하는 유전체 교정용 조성물 및 이를 이용한 유전체 교정 방법
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
KR20190123328A
(ko)
|
2017-03-09 |
2019-10-31 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
암 백신
|
|
CN110914310A
(zh)
|
2017-03-10 |
2020-03-24 |
哈佛大学的校长及成员们 |
胞嘧啶至鸟嘌呤碱基编辑器
|
|
EP3596217A1
(en)
|
2017-03-14 |
2020-01-22 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
IL306092A
(en)
|
2017-03-23 |
2023-11-01 |
Harvard College |
Nucleic base editors that include nucleic acid programmable DNA binding proteins
|
|
US11867661B2
(en)
|
2017-04-07 |
2024-01-09 |
Sage Science, Inc. |
Systems and methods for detection of genetic structural variation using integrated electrophoretic DNA purification
|
|
WO2018189360A1
(en)
*
|
2017-04-13 |
2018-10-18 |
Cellectis |
New sequence specific reagents targeting ccr5 in primary hematopoietic cells
|
|
US11913015B2
(en)
|
2017-04-17 |
2024-02-27 |
University Of Maryland, College Park |
Embryonic cell cultures and methods of using the same
|
|
CN116732106A
(zh)
|
2017-04-20 |
2023-09-12 |
E开创生物技术股份有限公司 |
产生基因修改的动物的方法
|
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
|
BR112019022737A2
(pt)
*
|
2017-05-05 |
2020-05-19 |
Inst Genetics & Developmental Biology Cas |
métodos para isolar células sem o uso de sequências marcadoras transgênicas
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CN108977442B
(zh)
*
|
2017-06-05 |
2023-01-06 |
广州市锐博生物科技有限公司 |
用于dna编辑的系统及其应用
|
|
DK3635102T3
(da)
|
2017-06-05 |
2025-10-27 |
Regeneron Pharma |
B4galt1-varianter og anvendelser deraf
|
|
CN110997908A
(zh)
|
2017-06-09 |
2020-04-10 |
爱迪塔斯医药公司 |
工程化的cas9核酸酶
|
|
CA3066750A1
(en)
|
2017-06-13 |
2018-12-20 |
Flagship Pioneering Innovations V, Inc. |
Compositions comprising curons and uses thereof
|
|
MY200418A
(en)
|
2017-06-15 |
2023-12-25 |
Univ California |
Targeted non-viral dna insertions
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
CN111511375A
(zh)
|
2017-06-30 |
2020-08-07 |
因提玛生物科学公司 |
用于基因治疗的腺相关病毒载体
|
|
CN107488710B
(zh)
|
2017-07-14 |
2020-09-22 |
上海吐露港生物科技有限公司 |
一种Cas蛋白的用途及靶标核酸分子的检测方法和试剂盒
|
|
EP3652312A1
(en)
|
2017-07-14 |
2020-05-20 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
EP3655961A4
(en)
*
|
2017-07-17 |
2021-09-01 |
Massachusetts Institute of Technology |
HEALTHY AND SICK BARRIER TISSUE CELL ATLAS
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
KR102712142B1
(ko)
|
2017-07-31 |
2024-10-07 |
리제너론 파마슈티칼스 인코포레이티드 |
Cas-형질전환 마우스 배아 줄기 세포 및 마우스 및 이것의 용도
|
|
CA3065579A1
(en)
|
2017-07-31 |
2019-02-07 |
Regeneron Pharmaceuticals, Inc. |
Assessment of crispr/cas-induced recombination with an exogenous donor nucleic acid in vivo
|
|
CN111182790A
(zh)
|
2017-07-31 |
2020-05-19 |
瑞泽恩制药公司 |
Crispr报告体非人类动物及其用途
|
|
CN111278848B
(zh)
|
2017-08-04 |
2023-06-27 |
北京大学 |
特异性识别甲基化修饰dna碱基的tale rvd及其应用
|
|
US11624077B2
(en)
|
2017-08-08 |
2023-04-11 |
Peking University |
Gene knockout method
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
WO2019051419A1
(en)
*
|
2017-09-08 |
2019-03-14 |
University Of North Texas Health Science Center |
Engineered cas9 variants
|
|
EP3686275A4
(en)
|
2017-09-18 |
2021-09-29 |
Edigene Inc. |
GENE EDITING LYMPHOCYTE T AND RELATED USE
|
|
WO2019066490A2
(ko)
*
|
2017-09-28 |
2019-04-04 |
주식회사 툴젠 |
유전자 발현 조절을 위한 인위적인 게놈 조작
|
|
US11572574B2
(en)
|
2017-09-28 |
2023-02-07 |
Toolgen Incorporated |
Artificial genome manipulation for gene expression regulation
|
|
IL311278B2
(en)
*
|
2017-09-29 |
2026-05-01 |
Intellia Therapeutics Inc |
Polynucleotides, compositions, and methods for genome editing
|
|
KR102207352B1
(ko)
*
|
2017-09-29 |
2021-01-26 |
서울대학교산학협력단 |
Klotho 유전자 넉아웃 질환모델 동물 및 이의 용도
|
|
WO2019067875A1
(en)
|
2017-09-29 |
2019-04-04 |
Regeneron Pharmaceuticals, Inc. |
NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
SG11202003798TA
(en)
|
2017-10-27 |
2020-05-28 |
Univ California |
Targeted replacement of endogenous t cell receptors
|
|
CN109722414A
(zh)
|
2017-10-27 |
2019-05-07 |
博雅辑因（北京）生物科技有限公司 |
一种高效制备成熟红细胞的方法以及用于制备成熟红细胞的培养基
|
|
WO2019089804A1
(en)
|
2017-11-01 |
2019-05-09 |
The Regents Of The University Of California |
Casy compositions and methods of use
|
|
CN108192956B
(zh)
*
|
2017-11-17 |
2021-06-01 |
东南大学 |
一种基于Cas9核酸酶的DNA检测分析方法及其应用
|
|
US11667917B2
(en)
|
2017-11-21 |
2023-06-06 |
Genkore Co. Ltd. |
Composition for genome editing using CRISPR/CPF1 system and use thereof
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
CN111566121A
(zh)
|
2018-01-12 |
2020-08-21 |
巴斯夫欧洲公司 |
小麦7a染色体上决定每穗小穗数QTL的基因
|
|
US12509492B2
(en)
|
2018-01-19 |
2025-12-30 |
Duke University |
Genome engineering with CRISPR-Cas systems in eukaryotes
|
|
US12391941B2
(en)
|
2018-01-23 |
2025-08-19 |
Institute For Basic Science |
Extended single guide RNA and use thereof
|
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
|
KR102086689B1
(ko)
*
|
2018-02-06 |
2020-03-09 |
주식회사 진씨커 |
돌연변이 세포 유리 유전자 분리 키트 및 이를 이용한 돌연변이 세포 유리 유전자 분리 방법
|
|
WO2019156475A1
(ko)
*
|
2018-02-06 |
2019-08-15 |
주식회사 진씨커 |
돌연변이 세포 유리 유전자 분리 키트 및 이를 이용한 돌연변이 세포 유리 유전자 분리 방법
|
|
KR20200124702A
(ko)
|
2018-02-23 |
2020-11-03 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
신규한 cas9 오르소로그
|
|
IL277234B2
(en)
|
2018-03-14 |
2026-03-01 |
Editas Medicine Inc |
Systems and methods for treating hemoglobin diseases
|
|
EP3592140A1
(en)
|
2018-03-19 |
2020-01-15 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems
|
|
AU2019255789B2
(en)
|
2018-04-19 |
2025-11-20 |
The Regents Of The University Of California |
Compositions and methods for gene editing
|
|
CN112020560B
(zh)
*
|
2018-04-25 |
2024-02-23 |
中国农业大学 |
一种RNA编辑的CRISPR/Cas效应蛋白及系统
|
|
CN112654710A
(zh)
|
2018-05-16 |
2021-04-13 |
辛瑟高公司 |
用于指导rna设计和使用的方法和系统
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
|
AU2019291918B2
(en)
|
2018-06-29 |
2025-06-12 |
Editas Medicine, Inc. |
Synthetic guide molecules, compositions and methods relating thereto
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
KR102035654B1
(ko)
*
|
2018-07-23 |
2019-10-24 |
대한민국 |
항균 펩타이드를 생산하는 돌연변이 곤충 세포주 또는 이의 제조방법
|
|
US12545910B2
(en)
|
2018-08-31 |
2026-02-10 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US11479762B1
(en)
|
2018-08-31 |
2022-10-25 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US12534743B2
(en)
|
2018-08-31 |
2026-01-27 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP3851528A4
(en)
*
|
2018-09-12 |
2023-12-06 |
Institute for Basic Science |
COMPOSITION FOR INDUCATING DEATH OF CELLS HAVING MUTATED GENE AND METHOD FOR INDUCATING DEATH OF CELLS HAVING MODIFIED GENE USING THE COMPOSITION
|
|
US12203123B2
(en)
|
2018-10-01 |
2025-01-21 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for screening for variant cells
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
US10711267B2
(en)
|
2018-10-01 |
2020-07-14 |
North Carolina State University |
Recombinant type I CRISPR-Cas system
|
|
WO2020072250A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
KR102081962B1
(ko)
*
|
2018-10-11 |
2020-02-26 |
충남대학교 산학협력단 |
아밀로이드 전구 단백질 유전자를 절단하기 위한 조성물
|
|
MX2021004276A
(es)
|
2018-10-18 |
2021-09-08 |
Intellia Therapeutics Inc |
Composiciones y metodos para tratar deficiencia de alfa-1 antitripsina.
|
|
CN113272428A
(zh)
|
2018-10-18 |
2021-08-17 |
英特利亚治疗股份有限公司 |
核酸构建体和使用方法
|
|
JP7578590B2
(ja)
|
2018-10-18 |
2024-11-06 |
インテリア セラピューティクス，インコーポレーテッド |
第ｉｘ因子を発現するための組成物及び方法
|
|
BR112021007343A2
(pt)
|
2018-10-18 |
2021-08-03 |
Intellia Therapeutics, Inc. |
composições e métodos para expressão de transgene a partir de um lócus de albumina
|
|
EP3875469A4
(en)
*
|
2018-10-29 |
2022-08-17 |
China Agricultural University |
NOVEL CRISPR/CAS12F ENZYME AND SYSTEM
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
EP3874048A1
(en)
*
|
2018-11-01 |
2021-09-08 |
Keygene N.V. |
Dual guide rna for crispr/cas genome editing in plants cells
|
|
EP3650557B1
(en)
*
|
2018-11-07 |
2021-10-20 |
Justus-Liebig-Universität Gießen |
Method for determination of restriction efficiency of endonucleases mediating double-strand breaks in dna target sequences
|
|
US12365923B2
(en)
|
2018-11-16 |
2025-07-22 |
Osaka University |
Method for producing genome-edited cell
|
|
KR20200071198A
(ko)
|
2018-12-10 |
2020-06-19 |
네오이뮨텍, 인코퍼레이티드 |
Nrf2 발현 조절 기반 T 세포 항암면역치료법
|
|
JP7553100B2
(ja)
*
|
2018-12-12 |
2024-09-18 |
国立大学法人九州大学 |
ゲノム編集された細胞の製造方法
|
|
CA3121528A1
(en)
|
2018-12-12 |
2020-06-18 |
Flagship Pioneering Innovations V, Inc. |
Anellosomes and methods of use
|
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
|
CN113166744B
(zh)
|
2018-12-14 |
2025-02-07 |
先锋国际良种公司 |
用于基因组编辑的新颖crispr-cas系统
|
|
WO2020131632A1
(en)
|
2018-12-20 |
2020-06-25 |
Regeneron Pharmaceuticals, Inc. |
Nuclease-mediated repeat expansion
|
|
CN113811611A
(zh)
*
|
2019-01-07 |
2021-12-17 |
克里斯普赫尔治疗公司 |
无毒cas9酶及其应用
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
CN109868275A
(zh)
*
|
2019-03-12 |
2019-06-11 |
中国农业大学 |
CRISPR/Cas9介导的羊FGF5基因敲除和定点整合MTNR1A基因的方法
|
|
EP4317950B1
(en)
|
2019-03-18 |
2026-01-28 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas screening platform to identify genetic modifiers of tau seeding or aggregation
|
|
JP7389135B2
(ja)
|
2019-03-18 |
2023-11-29 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
タウ凝集に関連する遺伝的脆弱性を明らかにするためのｃｒｉｓｐｒ／ｃａｓドロップアウトスクリーニングプラットフォーム
|
|
WO2020191241A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
KR20220004648A
(ko)
|
2019-03-28 |
2022-01-11 |
인텔리아 테라퓨틱스, 인크. |
Ttr 가이드 rna, 및 rna-가이드 dna 결합제를 암호화하는 폴리뉴클레오티드를 포함하는 조성물 및 방법
|
|
EP3945800A1
(en)
|
2019-04-03 |
2022-02-09 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for insertion of antibody coding sequences into a safe harbor locus
|
|
AU2020253531C1
(en)
|
2019-04-04 |
2022-06-16 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
|
JP7506686B2
(ja)
|
2019-04-04 |
2024-06-26 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒト化凝固因子１２遺伝子座を含む非ヒト動物
|
|
TWI887234B
(zh)
|
2019-04-14 |
2025-06-21 |
美國公爵大學 |
治療杜興氏（ｄｕｃｈｅｎｎｅ）肌肉失養症之大型突變熱點之ａａｖ載體介導之刪除
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CA3138029A1
(en)
|
2019-04-30 |
2020-11-05 |
Edigene Inc. |
Method for predicting effectiveness of treatment of hemoglobinopathy
|
|
US11692197B2
(en)
|
2019-05-06 |
2023-07-04 |
Inari Agriculture Technology, Inc. |
Delivery of biological molecules to plant cells
|
|
WO2020247452A1
(en)
|
2019-06-04 |
2020-12-10 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
|
|
CN111304180B
(zh)
*
|
2019-06-04 |
2023-05-26 |
山东舜丰生物科技有限公司 |
一种新的dna核酸切割酶及其应用
|
|
CN113939595A
(zh)
|
2019-06-07 |
2022-01-14 |
瑞泽恩制药公司 |
包括人源化白蛋白基因座的非人动物
|
|
KR20220024053A
(ko)
|
2019-06-14 |
2022-03-03 |
리제너론 파마슈티칼스 인코포레이티드 |
타우병증의 모델
|
|
AU2020301236A1
(en)
|
2019-06-25 |
2021-11-25 |
Inari Agriculture Technology, Inc. |
Improved homology dependent repair genome editing
|
|
US11746354B2
(en)
|
2019-07-19 |
2023-09-05 |
Inari Agriculture Technology, Inc. |
Homology dependent repair genome editing
|
|
US20250381301A1
(en)
*
|
2019-08-19 |
2025-12-18 |
Minghong Zhong |
Conjugates of Guide RNA-Cas Protein Complex
|
|
AU2020342207A1
(en)
|
2019-09-04 |
2022-04-21 |
Edigene (Guangzhou) Inc. |
Method for evaluating gene editing therapy based on off-target assessment
|
|
CN114616002A
(zh)
|
2019-09-13 |
2022-06-10 |
瑞泽恩制药公司 |
使用由脂质纳米颗粒递送的crispr/cas系统在动物中进行的转录调控
|
|
CN114729376A
(zh)
|
2019-09-23 |
2022-07-08 |
欧米茄治疗公司 |
用于调节肝细胞核因子4α(HNF4α)基因表达的组合物和方法
|
|
AU2020355000A1
(en)
|
2019-09-23 |
2022-03-17 |
Sepia Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein B (APOB) gene expression
|
|
JP7689949B2
(ja)
|
2019-10-03 |
2025-06-09 |
アーティサン ディベロップメント ラブズ インコーポレイテッド |
操作されたデュアルガイド核酸を有するｃｒｉｓｐｒシステム
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
CA3158555A1
(en)
|
2019-10-23 |
2021-04-29 |
Pairwise Plants Services, Inc. |
Compositions and methods for rna-templated editing in plants
|
|
JP7785002B2
(ja)
*
|
2019-11-05 |
2025-12-12 |
ペアーワイズ プランツ サービシズ， インコーポレイテッド |
対立遺伝子のｒｎａにコードされたｄｎａの置換のための組成物および方法
|
|
US12521451B2
(en)
|
2019-11-08 |
2026-01-13 |
Regeneron Pharmaceuticals, Inc. |
CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy
|
|
JP7448120B2
(ja)
*
|
2019-11-14 |
2024-03-12 |
国立研究開発法人農業・食品産業技術総合研究機構 |
プラズマを用いてゲノム編集酵素を植物細胞内に導入する方法
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
WO2021108442A2
(en)
*
|
2019-11-27 |
2021-06-03 |
The Regents Of The University Of California |
Modulators of cas9 polypeptide activity and methods of use thereof
|
|
EP4086340A1
(en)
|
2019-12-30 |
2022-11-09 |
Edigene Biotechnology Inc. |
Universal car-t targeting t-cell lymphoma cell and preparation method therefor and use thereof
|
|
US20230054266A1
(en)
|
2019-12-30 |
2023-02-23 |
Edigene Biotechnology Inc. |
Method for purifying ucart cell and use thereof
|
|
WO2021145700A1
(ko)
*
|
2020-01-14 |
2021-07-22 |
주식회사 툴젠 |
저산소 환경 하에서 높은 적응력을 가지는 세포 및 이의 용도
|
|
KR102616080B1
(ko)
|
2020-01-14 |
2023-12-21 |
주식회사 툴젠 |
알츠하이머 예방 또는 치료용 약학적 조성물 및 이의 용도
|
|
CN114945680A
(zh)
*
|
2020-01-14 |
2022-08-26 |
深圳华大智造科技股份有限公司 |
使用微流体隔室化快速多路复用基于crispr的诊断
|
|
WO2021155063A1
(en)
|
2020-01-29 |
2021-08-05 |
Readcoor, Llc |
Compositions and methods for analyte detection
|
|
WO2021163515A1
(en)
*
|
2020-02-12 |
2021-08-19 |
Temple University - Of The Commonwealth System Of Higher Education |
Crispr-cas9 mediated disruption of alcam gene inhibits adhesion and trans-endothelial migration of myeloid cells
|
|
KR102940466B1
(ko)
|
2020-02-27 |
2026-03-16 |
주식회사 엘지화학 |
원형질체를 활용한 식물 유전자 교정 효율 증대 방법
|
|
JP7837276B2
(ja)
|
2020-03-04 |
2026-03-30 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
免疫療法に対する腫瘍細胞の感作のための方法及び組成物
|
|
WO2021183720A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
|
US20230102342A1
(en)
|
2020-03-23 |
2023-03-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
WO2021202938A1
(en)
|
2020-04-03 |
2021-10-07 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
CA3177481A1
(en)
|
2020-05-08 |
2021-11-11 |
David R. Liu |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
CN111690720B
(zh)
*
|
2020-06-16 |
2021-06-15 |
山东舜丰生物科技有限公司 |
利用修饰的单链核酸进行靶核酸检测的方法
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
KR102638799B1
(ko)
*
|
2020-10-08 |
2024-02-22 |
주식회사 진코어 |
CRISPR/Cas12f1(Cas14a1) system 효율화를 위한 engineered guide RNA 및 이의 용도
|
|
IL302830A
(en)
|
2020-11-13 |
2023-07-01 |
Egenesis Inc |
Cells, tissues, organs and animals with one or more genes that have been modified for improved survival and tolerance of a different-sex transplant
|
|
US20240002839A1
(en)
|
2020-12-02 |
2024-01-04 |
Decibel Therapeutics, Inc. |
Crispr sam biosensor cell lines and methods of use thereof
|
|
KR102878872B1
(ko)
*
|
2020-12-09 |
2025-10-31 |
재단법인 아산사회복지재단 |
온-타겟 활성이 유지되고 오프-타겟 활성이 감소된 가이드 rna 및 이의 용도
|
|
CA3206361A1
(en)
|
2020-12-23 |
2022-06-30 |
Flagship Pioneering Innovations V, Inc. |
In vitro assembly of anellovirus capsids enclosing rna
|
|
JP2024502036A
(ja)
|
2020-12-30 |
2024-01-17 |
インテリア セラピューティクス，インコーポレイテッド |
操作されたｔ細胞
|
|
KR102285906B1
(ko)
*
|
2021-02-18 |
2021-08-04 |
주식회사 엔에이피 |
수생태계 교란어종 관리를 위한 큰입배스 불임 유도용 조성물
|
|
AU2022227650A1
(en)
|
2021-02-25 |
2023-10-12 |
Celyntra Therapeutics Sa |
Compositions and methods for targeting, editing, or modifying genes
|
|
EP4337769A1
(en)
|
2021-05-10 |
2024-03-20 |
SQZ Biotechnologies Company |
Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
|
|
KR102616916B1
(ko)
*
|
2021-05-11 |
2023-12-21 |
주식회사 애이마 |
발암성 돌연변이 유전자 검출용 가이드 rna 내지 이의 용도
|
|
KR20240028362A
(ko)
|
2021-05-28 |
2024-03-05 |
라이엘 이뮤노파마, 인크. |
Nr4a3-결핍 면역 세포 및 이의 용도
|
|
WO2022256448A2
(en)
|
2021-06-01 |
2022-12-08 |
Artisan Development Labs, Inc. |
Compositions and methods for targeting, editing, or modifying genes
|
|
KR20240027676A
(ko)
|
2021-06-02 |
2024-03-04 |
라이엘 이뮤노파마, 인크. |
Nr4a3-결핍 면역 세포 및 이의 용도
|
|
KR102618072B1
(ko)
|
2021-06-15 |
2023-12-28 |
대한민국 |
작물의 개화조절 관련 유전자 교정용 가이드 rna 및 이의 용도
|
|
CA3223311A1
(en)
|
2021-06-18 |
2022-12-22 |
Andrea BARGHETTI |
Compositions and methods for targeting, editing or modifying human genes
|
|
WO2023283359A2
(en)
|
2021-07-07 |
2023-01-12 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
|
KR20230010617A
(ko)
|
2021-07-09 |
2023-01-19 |
주식회사 툴젠 |
산화스트레스 저항성을 갖는 중간엽줄기세포, 이의 제조방법 및 용도
|
|
WO2023008933A1
(ko)
|
2021-07-29 |
2023-02-02 |
주식회사 툴젠 |
혈액 적합성을 갖는 중간엽 줄기세포, 이의 제조방법 및 용도
|
|
CN113584134B
(zh)
*
|
2021-09-06 |
2024-01-30 |
青岛金斯达生物技术有限公司 |
一种基于CRISPR-Cas9的等温核酸检测系统及其方法和应用
|
|
WO2023039586A1
(en)
|
2021-09-10 |
2023-03-16 |
Agilent Technologies, Inc. |
Guide rnas with chemical modification for prime editing
|
|
MX2024003887A
(es)
|
2021-10-14 |
2024-07-09 |
Arsenal Biosciences Inc |
Células inmunitarias que tienen arnch coespresados y sistemas de compuerta lógica.
|
|
CN118119702A
(zh)
|
2021-10-14 |
2024-05-31 |
隆萨销售股份有限公司 |
用于细胞外囊泡产生的经修饰的生产者细胞
|
|
EP4423271A2
(en)
|
2021-10-28 |
2024-09-04 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-related methods and compositions for knocking out c5
|
|
EP4426828A1
(en)
|
2021-11-01 |
2024-09-11 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
AU2022408167A1
(en)
|
2021-12-08 |
2024-06-06 |
Regeneron Pharmaceuticals, Inc. |
Mutant myocilin disease model and uses thereof
|
|
US20250057980A1
(en)
|
2021-12-22 |
2025-02-20 |
Tome Biosciences, Inc. |
Co-Delivery of a Gene Editor Construct and a Donor Template
|
|
CN118679257A
(zh)
|
2021-12-23 |
2024-09-20 |
马萨诸塞大学 |
用于脆性x相关病症的治疗性治疗
|
|
KR20240128067A
(ko)
|
2021-12-29 |
2024-08-23 |
브리스톨-마이어스 스큅 컴퍼니 |
랜딩 패드 세포주의 생성
|
|
US20250230412A1
(en)
|
2022-02-01 |
2025-07-17 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
IL314482A
(en)
|
2022-02-02 |
2024-09-01 |
Regeneron Pharma |
Anti-tfr:gaa and anti-cd63:gaa insertions for treatment of pompe disease
|
|
EP4486881A1
(en)
|
2022-03-01 |
2025-01-08 |
Celyntra Therapeutics SA |
Composition and methods for transgene insertion
|
|
CN118843688A
(zh)
|
2022-03-04 |
2024-10-25 |
株式会社图尔金 |
低免疫原性干细胞、由干细胞分化或衍生的低免疫原性细胞及其制备方法
|
|
CN114410609B
(zh)
*
|
2022-03-29 |
2022-07-12 |
舜丰生物科技(海南)有限公司 |
一种活性提高的Cas蛋白以及应用
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023205844A1
(en)
*
|
2022-04-26 |
2023-11-02 |
Peter Maccallum Cancer Institute |
Nucleic acids and uses thereof
|
|
CN117004604A
(zh)
*
|
2022-04-28 |
2023-11-07 |
南京北恒生物科技有限公司 |
一种ciita基因被敲除的工程化免疫细胞及其用途
|
|
WO2023212677A2
(en)
|
2022-04-29 |
2023-11-02 |
Regeneron Pharmaceuticals, Inc. |
Identification of tissue-specific extragenic safe harbors for gene therapy approaches
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
AU2023269134A1
(en)
|
2022-05-09 |
2024-12-12 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
|
WO2023219434A1
(ko)
|
2022-05-13 |
2023-11-16 |
주식회사 툴젠 |
혈액 적합성을 갖는 혈관 내 이식용 세포, 이의 제조방법 및 용도
|
|
US20260083846A1
(en)
|
2022-05-19 |
2026-03-26 |
Lyell Immunopharma, Inc. |
Polynucleotides targeting nr4a3 and uses thereof
|
|
EP4526884A2
(en)
|
2022-05-20 |
2025-03-26 |
Artisan Development Labs, Inc. |
Systems and methods for assessing risk of genome editing events
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
KR20250019772A
(ko)
|
2022-05-25 |
2025-02-11 |
플래그쉽 파이어니어링 이노베이션스 Vii, 엘엘씨 |
종양 억제인자 및 발암유전자를 조절하기 위한 조성물 및 방법
|
|
CN119563038A
(zh)
|
2022-05-25 |
2025-03-04 |
旗舰创业创新七公司 |
用于调节免疫应答的组合物和方法
|
|
EP4650780A3
(en)
|
2022-05-25 |
2026-01-21 |
Flagship Pioneering Innovations VII, LLC |
Compositions and methods for modulating circulating factors
|
|
AU2023275550A1
(en)
|
2022-05-25 |
2024-11-21 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating cytokines
|
|
AU2023277636A1
(en)
|
2022-05-25 |
2024-11-21 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating genetic drivers
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
WO2023235726A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr interference therapeutics for c9orf72 repeat expansion disease
|
|
CA3260237A1
(en)
|
2022-06-24 |
2023-12-28 |
Tune Therapeutics, Inc. |
Compositions, systems and methods for reducing low-density lipoprotein by targeted gene repression
|
|
WO2024006955A1
(en)
|
2022-06-29 |
2024-01-04 |
Intellia Therapeutics, Inc. |
Engineered t cells
|
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
CN117402827A
(zh)
*
|
2022-07-13 |
2024-01-16 |
中国科学院分子细胞科学卓越创新中心 |
一种稳定表达Cas9蛋白的细胞株及其制备方法和应用
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
CN120659627A
(zh)
|
2022-07-29 |
2025-09-16 |
瑞泽恩制药公司 |
用于转铁蛋白受体（tfr）介导的脑和肌肉递送的组合物和方法
|
|
EP4565603A1
(en)
|
2022-08-05 |
2025-06-11 |
Regeneron Pharmaceuticals, Inc. |
Aggregation-resistant variants of tdp-43
|
|
CN115386597B
(zh)
*
|
2022-09-19 |
2025-04-25 |
国家纳米科学中心 |
一种提高基因载体转染效率和/或转染精度的转染辅助试剂及其应用
|
|
WO2024064952A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells overexpressing c-jun
|
|
WO2024064958A1
(en)
|
2022-09-23 |
2024-03-28 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
KR20250075694A
(ko)
|
2022-09-28 |
2025-05-28 |
리제너론 파마슈티칼스 인코포레이티드 |
세포 기반 요법을 강화하기 위한 항체 저항성 변형 수용체
|
|
WO2024077174A1
(en)
|
2022-10-05 |
2024-04-11 |
Lyell Immunopharma, Inc. |
Methods for culturing nr4a-deficient cells
|
|
AU2023371614A1
(en)
|
2022-11-04 |
2025-05-15 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
|
EP4615424A1
(en)
|
2022-11-10 |
2025-09-17 |
Sail Biomedicines, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
|
AU2023379457A1
(en)
|
2022-11-14 |
2025-05-15 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
EP4654982A1
(en)
|
2023-01-27 |
2025-12-03 |
Regeneron Pharmaceuticals, Inc. |
Modified rhabdovirus glycoproteins and uses thereof
|
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
|
CN121443140A
(zh)
|
2023-04-21 |
2026-01-30 |
非营利性组织佛兰芒综合大学生物技术研究所 |
用于作物产量提升的等位基因组合
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
EP4716741A2
(en)
|
2023-05-23 |
2026-04-01 |
Flagship Labs 114, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
|
CN121568725A
(zh)
|
2023-06-15 |
2026-02-24 |
里珍纳龙药品有限公司 |
用于听力病症的基因疗法
|
|
US20250002946A1
(en)
|
2023-06-30 |
2025-01-02 |
Regeneron Pharmaceuticals, Inc. |
Methods And Compositions For Increasing Homology-Directed Repair
|
|
AR133384A1
(es)
|
2023-07-28 |
2025-09-24 |
Regeneron Pharma |
Anti-tfr:esfingomielinasa ácida para el tratamiento de la deficiencia de esfingomielinasa ácida
|
|
AU2024315073A1
(en)
|
2023-07-28 |
2026-01-22 |
Regeneron Pharmaceuticals, Inc. |
Use of bgh-sv40l tandem polya to enhance transgene expression during unidirectional gene insertion
|
|
IL326018A
(en)
|
2023-07-28 |
2026-03-01 |
Regeneron Pharma |
Introduction of anti-TFR:GAA and anti-CD63:GAA for the treatment of Pompe disease
|
|
WO2025038750A2
(en)
|
2023-08-14 |
2025-02-20 |
President And Fellows Of Harvard College |
Methods and compositions for treating cancer
|
|
EP4761751A1
(en)
*
|
2023-08-15 |
2026-06-24 |
University of Massachusetts |
Nick resection in cancer
|
|
EP4771049A1
(en)
|
2023-08-28 |
2026-07-08 |
Regeneron Pharmaceuticals, Inc. |
Cxcr4 antibody-resistant modified receptors
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
EP4777613A1
(en)
|
2023-09-13 |
2026-07-22 |
Medizinische Universität Graz |
Method for providing antigen-reactive lymphocytes
|
|
WO2025076141A1
(en)
|
2023-10-03 |
2025-04-10 |
Inari Agriculture Technology, Inc. |
Viral delivery of grna to the scion
|
|
IL330230A
(en)
|
2023-12-20 |
2026-08-01 |
Intellia Therapeutics Inc |
Engineered T cells
|
|
WO2025168705A1
(en)
|
2024-02-08 |
2025-08-14 |
Vib Vzw |
Means and methods for the production of saponins with endosomal escape-enhancing properties
|
|
WO2025184567A1
(en)
|
2024-03-01 |
2025-09-04 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
|
|
WO2025188676A1
(en)
*
|
2024-03-04 |
2025-09-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genetic engineering of cells for secretion of therapeutic antibodies
|
|
WO2025217398A1
(en)
|
2024-04-10 |
2025-10-16 |
Lyell Immunopharma, Inc. |
Methods for culturing cells with improved culture medium
|
|
WO2025224107A1
(en)
|
2024-04-22 |
2025-10-30 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
WO2025240947A1
(en)
|
2024-05-17 |
2025-11-20 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
|
WO2025259669A1
(en)
|
2024-06-10 |
2025-12-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for characterizing modified oligonucleotides
|
|
WO2025265017A1
(en)
|
2024-06-20 |
2025-12-26 |
Regeneron Pharmaceuticals, Inc. |
Ass1 gene insertion for the treatment of citrullinemia type i
|
|
WO2026036000A1
(en)
|
2024-08-08 |
2026-02-12 |
Invaio Sciences, Inc. |
Nature-derived lipid particles for use in agriculture
|
|
WO2026064425A2
(en)
|
2024-09-17 |
2026-03-26 |
Dxome Co., Ltd. |
Mirror image crispr-cas compositions
|
|
WO2026072529A1
(en)
|
2024-09-24 |
2026-04-02 |
University Of Florida Research Foundation, Incorporated |
Mettl7a for improved embryo competence
|
|
WO2026080515A2
(en)
|
2024-10-08 |
2026-04-16 |
Regeneron Pharmaceuticals, Inc. |
Crispr sam biosensor cells and cell lines and methods of use thereof
|
|
WO2026125579A1
(en)
|
2024-12-12 |
2026-06-18 |
Basf Agricultural Solutions Us Llc |
Recurrent selection to obtain optimal gene edit combinations
|