JP2015536948A5 - - Google Patents
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- JP2015536948A5 JP2015536948A5 JP2015540794A JP2015540794A JP2015536948A5 JP 2015536948 A5 JP2015536948 A5 JP 2015536948A5 JP 2015540794 A JP2015540794 A JP 2015540794A JP 2015540794 A JP2015540794 A JP 2015540794A JP 2015536948 A5 JP2015536948 A5 JP 2015536948A5
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- inhibitor
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- hematological malignancy
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- 239000000203 mixture Substances 0.000 claims 20
- 239000003112 inhibitor Substances 0.000 claims 19
- 230000002401 inhibitory effect Effects 0.000 claims 19
- 206010066476 Haematological malignancy Diseases 0.000 claims 18
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 12
- 239000000090 biomarker Substances 0.000 claims 8
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 7
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 7
- -1 WX-554 Chemical compound 0.000 claims 7
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 6
- 108040005185 1-phosphatidylinositol-3-kinase activity proteins Proteins 0.000 claims 6
- 102100013894 BCL2 Human genes 0.000 claims 6
- 108060000885 BCL2 Proteins 0.000 claims 6
- 102100009639 CXCL13 Human genes 0.000 claims 6
- 101710032192 CXCL13 Proteins 0.000 claims 6
- 102100006844 MMP9 Human genes 0.000 claims 6
- 101700067851 MMP9 Proteins 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- YTKUWDBFDASYHO-UHFFFAOYSA-N Bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 5
- 108010001645 Rituximab Proteins 0.000 claims 5
- 108090001123 antibodies Proteins 0.000 claims 5
- 102000004965 antibodies Human genes 0.000 claims 5
- 229960002707 bendamustine Drugs 0.000 claims 5
- 229960004641 rituximab Drugs 0.000 claims 5
- 101700041849 EZH2 Proteins 0.000 claims 4
- 102100016041 EZH2 Human genes 0.000 claims 4
- 108010001801 Tumor Necrosis Factor-alpha Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 102100009312 BTK Human genes 0.000 claims 3
- 102100009641 CXCL10 Human genes 0.000 claims 3
- 101710032181 CXCL10 Proteins 0.000 claims 3
- 206010008943 Chronic leukaemia Diseases 0.000 claims 3
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 claims 3
- 102000013462 Interleukin-12 Human genes 0.000 claims 3
- 108010065805 Interleukin-12 Proteins 0.000 claims 3
- 239000002177 L01XE27 - Ibrutinib Substances 0.000 claims 3
- 102100019436 PLK1 Human genes 0.000 claims 3
- 101700062434 PLK1 Proteins 0.000 claims 3
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 3
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 claims 3
- 229960001507 ibrutinib Drugs 0.000 claims 3
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 3
- MIMNFCVQODTQDP-NDLVEFNKSA-N oblimersen Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(S)(=O)O[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)CO)[C@@H](O)C1 MIMNFCVQODTQDP-NDLVEFNKSA-N 0.000 claims 3
- LQBVNQSMGBZMKD-UHFFFAOYSA-N 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide Chemical group C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 claims 2
- HPLNQCPCUACXLM-PGUFJCEWSA-N 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide Chemical compound C([C@@H](CCN(C)C)NC=1C(=CC(=CC=1)S(=O)(=O)NC(=O)C=1C=CC(=CC=1)N1CCN(CC=2C(=CC=CC=2)C=2C=CC(Cl)=CC=2)CC1)[N+]([O-])=O)SC1=CC=CC=C1 HPLNQCPCUACXLM-PGUFJCEWSA-N 0.000 claims 2
- 102100003279 CD38 Human genes 0.000 claims 2
- 101700044948 CD38 Proteins 0.000 claims 2
- 102100005832 CD69 Human genes 0.000 claims 2
- 101700080416 CD69 Proteins 0.000 claims 2
- 108091007936 ERK family Proteins 0.000 claims 2
- GOTYRUGSSMKFNF-UHFFFAOYSA-N Lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 2
- QGZYDVAGYRLSKP-UHFFFAOYSA-N N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide Chemical compound N1=CC(C(=O)NCCCCCCC(=O)NO)=CN=C1N(C=1C=CC=CC=1)C1=CC=CC=C1 QGZYDVAGYRLSKP-UHFFFAOYSA-N 0.000 claims 2
- JLYAXFNOILIKPP-KXQOOQHDSA-N Navitoclax Chemical compound C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 claims 2
- RFTSSZJZXOSICM-VXLYETTFSA-N Obatoclax Chemical compound COC1=CC(C=2NC3=CC=CC=C3C=2)=N\C1=C\C=1NC(C)=CC=1C RFTSSZJZXOSICM-VXLYETTFSA-N 0.000 claims 2
- 208000009052 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960004942 lenalidomide Drugs 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 229960003347 obinutuzumab Drugs 0.000 claims 2
- 108010045555 obinutuzumab Proteins 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 108091007934 protein kinase B family Proteins 0.000 claims 2
- 229960003452 romidepsin Drugs 0.000 claims 2
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 2
- 108010091666 romidepsin Proteins 0.000 claims 2
- 229960001183 venetoclax Drugs 0.000 claims 2
- FKSFKBQGSFSOSM-QFIPXVFZSA-N 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide Chemical compound C1=C2N([C@@H](C)CC)C=C(C)C2=C(C(=O)NCC=2C(NC(C)=CC=2C)=O)C=C1C(C=N1)=CC=C1N1CCNCC1 FKSFKBQGSFSOSM-QFIPXVFZSA-N 0.000 claims 1
- CODBZFJPKJDNDT-UHFFFAOYSA-N 2-[[5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl]amino]-9-(trifluoromethyl)-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione Chemical compound CN(C)CCCC1=CN=C(C)C(NC=2N=C3C4=CC=C(C=C4NC(=S)CC3=CN=2)C(F)(F)F)=C1 CODBZFJPKJDNDT-UHFFFAOYSA-N 0.000 claims 1
- OMKHWTRUYNAGFG-IEBDPFPHSA-N 3-Deazaneplanocin A Chemical compound C1=NC=2C(N)=NC=CC=2N1[C@@H]1C=C(CO)[C@@H](O)[C@H]1O OMKHWTRUYNAGFG-IEBDPFPHSA-N 0.000 claims 1
- RCLQNICOARASSR-SECBINFHSA-N 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione Chemical compound FC=1C(=O)N(C)C=2N=CN(C[C@@H](O)CO)C(=O)C=2C=1NC1=CC=C(I)C=C1F RCLQNICOARASSR-SECBINFHSA-N 0.000 claims 1
- GWRSATNRNFYMDI-UHFFFAOYSA-N 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide Chemical compound FC=1C=C(NC=2N=C3N(C4CCCC4)CC(F)(F)C(=O)N(C)C3=CN=2)C(OC)=CC=1C(=O)NC1CCN(C)CC1 GWRSATNRNFYMDI-UHFFFAOYSA-N 0.000 claims 1
- VVLHQJDAUIPZFH-UHFFFAOYSA-N 4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC=3N=C(NC=4C=C(NC(=O)C=C)C=CC=4)C(F)=CN=3)=CC=2)=C1 VVLHQJDAUIPZFH-UHFFFAOYSA-N 0.000 claims 1
- JIFCFQDXHMUPGP-UHFFFAOYSA-N 4-tert-butyl-N-[2-methyl-3-[4-methyl-6-[4-(morpholine-4-carbonyl)anilino]-5-oxopyrazin-2-yl]phenyl]benzamide Chemical compound C1=CC=C(C=2N=C(NC=3C=CC(=CC=3)C(=O)N3CCOCC3)C(=O)N(C)C=2)C(C)=C1NC(=O)C1=CC=C(C(C)(C)C)C=C1 JIFCFQDXHMUPGP-UHFFFAOYSA-N 0.000 claims 1
- ZHJGWYRLJUCMRT-QGZVFWFLSA-N 5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide Chemical compound O([C@H](C)C=1C(=CC=CC=1)C(F)(F)F)C(=C(S1)C(N)=O)C=C1N(C1=C2)C=NC1=CC=C2CN1CCN(C)CC1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 0.000 claims 1
- ACWZRVQXLIRSDF-UHFFFAOYSA-N 6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide Chemical compound OCCONC(=O)C=1C=C2N(C)C=NC2=C(F)C=1NC1=CC=C(Br)C=C1F ACWZRVQXLIRSDF-UHFFFAOYSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- 102100017507 AKT1S1 Human genes 0.000 claims 1
- 101710031851 AKT1S1 Proteins 0.000 claims 1
- 101710009063 CARD11 Proteins 0.000 claims 1
- 102100002586 CARD11 Human genes 0.000 claims 1
- 102100019449 CD79B Human genes 0.000 claims 1
- 101700045471 CD79B Proteins 0.000 claims 1
- 102100006400 CSF2 Human genes 0.000 claims 1
- BSMCAPRUBJMWDF-KRWDZBQOSA-N Cobimetinib Chemical compound C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F BSMCAPRUBJMWDF-KRWDZBQOSA-N 0.000 claims 1
- 229960002271 Cobimetinib Drugs 0.000 claims 1
- 230000008836 DNA modification Effects 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100015977 IL16 Human genes 0.000 claims 1
- 101700036616 IL16 Proteins 0.000 claims 1
- 102100019517 JAK1 Human genes 0.000 claims 1
- 101700034277 JAK1 Proteins 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 102100004961 MMP12 Human genes 0.000 claims 1
- 108090000028 MMP12 Proteins 0.000 claims 1
- 102100010074 MYD88 Human genes 0.000 claims 1
- 101700079836 MYD88 Proteins 0.000 claims 1
- 206010026798 Mantle cell lymphomas Diseases 0.000 claims 1
- OCKHRKSTDPOHEN-BQYQJAHWSA-N N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-1-ium-4-yl)ethenyl]phenyl]acetamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(C)=O)C1=CC=CC=C1\C=C\C1=CC=[N+]([O-])C=C1 OCKHRKSTDPOHEN-BQYQJAHWSA-N 0.000 claims 1
- NSQSAUGJQHDYNO-UHFFFAOYSA-N N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide Chemical compound C=1C(C=2C=CC(CN3CCOCC3)=CC=2)=CC(C(=O)NCC=2C(NC(C)=CC=2C)=O)=C(C)C=1N(CC)C1CCOCC1 NSQSAUGJQHDYNO-UHFFFAOYSA-N 0.000 claims 1
- ULNXAWLQFZMIHX-UHFFFAOYSA-N N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide Chemical compound C1=C(C)NC(=O)C(CNC(=O)C=2C=3C=NN(C=3C=C(C=2)C=2C=C(N=CC=2)N2CCN(C)CC2)C(C)C)=C1CCC ULNXAWLQFZMIHX-UHFFFAOYSA-N 0.000 claims 1
- RDSACQWTXKSHJT-NSHDSACASA-N N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide Chemical compound C1CC1(C[C@H](O)CO)S(=O)(=O)NC=1C(OC)=CC(F)=C(F)C=1NC1=CC=C(I)C=C1F RDSACQWTXKSHJT-NSHDSACASA-N 0.000 claims 1
- CDOOFZZILLRUQH-GDLZYMKVSA-N N-[3-[6-[4-[(2R)-1,4-dimethyl-3-oxopiperazin-2-yl]anilino]-4-methyl-5-oxopyrazin-2-yl]-2-methylphenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide Chemical compound CN1CCN(C)C(=O)[C@H]1C(C=C1)=CC=C1NC1=NC(C=2C(=C(NC(=O)C=3SC=4CCCCC=4C=3)C=CC=2)C)=CN(C)C1=O CDOOFZZILLRUQH-GDLZYMKVSA-N 0.000 claims 1
- KXBDTLQSDKGAEB-UHFFFAOYSA-N N-[3-[[5-fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide Chemical compound C1=CC(OCCOC)=CC=C1NC1=NC=C(F)C(NC=2C=C(NC(=O)C=C)C=CC=2)=N1 KXBDTLQSDKGAEB-UHFFFAOYSA-N 0.000 claims 1
- 101710033916 NRAS Proteins 0.000 claims 1
- 102100001119 NRAS Human genes 0.000 claims 1
- 229960002450 Ofatumumab Drugs 0.000 claims 1
- LZMPYSIUWPEIRA-XFXZXTDPSA-N Ofatumumab Chemical compound N1=C2C=3COCCC=3N=CC2=N\C1=C1\NOC=C1 LZMPYSIUWPEIRA-XFXZXTDPSA-N 0.000 claims 1
- 206010025310 Other lymphomas Diseases 0.000 claims 1
- SUDAHWBOROXANE-VIFPVBQESA-N PD 0325901-Cl Chemical compound OC[C@H](O)CONC(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F SUDAHWBOROXANE-VIFPVBQESA-N 0.000 claims 1
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- FWZRWHZDXBDTFK-ZHACJKMWSA-N Panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 1
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- OWBFCJROIKNMGD-BQYQJAHWSA-N Rigosertib Chemical compound COC1=CC(OC)=CC(OC)=C1\C=C\S(=O)(=O)CC1=CC=C(OC)C(NCC(O)=O)=C1 OWBFCJROIKNMGD-BQYQJAHWSA-N 0.000 claims 1
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- 101700038204 TGFA Proteins 0.000 claims 1
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- LIRYPHYGHXZJBZ-UHFFFAOYSA-N Trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 1
- 102000006747 Transforming growth factor alpha Human genes 0.000 claims 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims 1
- 229960004528 Vincristine Drugs 0.000 claims 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N Vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 1
- 229960000237 Vorinostat Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000003247 decreasing Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960000435 oblimersen Drugs 0.000 claims 1
- 108010052070 ofatumumab Proteins 0.000 claims 1
- 229960005184 panobinostat Drugs 0.000 claims 1
- 229960005267 tositumomab Drugs 0.000 claims 1
- 229960004066 trametinib Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- LFUYRYYQBCVUSJ-UHFFFAOYSA-N CC(C(N1c2ccccc2)=Cc2cccc(C)c2C1=O)NC1N(C)C=Nc2c1nc[nH]2 Chemical compound CC(C(N1c2ccccc2)=Cc2cccc(C)c2C1=O)NC1N(C)C=Nc2c1nc[nH]2 LFUYRYYQBCVUSJ-UHFFFAOYSA-N 0.000 description 1
Claims (15)
- 前記第二の活性剤が、下記からなる群から選択される、請求項1又は2記載の医薬組成物又は使用:
(i)ベリノスタット、ボリノスタット、パノビノスタット、ACY-1215、及びロミデプシンからなる群から選択されるHDAC阻害剤;
(ii)タメチニブ/GSK1120212、セルメチノブ、ピマセルチブ/AS703026/MSC1935369、XL-518/GDC-0973、ラファメチニブ/BAY869766/RDEA119、PD-0325901、TAK733、MEK162/ARRY438162、RO5126766、WX-554、RO4987655/CH4987655、及びAZD8330からなる群から選択されるMEK阻害剤;
(iii)EPZ-6438、GSK-126、GSK-343、El1、及び3-デアザネプラノシンA(DNNep)からなる群から選択されるEZH2阻害剤;並びに
(iv)ボラセルチブ(BI6727)、BI2536、ZK-チアゾリドン、TAK-960、MLN0905、GSK461364、リゴセルチブ(ON-01910)、及びHMN-214からなる群から選択されるPLK-1阻害剤。 - 前記PI3K阻害剤が、bcl-2阻害剤と組合せて使用するように製剤化されており、該bcl-2阻害剤が、ABT-199、ABT-737、ABT-263、GX15-070(メシル酸オバトクラックス)、又はG3139(オブリメルセン)からなる群から任意に選択される、請求項1〜3のいずれか一項記載の医薬組成物又は使用。
- 前記PI3K阻害剤が、下記からなる群から選択される第二の活性剤と組合せて使用するように製剤化されている、請求項1〜4のいずれか一項記載の医薬組成物又は使用:
(i)抗CD37抗体;
(ii)131I トシツモマブ、90Y イブリツモマブ、111I イブリツモマブ、オビヌツズマブ、及びオファツムマブからなる群から選択される抗CD20抗体;及び
(iii)抗CD52抗体。 - 前記PI3K阻害剤が、抗CD20抗体と組合せて投与され、該抗CD20抗体が、任意にオビヌツズマブである、請求項1〜5のいずれか一項記載の医薬組成物又は使用。
- 前記PI3K阻害剤が、下記からなる群から選択される第二の活性剤と組合せて投与される、請求項1〜6のいずれか一項記載の医薬組成物又は使用:
(i)前記血液悪性腫瘍がiNHLである場合の、リツキシマブ、ベンダムスチン、もしくはレナリドマイド、又はこれらの組合せである第二の活性剤;
(ii)前記血液悪性腫瘍がCLLである場合の、リツキシマブ、ベンダムスチン、もしくはレナリドマイド、又はこれらの組合せである第二の活性剤;
(iii)前記血液悪性腫瘍がDLBCLである場合の、リツキシマブ、ベンダムスチン、R-GDP、もしくはイブルチニブ、又はこれらの組合せである第二の活性剤;
(iv)前記血液悪性腫瘍がDLBCLである場合の、ACY-1215である第二の活性剤;
(v)前記血液悪性腫瘍がT細胞リンパ腫である場合の、リツキシマブ、ベンダムスチン、もしくはロミデプシン、又はこれらの組合せである第二の活性剤;
(vi)前記血液悪性腫瘍がマントル細胞リンパ腫である場合の、リツキシマブ、ベンダムスチン、もしくはイブルチニブ、又はこれらの組合せである第二の活性剤;並びに
(vii)前記血液悪性腫瘍がT-ALLであり、かつ前記対象がPTEN欠損を有する場合の、ドキソルビシン及び/又はビンクリスチンである第二の活性剤。 - 前記対象が、一定の期間にわたってバイオマーカーのレベルの変化をモニタリングされる、請求項1〜7のいずれか一項記載の医薬組成物又は使用。
- 前記バイオマーカーが、CXCL13、CCL4、CCL17、CCL22、TNF-α、もしくはMMP-9、又はこれらの組合せから選択され、該バイオマーカーのレベルが前記一定の期間にわたって減少する場合に、前記対象が、前記治療に対して応答性である、請求項8記載の医薬組成物又は使用。
- 前記対象が、下記の1以上のレベルの変化についてモニタリングされる、請求項1〜9のいずれか一項記載の医薬組成物又は使用:
(i)IGH7、KRAS、NRAS、A20、CD79B、TP53、CARD11、MYD88、EZH2、JAK1/2、PTEN、及びPIK3CAのうちの1つ又は複数の突然変異;
(ii)PTEN発現の低下、PTENのDNA修飾、PTEN欠失、PTEN突然変異、又はこれらの組合せ:
(iii)1以上のPI3Kアイソフォームの発現レベル;及び/又は
(iv)RAS経路の活性化、PI3K経路の活性化、又はその両方。 - (i)前記血液悪性腫瘍がCLL又はSLLであり、前記バイオマーカーが、CCL1、IL-10、CXCL13、CCL3、CCL4、CCL17、CCL22、TNFα、IL-12(p40)、CXCL10、もしくはMMP-9、又はこれらの組合せである;
(ii)前記血液悪性腫瘍がリンパ腫であり、前記バイオマーカーが、CXCL13、CCL17、もしくはMMP-9、又はこれらの組合せである;
(iii)前記血液悪性腫瘍がiNHLであり、前記バイオマーカーが、CCL1、CCL17、CCL22、CXCL13、IL-12(p40)、MMP-12、MMP-9、TNFα、もしくはIL-16、又はこれらの組合せである;
(iv)前記血液悪性腫瘍がMCLであり、前記バイオマーカーが、CCL17、CCL22、CXCL10、CXCL13、もしくはMMP-9、又はこれらの組合せである;
(v)前記血液悪性腫瘍がT細胞リンパ腫であり、前記バイオマーカーが、CCL17、CCL22、CXCL10、CXCL13、MMP-9、GM-CSF、IL-12(p40)、TNF-α、TGF-α、ERK(細胞外シグナル調節キナーゼ)、PRAS40、もしくはpS6、又はこれらの組合せである;
(vi)前記血液悪性腫瘍がCLLであり、前記患者が、CD38陽性、CD69陽性、CD38/CD69二重陽性、Ki67陽性、pAKT陽性、又はKi67/pAKT二重陽性癌細胞を有する;又は
(vii)前記血液悪性腫瘍がT-ALLであり、前記対象がPTEN欠損を有する、
請求項8又は9記載の医薬組成物又は使用。 - 前記BTK阻害剤が、イブルチニブ、GDC-0834、CGI-560、CGI-1746、HM-71224、AVL-292、ONO-4059、CNX-774、又はLFM-A13から選択される、請求項12記載の医薬組成物。
- 前記BCL-2阻害剤が、ABT-199、ABT-737、ABT-263、GX15-070(メシル酸オバトクラックス)、又はG3139(オブリメルセン)から選択される、請求項14記載の医薬組成物。
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