JP2015530985A5 - - Google Patents
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- Publication number
- JP2015530985A5 JP2015530985A5 JP2015525884A JP2015525884A JP2015530985A5 JP 2015530985 A5 JP2015530985 A5 JP 2015530985A5 JP 2015525884 A JP2015525884 A JP 2015525884A JP 2015525884 A JP2015525884 A JP 2015525884A JP 2015530985 A5 JP2015530985 A5 JP 2015530985A5
- Authority
- JP
- Japan
- Prior art keywords
- vial
- reactor
- water
- deprotecting agent
- mecn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 8
- 239000012351 deprotecting agent Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000010511 deprotection reaction Methods 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- NTEDWGYJNHZKQW-DGMDOPGDSA-N fluciclovine ((18)F) Chemical compound OC(=O)[C@]1(N)C[C@H]([18F])C1 NTEDWGYJNHZKQW-DGMDOPGDSA-N 0.000 description 3
- 229940027541 fluciclovine f-18 Drugs 0.000 description 3
- KRHYYFGTRYWZRS-BJUDXGSMSA-M fluorine-18(1-) Chemical compound [18F-] KRHYYFGTRYWZRS-BJUDXGSMSA-M 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 2
- 125000006242 amine protecting group Chemical group 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1214220.4A GB201214220D0 (en) | 2012-08-09 | 2012-08-09 | Radiosynthesis |
| GB1214220.4 | 2012-08-09 | ||
| PCT/EP2013/066570 WO2014023775A1 (en) | 2012-08-09 | 2013-08-07 | Preparation of 18f-fluciclovine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015530985A JP2015530985A (ja) | 2015-10-29 |
| JP2015530985A5 true JP2015530985A5 (enExample) | 2017-07-27 |
| JP6574379B2 JP6574379B2 (ja) | 2019-09-11 |
Family
ID=46935146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525884A Active JP6574379B2 (ja) | 2012-08-09 | 2013-08-07 | １８ｆ−フルシクロビンの製造 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9359288B2 (enExample) |
| EP (1) | EP2885271A1 (enExample) |
| JP (1) | JP6574379B2 (enExample) |
| KR (1) | KR102109225B1 (enExample) |
| CN (2) | CN104507905A (enExample) |
| AU (1) | AU2013301499B2 (enExample) |
| BR (1) | BR112015002077A2 (enExample) |
| CA (1) | CA2878636A1 (enExample) |
| GB (2) | GB201214220D0 (enExample) |
| IL (1) | IL236312A0 (enExample) |
| IN (1) | IN2014DN10962A (enExample) |
| MX (2) | MX368668B (enExample) |
| RU (1) | RU2640805C2 (enExample) |
| WO (1) | WO2014023775A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130132892A (ko) * | 2010-12-29 | 2013-12-05 | 지이 헬쓰케어 리미티드 | 용리제 용액 |
| GB201411569D0 (en) * | 2014-06-30 | 2014-08-13 | Ge Healthcare Ltd | Novel formulation and method of synthesis |
| US11534494B2 (en) | 2011-12-21 | 2022-12-27 | Ge Healthcare Limited | Formulation and method of synthesis |
| GB201214220D0 (en) | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
| JP6755862B2 (ja) * | 2015-06-05 | 2020-09-16 | 日本メジフィジックス株式会社 | 放射性標識化合物の製造装置及び製造方法 |
| GB201621864D0 (en) | 2016-12-21 | 2017-02-01 | Ge Healthcare Ltd | Solid phase conditioning |
| CN106770883B (zh) * | 2017-01-03 | 2019-01-29 | 原子高科股份有限公司 | 一种氟[18f]化钠注射液放化纯的薄层色谱分析方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| AU2007251015B2 (en) * | 2006-05-11 | 2011-09-01 | Nihon Medi-Physics Co., Ltd. | Process for production of radioactive fluorine-labeled organic compound |
| JP5518337B2 (ja) * | 2006-12-27 | 2014-06-11 | 日本メジフィジックス株式会社 | 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法 |
| KR101485445B1 (ko) * | 2007-02-13 | 2015-01-22 | 니혼 메디피직스 가부시키가이샤 | 방사성 화상진단제의 제조 방법 |
| SI2230229T1 (sl) | 2007-12-19 | 2017-03-31 | Nihon Medi-Physics,Ltd. | Postopek za proizvodnjo z radioaktivnim fluorom markirane organske spojine |
| SG2014012686A (en) | 2009-10-08 | 2014-06-27 | Ge Healthcare Ltd | Purification method |
| ES2643500T3 (es) * | 2010-11-29 | 2017-11-23 | Blue Earth Diagnostics Limited | Preparación de precursor de PET |
| GB201021523D0 (en) | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Process simplification for precursor compound |
| MX2013007186A (es) | 2010-12-20 | 2013-07-12 | Ge Healthcare Ltd | Purificacion de compuesto precursor mediante cristalizacion. |
| GB201021530D0 (en) * | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Purification of precursor compound by crystallisation |
| KR20130132892A (ko) | 2010-12-29 | 2013-12-05 | 지이 헬쓰케어 리미티드 | 용리제 용액 |
| GB201214220D0 (en) | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
-
2012
- 2012-08-09 GB GBGB1214220.4A patent/GB201214220D0/en not_active Ceased
-
2013
- 2013-08-07 JP JP2015525884A patent/JP6574379B2/ja active Active
- 2013-08-07 BR BR112015002077A patent/BR112015002077A2/pt not_active Application Discontinuation
- 2013-08-07 RU RU2015101998A patent/RU2640805C2/ru active
- 2013-08-07 MX MX2015001724A patent/MX368668B/es active IP Right Grant
- 2013-08-07 AU AU2013301499A patent/AU2013301499B2/en active Active
- 2013-08-07 US US14/420,493 patent/US9359288B2/en active Active
- 2013-08-07 MX MX2019012139A patent/MX388930B/es unknown
- 2013-08-07 CN CN201380041838.9A patent/CN104507905A/zh active Pending
- 2013-08-07 CA CA2878636A patent/CA2878636A1/en not_active Abandoned
- 2013-08-07 CN CN201810568649.1A patent/CN108997169A/zh active Pending
- 2013-08-07 WO PCT/EP2013/066570 patent/WO2014023775A1/en not_active Ceased
- 2013-08-07 EP EP13750668.9A patent/EP2885271A1/en not_active Withdrawn
- 2013-08-07 IN IN10962DEN2014 patent/IN2014DN10962A/en unknown
- 2013-08-07 GB GB1501016.8A patent/GB2519026B/en active Active
- 2013-08-07 KR KR1020157003004A patent/KR102109225B1/ko active Active
-
2014
- 2014-12-17 IL IL236312A patent/IL236312A0/en unknown
-
2016
- 2016-06-06 US US15/173,839 patent/US10023525B2/en active Active
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