MX2013007186A - Purificacion de compuesto precursor mediante cristalizacion. - Google Patents

Purificacion de compuesto precursor mediante cristalizacion.

Info

Publication number
MX2013007186A
MX2013007186A MX2013007186A MX2013007186A MX2013007186A MX 2013007186 A MX2013007186 A MX 2013007186A MX 2013007186 A MX2013007186 A MX 2013007186A MX 2013007186 A MX2013007186 A MX 2013007186A MX 2013007186 A MX2013007186 A MX 2013007186A
Authority
MX
Mexico
Prior art keywords
preparation
crystallisation
purification
precursor compound
relates
Prior art date
Application number
MX2013007186A
Other languages
English (en)
Inventor
Anne Nilsen
Sondre Nilsen
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1021530.9A external-priority patent/GB201021530D0/en
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of MX2013007186A publication Critical patent/MX2013007186A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invención se refiere a un proceso para la preparación de precursores radiofarmacéuticos, y en particular derivados de aminoácidos protegidos, los cuales son usados como precursores para la producción de aminoácidos radioetiquetados para uso en procedimientos de imagenología in vivo, tal como tomografía de emisión de positrones (PET). En particular, la invención se refiere a un proceso para la preparación de un precursor útil en la preparación del trazador de PET ácido [18F]-1-amino-3-fluorocic lobutanocarboxílico ([18F] FACBC.).
MX2013007186A 2010-12-20 2011-12-19 Purificacion de compuesto precursor mediante cristalizacion. MX2013007186A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061424695P 2010-12-20 2010-12-20
GBGB1021530.9A GB201021530D0 (en) 2010-12-20 2010-12-20 Purification of precursor compound by crystallisation
PCT/EP2011/073247 WO2012084831A1 (en) 2010-12-20 2011-12-19 Purification of precursor compound by crystallisation

Publications (1)

Publication Number Publication Date
MX2013007186A true MX2013007186A (es) 2013-07-12

Family

ID=49385661

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007186A MX2013007186A (es) 2010-12-20 2011-12-19 Purificacion de compuesto precursor mediante cristalizacion.

Country Status (3)

Country Link
US (1) US9061977B2 (es)
JP (1) JP6450808B2 (es)
MX (1) MX2013007186A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201214220D0 (en) 2012-08-09 2012-09-19 Ge Healthcare Ltd Radiosynthesis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2559766B1 (fr) * 1984-02-16 1986-05-16 Poudres & Explosifs Ste Nale Procede de preparation de derives de l'acide carbamique
JP3705657B2 (ja) * 1996-09-05 2005-10-12 信越化学工業株式会社 Ｎ，ｎ−ジアルキルカルバミン酸２−ニトロベンジルエステル類の製造方法
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
KR101608755B1 (ko) * 2005-11-29 2016-04-04 니혼 메디피직스 가부시키가이샤 방사성 할로겐 표식 유기 화합물의 전구체 화합물
RU2434846C2 (ru) * 2006-05-11 2011-11-27 Нихон Меди-Физикс Ко., Лтд. Способ получения радиоактивного фтор-меченного органического соединения
JP5518337B2 (ja) 2006-12-27 2014-06-11 日本メジフィジックス株式会社 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法
SI2230229T1 (sl) 2007-12-19 2017-03-31 Nihon Medi-Physics,Ltd. Postopek za proizvodnjo z radioaktivnim fluorom markirane organske spojine
EP2325167A4 (en) * 2008-07-28 2012-03-07 Ube Industries METHOD FOR PRODUCING A CARBAMATE COMPOUND

Also Published As

Publication number Publication date
US20130267730A1 (en) 2013-10-10
US9061977B2 (en) 2015-06-23
JP6450808B2 (ja) 2019-01-09
JP2017214389A (ja) 2017-12-07

Similar Documents

Publication Publication Date Title
MX2013012793A (es) Aminoacidos radiomarcados para imagen de diagnostico.
MX348958B (es) Métodos y aparatos para sintetizar agentes formadores de imagen e intermedios de estos.
MX2014006209A (es) Radioligandos marcados con fluor-18 y carbono-11 para la formacion de imagenes por tomografia de emision de positrones para proteina cinasa 2 de repeticion rica en leucina (lrrk2).
NZ590923A (en) Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment
NZ705827A (en) Method of synthesizing thyroid hormone analogs and polymorphs thereof
MY164274A (en) Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
NZ603155A (en) Phospholipid drug analogs
MY183588A (en) New salvianolic acid compound l, preparation method and use thereof
MX2013007699A (es) Solucion de eluyente.
TW200738271A (en) Methods of making radiolabeled tracers and precursors thereof
MX2013010012A (es) Analogos de octreotato radiomarcado como trazadores de tomografia por emision de positrones.
MX2014001784A (es) Compuesto para la union de glicoproteina iib/iiia especifica a plaquetas y su uso para la formacion de imagenes de un trombo.
WO2011044406A3 (en) Purification method
MX2011010295A (es) Reactivos de radiomarcado y metodos.
MX2012007868A (es) Metodo para preparar sales de acido tetrazol-mentasulfonico, y un nuevo compuesto utilizado en las mismas.
MX2011009898A (es) Proceso para la obtencion de derivados de acido propionico.
EA201300647A1 (ru) Оптимизированный синтез чистых неполиморфных кристаллических жёлчных кислот с заданным размером частиц
MX340407B (es) Simplificacion de proceso para compuesto precursor.
IN2012DN01292A (es)
AR073230A1 (es) Derivados del acido benzofuran-piridin carbamico, utiles en la preparacion de compuestos marcados, proceso para prepararlos y proceso para preparar precursores de sintesis.
WO2007148083A3 (en) Stabilisation of radiopharmaceutical precursors
MX340487B (es) Compuestos para usarse en la formacion de imagenes, diagnostico y/o tratamiento de enfermedades del sistema nervioso central.
MX2013007186A (es) Purificacion de compuesto precursor mediante cristalizacion.
MX2013012795A (es) Procursores novedosos de derivados de glutamato.
IN2014DN06805A (es)

Legal Events

Date Code Title Description
FG Grant or registration