MX2010006901A - Proceso para la produccion del compuesto organico marcado con fluor radioactivo. - Google Patents
Proceso para la produccion del compuesto organico marcado con fluor radioactivo.Info
- Publication number
- MX2010006901A MX2010006901A MX2010006901A MX2010006901A MX2010006901A MX 2010006901 A MX2010006901 A MX 2010006901A MX 2010006901 A MX2010006901 A MX 2010006901A MX 2010006901 A MX2010006901 A MX 2010006901A MX 2010006901 A MX2010006901 A MX 2010006901A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- substituent
- radioactive
- fluorine
- linear
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Se proporciona un proceso para la producción de un compuesto orgánico marcado con flúor radiactivo que puede mejorar el rendimiento de fluoración radiactiva. Se proporciona un proceso en el cual un compuesto representado por la fórmula siguiente (1): (ver fórmula (I)) (en donde R1 es una cadena de alquilo lineal o ramificada con 1-10 átomos de carbono o un sustituyente aromático, R2 es un sustituyente del ácido haloalquilsulfónico lineal o ramificado con 1-10 tomos de carbono, un sustituyente del ácido alquilsulfónico lineal o ramificado con 1-10 tomos de carbono, un sustituyente del ácido fluorosulfónico o un sustituyente del ácido sulfónico aromático, y R3 es un grupo protector) se calienta bajo agitación en un solvente orgánico inerte en presencia de un catalizador de transferencia de fase, iones 18F e iones de potasio, para efectuar el marcado con un flúor radiactivo, en donde la temperatura de calentamiento es 40-90°C, y la concentración del catalizador de transferencia de fase en el solvente orgánico inerte es 70 mmol/I o más. Preferiblemente, la relación molar del catalizador de transferencia de fase es 0.7 o más con relación al compuesto de fórmula (1), y la concentración del compuesto de fórmula (1) en el solvente orgánico inerte es 50 mmol/l o más.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007327444 | 2007-12-19 | ||
| PCT/JP2008/072827 WO2009078396A1 (ja) | 2007-12-19 | 2008-12-16 | 放射性フッ素標識有機化合物の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010006901A true MX2010006901A (es) | 2010-09-30 |
Family
ID=40795511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010006901A MX2010006901A (es) | 2007-12-19 | 2008-12-16 | Proceso para la produccion del compuesto organico marcado con fluor radioactivo. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8269035B2 (es) |
| EP (1) | EP2230229B1 (es) |
| JP (1) | JP5732198B2 (es) |
| KR (1) | KR101583544B1 (es) |
| CN (1) | CN101939290B (es) |
| AU (1) | AU2008339435B2 (es) |
| BR (1) | BRPI0821241B1 (es) |
| CA (1) | CA2709558C (es) |
| DK (1) | DK2230229T3 (es) |
| ES (1) | ES2610574T3 (es) |
| HK (1) | HK1151513A1 (es) |
| IL (1) | IL206332A (es) |
| MX (1) | MX2010006901A (es) |
| NZ (1) | NZ586636A (es) |
| PL (1) | PL2230229T3 (es) |
| RU (1) | RU2476423C2 (es) |
| SI (1) | SI2230229T1 (es) |
| TW (1) | TWI458494B (es) |
| WO (1) | WO2009078396A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11504430B2 (en) | 2010-12-29 | 2022-11-22 | Ge Healthcare Limited | Eluent solution |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007063824A1 (ja) | 2005-11-29 | 2007-06-07 | Nihon Medi-Physics Co., Ltd. | 放射性ハロゲン標識有機化合物の前駆体化合物 |
| GB201021523D0 (en) | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Process simplification for precursor compound |
| GB201021530D0 (en) * | 2010-12-20 | 2011-02-02 | Ge Healthcare Ltd | Purification of precursor compound by crystallisation |
| US9061977B2 (en) | 2010-12-20 | 2015-06-23 | Ge Healthcare Limited | Purification of precursor compound by crystallisation |
| GB201214220D0 (en) | 2012-08-09 | 2012-09-19 | Ge Healthcare Ltd | Radiosynthesis |
| GB201305687D0 (en) | 2013-03-28 | 2013-05-15 | Ge Healthcare Ltd | Radiolabelling process |
| GB201411571D0 (en) | 2014-06-30 | 2014-08-13 | Ge Healthcare Ltd | Radiolabelling method |
| CN107614482B (zh) * | 2015-06-05 | 2020-10-20 | 日本医事物理股份有限公司 | 放射性标记化合物的制造装置及制造方法 |
| KR101842989B1 (ko) * | 2018-01-02 | 2018-03-28 | (주)퓨쳐켐 | 카보닐기를 갖는 알코올 용매를 이용한 플루오르화 화합물의 제조방법 |
| KR20210093802A (ko) | 2021-07-08 | 2021-07-28 | 서정철 | 펄스파를 이용한 직류 접지회선 추적 방법과 접지 전류의 위상분석을 통한 접지 극성 판단 장치 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| JPH11295494A (ja) * | 1998-04-08 | 1999-10-29 | Nippon Meji Physics Kk | ［ｆ−１８］−フッ化物イオンの製造方法 |
| DE10127126A1 (de) * | 2001-06-05 | 2002-12-19 | Forschungszentrum Juelich Gmbh | Geschützte Tyrosinderivate, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von O-(2-[·18·F]-Fluorethyl)-L-tyrosin |
| GB0229695D0 (en) | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase preparation of 18F-labelled amino acids |
| EP1893246A4 (en) * | 2005-06-23 | 2009-05-06 | Univ Emory | STEREOSELECTIVE SYNTHESIS OF AMINO ACID ANALOGUE FOR TUMOR IMAGING |
| CA2632553A1 (en) | 2005-12-02 | 2007-06-07 | Nihon Medi-Physics Co., Ltd. | Process for production of compound labeled with radioactive fluorine |
| US7897811B2 (en) | 2006-05-11 | 2011-03-01 | Nihon Medi-Physics Co., Ltd. | Process for production of radioactive fluorine-labeled organic compound |
-
2008
- 2008-12-16 JP JP2009546266A patent/JP5732198B2/ja active Active
- 2008-12-16 EP EP08863261.7A patent/EP2230229B1/en active Active
- 2008-12-16 MX MX2010006901A patent/MX2010006901A/es active IP Right Grant
- 2008-12-16 DK DK08863261.7T patent/DK2230229T3/en active
- 2008-12-16 CA CA2709558A patent/CA2709558C/en active Active
- 2008-12-16 KR KR1020107013207A patent/KR101583544B1/ko active IP Right Grant
- 2008-12-16 CN CN2008801217441A patent/CN101939290B/zh active Active
- 2008-12-16 RU RU2010129950/04A patent/RU2476423C2/ru active
- 2008-12-16 SI SI200831746A patent/SI2230229T1/sl unknown
- 2008-12-16 NZ NZ586636A patent/NZ586636A/en unknown
- 2008-12-16 PL PL08863261T patent/PL2230229T3/pl unknown
- 2008-12-16 WO PCT/JP2008/072827 patent/WO2009078396A1/ja active Application Filing
- 2008-12-16 AU AU2008339435A patent/AU2008339435B2/en active Active
- 2008-12-16 US US12/747,726 patent/US8269035B2/en active Active
- 2008-12-16 ES ES08863261.7T patent/ES2610574T3/es active Active
- 2008-12-16 BR BRPI0821241-4A patent/BRPI0821241B1/pt active IP Right Grant
- 2008-12-17 TW TW097149289A patent/TWI458494B/zh active
-
2010
- 2010-06-13 IL IL206332A patent/IL206332A/en active IP Right Grant
-
2011
- 2011-05-31 HK HK11105401.9A patent/HK1151513A1/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11504430B2 (en) | 2010-12-29 | 2022-11-22 | Ge Healthcare Limited | Eluent solution |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010129950A (ru) | 2012-01-27 |
| EP2230229A4 (en) | 2010-11-24 |
| IL206332A (en) | 2013-10-31 |
| ES2610574T3 (es) | 2017-04-28 |
| NZ586636A (en) | 2012-05-25 |
| HK1151513A1 (en) | 2012-02-03 |
| AU2008339435B2 (en) | 2012-08-16 |
| RU2476423C2 (ru) | 2013-02-27 |
| JPWO2009078396A1 (ja) | 2011-04-28 |
| AU2008339435A1 (en) | 2009-06-25 |
| TWI458494B (zh) | 2014-11-01 |
| US8269035B2 (en) | 2012-09-18 |
| CA2709558C (en) | 2016-08-16 |
| IL206332A0 (en) | 2010-12-30 |
| KR101583544B1 (ko) | 2016-01-08 |
| CN101939290B (zh) | 2013-11-06 |
| KR20100108519A (ko) | 2010-10-07 |
| CN101939290A (zh) | 2011-01-05 |
| CA2709558A1 (en) | 2009-06-25 |
| WO2009078396A1 (ja) | 2009-06-25 |
| US20100261931A1 (en) | 2010-10-14 |
| EP2230229B1 (en) | 2016-10-12 |
| BRPI0821241B1 (pt) | 2021-04-06 |
| JP5732198B2 (ja) | 2015-06-10 |
| BRPI0821241A2 (pt) | 2015-06-16 |
| DK2230229T3 (en) | 2017-01-23 |
| SI2230229T1 (sl) | 2017-03-31 |
| EP2230229A1 (en) | 2010-09-22 |
| TW200930410A (en) | 2009-07-16 |
| PL2230229T3 (pl) | 2017-04-28 |
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