JP2015528003A - 抗ｃｄ３構築物を含む二重特異性の非対称ヘテロ二量体 - Google Patents

抗ｃｄ３構築物を含む二重特異性の非対称ヘテロ二量体 Download PDF

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JP2015528003A
JP2015528003A JP2015521877A JP2015521877A JP2015528003A JP 2015528003 A JP2015528003 A JP 2015528003A JP 2015521877 A JP2015521877 A JP 2015521877A JP 2015521877 A JP2015521877 A JP 2015521877A JP 2015528003 A JP2015528003 A JP 2015528003A
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polypeptide
cell
construct
binding
cells
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JP2015528003A5 (OSRAM
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スールジット ビーマラオ ディキシット
スールジット ビーマラオ ディキシット
フォン クロイデンシュタイン トマス スプレッター
フォン クロイデンシュタイン トマス スプレッター
ゴードン イウ コン エング
ゴードン イウ コン エング
ニーナ イー． ワイサー
ニーナ イー． ワイサー
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ザイムワークス，インコーポレイテッド
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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JP2015521877A 2012-07-13 2013-07-13 抗ｃｄ３構築物を含む二重特異性の非対称ヘテロ二量体 Pending JP2015528003A (ja)

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US201261671640P 2012-07-13 2012-07-13
US61/671,640 2012-07-13
US201361845948P 2013-07-12 2013-07-12
US61/845,948 2013-07-12
PCT/US2013/050411 WO2014012085A2 (en) 2012-07-13 2013-07-13 Bispecific asymmetric heterodimers comprising anti-cd3 constructs

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JP2015528003A true JP2015528003A (ja) 2015-09-24
JP2015528003A5 JP2015528003A5 (OSRAM) 2016-09-01

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US (4) US20140154253A1 (OSRAM)
EP (1) EP2872170A4 (OSRAM)
JP (1) JP2015528003A (OSRAM)
KR (1) KR20150036606A (OSRAM)
CN (1) CN104640562A (OSRAM)
AU (1) AU2013289883B2 (OSRAM)
BR (1) BR112015000798A2 (OSRAM)
CA (1) CA2878843A1 (OSRAM)
HK (1) HK1207575A1 (OSRAM)
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JP2021514638A (ja) * 2018-02-26 2021-06-17 アブリンクス・エヌ・フェー ペプチドリンカーをコードする改良されたヌクレオチド配列
JP2022023132A (ja) * 2015-05-01 2022-02-07 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニア グリカン依存性免疫療法分子
JP2022512629A (ja) * 2018-10-23 2022-02-07 マジェンタ セラピューティクス インコーポレイテッド Ｆｃサイレンス化抗体薬物コンジュゲート（ＡＤＣ）及びその使用
JP2022518530A (ja) * 2019-01-28 2022-03-15 ウーシー バイオロジクス アイルランド リミティド 新規二重特異性ｃｄ３／ｃｄ２０ポリペプチド複合体
JP2022064939A (ja) * 2016-05-20 2022-04-26 ハープーン セラピューティクス，インク． 単鎖可変フラグメントｃｄ３結合タンパク質
JP2023123725A (ja) * 2017-08-01 2023-09-05 エービー ストゥーディオ インコーポレイテッド 二重特異性抗体およびその使用
US11807692B2 (en) 2018-09-25 2023-11-07 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
US12084518B2 (en) 2015-05-21 2024-09-10 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
US12371504B2 (en) 2017-10-13 2025-07-29 Harpoon Therapeutics, Inc. Trispecific proteins and methods of use

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RU2604490C2 (ru) 2010-11-05 2016-12-10 Займворкс Инк. ДИЗАЙН УСТОЙЧИВОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В Fc ДОМЕНЕ
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KR102052774B1 (ko) 2011-11-04 2019-12-04 자임워크스 인코포레이티드 Ｆｃ 도메인 내의 돌연변이를 갖는 안정한 이종이합체 항체 설계
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CN120365432A (zh) 2012-11-21 2025-07-25 武汉友芝友生物制药股份有限公司 双特异性抗体
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US20190248897A1 (en) 2019-08-15
US20210317212A1 (en) 2021-10-14
EP2872170A4 (en) 2016-06-22
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RU2015102193A (ru) 2016-08-27
AU2013289883B2 (en) 2018-11-01
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