JP2015524844A5 - - Google Patents

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JP2015524844A5
JP2015524844A5 JP2015527540A JP2015527540A JP2015524844A5 JP 2015524844 A5 JP2015524844 A5 JP 2015524844A5 JP 2015527540 A JP2015527540 A JP 2015527540A JP 2015527540 A JP2015527540 A JP 2015527540A JP 2015524844 A5 JP2015524844 A5 JP 2015524844A5
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mir
composition
sphingomyelinase
cardiomyocyte
tissue
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JP2015527540A 2012-08-13 2013-08-13 組織再生のためのエキソソームおよびマイクロリボ核酸 Active JP6433896B2 (ja)

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US201261682666P 2012-08-13 2012-08-13
US61/682,666 2012-08-13
PCT/US2013/054732 WO2014028493A2 (en) 2012-08-13 2013-08-13 Exosomes and micro-ribonucleic acids for tissue regeneration

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JP2018209427A Division JP6726726B2 (ja) 2012-08-13 2018-11-07 組織再生のためのエキソソームおよびマイクロリボ核酸

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JP2015524844A JP2015524844A (ja) 2015-08-27
JP2015524844A5 true JP2015524844A5 (enExample) 2016-09-29
JP6433896B2 JP6433896B2 (ja) 2018-12-05

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JP2018209427A Active JP6726726B2 (ja) 2012-08-13 2018-11-07 組織再生のためのエキソソームおよびマイクロリボ核酸

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US (4) US9828603B2 (enExample)
EP (2) EP3563859B1 (enExample)
JP (2) JP6433896B2 (enExample)
AU (1) AU2013302799B2 (enExample)
CA (1) CA2881394C (enExample)
WO (1) WO2014028493A2 (enExample)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
US9828603B2 (en) * 2012-08-13 2017-11-28 Cedars Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
CN105209881B (zh) 2013-03-13 2021-01-22 迈阿密大学 从细胞培养上清液和生物流体分离并纯化微泡的方法
EP3003290B1 (en) 2013-06-05 2021-03-10 AgeX Therapeutics, Inc. Compositions for use in the treatment of wounds in mammalian species
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
WO2015095794A1 (en) 2013-12-20 2015-06-25 Advanced ReGen Medical Technologies, LLC Compositions for cellular restoration and methods of making and using same
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
EP4445915A3 (en) * 2014-03-24 2025-01-22 Advanced Regen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
US10513710B2 (en) 2014-04-18 2019-12-24 University Of Massachusetts Exosomal loading using hydrophobically modified oligonucleotides
US10568945B2 (en) 2014-04-25 2020-02-25 University Of Cincinnati Compositions and methods for inducing liver regeneration by administering hepatocyte-derived exosomes
US20150328263A1 (en) 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
RU2620069C2 (ru) * 2014-06-26 2017-05-22 Аоварт Гмбх Вещество и способ модуляции пролиферации и дифференцировки регуляторных, стволовых и других соматических клеток
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
US11357799B2 (en) 2014-10-03 2022-06-14 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2016057560A1 (en) * 2014-10-06 2016-04-14 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
CN107106615A (zh) * 2014-10-09 2017-08-29 人类起源公司 胎盘来源的贴壁细胞外泌体及其用途
EP3227434A4 (en) * 2014-12-03 2018-07-11 Capricor, Inc. Processes for producing exosomes in reduced oxygen culture conditions
WO2016196822A1 (en) * 2015-06-02 2016-12-08 Cedars-Sinai Medical Center Urodele exosomes as therapeutic agents
US11833172B2 (en) 2015-11-25 2023-12-05 The Regents Of The University Of Colorado Use of microRNA-146A and nanoceria conjugate to improve wound healing and promote tissue regeneration
JP2018536438A (ja) 2015-12-07 2018-12-13 バイオタイム,インコーポレーテッド 多様な多能性幹細胞から誘導された褐色脂肪細胞の再誘導のための方法
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
EP3429557A4 (en) 2016-03-14 2020-02-26 Capricor, Inc. METHODS OF TREATING EYE INFLAMMATION AND CHEMICAL EYE DAMAGE USING EXTRACELLULAR VESICLES
JP7120628B2 (ja) * 2016-03-22 2022-08-17 カプリコール,インコーポレイテッド 細胞外小胞による放射線誘発性皮膚炎を予防するまたは治療する方法
US20200289583A1 (en) * 2016-03-24 2020-09-17 Stemlab, Sa Use of umbilical cord blood derived exosomes for tissue repair
WO2017190000A1 (en) * 2016-04-29 2017-11-02 Advanced ReGen Medical Technologies, LLC Microrna compositions and methods of making and using same
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
CN107557464B (zh) * 2016-07-02 2021-06-04 上海市公共卫生临床中心 用于干扰素治疗慢性乙型肝炎早期病毒学反应的预测模型及检测试剂盒
CR20190139A (es) * 2016-08-17 2019-06-03 Orthogen Ag Preparación farmacéutica anti envejecimiento
US20210290556A1 (en) * 2016-08-22 2021-09-23 Codiak Biosciences, Inc. Methods of suppressing delivery of exosomes to liver and spleen
JP2019529400A (ja) * 2016-09-09 2019-10-17 コーネル・ユニバーシティーCornell University 硝子体小胞中の核酸、タンパク質及び小分子の送達方法
FR3055805B1 (fr) * 2016-09-09 2020-05-15 Assistance Publique - Hopitaux De Paris (Ap-Hp) Biomateriau a usage therapeutique
EP3515459A4 (en) * 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
WO2018177583A1 (en) * 2017-03-30 2018-10-04 Lugano Technology Transfer (LTT) SA Device and method for producing and purifying exosomes
IT201700035315A1 (it) * 2017-03-30 2018-09-30 Foundation For Cardiological Res And Education Fcre Dispositivo e metodo di produzione e purificazione di esosomi
US20200087625A1 (en) * 2017-03-30 2020-03-19 Dennis A. Carson Methods for isolating, expanding and administering cancer specific cd8+ t cells
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
JP7083818B2 (ja) * 2017-04-28 2022-06-13 一丸ファルコス株式会社 プラセンタ抽出物
EP3600151A4 (en) * 2017-05-05 2021-01-13 Capricor, Inc. METHODS FOR TREATING SYSTEMIC HOST-AGAINST GRAFT DISEASE USING EXTRACELLULAR VESICLES
US20200113943A1 (en) * 2017-06-05 2020-04-16 The Regents Of The University Of California Methods for enhanced production and isolation of cell-derived vesicles and treatment of inflammation and neurological damage
JP2020529477A (ja) * 2017-08-04 2020-10-08 シーダーズ—シナイ メディカル センター がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞
US11446323B2 (en) 2017-08-31 2022-09-20 Tel Hashomer Medical Research Infrastructure And Services Ltd. Compositions and methods for the treatment of fibrotic diseases
AU2018324301A1 (en) * 2017-09-01 2020-04-16 Orig3N, Inc. I-PSC derived secretome compositions, and related systems and methods
WO2019055337A1 (en) * 2017-09-13 2019-03-21 Children's Hospital Medical Center ROLE OF EXOSOMES, EXTRACELLULAR VESICLES IN THE REGULATION OF METABOLIC HOMÉOSTASIE
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3740576A4 (en) 2018-01-18 2021-10-20 Advanced Regen Medical Technologies, LLC THERAPEUTIC COMPOSITIONS AND THEIR PREPARATION AND USE METHODS
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
US12453743B2 (en) 2018-05-30 2025-10-28 Direct Biologics, Llc Mesenchymal stem cell (MSC) growth factor and extracellular vesicle preparation in frozen or powdered form and methods of use
WO2020069313A2 (en) * 2018-09-28 2020-04-02 Henry Ford Health System Use of extracellular vesicles in combination with tissue plasminogen activator and/or thrombectomy to treat stroke
WO2020070700A2 (en) * 2018-10-04 2020-04-09 Exogenus Therapeutics, Sa Compositions comprising small extracellular vesicles derived from umbilical cord blood mononuclear cells with anti-inflammatory and immunomodulatory properties and process for obtaining them
AU2020217808A1 (en) * 2019-02-07 2021-09-02 Direct Biologics Llc Method for treating osteoarthritis with a combination of mesenchymal stem cell exosomes, synovial mesencymal stem cells, and scaffolds
AU2020217747B2 (en) * 2019-02-08 2025-01-02 Board Of Regents, The University Of Texas System Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction
CA3133397A1 (en) * 2019-03-15 2020-09-24 Unicyte Ev Ag Method for predicting proangiogenic potential of extracellular vesicles (evs)
WO2020190672A1 (en) * 2019-03-15 2020-09-24 North Carolina State University Cardiomyocyte-derived exosomes inducing regeneration of damaged heart tissue
US20220160786A1 (en) * 2019-04-09 2022-05-26 International Space Medical Co., Ltd. Therapeutic agent for fibrosis, inflammation, and/or aging disease
EP3999083A4 (en) 2019-07-18 2023-07-26 Direct Biologics LLC Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
TW202122572A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 胞外體的產生方法
TW202134437A (zh) * 2019-11-29 2021-09-16 比利時商諾瓦迪生物科學公司 用於預防及治療組織疾病之基於miRNA之醫藥組成物及其用途
US20210186831A1 (en) * 2019-12-19 2021-06-24 North Carolina State University Therapeutic compositions and methods using exosomes derived from human dermal fibroblasts
EP4093408A4 (en) * 2020-01-22 2024-04-24 AgeX Therapeutics, Inc. THERAPEUTIC EXOSOMES AND THEIR PRODUCTION METHOD
WO2021178514A1 (en) * 2020-03-04 2021-09-10 Cedars-Sinai Medical Center Cardiosphere-derived cells, exosomes derived therefrom, and methods of using same to treat volumetric muscle loss
US20230220336A1 (en) * 2020-06-01 2023-07-13 Figene, Llc Fibroblasts as a regenerative cellular source for the treatment of blindness
US20230414673A1 (en) * 2020-11-23 2023-12-28 Tiffani C. Chance Extracellular vesicles derived from cardiosphere-derived cells as anti-shock therapeutics
EP4252761A4 (en) * 2020-11-26 2024-06-05 Samsung Life Public Welfare Foundation COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES, COMPRISING EXOSOMES DERIVED FROM THROMBIN-PROCESSED STEM CELLS
CN112852713B (zh) * 2021-02-07 2023-08-18 广州四叶草健康科技有限公司 一种人体皮肤成纤维细胞外泌体制备分离方法
WO2022202930A1 (ja) * 2021-03-23 2022-09-29 国立大学法人京都大学 組成物および医薬組成物
CN117320733A (zh) * 2021-05-04 2023-12-29 Se生物制药股份有限公司 包含三维球状体型细胞聚集体来源细胞外囊泡的用于促进神经再生的组合物
EP4349347A4 (en) * 2021-05-04 2025-05-14 S&E Bio Co., Ltd. Composition for promoting angiogenesis with extracellular vesicles made from three-dimensional spheroid cell aggregates
US20250215403A1 (en) * 2022-02-08 2025-07-03 Temple University - Of The Commonwealth System Of Higher Education Compositions and Methods for Cardiac Tissue Regeneration
US20250161367A1 (en) * 2022-03-03 2025-05-22 Fibrobiologics, Inc. Therapeutic use of fibroblasts to stimulate regeneration and repair of atrophied spleen
EP4501338A1 (en) 2022-03-28 2025-02-05 Hiroko Science Inc. Pharmaceutical composition containing mir-140 and method for producing same

Family Cites Families (350)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470876A (en) 1966-09-28 1969-10-07 John Barchilon Dirigible catheter
US4106488A (en) 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
US3964468A (en) 1975-05-30 1976-06-22 The Board Of Trustees Of Leland Stanford Junior University Bioptome
US4659839A (en) 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
GB8711614D0 (en) 1987-05-16 1987-06-24 Medical Res Council Proteins
US4960134A (en) 1988-11-18 1990-10-02 Webster Wilton W Jr Steerable catheter
US5175004A (en) 1988-12-27 1992-12-29 Matsumura Kenneth N Propagatable, new combinant cells for cellular replacement therapy
US4921482A (en) 1989-01-09 1990-05-01 Hammerslag Julius G Steerable angioplasty device
US5052402A (en) 1989-01-31 1991-10-01 C.R. Bard, Inc. Disposable biopsy forceps
US5104787A (en) 1990-03-05 1992-04-14 Lindstrom Richard L Method for apparatus for a defined serumfree medical solution useful for corneal preservation
US6326198B1 (en) 1990-06-14 2001-12-04 Regents Of The University Of Michigan Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
ATE123957T1 (de) 1990-12-07 1995-07-15 Ruesch Willy Ag Medizinisches instrument mit lenkbarer spitze.
US5315996A (en) 1991-02-15 1994-05-31 Lundquist Ingemar H Torquable catheter and method
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5329923A (en) 1991-02-15 1994-07-19 Lundquist Ingemar H Torquable catheter
US5454787A (en) 1991-02-15 1995-10-03 Lundquist; Ingemar H. Torquable tubular assembly and torquable catheter utilizing the same
US5228441A (en) 1991-02-15 1993-07-20 Lundquist Ingemar H Torquable catheter and method
US5981165A (en) 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US5287857A (en) 1992-06-22 1994-02-22 David Mann Apparatus and method for obtaining an arterial biopsy
US5243167A (en) 1992-09-16 1993-09-07 Ingemar H. Lundquist Apparatus and method for manufacturing a slotted torque tube
US5334145A (en) 1992-09-16 1994-08-02 Lundquist Ingemar H Torquable catheter
US5383852A (en) 1992-12-04 1995-01-24 C. R. Bard, Inc. Catheter with independent proximal and distal control
US5368564A (en) 1992-12-23 1994-11-29 Angeion Corporation Steerable catheter
US5492825A (en) 1993-08-06 1996-02-20 The Regents Of The University Of California Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5454827A (en) 1994-05-24 1995-10-03 Aust; Gilbert M. Surgical instrument
US5840502A (en) 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US5702905A (en) 1994-09-28 1997-12-30 Spectral Diagnostics Monoclonal antibody to human ventricular myosin light chains
DE69621528T2 (de) 1995-02-07 2003-01-16 Shiseido Co. Ltd., Tokio/Tokyo Anti-inflamatorische agenzien
US5551427A (en) 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5715832A (en) 1995-02-28 1998-02-10 Boston Scientific Corporation Deflectable biopsy catheter
US5925567A (en) 1995-05-19 1999-07-20 T. Breeders, Inc. Selective expansion of target cell populations
US5702433A (en) 1995-06-27 1997-12-30 Arrow International Investment Corp. Kink-resistant steerable catheter assembly for microwave ablation
AU705563B2 (en) 1995-07-28 1999-05-27 Marie Curie Cancer Care Transport proteins and their uses
FR2739621B1 (fr) 1995-10-05 1997-12-05 Centre Nat Rech Scient Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives
DE69635899T2 (de) 1995-11-17 2006-11-23 Asahi Kasei Kabushiki Kaisha Polypeptid, das die differenzierung unterdrueckt
US5762069A (en) 1995-12-29 1998-06-09 Akos Biomedical, Inc. Multiple sample biopsy forceps
US5856155A (en) 1996-02-23 1999-01-05 The Johns Hopkins University School Of Medicine Compounds and related methods for modulating potassium ion channels and assays for such compounds
US6132390A (en) 1996-02-28 2000-10-17 Eupalamus Llc Handle for manipulation of a stylet used for deflecting a tip of a lead or catheter
US5824031A (en) 1996-02-28 1998-10-20 Cardio Source Apparatus and method for deflecting a tip of a lead or catheter
US5782748A (en) 1996-07-10 1998-07-21 Symbiosis Corporation Endoscopic surgical instruments having detachable proximal and distal portions
GB9615726D0 (en) 1996-07-26 1996-09-04 Medical Res Council Anti-viral agent 11
US5955275A (en) 1997-02-14 1999-09-21 Arcaris, Inc. Methods for identifying nucleic acid sequences encoding agents that affect cellular phenotypes
US6017735A (en) 1997-01-23 2000-01-25 Marie Curie Cancer Care Materials and methods for intracellular transport and their uses
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6511477B2 (en) 1997-03-13 2003-01-28 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6443949B2 (en) 1997-03-13 2002-09-03 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6547787B1 (en) 1997-03-13 2003-04-15 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
DE69841002D1 (de) 1997-05-14 2009-09-03 Univ British Columbia Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
US6099832A (en) 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
US5899914A (en) 1997-06-11 1999-05-04 Endius Incorporated Surgical instrument
US5851212A (en) 1997-06-11 1998-12-22 Endius Incorporated Surgical instrument
CA2241615A1 (en) 1997-06-26 1998-12-26 An-Go-Gen Inc. Catheters
DK1007631T4 (da) 1997-07-14 2009-04-27 Osiris Therapeutics Inc Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller
US7514074B2 (en) 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
GB9718609D0 (en) 1997-09-02 1997-11-05 Imp College Innovations Ltd Fusion protein
US6123699A (en) 1997-09-05 2000-09-26 Cordis Webster, Inc. Omni-directional steerable catheter
US7037648B1 (en) 1997-11-07 2006-05-02 John Hopkins University Somatic transfer of modified genes to predict drug effects
US5938603A (en) 1997-12-01 1999-08-17 Cordis Webster, Inc. Steerable catheter with electromagnetic sensor
US6203487B1 (en) 1997-12-31 2001-03-20 Thomas Jefferson University Use of magnetic particles in the focal delivery of cells
JP4535468B2 (ja) 1998-02-05 2010-09-01 バイオセンス・ウエブスター・インコーポレーテツド 心臓内薬物送達
JP2002507407A (ja) 1998-03-23 2002-03-12 ザイモジェネティクス,インコーポレイティド 心臓由来幹細胞
US20010044619A1 (en) 1998-04-08 2001-11-22 Peter A. Altman Cardiac drug delivery system and method for use
US6296630B1 (en) 1998-04-08 2001-10-02 Biocardia, Inc. Device and method to slow or stop the heart temporarily
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6165164A (en) 1999-03-29 2000-12-26 Cordis Corporation Catheter for injecting therapeutic and diagnostic agents
US6540725B1 (en) 1998-06-04 2003-04-01 Biosense Webster, Inc. Injection catheter with controllably extendable injection needle
DE19833476B4 (de) 1998-07-24 2005-08-25 Huss, Ralf, Dr. Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie
US6102887A (en) 1998-08-11 2000-08-15 Biocardia, Inc. Catheter drug delivery system and method for use
US6074408A (en) 1998-10-13 2000-06-13 Freeman; Kenneth V. Modular medical instrument and method of using same
US6153582A (en) 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
US6572611B1 (en) 1998-11-23 2003-06-03 C. R. Bard, Inc. Intracardiac grasp catheter
US6193763B1 (en) 1998-12-17 2001-02-27 Robert A. Mackin Apparatus and method for contemporaneous treatment and fluoroscopic mapping of body tissue
AUPP785098A0 (en) 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6783510B1 (en) 1999-07-08 2004-08-31 C.R. Bard, Inc. Steerable catheter
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US6488659B1 (en) 1999-08-05 2002-12-03 Biocardia, Inc. System and method for delivering thermally sensitive and reverse-thermal gelation materials
SE9903185D0 (sv) 1999-09-08 1999-09-08 Europ I Of Science Ab Terapeutisk metod och anordning baserad på magnetism
EP1218489B1 (en) 1999-09-24 2009-03-18 Cybios LLC Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
US20030161817A1 (en) 2001-03-28 2003-08-28 Young Henry E. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
WO2001026585A1 (en) 1999-10-13 2001-04-19 Biocardia, Inc. Pulmonary vein stent and method for use
US6716242B1 (en) 1999-10-13 2004-04-06 Peter A. Altman Pulmonary vein stent and method for use
US6224587B1 (en) 1999-11-22 2001-05-01 C.R. Bard, Inc. Steerable catheter
AU4305101A (en) 1999-11-22 2001-06-04 Research Foundation Of The State University Of New York, The Magnetic nanoparticles for selective therapy
EP1257282A4 (en) 1999-12-06 2003-05-02 Gen Hospital Corp PANCREATIC STEM CELLS AND THEIR USE IN TRANSPLANTATION
AU784618B2 (en) 1999-12-28 2006-05-18 Kyowa Hakko Kogyo Co. Ltd. Cells capable of differentiating into heart muscle cells
CA2396348A1 (en) 2000-01-14 2001-07-19 Beth Israel Deaconess Medical Center Cardiac-cell specific enhancer elements and uses thereof
US6530944B2 (en) 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US6585716B2 (en) 2000-04-05 2003-07-01 Biocardia, Inc. Method of treating the heart
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US20040087016A1 (en) 2000-05-12 2004-05-06 University Of Utah Research Foundation Compositions and methods for cell dedifferentiation and tissue regeneration
EP1301228B1 (en) 2000-07-13 2008-07-23 Abbott Cardiovascular Systems Inc. Deployment system for myocardial cellular material
US20110091428A1 (en) 2000-07-31 2011-04-21 New York Medical College Compositions of adult organ stem cells and uses thereof
US20020061587A1 (en) 2000-07-31 2002-05-23 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
US7547674B2 (en) 2001-06-06 2009-06-16 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US7862810B2 (en) 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
AU2001283088A1 (en) 2000-07-31 2002-02-25 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
AU8880701A (en) 2000-09-06 2002-03-22 Univ Johns Hopkins Cardiac arrhythmia treatment methods
US6569105B1 (en) 2000-09-14 2003-05-27 Syntheon, Llc Rotatable and deflectable biopsy forceps
FR2814752A1 (fr) 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations
US6511471B2 (en) 2000-12-22 2003-01-28 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
NZ527849A (en) 2001-02-14 2006-09-29 Anthrogenesis Corp Post-partum mammalian placenta, its use and placental stem cells therefrom
US20040168341A1 (en) 2001-03-21 2004-09-02 Petersen Peter Mosborg Methods for performing operations, a housing for such methods, and furnishings for such housing
AU2002306865A1 (en) 2001-03-23 2003-03-03 Warren J. Alilain Generation of multipotent central nervous system stem cells
EP2314306A1 (en) 2001-04-27 2011-04-27 Johns Hopkins University Biological pacemaker
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
CA2351156A1 (en) 2001-07-04 2003-01-04 Peter W. Zandstra A bioprocess for the generation of pluripotent cell derived cells and tissues
US6796963B2 (en) 2001-07-10 2004-09-28 Myocardial Therapeutics, Inc. Flexible tissue injection catheters with controlled depth penetration
IL159580A0 (en) 2001-07-12 2004-06-01 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
IL159895A0 (en) 2001-07-20 2004-06-20 Technion Res & Dev Foundation Methods of generating human cardiac cells and tissues and uses thereof
US6997863B2 (en) 2001-07-25 2006-02-14 Triton Biosystems, Inc. Thermotherapy via targeted delivery of nanoscale magnetic particles
US7074175B2 (en) 2001-07-25 2006-07-11 Erik Schroeder Handy Thermotherapy via targeted delivery of nanoscale magnetic particles
US7731648B2 (en) 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
US20030044976A1 (en) 2001-08-27 2003-03-06 Advanced Cell Technology De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
US6805860B1 (en) 2001-09-30 2004-10-19 Eckhard Alt Method of transluminal application of myogenic cells for repair or replacement of heart tissue
US7452532B2 (en) 2001-09-30 2008-11-18 Scicotec Gmbh Transluminal application of adult stem cells for body organ tissue repair
US20030082153A1 (en) 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
CN101352365B (zh) 2001-11-05 2010-09-08 迈德詹尼克斯公司 用于固定微器官的定位器
DE10162353A1 (de) 2001-12-18 2003-07-03 Roehm Gmbh Extrusionsdüse für Folien oder Platten mit seitlicher Schmelzeeinspeisung
US20040014209A1 (en) 2002-01-23 2004-01-22 Lassar Andrew B. Compositions and methods for modulating cell differentiation
GB0202149D0 (en) 2002-01-30 2002-03-20 Univ Edinburgh Pluripotency determining factors and uses thereof
TWI288779B (en) 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
US6866117B2 (en) 2002-04-05 2005-03-15 Wing Enterprises, Inc. Light weight ladder systems and methods
US7840261B2 (en) 2002-06-05 2010-11-23 Biocardia, Inc. Catheter systems and methods for placing bi-ventricular pacing leads
US20050176620A1 (en) 2002-06-21 2005-08-11 Prestwich Glenn D. Crosslinked compounds and methods of making and using thereof
AU2003259152A1 (en) 2002-07-23 2004-02-09 Boston Scientific Limited Cell therapy for regeneration
CA2494040A1 (en) 2002-07-29 2004-02-05 Es Cell International Pte Ltd. Multi-step method for the differentiation of insulin positive, glucose
AU2003270051A1 (en) 2002-08-29 2004-03-19 Baylor College Of Medicine Heart derived cells for cardiac repair
US20040258669A1 (en) 2002-11-05 2004-12-23 Dzau Victor J. Mesenchymal stem cells and methods of use thereof
US7794702B2 (en) 2003-01-15 2010-09-14 The Trustees Of Columbia University In The City Of New York Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures
EP1590446A4 (en) 2003-01-31 2006-12-27 Univ California USE OF ISLET 1 AS A MARKER FOR ISOLATING OR GENERATING STEM CELLS
DE10331439B3 (de) 2003-07-10 2005-02-03 Micromod Partikeltechnologie Gmbh Magnetische Nanopartikel mit verbesserten Magneteigenschaften
JP2004248382A (ja) 2003-02-12 2004-09-02 Mitsubishi Motors Corp ハイブリッド車
DK1601770T3 (da) 2003-03-04 2009-11-02 Intercell Ag Streptococcus pyogenes antigener
US7837631B2 (en) 2003-03-14 2010-11-23 Boston Scientific Scimed Inc. Biopsy forceps with removable jaw segments
US20060041182A1 (en) 2003-04-16 2006-02-23 Forbes Zachary G Magnetically-controllable delivery system for therapeutic agents
US20040214182A1 (en) 2003-04-25 2004-10-28 Vinod Sharma Genetic modification of targeted regions of the cardiac conduction system
US7329638B2 (en) 2003-04-30 2008-02-12 The Regents Of The University Of Michigan Drug delivery compositions
US20060025713A1 (en) 2003-05-12 2006-02-02 Alex Rosengart Magnetic particle-based therapy
CA2431425A1 (en) 2003-06-05 2004-12-05 Angiogene, Inc. Epas1 gene transfer to improve cell therapy
GB0313259D0 (en) 2003-06-09 2003-07-16 Consejo Superior Investigacion Magnetic nanoparticles
CA2528869A1 (en) 2003-06-12 2004-12-23 Regents Of The University Of Minnesota Directing cells to target tissues or organs
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
CA2530421C (en) 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
CN101173250B (zh) 2003-06-30 2011-01-26 卫材R&D管理有限公司 磁性细胞及其使用方法
US20060205071A1 (en) 2003-07-17 2006-09-14 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US20080213812A1 (en) 2003-09-29 2008-09-04 Andrews William H Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression
JP2005110565A (ja) 2003-10-07 2005-04-28 Nobuya Yamanaka 分化多能性維持剤
US7280863B2 (en) 2003-10-20 2007-10-09 Magnetecs, Inc. System and method for radar-assisted catheter guidance and control
CN1537646A (zh) 2003-10-22 2004-10-20 高春平 肿瘤局部综合治疗方法和装置
US20050090732A1 (en) 2003-10-28 2005-04-28 Triton Biosystems, Inc. Therapy via targeted delivery of nanoscale particles
ES2398239T3 (es) 2003-11-10 2013-03-14 The Scripps Research Institute Composiciones y procedimientos para inducir la desdiferenciación celular
GB0329310D0 (en) 2003-12-18 2004-01-21 Univ Keele Method
US7625581B2 (en) 2003-12-19 2009-12-01 Ethicon, Inc. Tissue scaffolds for use in muscoloskeletal repairs
WO2005065282A2 (en) 2003-12-31 2005-07-21 The Regents Of The University Of California Remote magnetically induced treatment of cancer
US20080274998A1 (en) 2004-02-17 2008-11-06 Yeda Research And Development Co. Ltd. Disaccharide Molecules and Derivatives Thereof and Methods of Using Same
US20050260748A1 (en) 2004-02-27 2005-11-24 Michigan State University Adult stem cells and uses thereof
US20050214938A1 (en) 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
WO2005095652A2 (en) 2004-03-31 2005-10-13 Georgetown University Pnmt as a novel marker for progenitor cells
US20070231393A1 (en) 2004-05-19 2007-10-04 University Of South Carolina System and Device for Magnetic Drug Targeting with Magnetic Drug Carrier Particles
WO2005113754A1 (en) 2004-05-20 2005-12-01 New York Medical College Pluripotent adult stem cells
JP2006006125A (ja) 2004-06-22 2006-01-12 Nipro Corp 骨髄単核細胞の調製方法及び細胞調製装置
WO2006004910A2 (en) 2004-06-28 2006-01-12 Transtarget Inc. Improved bispecific antibodies
KR20070058441A (ko) 2004-07-01 2007-06-08 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 면역억제성 엑소솜
WO2006014156A1 (en) 2004-07-02 2006-02-09 Macropore Biosurgery, Inc. Systems and methods for isolating and using clinically safe adipose derived regenerative cells
US20070196918A1 (en) 2004-07-15 2007-08-23 Sayre Chauncey B Reprogramming of adult human testicular stem cells to pluripotent germ-line stem cells
WO2006017428A2 (en) 2004-08-03 2006-02-16 Becton, Dickinson And Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
US8431397B2 (en) 2004-09-14 2013-04-30 The Trustees Of Columbia University In The City Of New York Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair
US20060234375A1 (en) 2004-09-30 2006-10-19 Doronin Sergey V Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division
EP1812556A4 (en) 2004-10-05 2011-02-02 Univ Georgia NEURONAL PRECURSORS OF FEEDER-FREE HUMAN EMBRYONIC STEM CELL CULTURE
FR2877571B1 (fr) 2004-11-05 2007-04-13 Nanobiotix Sarl Nanoparticules pourvues d'un element de ciblage intracellulaire, preparation et utilisations
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
AU2005304708B2 (en) 2004-11-08 2012-01-19 The Johns Hopkins University Cardiac stem cells
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
EP1674128A1 (en) 2004-12-22 2006-06-28 Steinbeis-Transferzentrum für Herz-Kreislaufforschung Magnetic pole matrices useful for tissue engineering and treatment of disease
US7850960B2 (en) 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
AU2006208241B2 (en) 2005-01-25 2011-08-04 Five Prime Therapeutics, Inc. Compositions and methods for treating cardiac conditions
CA2600653C (en) 2005-03-04 2014-09-09 Kyoto University Pluripotent stem cell derived from cardiac tissue
DE102005016873A1 (de) 2005-04-12 2006-10-19 Magforce Nanotechnologies Ag Nanopartikel-Wirstoff-Konjugate
KR101617319B1 (ko) 2005-04-12 2016-05-02 메소블라스트, 아이엔씨. 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체 세포의 분리
US7846393B2 (en) 2005-04-21 2010-12-07 California Institute Of Technology Membrane filter for capturing circulating tumor cells
GB0508110D0 (en) 2005-04-22 2005-06-01 Univ Keele Gene delivery
US20060281791A1 (en) 2005-04-29 2006-12-14 Children's Medical Center Corporation Methods of increasing proliferation of adult mammalian cardiomyocytes through p38 map kinase inhibition
US20070003528A1 (en) 2005-06-29 2007-01-04 Paul Consigny Intracoronary device and method of use thereof
US20070014869A1 (en) 2005-07-15 2007-01-18 Cormatrix Cardiovascular, Inc. Compositions for reconstruction, replacement or repair of intracardiac tissue
CA2659945C (en) 2005-08-03 2014-12-16 Advanced Cell Technology, Inc. Improved methods of reprogramming animal somatic cells
US20070048383A1 (en) 2005-08-25 2007-03-01 Helmus Michael N Self-assembled endovascular structures
US20070054397A1 (en) 2005-08-26 2007-03-08 Harald Ott Adult cardiac uncommitted progenitor cells
EP1931783A1 (en) 2005-09-09 2008-06-18 The Trustees of Columbia University in the City of New York Chimeric hcn channels
EP2368973A1 (en) 2005-10-13 2011-09-28 Anthrogenesis Corporation Production Of Oligodendrocytes From Placenta-Derived Stem Cells
US7736346B2 (en) 2005-10-18 2010-06-15 Biocardia, Inc. Bio-interventional therapeutic treatments for cardiovascular diseases
BRPI0617664B8 (pt) 2005-10-21 2021-05-25 Chugai Pharmaceutical Co Ltd uso de um anticorpo que reconhece a il-6 para a produção de uma composição farmacêutica para tratar o enfarte do miocárdio ou suprimir a remodelagem ventricular esquerda depois do enfarte do miocárdio
CN100355454C (zh) 2005-10-25 2007-12-19 南京工业大学 磁热疗用纳米磁粉-抗人肝癌单抗HAb18靶向药物
CN100509059C (zh) 2005-10-25 2009-07-08 南京工业大学 磁热疗用纳米磁粉-抗cea抗体靶向药物
US8574571B2 (en) 2005-10-25 2013-11-05 Womens & Childrens Health Research Institute Methods and compositions for modulating wound repair
KR101420740B1 (ko) 2005-12-13 2014-07-17 교또 다이가꾸 핵초기화 인자
US20090011004A1 (en) 2005-12-30 2009-01-08 Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine Improved carriers for delivery of nucleic acid agents to cells and tissues
US7875451B2 (en) 2006-01-19 2011-01-25 The University Of Washington Formulation to improve survival of transplanted cells
US7869854B2 (en) 2006-02-23 2011-01-11 Magnetecs, Inc. Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation
AU2007232356A1 (en) 2006-04-03 2007-10-11 Keele University Targeted therapy
EP2032149A4 (en) 2006-06-13 2010-09-01 Fmc Biopolymer As METHOD AND SYSTEMS FOR THE USE OF BIOPOLYMER-BASED BEADS AND HYDROGELS
US8568286B2 (en) 2006-06-14 2013-10-29 Cardiac Pacemakers, Inc. Methods to position therapeutic agents using a magnetic field
US9149564B2 (en) 2006-06-23 2015-10-06 The Regents Of The University Of California Articles comprising large-surface-area bio-compatible materials and methods for making and using them
WO2008008857A2 (en) 2006-07-11 2008-01-17 University Of Utah Research Foundation Thiolated macromolecules and methods of making and using thereof
CA2662795A1 (en) 2006-09-05 2008-03-13 Columbus Nanoworks, Inc. Magnetic particles and methods of making and using the same
JP2010510964A (ja) 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、miR−15、miR−26、miR−31、miR−145、miR−147、miR−188、miR−215、miR−216、miR−331、mmu−miR−292−3pによって調節される遺伝子および経路
WO2008040027A2 (en) 2006-09-28 2008-04-03 The Regents Of The University Of California Directed differentiation and maturation of stem cell-derived cardiomyocytes
WO2008043521A2 (de) 2006-10-09 2008-04-17 Julius-Maximilians-Universität Würzburg Microrna (mirna) zur diagnose und therapie von herzerkrankungen
CA2850793A1 (en) 2006-10-23 2008-05-02 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
US7787949B2 (en) 2006-10-30 2010-08-31 Medtronic, Inc. Biological pacemaker compositions and systems incorporating interstitial cells of Cajal
EP2079831A2 (en) 2006-11-07 2009-07-22 Keck Graduate Institute Enriched stem cell and progenitor cell populations, and methods of producing and using such populations
WO2008058273A2 (en) 2006-11-09 2008-05-15 The Johns Hopkins University Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells
US8076305B2 (en) 2006-11-30 2011-12-13 Medtronic, Inc. Biological pacemakers including mutated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
KR100830889B1 (ko) 2006-12-18 2008-05-21 주식회사 케이티 세툭시맵이 결합된 나노 입자 및 이의 제조 방법
DE102007008650B4 (de) 2007-02-20 2012-06-06 Charité - Universitätsmedizin Berlin Zellen zur Therapie des Herzens
EP2137296A2 (en) 2007-03-23 2009-12-30 Wisconsin Alumni Research Foundation Somatic cell reprogramming
CN105861443A (zh) 2007-04-07 2016-08-17 怀特黑德生物医学研究所 体细胞重编程
US8496926B2 (en) 2007-04-16 2013-07-30 Biocardia, Inc. Treatment for chronic myocardial infarction
US9205112B2 (en) 2007-04-23 2015-12-08 Creative Medical Health, Inc. Combination treatment of cardiovascular disease
US20080297287A1 (en) 2007-05-30 2008-12-04 Magnetecs, Inc. Magnetic linear actuator for deployable catheter tools
FI20075417A0 (fi) 2007-06-05 2007-06-05 Marjo-Riitta Suuronen Koostumuksia ja menetelmiä alkion kantasolujen kasvatukseen
US20120282229A1 (en) 2007-08-01 2012-11-08 Christian Kannemeier Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
US20090136582A1 (en) 2007-08-03 2009-05-28 Albrecht Ralph M Colloidal magnetic nanobioparticles for cytotoxicity and drug delivery
US8292873B2 (en) 2007-08-09 2012-10-23 Boston Scientific Scimed, Inc. Catheter devices for myocardial injections or other uses
US20090081276A1 (en) 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
US20090081170A1 (en) 2007-09-13 2009-03-26 Paul Riley Cardiac progenitor cells
US8541185B2 (en) 2007-09-24 2013-09-24 Technion Research & Development Foundation Limited Method of predicting responsiveness to autologous adoptive cell transfer therapy
US8414924B2 (en) 2007-10-10 2013-04-09 Kyoto University Preparation for treating heart disease used in cell therapy
JP5719171B2 (ja) 2007-10-15 2015-05-13 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 内皮細胞移植、特に膵島移植による糖尿病の処置におけるアジュバント活性を有する医薬を調製するための微小胞(mv)の使用、および関連方法
WO2009058818A2 (en) 2007-10-29 2009-05-07 The Board Of Regents Of The University Of Texas System Compositions comprising a micro-rna and methods of their use in regulating cardiac remodeling
DE102007052114B4 (de) 2007-10-30 2011-01-05 T2Cure Gmbh Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle
WO2009061382A2 (en) 2007-11-02 2009-05-14 Marban Eduardo T Cardiac stem cell and myocyte secreted paracrine factors and uses thereof
CA2705325C (en) 2007-11-09 2016-11-01 The Board Of Regents Of The University Of Texas System Micro-rnas of the mir-15 family modulate cardiomyocyte survival and cardiac repair
AU2008323719B2 (en) 2007-11-09 2013-04-04 New York Medical College Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor
US8968699B2 (en) 2007-11-15 2015-03-03 The Regents Of The University Of California Switchable nano-vehicle delivery systems, and methods for making and using them
WO2009067644A1 (en) 2007-11-21 2009-05-28 University Of Miami Compositions, systems and methods for obtaining and expanding insulin-producing cells
WO2009070282A1 (en) 2007-11-26 2009-06-04 Stc.Unm Active nanoparticles and method of using
WO2009073518A1 (en) 2007-11-30 2009-06-11 New York Medical College Methods of isolating non-senescent cardiac stem cells and uses thereof
WO2009073618A2 (en) 2007-11-30 2009-06-11 New York Medical College Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure
US8512696B2 (en) 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
CA2743682A1 (en) 2007-11-30 2009-06-11 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
EP2227238A2 (en) 2007-11-30 2010-09-15 New York Medical College Compositions comprising vascular and myocyte progenitor cells and methods of their use
WO2009079592A2 (en) 2007-12-17 2009-06-25 California Institute Of Technology Modulating immune system development and function through microrna mir-146
US20110110897A1 (en) 2008-01-11 2011-05-12 Schwarz Richard P Adult Human Cardiac-Derived Progenitor Cells
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
US7999025B2 (en) 2008-01-28 2011-08-16 University Of Utah Research Foundation Asymmetrically-functionalized nanoparticles organized on one-dimensional chains
US9078932B2 (en) 2008-02-04 2015-07-14 Emmetrope, Inc. Magnetic cells for localizing delivery and tissue repair
WO2009103818A1 (en) 2008-02-22 2009-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for obtaining progenitor cells and uses thereof in the treatment of tissue or organ damage
US20110003008A1 (en) * 2008-02-22 2011-01-06 Agency For Science, Technology And Research (A*Star) Mesenchymal stem cell particles
WO2009120702A2 (en) 2008-03-25 2009-10-01 Emory University Elemental iron nanoparticles
WO2009136283A2 (en) 2008-05-08 2009-11-12 Coretherapix Slu Multipotent adult stem cell population
EP2294196A1 (en) * 2008-06-06 2011-03-16 Centre National de la Recherche Scientifique - CNRS Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
AU2009257663B2 (en) 2008-06-09 2014-06-26 New York Medical College Compositions comprising cardiac stem cells overexpressing specific microRNA and methods of their use in repairing damaged myocardium
WO2009149599A1 (zh) 2008-06-11 2009-12-17 Liu Yanfang 脂质体药剂及其制备方法和用途
US8481492B2 (en) 2008-06-13 2013-07-09 Life & Brain Gmbh Fusion protein and use thereof
US20110225661A1 (en) 2008-06-26 2011-09-15 Spectrum Health Innovations, LLC Method for treating and preventing radiation damage using genetically modified mesenchymal stem cells
US20130309304A1 (en) 2008-08-05 2013-11-21 Bernardo Nadal-Ginard Compounds and methods
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
US20120034155A1 (en) 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
US8172831B2 (en) 2008-09-02 2012-05-08 Abbott Cardiovascular Systems Inc. Catheter configured for incremental rotation
US20110300111A1 (en) 2008-11-20 2011-12-08 Cedars-Sinai Medical Center Generation of induced pluripotent stem cells without the use of viral vectors
US20120046242A1 (en) 2008-12-24 2012-02-23 Massachusetts Institute Of Technology Molecular activators of the wnt/beta-catenin pathway
WO2010083466A1 (en) 2009-01-16 2010-07-22 Cedars-Sinai Medical Center Methods and compositions for cardiac tissue regeneration
EP2228444A1 (en) 2009-03-09 2010-09-15 Julius-Maximilians-Universität Würzburg microRNA for diagnostic and therapeutic purposes in cardiovascular diseases
US20120039857A1 (en) 2009-04-06 2012-02-16 Capricor, Inc. Systems and methods for cardiac tissue repair
US20120201795A1 (en) 2009-04-29 2012-08-09 Guardian Food Technologies, Llc Inhibition Of Pathogenic Growth On Plant Materials Using Lactic Acid Producing Microorganisms
CA2763156A1 (en) 2009-05-20 2010-11-25 Board Of Regents, The University Of Texas System Identification of micro-rnas involved in post-myocardial infarction remodeling and heart failure
CN102596177B (zh) 2009-07-01 2014-05-28 阿昂梅迪克斯公司 来源于有核哺乳动物细胞的微囊泡及其应用
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
US8609617B2 (en) 2009-09-04 2013-12-17 University Of Miami KLF family members regulate intrinsic axon regeneration ability
EP2475372B2 (en) 2009-09-10 2020-10-21 Velin-Pharma A/S Method for the preparation of micro-rna and its therapeutic application
CN102686264A (zh) 2009-10-27 2012-09-19 雪松-西奈医疗中心 用于具有增强的细胞滞留的靶向细胞递送的外部磁力
US20150010640A1 (en) 2009-10-27 2015-01-08 Cedars-Sinai Medical Center Bi-functional compositions for targeting cells to diseased tissues and methods of using same
WO2011053901A2 (en) 2009-10-30 2011-05-05 Northwestern University Magnetic nanostructures as theranostic agents
US20120321595A1 (en) 2009-11-09 2012-12-20 The Brigham And Women's Hospital, Inc. Treatment of heart disease
US20120288481A1 (en) 2009-11-09 2012-11-15 The Brigham And Women's Hospital, Inc. Treatment of heart disease
WO2011062244A1 (ja) 2009-11-18 2011-05-26 Kuroda Masahiko キャリア、その製造方法およびその用途
EP2327781A1 (en) 2009-11-27 2011-06-01 RWTH Aachen Micro-RNA and tissue repair
US20110135577A1 (en) 2009-12-03 2011-06-09 National Taiwan University Superparamagnetic nanoparticles IN MEDICAL THERAPEUTICS and manufacturing method THEREOF
US20130005658A1 (en) 2009-12-15 2013-01-03 Board Of Regents, The University Of Texas System Micro-rna regulation in ischemia and ischemia-reperfusion injury
US20130189780A1 (en) 2009-12-31 2013-07-25 Fate Therapeutics, Inc. Reprogramming compositions
EP2371370A1 (en) 2010-04-01 2011-10-05 Johann Wolfgang Goethe-Universität Frankfurt am Main Antagonists of miRNA-29 expression and their use in the prevention and treatment of aortic aneurysms and atherosclerotic plaque destabilization
US9821009B2 (en) 2010-04-13 2017-11-21 Jiangsu Mingma Biotech Co., Ltd. Method for modulating microRNA content in living beings and the use thereof
EP2563907B1 (en) 2010-04-28 2019-06-19 The J. David Gladstone Institutes Methods for generating cardiomyocytes
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
EP2385120A1 (en) 2010-05-04 2011-11-09 Justus-Liebig- Universitat Giessen Use of anti-miRNA antisense oligonucleotides for the treatment of pulmonary hypertension
EP2569418B1 (en) 2010-05-12 2016-11-02 RegenMed (Cayman) Ltd. Bioactive renal cells
US8568781B2 (en) 2010-06-10 2013-10-29 Midatech Limited Peptide-carrying nanoparticles
US8980279B2 (en) 2010-07-26 2015-03-17 Qu Biologics Personalized site-specific immunomodulation
BR112013002859B1 (pt) 2010-08-06 2020-10-06 The General Hospital Corporation D/B/A Massachusetts General Hospital Método e aparelho para tratamento de células
JP2013537538A (ja) * 2010-08-13 2013-10-03 ザ ユニバーシティ コート オブ ザ ユニバーシティ オブ グラスゴー 微小水泡および関連するマイクロrnaの治療用途
US20120093885A1 (en) 2010-10-18 2012-04-19 Northwestern University Therapeutic vesicles
EP2446929A1 (en) 2010-10-27 2012-05-02 Johann Wolfgang Goethe-Universität Frankfurt am Main Microvesicles derived from atheroprotective endothelial cells for the treatment and prevention of atherosclerotic diseases
EP2638159B1 (en) 2010-11-11 2019-04-24 University of Miami Compositions, kits and methods for treatment of cardiovascular, immunological, and inflammatory diseases
SG183579A1 (en) 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
CN109432126B (zh) 2011-03-11 2022-06-14 儿童医学中心公司 与间充质干细胞外来体相关的方法和组合物
US8871731B2 (en) 2011-03-16 2014-10-28 Migagen Therapeutics, Inc. Micro-RNA for the regulation of cardiac apoptosis and contractile function
US20140329314A1 (en) 2011-03-29 2014-11-06 Christopher O'Sullivan Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
WO2012149557A1 (en) 2011-04-28 2012-11-01 New York University miR-33 INHIBITORS AND USES THEREOF TO DECREASE INFLAMMATION
WO2012162741A1 (en) 2011-06-01 2012-12-06 Monash University Enrichment of cardiomyocytes
EP2535412A1 (en) 2011-06-17 2012-12-19 Universitat Pompeu-Fabra New treatment for muscular dystrophies
EP2549399A1 (en) 2011-07-19 2013-01-23 Koninklijke Philips Electronics N.V. Assessment of Wnt pathway activity using probabilistic modeling of target gene expression
WO2013028968A1 (en) 2011-08-25 2013-02-28 Wisconsin Alumni Research Foundation 3-dimensional cardiac fibroblast derived extracellular matrix
WO2013048734A1 (en) 2011-09-28 2013-04-04 Tufts Medical Center, Inc. Treatment and prevention of cardiovascular disease with cell derived lipid vesicles, microvesicles and exosomes
US20130280205A1 (en) 2012-01-13 2013-10-24 Georgia Regents University Activators of SGK-1 for Use as Cardioprotective Agents
KR101389850B1 (ko) 2012-05-04 2014-04-29 이화여자대학교 산학협력단 심장전구세포의 배양방법 및 그 용도
WO2013170170A2 (en) 2012-05-10 2013-11-14 Board Of Regents Of The University Of Nebraska Compositions and methods for gene therapy
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
EP2687219A1 (en) 2012-07-18 2014-01-22 Universität Duisburg-Essen Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions
EP2877187B1 (en) 2012-07-19 2019-06-12 Reneuron Limited Stem cell microparticles
US9828603B2 (en) * 2012-08-13 2017-11-28 Cedars Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
US9492484B2 (en) 2012-09-27 2016-11-15 The Regents Of The University Of California Cardiosphere derived cell population and methods of use
WO2014066545A1 (en) 2012-10-26 2014-05-01 Cedars-Sinai Medical Center Therapeutic cells depleted of specific subpopulations of cells for use in tissue repair of regeneration
US10526581B2 (en) 2013-01-24 2020-01-07 Bernardo Nadal-Ginard Modulation of cardiac stem-progenitor cell differentiation, assays and uses thereof
MX376077B (es) 2013-03-13 2025-03-07 Univ Cincinnati Tratamiento de una disfuncion cardiaca diastolica con un agonista del receptor trpv2.
US20140275976A1 (en) 2013-03-15 2014-09-18 Adventist Health System/Sunbelt, Inc. Global Ventricular Cardiac Diastolic Function Evaluation System and Associated Methods
US10208351B2 (en) 2013-10-18 2019-02-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) RNY-derived small RNAs as biomarkers for atherosclerosis-related disorders
US11377639B2 (en) 2013-11-15 2022-07-05 Wisconsin Alumni Research Foundation Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors
DK3076949T3 (da) 2013-12-04 2019-11-25 Univ Texas Fremgangsmåde til isolering af kræftcelle-afledte eksosomer
SI3083997T1 (sl) 2013-12-20 2020-12-31 Universite De Lausanne Diagnostične, prognostične in terapevtske uporabe dolgih nekodirajočih RNA-jev za srčno bolezen in regenerativno zdravilo
WO2015120150A1 (en) 2014-02-05 2015-08-13 Stc.Unm Exosomes as a therapeutic for cancer
US20150328263A1 (en) 2014-05-14 2015-11-19 University Of Maryland, Baltimore Cardiac stem cells for cardiac repair
US11357799B2 (en) 2014-10-03 2022-06-14 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2016057560A1 (en) 2014-10-06 2016-04-14 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
EP3227434A4 (en) 2014-12-03 2018-07-11 Capricor, Inc. Processes for producing exosomes in reduced oxygen culture conditions
US10131878B2 (en) 2015-04-06 2018-11-20 Wisconsin Alumni Research Foundation Methods for epicardial differentiation of human pluripotent stem cells
KR101818560B1 (ko) 2015-05-18 2018-01-16 가톨릭관동대학교기술지주 주식회사 줄기세포 유래 미세소포체를 포함하는 부정맥 예방 또는 치료용 약제학적 조성물
US10624849B2 (en) 2015-09-28 2020-04-21 Northwestern University Targeted extracellular vesicles comprising membrane proteins with engineered glycosylation sites
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
CN109072240A (zh) 2016-02-26 2018-12-21 耶鲁大学 使用piRNA诊断和治疗癌症的组合物和方法
EP3429557A4 (en) 2016-03-14 2020-02-26 Capricor, Inc. METHODS OF TREATING EYE INFLAMMATION AND CHEMICAL EYE DAMAGE USING EXTRACELLULAR VESICLES
WO2017173034A1 (en) 2016-03-30 2017-10-05 The University Of North Carolina At Chapel Hill Biological agent-exosome compositions and uses thereof
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
EP3515459A4 (en) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
PL3431609T3 (pl) 2017-07-17 2020-11-02 Masarykova Univerzita Sposób diagnozowania raka jelita grubego
JP2020529477A (ja) 2017-08-04 2020-10-08 シーダーズ—シナイ メディカル センター がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞
WO2019050071A1 (ko) 2017-09-08 2019-03-14 고려대학교 산학협력단 엑소좀 또는 엑소좀 유래 리보핵산을 포함하는 간섬유증 예방 또는 치료용 조성물
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
JP2021512595A (ja) 2018-01-30 2021-05-20 カプリコール,インコーポレイテッド 細胞療法に適した活性化誘導組織エフェクター細胞およびそれに由来する細胞外小胞
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
EP3965800A4 (en) 2019-05-08 2023-02-15 Cedars-Sinai Medical Center Therapeutically active cells and exosomes
WO2021178514A1 (en) 2020-03-04 2021-09-10 Cedars-Sinai Medical Center Cardiosphere-derived cells, exosomes derived therefrom, and methods of using same to treat volumetric muscle loss
WO2021188899A1 (en) 2020-03-20 2021-09-23 Cedars-Sinai Medical Center Cardiosphere-derived cell (cdc) therapy for the treatment of viral infections

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