JP2015524799A5 - - Google Patents
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- JP2015524799A5 JP2015524799A5 JP2015521875A JP2015521875A JP2015524799A5 JP 2015524799 A5 JP2015524799 A5 JP 2015524799A5 JP 2015521875 A JP2015521875 A JP 2015521875A JP 2015521875 A JP2015521875 A JP 2015521875A JP 2015524799 A5 JP2015524799 A5 JP 2015524799A5
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- Prior art keywords
- polypeptide
- heteromultimer
- albumin
- transporter
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Images
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261671640P | 2012-07-13 | 2012-07-13 | |
| US61/671,640 | 2012-07-13 | ||
| US201261697245P | 2012-09-05 | 2012-09-05 | |
| US61/697,245 | 2012-09-05 | ||
| US201361758701P | 2013-01-30 | 2013-01-30 | |
| US61/758,701 | 2013-01-30 | ||
| US201361845945P | 2013-07-12 | 2013-07-12 | |
| PCT/US2013/050408 WO2014012082A2 (en) | 2012-07-13 | 2013-07-12 | Multivalent heteromultimer scaffold design an constructs |
| US61/845,945 | 2013-07-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524799A JP2015524799A (ja) | 2015-08-27 |
| JP2015524799A5 true JP2015524799A5 (enExample) | 2016-09-01 |
| JP6498601B2 JP6498601B2 (ja) | 2019-04-10 |
Family
ID=49916710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521875A Active JP6498601B2 (ja) | 2012-07-13 | 2013-07-12 | 多価ヘテロ多量体足場設計および構築物 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9388231B2 (enExample) |
| JP (1) | JP6498601B2 (enExample) |
| CN (1) | CN104768571B (enExample) |
| AU (1) | AU2013289881B2 (enExample) |
| CA (1) | CA2878640C (enExample) |
| IN (1) | IN2015DN01115A (enExample) |
| WO (1) | WO2014012082A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2815266C (en) | 2010-11-05 | 2023-09-05 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the fc domain |
| DK2681245T3 (en) | 2011-03-03 | 2018-08-13 | Zymeworks Inc | MULTIVALENT HEAT-MULTIMED SCAFFOLD DESIGN AND CONSTRUCTIONS |
| HRP20211773T1 (hr) | 2011-11-04 | 2022-03-04 | Zymeworks Inc. | Stabilna heterodimerni dizajn antitijela s mutacijama u fc domeni |
| WO2014004586A1 (en) | 2012-06-25 | 2014-01-03 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
| JP6498601B2 (ja) | 2012-07-13 | 2019-04-10 | ザイムワークス，インコーポレイテッド | 多価ヘテロ多量体足場設計および構築物 |
| US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
| HK1221260A1 (zh) * | 2013-06-24 | 2017-05-26 | Celgene Corporation | 扩增t细胞的方法 |
| WO2015143271A1 (en) | 2014-03-21 | 2015-09-24 | X-Body, Inc. | Bi-specific antigen-binding polypeptides |
| KR102493430B1 (ko) | 2014-05-28 | 2023-01-31 | 자임워크스 비씨 인코포레이티드 | 변형된 항원 결합 폴리펩티드 작제물 및 이의 용도 |
| RS66070B1 (sr) * | 2014-12-22 | 2024-11-29 | Systimmune Inc | Bispecifična tetravalentna antitela i metode njihovog dobijanja i upotrebe |
| JP2018524373A (ja) | 2015-07-15 | 2018-08-30 | ザイムワークス，インコーポレイテッド | 薬物がコンジュゲートされた二重特異性抗原結合コンストラクト |
| US10946063B2 (en) * | 2016-10-11 | 2021-03-16 | Welltat Ophthalmics Corporation | Fusion protein between short form rod-derived cone viability factor and a hydrophilic peptide |
| EP3596108A4 (en) | 2017-03-15 | 2020-12-23 | Pandion Operations, Inc. | TARGETED IMMUNOTOLERANCE |
| JOP20190222A1 (ar) | 2017-04-11 | 2019-09-24 | Zymeworks Inc | الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 |
| US11531030B2 (en) | 2017-04-21 | 2022-12-20 | Mayo Foundation For Medical Education And Research | Polypeptide-antibody complexes and uses thereof |
| CN111010866A (zh) | 2017-05-24 | 2020-04-14 | 潘迪恩治疗公司 | 靶向免疫耐受性 |
| CA3064966A1 (en) | 2017-06-30 | 2019-01-03 | Zymeworks Inc. | Stabilized chimeric fabs |
| AR112603A1 (es) | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| EP3749331A4 (en) * | 2018-02-06 | 2021-08-04 | Mayo Foundation for Medical Education and Research | ANTIBODY PEPTIDE COMPLEX AND THEIR USES |
| US20210260210A1 (en) | 2018-03-13 | 2021-08-26 | Zymeworks Inc. | Anti-her2 biparatopic antibody-drug conjugates and methods of use |
| JP7383704B2 (ja) * | 2018-06-07 | 2023-11-20 | カリナン オンコロジー インコーポレイテッド | 多重特異性結合タンパク質およびその使用方法 |
| WO2020176478A1 (en) | 2019-02-25 | 2020-09-03 | The University Of Chicago | Methods and compositions for treating inflammatory and autoimmune conditions with ecm-affinity peptides linked to anti-inflammatory agents |
| CN113677702B (zh) * | 2019-04-01 | 2025-06-13 | 诺和诺德股份有限公司 | 针对利拉鲁肽的抗体及其用途 |
| KR102244760B1 (ko) * | 2019-04-29 | 2021-04-27 | 주식회사 다나그린 | 혈청유래 단백질을 포함하는 다공성 세포지지체 및 제조방법 |
| CN114679909A (zh) | 2019-05-20 | 2022-06-28 | 潘迪恩运营公司 | MAdCAM靶向的免疫耐受 |
| AU2020282736B2 (en) * | 2019-05-29 | 2025-10-30 | Cue Biopharma, Inc. | Multimeric T-cell modulatory polypeptides and methods of use thereof |
| IL293725A (en) | 2019-12-11 | 2022-08-01 | Cullinan Oncology Inc | Anti-cd19 antibodies and multispecific binding proteins |
| EP4107187A4 (en) | 2020-02-21 | 2024-07-03 | Pandion Operations, Inc. | TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR |
| US20230372503A1 (en) * | 2020-09-25 | 2023-11-23 | Proabtech Inc. | Conjugate of functional polypeptide variant, and use thereof |
| KR20230059777A (ko) | 2020-09-25 | 2023-05-03 | 주식회사 프로앱텍 | 요산산화효소-알부민 접합체, 그 제조방법 및 용도 |
| CN114736291B (zh) * | 2021-01-07 | 2023-08-11 | 中国科学院微生物研究所 | 特异性结合发热伴血小板减少综合征病毒的囊膜蛋白Gn的人源单克隆抗体及其用途 |
| CN113563474B (zh) * | 2021-06-11 | 2023-05-02 | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | EpCAM-CD16-NKG2D三特异性抗体及其应用 |
| CN118984840A (zh) * | 2022-01-28 | 2024-11-19 | 西吉隆医疗股份有限公司 | 用于治疗cns病症的组合物、设备和方法 |
| CN115057925B (zh) * | 2022-06-22 | 2024-03-26 | 中国检验检疫科学研究院 | 一种抗赤羽病病毒单克隆抗体及其应用 |
| CN117024578B (zh) * | 2023-07-19 | 2024-05-24 | 重庆明道捷测生物科技有限公司 | 一种用于捕获HBV核心颗粒的IgG抗体及应用 |
| CN116990504B (zh) * | 2023-09-27 | 2023-12-01 | 苏州旭光科星抗体生物科技有限公司 | 检测人可溶性cd4的双抗体夹心酶联免疫试剂盒 |
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- 2013-07-12 WO PCT/US2013/050408 patent/WO2014012082A2/en not_active Ceased
- 2013-07-12 CN CN201380036536.2A patent/CN104768571B/zh active Active
- 2013-07-12 CA CA2878640A patent/CA2878640C/en active Active
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