|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
GB2183662B
(en)
|
1985-04-01 |
1989-01-25 |
Celltech Ltd |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
GB8510219D0
(en)
|
1985-04-22 |
1985-05-30 |
Bass Plc |
Isolation of fermentation products
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
JPS6296086A
(ja)
|
1985-10-21 |
1987-05-02 |
Agency Of Ind Science & Technol |
複合プラスミド
|
|
US5576195A
(en)
|
1985-11-01 |
1996-11-19 |
Xoma Corporation |
Vectors with pectate lyase signal sequence
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
GB8615701D0
(en)
|
1986-06-27 |
1986-08-06 |
Delta Biotechnology Ltd |
Stable gene integration vector
|
|
US4857467A
(en)
|
1986-07-23 |
1989-08-15 |
Phillips Petroleum Company |
Carbon and energy source markers for transformation of strains of the genes Pichia
|
|
GB8620926D0
(en)
|
1986-08-29 |
1986-10-08 |
Delta Biotechnology Ltd |
Yeast promoter
|
|
US5869620A
(en)
|
1986-09-02 |
1999-02-09 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
GB8725529D0
(en)
|
1987-10-30 |
1987-12-02 |
Delta Biotechnology Ltd |
Polypeptides
|
|
DK159088C
(da)
|
1988-04-06 |
1991-01-28 |
Oce Helioprint As |
Skanner til aftastning af en original
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
ATE135045T1
(de)
|
1988-07-23 |
1996-03-15 |
Delta Biotechnology Ltd |
Sekretorische leader-sequenzen
|
|
FR2649991B2
(fr)
|
1988-08-05 |
1994-03-04 |
Rhone Poulenc Sante |
Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
|
|
DD275463A1
(de)
|
1988-09-07 |
1990-01-24 |
Forschungsstelle Fuer Medizini |
Verfahren zur herstellung von serumeiweissen mit gesteigertem dipolmoment zu therapeutischen zwecken
|
|
EP0394827A1
(en)
|
1989-04-26 |
1990-10-31 |
F. Hoffmann-La Roche Ag |
Chimaeric CD4-immunoglobulin polypeptides
|
|
US5108910A
(en)
|
1989-08-22 |
1992-04-28 |
Immunex Corporation |
DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
|
|
US5073627A
(en)
|
1989-08-22 |
1991-12-17 |
Immunex Corporation |
Fusion proteins comprising GM-CSF and IL-3
|
|
GB8924021D0
(en)
|
1989-10-25 |
1989-12-13 |
Celltech Ltd |
Recombinant dna method and vectors for the use therein
|
|
US6270989B1
(en)
|
1991-11-05 |
2001-08-07 |
Transkaryotic Therapies, Inc. |
Protein production and delivery
|
|
US5641670A
(en)
|
1991-11-05 |
1997-06-24 |
Transkaryotic Therapies, Inc. |
Protein production and protein delivery
|
|
US5932448A
(en)
*
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
CA2372813A1
(en)
|
1992-02-06 |
1993-08-19 |
L.L. Houston |
Biosynthetic binding protein for cancer marker
|
|
US6096289A
(en)
|
1992-05-06 |
2000-08-01 |
Immunomedics, Inc. |
Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy
|
|
WO1994012520A1
(en)
|
1992-11-20 |
1994-06-09 |
Enzon, Inc. |
Linker for linked fusion polypeptides
|
|
TW402639B
(en)
|
1992-12-03 |
2000-08-21 |
Transkaryotic Therapies Inc |
Protein production and protein delivery
|
|
GB9225453D0
(en)
|
1992-12-04 |
1993-01-27 |
Medical Res Council |
Binding proteins
|
|
US5780594A
(en)
|
1993-03-01 |
1998-07-14 |
The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration |
Biologically active protein fragments containing specific binding regions of serum albumin or related proteins
|
|
US6001606A
(en)
|
1994-03-08 |
1999-12-14 |
Human Genome Sciences, Inc. |
Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
|
|
GB9404270D0
(en)
|
1994-03-05 |
1994-04-20 |
Delta Biotechnology Ltd |
Yeast strains and modified albumins
|
|
US6077692A
(en)
|
1995-02-14 |
2000-06-20 |
Human Genome Sciences, Inc. |
Keratinocyte growth factor-2
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
CN1125082C
(zh)
|
1995-05-05 |
2003-10-22 |
人类基因组科学公司 |
人类趋化因子β－8,趋化因子β－1和巨噬细胞炎性蛋白－4
|
|
US6291207B1
(en)
|
1995-07-28 |
2001-09-18 |
Northwestern University |
Herpes virus entry receptor protein
|
|
GB9526733D0
(en)
|
1995-12-30 |
1996-02-28 |
Delta Biotechnology Ltd |
Fusion proteins
|
|
US7357927B2
(en)
|
1996-03-12 |
2008-04-15 |
Human Genome Sciences, Inc. |
Death domain containing receptors
|
|
EP0979281B1
(en)
|
1997-05-02 |
2005-07-20 |
Genentech, Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
AU7464998A
(en)
|
1997-10-27 |
1999-05-17 |
Trega Biosciences, Inc. |
Melanocortin receptor ligands and methods of using same
|
|
WO1999058662A1
(fr)
|
1998-05-14 |
1999-11-18 |
Merck Patent Gmbh |
Proteine fusionnee
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
CA2361615A1
(en)
|
1999-02-08 |
2000-08-10 |
Human Genome Sciences, Inc. |
The use of vascular endothelial growth factor 2 antagonist in the treatment of an injury to or disorder of an eye
|
|
AU2509900A
(en)
|
1999-07-21 |
2001-02-13 |
Human Genome Sciences, Inc. |
Keratinocyte derived interferon
|
|
EP1206541A4
(en)
|
1999-08-05 |
2002-09-18 |
Human Genome Sciences Inc |
SECRETIED LYMPHOCYTE ACTIVATION MOLECUE, ENRICHED BY DENDRITIC CELLS
|
|
AU7603800A
(en)
|
1999-09-24 |
2001-04-24 |
Human Genome Sciences, Inc. |
32 human secreted proteins
|
|
DE19963859A1
(de)
|
1999-12-30 |
2001-07-12 |
Apotech Res & Dev Ltd |
Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
|
|
US6946134B1
(en)
|
2000-04-12 |
2005-09-20 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US20050100991A1
(en)
|
2001-04-12 |
2005-05-12 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US6926898B2
(en)
|
2000-04-12 |
2005-08-09 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
SI1724284T1
(sl)
|
2000-12-07 |
2009-12-31 |
Lilly Co Eli |
Glp-1 fuzijski proteini
|
|
US7507413B2
(en)
|
2001-04-12 |
2009-03-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US6833441B2
(en)
|
2001-08-01 |
2004-12-21 |
Abmaxis, Inc. |
Compositions and methods for generating chimeric heteromultimers
|
|
EP2292273A3
(en)
|
2001-10-10 |
2011-11-23 |
BioGeneriX AG |
Remodeling and glycoconjugation of peptides
|
|
CA2841097A1
(en)
|
2001-12-21 |
2003-07-24 |
Human Genome Sciences, Inc. |
Albumin and g-csf fusion proteins
|
|
WO2003059934A2
(en)
|
2001-12-21 |
2003-07-24 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
WO2005003296A2
(en)
|
2003-01-22 |
2005-01-13 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US7332580B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The University Of California |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
CA2832136C
(en)
|
2002-09-27 |
2015-11-17 |
Xencor |
Optimized fc variants and methods for their generation
|
|
WO2004082640A2
(en)
|
2003-03-19 |
2004-09-30 |
New Century Pharmaceuticals, Inc. |
Human serum albumin conjugates with therapeutic compounds
|
|
CN102816241B
(zh)
|
2004-02-09 |
2015-07-22 |
人类基因科学公司 |
清蛋白融合蛋白
|
|
KR101374454B1
(ko)
|
2005-03-31 |
2014-03-17 |
추가이 세이야쿠 가부시키가이샤 |
회합제어에 의한 폴리펩티드 제조방법
|
|
CA2628253A1
(en)
|
2005-11-03 |
2007-08-30 |
Genentech, Inc. |
Therapeutic anti-her2 antibody fusion polypeptides
|
|
US8441210B2
(en)
|
2006-01-20 |
2013-05-14 |
Point Somee Limited Liability Company |
Adaptive current regulation for solid state lighting
|
|
WO2007136778A2
(en)
|
2006-05-19 |
2007-11-29 |
Teva Pharmaceutical Industries, Ltd. |
Fusion proteins, uses thereof and processes for producing same
|
|
EP2799449A1
(en)
|
2006-05-25 |
2014-11-05 |
Bayer Intellectual Property GmbH |
Dimeric molecular complexes
|
|
WO2007144173A1
(en)
|
2006-06-14 |
2007-12-21 |
Csl Behring Gmbh |
Proteolytically cleavable fusion protein comprising a blood coagulation factor
|
|
AU2007353412A1
(en)
|
2006-11-21 |
2008-11-20 |
Fox Chase Cancer Center |
Anti-EGFR family antibodies, bispecific anti-EGFR family antibodies and methods of use thereof
|
|
CA2682605A1
(en)
|
2007-04-18 |
2008-10-30 |
Zymogenetics, Inc. |
Single chain fc, methods of making and methods of treatment
|
|
WO2009012784A2
(en)
|
2007-07-20 |
2009-01-29 |
Nya Hamlet Pharma Ab |
Methods for preparing cytotoxic complexes of emulsifier and fatty acid
|
|
US8197196B2
(en)
|
2007-08-31 |
2012-06-12 |
General Electric Company |
Bushing and clock spring assembly for moveable turbine vane
|
|
EP3663318A1
(en)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
|
EP2803675A3
(en)
|
2008-01-25 |
2014-12-24 |
Amgen, Inc |
Ferroportin antibodies and methods of use
|
|
US20110091462A1
(en)
|
2008-03-05 |
2011-04-21 |
Ablynx N.V. |
Novel antigen binding dimer-complexes, methods of making and uses thereof
|
|
CA3020928C
(en)
|
2008-05-15 |
2023-08-08 |
National Research Council Of Canada |
Expression systems encoding truncated ebna1, methods, and use thereof
|
|
WO2010027903A2
(en)
|
2008-09-08 |
2010-03-11 |
Fred Hutchinson Cancer Research Center |
Lung cancer diagnosis
|
|
CN102282168A
(zh)
|
2008-11-18 |
2011-12-14 |
梅里麦克制药股份有限公司 |
人血清白蛋白接头以及其结合物
|
|
SG172789A1
(en)
*
|
2009-02-11 |
2011-08-29 |
Novozymes Biopharma Dk As |
Albumin variants and conjugates
|
|
WO2010118169A2
(en)
*
|
2009-04-08 |
2010-10-14 |
The Regents Of The University Of California |
Human protein scaffold with controlled serum pharmacokinetics
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
JP2013507926A
(ja)
|
2009-10-14 |
2013-03-07 |
メリマック ファーマシューティカルズ インコーポレーティッド |
ＩＧＦ−１Ｒ及びＥｒｂＢ３シグナル伝達を標的とする二重特異的結合剤及びその使用
|
|
AU2010311332B2
(en)
|
2009-10-30 |
2015-04-23 |
Albumedix Ltd. |
Albumin variants
|
|
EP2496598B1
(en)
*
|
2009-11-04 |
2017-08-02 |
Affibody AB |
Her3 binding polypeptides
|
|
WO2011069090A1
(en)
|
2009-12-04 |
2011-06-09 |
Alavita Pharmaceuticals, Inc. |
Inhibition of the activation of coagulation factor xii by ligands of phosphatidylserine
|
|
US20130108623A1
(en)
|
2010-03-29 |
2013-05-02 |
Zymeworks Inc |
Antibodies with Enhanced or Suppressed Effector Function
|
|
WO2011133886A2
(en)
*
|
2010-04-23 |
2011-10-27 |
Genentech, Inc. |
Production of heteromultimeric proteins
|
|
WO2011143545A1
(en)
|
2010-05-14 |
2011-11-17 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
|
NZ604007A
(en)
|
2010-05-27 |
2015-03-27 |
Genmab As |
Monoclonal antibodies against her2 epitope
|
|
PT2591006T
(pt)
|
2010-07-09 |
2019-07-29 |
Bioverativ Therapeutics Inc |
Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas
|
|
CN103429620B
(zh)
|
2010-11-05 |
2018-03-06 |
酵活有限公司 |
在Fc结构域中具有突变的稳定异源二聚的抗体设计
|
|
AU2012222833B2
(en)
*
|
2011-03-03 |
2017-03-16 |
Zymeworks Inc. |
Multivalent heteromultimer scaffold design and constructs
|
|
LT2748201T
(lt)
|
2011-08-23 |
2018-02-26 |
Roche Glycart Ag |
Dvigubai specifinė t ląsteles aktyvinantį antigeną surišanti molekulė
|
|
US9574010B2
(en)
|
2011-11-04 |
2017-02-21 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the Fc domain
|
|
EP2847224A4
(en)
|
2012-05-10 |
2016-04-27 |
Zymeworks Inc |
SINGLE ARM MONOVALENT ANTIBODY CONSTRUCTS AND USES THEREOF
|
|
JP6351572B2
(ja)
|
2012-05-10 |
2018-07-04 |
ザイムワークス，インコーポレイテッド |
Ｆｃドメインに突然変異を有する免疫グロブリン重鎖のヘテロ多量体構築物
|
|
WO2014004586A1
(en)
|
2012-06-25 |
2014-01-03 |
Zymeworks Inc. |
Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
|
|
BR112015000798A2
(pt)
|
2012-07-13 |
2017-06-27 |
Zymeworks Inc |
heterodímeros assimétricos biespecíficos compreendendo construtos anti-cd3
|
|
IN2015DN01115A
(enExample)
|
2012-07-13 |
2015-06-26 |
Zymeworks Inc |
|
|
CN104640561A
(zh)
|
2012-07-23 |
2015-05-20 |
酵活有限公司 |
包含轻链和重链的选择性配对的免疫球蛋白构建体
|
|
US9914785B2
(en)
|
2012-11-28 |
2018-03-13 |
Zymeworks Inc. |
Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
|
|
MX385344B
(es)
|
2012-11-28 |
2025-03-18 |
Zymeworks Bc Inc |
Pares de cadena pesada-cadena ligera de inmunoglobulina modificados genéticamente y usos de estos.
|
|
US10239951B2
(en)
|
2013-05-08 |
2019-03-26 |
Zymeworks Inc. |
Bispecific HER2 and HER3 antigen binding constructs
|
|
BR112016000666A2
(pt)
|
2013-07-12 |
2017-10-03 |
Zymeworks Inc |
Constructos de ligação de antígeno cd3 e cd19 biespecíficos
|
|
US9870656B2
(en)
|
2015-12-08 |
2018-01-16 |
Smartcar, Inc. |
System and method for processing vehicle requests
|
