JP2015523362A5 - - Google Patents
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- JP2015523362A5 JP2015523362A5 JP2015520531A JP2015520531A JP2015523362A5 JP 2015523362 A5 JP2015523362 A5 JP 2015523362A5 JP 2015520531 A JP2015520531 A JP 2015520531A JP 2015520531 A JP2015520531 A JP 2015520531A JP 2015523362 A5 JP2015523362 A5 JP 2015523362A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- urolithin
- pharmaceutical composition
- disease
- food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261665137P | 2012-06-27 | 2012-06-27 | |
| US61/665,137 | 2012-06-27 | ||
| US201261712886P | 2012-10-12 | 2012-10-12 | |
| US61/712,886 | 2012-10-12 | ||
| US201361791137P | 2013-03-15 | 2013-03-15 | |
| US61/791,137 | 2013-03-15 | ||
| PCT/US2013/048310 WO2014004902A2 (en) | 2012-06-27 | 2013-06-27 | Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018140453A Division JP6879980B2 (ja) | 2012-06-27 | 2018-07-26 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015523362A JP2015523362A (ja) | 2015-08-13 |
| JP2015523362A5 true JP2015523362A5 (enExample) | 2016-10-06 |
| JP6422163B2 JP6422163B2 (ja) | 2018-11-14 |
Family
ID=48782652
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520531A Active JP6422163B2 (ja) | 2012-06-27 | 2013-06-27 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
| JP2018140453A Active JP6879980B2 (ja) | 2012-06-27 | 2018-07-26 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
| JP2021077856A Active JP7339296B2 (ja) | 2012-06-27 | 2021-04-30 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
| JP2023097670A Pending JP2023107934A (ja) | 2012-06-27 | 2023-06-14 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
| JP2025135511A Pending JP2025161884A (ja) | 2012-06-27 | 2025-08-15 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018140453A Active JP6879980B2 (ja) | 2012-06-27 | 2018-07-26 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
| JP2021077856A Active JP7339296B2 (ja) | 2012-06-27 | 2021-04-30 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
| JP2023097670A Pending JP2023107934A (ja) | 2012-06-27 | 2023-06-14 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
| JP2025135511A Pending JP2025161884A (ja) | 2012-06-27 | 2025-08-15 | ウロリチンまたはその前駆体の投与によるオートファジーの増強または寿命の延長 |
Country Status (16)
| Country | Link |
|---|---|
| US (10) | US11020373B2 (enExample) |
| EP (3) | EP2866804B1 (enExample) |
| JP (5) | JP6422163B2 (enExample) |
| KR (4) | KR20210128511A (enExample) |
| CN (2) | CN110934863A (enExample) |
| AR (1) | AR091604A1 (enExample) |
| AU (6) | AU2013284419A1 (enExample) |
| BR (1) | BR112014032809A8 (enExample) |
| CA (2) | CA2877718C (enExample) |
| DK (1) | DK4233858T3 (enExample) |
| ES (2) | ES2968368T3 (enExample) |
| MX (3) | MX378354B (enExample) |
| PL (1) | PL4233858T3 (enExample) |
| PT (2) | PT2866804T (enExample) |
| SG (3) | SG11201408539UA (enExample) |
| WO (1) | WO2014004902A2 (enExample) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2866804B1 (en) | 2012-06-27 | 2023-09-13 | Amazentis SA | Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof |
| CA2895914C (en) * | 2013-01-18 | 2023-06-20 | Procell Sprl | Urolithin b with testosterone, leucine and/or creatine for muscle growth |
| US9901596B2 (en) * | 2013-09-09 | 2018-02-27 | Natreon, Inc. | Regulation of body weight gain by using dibenzo-alpha-pyrones |
| EP2862568A1 (en) | 2013-10-15 | 2015-04-22 | Centre National de la Recherche Scientifique (CNRS) | Compositions comprising urolithins and uses thereof for the stimulation of insulin secretion |
| US9394269B2 (en) | 2013-12-23 | 2016-07-19 | Amazentis Sa | Process-scale synthesis of urolithins |
| GB201323008D0 (en) | 2013-12-24 | 2014-02-12 | Amazentis As | Compounds and uses thereof |
| GB201413228D0 (en) | 2014-07-25 | 2014-09-10 | Nugerontix Ltd | Polyphenol compositions |
| US20170367390A1 (en) * | 2014-12-19 | 2017-12-28 | Halo Life Science, Llc | Use of ellagic acid dihydrate in food products and nutraceuticals |
| EP3284734B1 (en) * | 2015-04-13 | 2021-12-01 | Sumitomo Seika Chemicals Co., Ltd. | Method for producing 2-halogenated benzoic acids |
| JP6740548B2 (ja) * | 2015-05-15 | 2020-08-19 | 公立大学法人岡山県立大学 | ウロリチン類を含有する育毛剤、及び、ウロリチン類を含有する５αレダクターゼ活性阻害剤 |
| JP2017014154A (ja) * | 2015-07-01 | 2017-01-19 | 公立大学法人岡山県立大学 | ウロリチン類を含有するヒアルロン酸産生促進剤 |
| JP6799767B2 (ja) * | 2015-07-07 | 2020-12-16 | 公立大学法人岡山県立大学 | ウロリチン類を含有するメラニン産生抑制剤 |
| GB201515391D0 (en) | 2015-08-28 | 2015-10-14 | Amazentis Sa | Compositions |
| RU2751638C2 (ru) * | 2015-12-24 | 2021-07-15 | Амазентис Са | Композиции, содержащие никотинамидрибозид и уролитин |
| JP6791478B2 (ja) * | 2016-05-26 | 2020-11-25 | 株式会社ダイセル | ウロリチン類を含有するアンジオテンシン変換酵素阻害剤 |
| JP2017210444A (ja) * | 2016-05-26 | 2017-11-30 | 株式会社ダイセル | ウロリチン類を含有するリパーゼ阻害剤 |
| WO2018002888A1 (en) * | 2016-06-29 | 2018-01-04 | Halo Life Science, Llc | Methods of making low odor choline salts of an organic compound |
| WO2018013568A1 (en) * | 2016-07-11 | 2018-01-18 | University Of North Texas Health Science Center At Fort Worth | Treatment for glaucoma and other eye diseases |
| US11634686B2 (en) | 2016-11-01 | 2023-04-25 | Jian Feng | Method of producing naive pluripotent stem cells |
| EP3354645A1 (en) | 2017-01-26 | 2018-08-01 | Patheon Austria GmbH & Co KG | Process for preparing urolithins |
| JP7761372B2 (ja) * | 2017-03-08 | 2025-10-28 | アマゼンティス エスアー | 対象におけるマイトファジーを改善するための方法 |
| WO2018162645A1 (en) | 2017-03-08 | 2018-09-13 | Amazentis Sa | Skin treatment methods |
| JP7761371B2 (ja) * | 2017-03-08 | 2025-10-28 | アマゼンティス エスアー | 対象におけるマイトファジーを改善するための方法 |
| JP2019097566A (ja) * | 2017-12-07 | 2019-06-24 | 大正製薬株式会社 | 体内時計調整用組成物 |
| AU2018390799B2 (en) * | 2017-12-20 | 2024-10-03 | Societe Des Produits Nestle S.A. | Compositions and methods using high protein for induction of autophagy |
| BR112020009765A2 (pt) * | 2017-12-20 | 2020-11-03 | Société des Produits Nestlé S.A. | composições e métodos que usam uma combinação de indutor de autofagia e alto teor de proteína para indução de autofagia |
| CN111727040A (zh) * | 2018-02-19 | 2020-09-29 | 纳特雷恩公司 | 用于改善认知能力或认知功能的尿石素a和b的协同组合 |
| WO2019163437A1 (ja) | 2018-02-21 | 2019-08-29 | 株式会社ダイセル | ウロリチン類を含有する破骨細胞分化抑制剤 |
| CN112074510A (zh) * | 2018-02-27 | 2020-12-11 | 阿马曾提斯公司 | 尿石素a的工业规模合成 |
| JP7217542B2 (ja) * | 2018-03-29 | 2023-02-03 | 国立大学法人 琉球大学 | 分化コントロール化合物を用いて造腫瘍性をもつおそれのある未分化ｉＰＳ細胞等の混入を除去する方法 |
| US10792276B2 (en) * | 2018-04-30 | 2020-10-06 | Amazentis Sa | Urolithins as immune response enhancers |
| WO2019222146A1 (en) | 2018-05-15 | 2019-11-21 | University Of Louisville Research Foundation, Inc. | Urolithin a and derivatives thereof for use in therapy |
| WO2019236765A1 (en) * | 2018-06-05 | 2019-12-12 | Flagship Pioneering Innovations V, Inc. | Acylated catechin polyphenols and methods of their use for the treatment of cancer |
| KR20210016407A (ko) | 2018-06-05 | 2021-02-15 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 대사 장애 및 비알코올성 지방 간 질환의 치료를 위한 활성제 및 그 사용 방법 |
| CN108676013B (zh) * | 2018-06-25 | 2021-01-01 | 中国医学科学院医药生物技术研究所 | 具有自噬激活活性的黄醇酮类化合物、其制备方法及其制药应用 |
| CN109316478A (zh) * | 2018-11-06 | 2019-02-12 | 上海出入境检验检疫局动植物与食品检验检疫技术中心 | 一种尿石素a在制备抗衰老的药物、化妆品中的应用及药物、化妆品 |
| PL245399B1 (pl) | 2018-11-29 | 2024-07-15 | Univ Warszawski Medyczny | Kompozycja farmaceutyczna zawierająca urolitynę A lub jej pochodną do zastosowania zewnętrznego miejscowego w leczeniu, hamowaniu i zapobieganiu chorobom skóry i błon śluzowych o podłożu zapalnym |
| CA3126190A1 (en) * | 2019-01-18 | 2020-07-23 | Societe Des Produits Nestle S.A. | Agents and methods for increasing stem cell function |
| CN110066284B (zh) * | 2019-02-01 | 2021-06-04 | 贵阳倍隆生物科技有限公司 | 一种一锅法合成鞣花酸的方法 |
| CN110229167B (zh) * | 2019-05-22 | 2020-11-24 | 珠海萱嘉君行健康产业发展有限公司 | 一种利用五倍子制备鞣花酸的方法、制得的鞣花酸及其应用 |
| CN111995610A (zh) * | 2019-05-27 | 2020-11-27 | 首都医科大学 | 一种尿石素类化合物用于治疗胶质母细胞瘤药物的应用 |
| EP3986420A1 (en) * | 2019-06-18 | 2022-04-27 | Mitopower LLC | Nicotinyl riboside compounds and their uses |
| US20220184015A1 (en) * | 2019-06-20 | 2022-06-16 | Societe Des Produits Nestle S.A. | Compositions and methods to potentiate musculoskeletal effect of one or more anabolic amino acids on bone health |
| GB201912107D0 (en) | 2019-08-22 | 2019-10-09 | Amazentis Sa | Combination |
| GB201915191D0 (en) * | 2019-10-21 | 2019-12-04 | Floratek Gmbh | Novel heterocyclic compounds |
| GB201916046D0 (en) | 2019-11-04 | 2019-12-18 | Amazentis Sa | Diagnostic method |
| CN114727980A (zh) * | 2019-11-27 | 2022-07-08 | 雀巢产品有限公司 | 苯并香豆素ampk活化剂化合物、组合物、方法及其用途 |
| CN114760996A (zh) * | 2019-11-27 | 2022-07-15 | 雀巢产品有限公司 | 与间接ampk活化剂化合物组合的直接ampk活化剂化合物、组合物、方法和其用途 |
| CN113018305A (zh) * | 2019-12-24 | 2021-06-25 | 兰州大学 | 一种化合物在制备治疗阿尔兹海默症药物中的应用 |
| WO2021163802A1 (en) * | 2020-02-20 | 2021-08-26 | The Royal Institution For The Advancement Of Learning/Mcgill University | Use of castalagin or analogs thereof for anti-cancer efficacy and to increase the response to immune checkpoint inhibitors |
| WO2022016138A2 (en) * | 2020-07-17 | 2022-01-20 | The Trustees Of Columbia University In The City Of New York | Methods and compositions to increase lifespan and healthspan by mimicking the effects of time-restricted feeding |
| CN111983058B (zh) * | 2020-07-30 | 2023-06-23 | 云南中医药大学 | 中药抗非酒精性脂肪肝活性物质的筛选方法 |
| WO2022051643A1 (en) * | 2020-09-04 | 2022-03-10 | Natreon, Inc. | Methods of treating and preventing hepatotoxicity |
| US20230372291A1 (en) | 2020-09-25 | 2023-11-23 | Societe Des Produits Nestle S.A. | Compositions and methods using xanthan gum to stabilize at least one urolithin in an aqueous matrix |
| KR102623664B1 (ko) | 2020-12-10 | 2024-01-12 | 서울대학교산학협력단 | 유로리틴 a를 이용한 당뇨성 알츠하이머병의 치료 조성물 및 치료 방법 |
| AU2022212883A1 (en) | 2021-01-27 | 2023-08-17 | Vandria Sa | Urolithin derivatives and methods of use thereof |
| CN112716938A (zh) * | 2021-02-25 | 2021-04-30 | 新疆医科大学 | 鞣花酸在制备缓解眼组织病变的药物中的用途 |
| KR102677423B1 (ko) * | 2021-09-17 | 2024-06-21 | 조선대학교산학협력단 | 망기페린을 포함하는 자가포식 활성화용 조성물 |
| KR102690860B1 (ko) * | 2021-10-13 | 2024-08-05 | 한국해양과학기술원 | 남극 진균 균주 Pleosporales sp. SF-7343 유래 대사화합물을 포함하는 염증질환 예방 또는 치료용 조성물 |
| US20250009687A1 (en) * | 2021-10-28 | 2025-01-09 | Societe Des Produits Nestle S.A. | Compositions and methods using a combination of nutrients to support cognition and emotional health in a mammal |
| WO2023161453A1 (en) | 2022-02-24 | 2023-08-31 | Amazentis Sa | Uses of urolithins |
| CA3246412A1 (en) | 2022-03-22 | 2023-09-28 | Amazentis Sa | COMPOSITIONS |
| WO2023237926A2 (en) * | 2022-06-06 | 2023-12-14 | Amazentis Sa | Urolithins for improving cardiac function and health |
| AU2023314261A1 (en) * | 2022-07-27 | 2025-02-20 | Vandria Sa | Therapeutic uses of urolithin derivatives |
| CN115433151A (zh) * | 2022-09-02 | 2022-12-06 | 苏州大学 | 一种6，7，8-三羟基香豆素的制备方法 |
| CN115581689B (zh) * | 2022-10-17 | 2024-05-14 | 常州大学 | 尿石素b酰胺类衍生物的应用 |
| GB202219317D0 (en) | 2022-12-20 | 2023-02-01 | Amazentis Sa | Methods for improving mitophagy in subjects |
| GB202308224D0 (en) | 2023-06-01 | 2023-07-19 | Amazentis Sa | Formulation |
| CN116966188A (zh) * | 2023-07-14 | 2023-10-31 | 天津医科大学总医院 | 丁香素在制备治疗和/或预防炎症性肠病药物中的应用 |
| GB202312220D0 (en) | 2023-08-09 | 2023-09-20 | Amazentis Sa | Formulation |
| WO2025076497A1 (en) * | 2023-10-06 | 2025-04-10 | Northeast Ohio Medical University | Combination treatment of tau pathology |
| WO2025078645A1 (en) * | 2023-10-13 | 2025-04-17 | L'oreal | Cosmetic use of at least urolithin b or c on a sensitive skin |
| FR3153997A1 (fr) * | 2023-10-13 | 2025-04-18 | L'oreal | Utilisation cosmétique d'au moins l’urolithine B sur une peau sensible |
| FR3153996A1 (fr) * | 2023-10-13 | 2025-04-18 | L'oreal | Utilisation cosmétique d'au moins l’urolithine C sur une peau sensible |
| FR3153998A1 (fr) * | 2023-10-13 | 2025-04-18 | L'oreal | Utilisation cosmétique d’iso-urolithine A sur une peau sensible |
| GB202316295D0 (en) | 2023-10-24 | 2023-12-06 | Amazentis Sa | Composition |
| GB202319994D0 (en) | 2023-12-22 | 2024-02-07 | Amazentis Sa | Compositions for use |
| CN117771237B (zh) * | 2024-02-27 | 2024-05-03 | 南昌医学院 | 一种松香烷型二萜化合物的用途和制备方法 |
| WO2025194036A1 (en) * | 2024-03-14 | 2025-09-18 | Washington University | Autophagy enhancers |
| WO2025224366A1 (en) | 2024-04-26 | 2025-10-30 | Amazentis Sa | Immune health improvers |
| CN119792272B (zh) * | 2025-02-07 | 2025-10-03 | 陕西中鸿科瑞再生医学研究院有限公司 | 一种改善睡眠的组合物及其制备方法与制剂 |
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| US20050282781A1 (en) | 2004-06-18 | 2005-12-22 | Shibnath Ghosal | Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids |
| US20060257337A1 (en) * | 2005-04-28 | 2006-11-16 | David Sherris | Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis |
| JP2009528381A (ja) | 2006-02-28 | 2009-08-06 | パロマ ファーマシューティカルズ，インク． | 細胞増殖および血管新生を特徴とする疾患を治療する組成物および方法 |
| US8183282B2 (en) * | 2006-04-26 | 2012-05-22 | The Regents Of The University Of California | Therapeutic uses of urolithins |
| US8894993B2 (en) * | 2006-08-04 | 2014-11-25 | Natreon Inc. | Mitochondria-targeted antioxidants |
| EP2155186A2 (fr) * | 2007-05-11 | 2010-02-24 | Galderma Research & Development | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations |
| US20110263521A1 (en) * | 2007-05-11 | 2011-10-27 | Marc Moutet | Pharmaceutical or cosmetic preparations for topical and/or parenteral application, preparation methods thereof and use of same |
| TW200929211A (en) | 2007-12-17 | 2009-07-01 | Etron Technology Inc | Method of reducing current of memory in self-refreshing mode |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| MX2010010431A (es) | 2008-03-25 | 2010-11-25 | Paloma Pharmaceuticals Inc | Metodos para tratar desordenes fibroticos. |
| EP2416792A4 (en) * | 2009-04-10 | 2012-10-24 | Haiyan Qi | NOVEL ANTI-AGING AGENTS AND METHODS OF IDENTIFICATION |
| JP5385686B2 (ja) | 2009-06-05 | 2014-01-08 | サントリーホールディングス株式会社 | 血小板凝集抑制剤 |
| CN102762573B (zh) * | 2009-07-24 | 2015-09-16 | 阿马曾提斯公司 | 用于在神经退行性障碍中保护脑部健康的化合物、组合物和方法 |
| US9872850B2 (en) | 2010-12-23 | 2018-01-23 | Amazentis Sa | Compositions and methods for improving mitochondrial function and treating neurodegenerative diseases and cognitive disorders |
| US20130324595A1 (en) | 2011-02-22 | 2013-12-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | C-glucosidic ellagitannin compounds for use for altering the supramolecular arrangement of actin and for the treatment of osteoporosis, cancer, bacterial infection and viral infection |
| EP2866804B1 (en) | 2012-06-27 | 2023-09-13 | Amazentis SA | Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof |
| RU2751638C2 (ru) | 2015-12-24 | 2021-07-15 | Амазентис Са | Композиции, содержащие никотинамидрибозид и уролитин |
-
2013
- 2013-06-27 EP EP13735543.4A patent/EP2866804B1/en active Active
- 2013-06-27 EP EP25157187.3A patent/EP4566677A3/en active Pending
- 2013-06-27 MX MX2014016044A patent/MX378354B/es unknown
- 2013-06-27 KR KR1020217033621A patent/KR20210128511A/ko not_active Ceased
- 2013-06-27 AU AU2013284419A patent/AU2013284419A1/en not_active Abandoned
- 2013-06-27 WO PCT/US2013/048310 patent/WO2014004902A2/en not_active Ceased
- 2013-06-27 PT PT137355434T patent/PT2866804T/pt unknown
- 2013-06-27 MX MX2020008468A patent/MX393128B/es unknown
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