JP2015510770A5 - - Google Patents

Info

Publication number

JP2015510770A5

JP2015510770A5 JP2015500714A JP2015500714A JP2015510770A5 JP 2015510770 A5 JP2015510770 A5 JP 2015510770A5 JP 2015500714 A JP2015500714 A JP 2015500714A JP 2015500714 A JP2015500714 A JP 2015500714A JP 2015510770 A5 JP2015510770 A5 JP 2015510770A5

Authority

JP

Japan

Prior art keywords

peptide

vsdl

cleavage site

fusion polypeptide

terminus

Prior art date

2013-03-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 27
• 108010090012 atrial natriuretic factor prohormone (31-67) Proteins 0.000 claims 26
• 230000004927 fusion Effects 0.000 claims 22
• 230000007030 peptide scission Effects 0.000 claims 19
• 229920001184 polypeptide Polymers 0.000 claims 18
• 102000004196 processed proteins & peptides Human genes 0.000 claims 18
• 210000004899 c-terminal region Anatomy 0.000 claims 13
• 238000000034 method Methods 0.000 claims 13
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 10
• 102000004142 Trypsin Human genes 0.000 claims 4
• 108090000631 Trypsin Proteins 0.000 claims 4
• 238000003776 cleavage reaction Methods 0.000 claims 4
• 230000007017 scission Effects 0.000 claims 4
• 239000012588 trypsin Substances 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 108091028732 Concatemer Proteins 0.000 claims 3
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• 239000004475 Arginine Substances 0.000 claims 1
• 101800001415 Bri23 peptide Proteins 0.000 claims 1
• 102400000107 C-terminal peptide Human genes 0.000 claims 1
• 101800000655 C-terminal peptide Proteins 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 238000005349 anion exchange Methods 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 238000004108 freeze drying Methods 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 238000001694 spray drying Methods 0.000 claims 1
• 230000001810 trypsinlike Effects 0.000 claims 1
• 229940124549 vasodilator Drugs 0.000 claims 1
• 239000003071 vasodilator agent Substances 0.000 claims 1