JP2017506886A5 - - Google Patents

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Publication number

JP2017506886A5

JP2017506886A5 JP2016548219A JP2016548219A JP2017506886A5 JP 2017506886 A5 JP2017506886 A5 JP 2017506886A5 JP 2016548219 A JP2016548219 A JP 2016548219A JP 2016548219 A JP2016548219 A JP 2016548219A JP 2017506886 A5 JP2017506886 A5 JP 2017506886A5

Authority

JP

Japan

Prior art keywords

fusion protein

item

ids

linker

polypeptide

Prior art date

2015-02-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108020001507 fusion proteins Proteins 0.000 claims description 52
• 102000037865 fusion proteins Human genes 0.000 claims description 52
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 22
• 229920001184 polypeptide Polymers 0.000 claims description 16
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 16
• 108010076504 Protein Sorting Signals Proteins 0.000 claims description 13
• 208000015439 Lysosomal storage disease Diseases 0.000 claims description 9
• 239000008194 pharmaceutical composition Substances 0.000 claims description 9
• 239000003937 drug carrier Substances 0.000 claims description 2
• 230000001698 pyrogenic effect Effects 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 1
• 101710190709 Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 description 49
• 101710132062 Transitional endoplasmic reticulum ATPase Proteins 0.000 description 49
• 210000004027 cell Anatomy 0.000 description 15
• 125000003275 alpha amino acid group Chemical group 0.000 description 12
• 238000000034 method Methods 0.000 description 9
• 108091033319 polynucleotide Proteins 0.000 description 7
• 102000040430 polynucleotide Human genes 0.000 description 7
• 239000002157 polynucleotide Substances 0.000 description 7
• 210000003169 central nervous system Anatomy 0.000 description 6
• 238000007912 intraperitoneal administration Methods 0.000 description 4
• 238000001990 intravenous administration Methods 0.000 description 4
• 238000007792 addition Methods 0.000 description 3
• 150000001413 amino acids Chemical class 0.000 description 3
• 238000012217 deletion Methods 0.000 description 3
• 230000037430 deletion Effects 0.000 description 3
• 238000003780 insertion Methods 0.000 description 3
• 230000037431 insertion Effects 0.000 description 3
• 210000004962 mammalian cell Anatomy 0.000 description 3
• 238000006467 substitution reaction Methods 0.000 description 3
• 241000238631 Hexapoda Species 0.000 description 2
• 101000940535 Homo sapiens Cold shock domain-containing protein E1 Proteins 0.000 description 2
• 101001034811 Homo sapiens Eukaryotic translation initiation factor 4 gamma 2 Proteins 0.000 description 2
• 101000834991 Homo sapiens Transitional endoplasmic reticulum ATPase Proteins 0.000 description 2
• 230000001580 bacterial effect Effects 0.000 description 2
• 102000046317 human CSDE1 Human genes 0.000 description 2
• 238000001802 infusion Methods 0.000 description 2
• 238000002347 injection Methods 0.000 description 2
• 239000007924 injection Substances 0.000 description 2
• 201000002273 mucopolysaccharidosis II Diseases 0.000 description 2
• 208000022018 mucopolysaccharidosis type 2 Diseases 0.000 description 2
• 229920002704 polyhistidine Polymers 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 210000005253 yeast cell Anatomy 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 108020004705 Codon Proteins 0.000 description 1
• 241000699802 Cricetulus griseus Species 0.000 description 1
• XZWYTXMRWQJBGX-VXBMVYAYSA-N FLAG peptide Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)CC1=CC=C(O)C=C1 XZWYTXMRWQJBGX-VXBMVYAYSA-N 0.000 description 1
• 201000008808 Fibrosarcoma Diseases 0.000 description 1
• 101000840540 Homo sapiens Iduronate 2-sulfatase Proteins 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
• 108010076818 TEV protease Proteins 0.000 description 1
• 102000057422 human IDS Human genes 0.000 description 1
• 210000001672 ovary Anatomy 0.000 description 1
• 238000000746 purification Methods 0.000 description 1