JP2011501971A5 - - Google Patents

Info

Publication number

JP2011501971A5

JP2011501971A5 JP2010532293A JP2010532293A JP2011501971A5 JP 2011501971 A5 JP2011501971 A5 JP 2011501971A5 JP 2010532293 A JP2010532293 A JP 2010532293A JP 2010532293 A JP2010532293 A JP 2010532293A JP 2011501971 A5 JP2011501971 A5 JP 2011501971A5

Authority

JP

Japan

Prior art keywords

meganuclease

laglidadg

residues

seq

cleavage site

Prior art date

2008-10-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 238000003776 cleavage reaction Methods 0.000 claims 22
• 230000007017 scission Effects 0.000 claims 22
• 150000007523 nucleic acids Chemical group 0.000 claims 19
• 108020004707 nucleic acids Proteins 0.000 claims 17
• 102000039446 nucleic acids Human genes 0.000 claims 17
• 210000003527 eukaryotic cell Anatomy 0.000 claims 14
• 210000000349 chromosome Anatomy 0.000 claims 10
• 238000004519 manufacturing process Methods 0.000 claims 9
• 238000000034 method Methods 0.000 claims 9
• 108010050663 endodeoxyribonuclease CreI Proteins 0.000 claims 6
• 238000012986 modification Methods 0.000 claims 6
• 230000004048 modification Effects 0.000 claims 6
• 244000052769 pathogen Species 0.000 claims 6
• 230000006780 non-homologous end joining Effects 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 4
• 230000006801 homologous recombination Effects 0.000 claims 4
• 238000002744 homologous recombination Methods 0.000 claims 4
• 230000001717 pathogenic effect Effects 0.000 claims 4
• 244000052613 viral pathogen Species 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 101100162704 Emericella nidulans I-AniI gene Proteins 0.000 claims 3
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
• 230000003612 virological effect Effects 0.000 claims 3
• 235000003869 genetically modified organism Nutrition 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 1
• 210000002459 blastocyst Anatomy 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 210000001671 embryonic stem cell Anatomy 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 210000001938 protoplast Anatomy 0.000 claims 1
• 241000894007 species Species 0.000 claims 1