DK2660317T3 - Rationally designed single-chain meganucleases with non-palindromic recognition sequences - Google Patents

Rationally designed single-chain meganucleases with non-palindromic recognition sequences Download PDF

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DK2660317T3
DK2660317T3 DK13165733.0T DK13165733T DK2660317T3 DK 2660317 T3 DK2660317 T3 DK 2660317T3 DK 13165733 T DK13165733 T DK 13165733T DK 2660317 T3 DK2660317 T3 DK 2660317T3
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James Jefferson Smith
Derek Jantz
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Prec Biosciences Inc
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)

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  • Tropical Medicine & Parasitology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DK13165733.0T 2007-10-31 2008-10-31 Rationally designed single-chain meganucleases with non-palindromic recognition sequences DK2660317T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US124707P 2007-10-31 2007-10-31
EP08845549.8A EP2215223B1 (en) 2007-10-31 2008-10-31 Rationally-designed single-chain meganucleases with non-palindromic recognition sequences

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DK2660317T3 true DK2660317T3 (en) 2016-08-01

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DK13165733.0T DK2660317T3 (en) 2007-10-31 2008-10-31 Rationally designed single-chain meganucleases with non-palindromic recognition sequences
DK08845549.8T DK2215223T3 (da) 2007-10-31 2008-10-31 Rationelt konstruerede enkeltkæde-meganucleaser med ikke-palindrome genkendelsessekvenser
DK16163925.7T DK3098309T3 (da) 2007-10-31 2008-10-31 Rationelt designet enkeltkædet meganuclease med ikke-palindrome genkendelsessekvenser

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DK08845549.8T DK2215223T3 (da) 2007-10-31 2008-10-31 Rationelt konstruerede enkeltkæde-meganucleaser med ikke-palindrome genkendelsessekvenser
DK16163925.7T DK3098309T3 (da) 2007-10-31 2008-10-31 Rationelt designet enkeltkædet meganuclease med ikke-palindrome genkendelsessekvenser

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US (10) US8445251B2 (enExample)
EP (4) EP2215223B1 (enExample)
JP (7) JP5761996B2 (enExample)
AU (1) AU2008318430A1 (enExample)
CA (1) CA2704383A1 (enExample)
DK (3) DK2660317T3 (enExample)
ES (3) ES2575412T3 (enExample)
WO (1) WO2009059195A2 (enExample)

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