JP2015508749A5 - - Google Patents
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- JP2015508749A5 JP2015508749A5 JP2014554828A JP2014554828A JP2015508749A5 JP 2015508749 A5 JP2015508749 A5 JP 2015508749A5 JP 2014554828 A JP2014554828 A JP 2014554828A JP 2014554828 A JP2014554828 A JP 2014554828A JP 2015508749 A5 JP2015508749 A5 JP 2015508749A5
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- 150000003839 salts Chemical class 0.000 claims description 12
- 239000011780 sodium chloride Substances 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- -1 4-Cyclopropyl-1H-imidazol-1-yl Chemical group 0.000 description 2
- 208000007342 Diabetic Nephropathy Diseases 0.000 description 2
- 206010038444 Renal failure chronic Diseases 0.000 description 2
- 201000000522 chronic kidney disease Diseases 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- PLKJXPACQBBJDC-UHFFFAOYSA-N 2-fluoro-4-methylbenzamide Chemical compound CC1=CC=C(C(N)=O)C(F)=C1 PLKJXPACQBBJDC-UHFFFAOYSA-N 0.000 description 1
- ANMJVFKRCBKCFN-UHFFFAOYSA-N 5-(4-cyclopropylimidazol-1-yl)-2-fluoro-4-methylbenzoic acid Chemical compound CC1=CC(F)=C(C(O)=O)C=C1N1C=C(C2CC2)N=C1 ANMJVFKRCBKCFN-UHFFFAOYSA-N 0.000 description 1
- ONHJPHNRRMKWHZ-UHFFFAOYSA-N 5-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-amine Chemical compound CC(C)N1C=NN=C1C1=CC=C(N)N=C1 ONHJPHNRRMKWHZ-UHFFFAOYSA-N 0.000 description 1
- YIDDLAAKOYYGJG-UHFFFAOYSA-N CC(C)[n]1c(-c2nc(NC(c(cc(c(C)c3)-[n]4cnc(C5CC5)c4)c3F)=O)ccc2)nnc1 Chemical compound CC(C)[n]1c(-c2nc(NC(c(cc(c(C)c3)-[n]4cnc(C5CC5)c4)c3F)=O)ccc2)nnc1 YIDDLAAKOYYGJG-UHFFFAOYSA-N 0.000 description 1
- 206010061835 Diabetic nephropathy Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 210000004185 Liver Anatomy 0.000 description 1
- 208000005069 Pulmonary Fibrosis Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 201000002793 renal fibrosis Diseases 0.000 description 1
Description
さらに別の実施形態では、本発明は、治療における使用のための式(I)の化合物に関する。
本発明の好ましい実施形態において、例えば以下の項目が提供される。
(項目1)
5−(4−シクロプロピル−1H−イミダゾール−1−イル)−N−(6−(4−イソプロピル−4H−1,2,4−トリアゾール−3−イル)ピリジン−2−イル)−2−フルオロ−4−メチルベンズアミドである、式(I)
の化合物または薬学的に許容されるその塩。
(項目2)
5−((4−シクロプロピル−1H−イミダゾール(imdazol)−1−イル)−2−フルオロ−N−(6−(4−イソプロピル−4H−1,2,4−トリアゾール−3−イル)ピリジン−2−イル)−4−メチルベンズアミドである、式(I)
の化合物。
(項目3)
項目1に記載の化合物または塩の治療有効量と、薬学的に許容されるキャリアとを含む、医薬組成物。
(項目4)
項目2に記載の化合物の治療有効量と、薬学的に許容されるキャリアとを含む、医薬組成物。
(項目5)
慢性腎疾患を処置する方法であって、項目2に記載の化合物または薬学的に許容されるその塩の治療有効量を、それを必要とする患者に投与する工程を含む、方法。
(項目6)
糖尿病性腎症を処置する方法であって、項目2に記載の化合物または薬学的に許容されるその塩の治療有効量を、それを必要とする患者に投与する工程を含む、方法。
(項目7)
腎線維症、肝線維症、または肺線維症を処置する方法であって、項目1に記載の化合物または塩の治療有効量を、それを必要とする患者に投与する工程を含む、方法。
(項目8)
糖尿病性腎疾患を処置する方法であって、項目1に記載の化合物または塩の治療有効量を、それを必要とする患者に投与する工程を含む、方法。
(項目9)
慢性腎疾患の処置のための医薬品の製造における、項目1に記載の化合物または塩の使用。
(項目10)
治療における項目1に記載の化合物または塩の使用。
(項目11)
2−アミノ,5−(4−イソプロピル−4H−1,2,4−トリアゾール−3−イル)ピリジンである、式:
の中間体またはその塩もしくは保護された形態。
(項目12)
5−(4−シクロプロピル−1H−イミダゾール−1−イル)−2−フルオロ−4−メチル安息香酸である、式:
の中間体、その塩または保護された形態。
本発明の好ましい実施形態において、例えば以下の項目が提供される。
(項目1)
5−(4−シクロプロピル−1H−イミダゾール−1−イル)−N−(6−(4−イソプロピル−4H−1,2,4−トリアゾール−3−イル)ピリジン−2−イル)−2−フルオロ−4−メチルベンズアミドである、式(I)
の化合物または薬学的に許容されるその塩。
(項目2)
5−((4−シクロプロピル−1H−イミダゾール(imdazol)−1−イル)−2−フルオロ−N−(6−(4−イソプロピル−4H−1,2,4−トリアゾール−3−イル)ピリジン−2−イル)−4−メチルベンズアミドである、式(I)
の化合物。
(項目3)
項目1に記載の化合物または塩の治療有効量と、薬学的に許容されるキャリアとを含む、医薬組成物。
(項目4)
項目2に記載の化合物の治療有効量と、薬学的に許容されるキャリアとを含む、医薬組成物。
(項目5)
慢性腎疾患を処置する方法であって、項目2に記載の化合物または薬学的に許容されるその塩の治療有効量を、それを必要とする患者に投与する工程を含む、方法。
(項目6)
糖尿病性腎症を処置する方法であって、項目2に記載の化合物または薬学的に許容されるその塩の治療有効量を、それを必要とする患者に投与する工程を含む、方法。
(項目7)
腎線維症、肝線維症、または肺線維症を処置する方法であって、項目1に記載の化合物または塩の治療有効量を、それを必要とする患者に投与する工程を含む、方法。
(項目8)
糖尿病性腎疾患を処置する方法であって、項目1に記載の化合物または塩の治療有効量を、それを必要とする患者に投与する工程を含む、方法。
(項目9)
慢性腎疾患の処置のための医薬品の製造における、項目1に記載の化合物または塩の使用。
(項目10)
治療における項目1に記載の化合物または塩の使用。
(項目11)
2−アミノ,5−(4−イソプロピル−4H−1,2,4−トリアゾール−3−イル)ピリジンである、式:
の中間体またはその塩もしくは保護された形態。
(項目12)
5−(4−シクロプロピル−1H−イミダゾール−1−イル)−2−フルオロ−4−メチル安息香酸である、式:
の中間体、その塩または保護された形態。
Claims (2)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261591710P | 2012-01-27 | 2012-01-27 | |
US61/591,710 | 2012-01-27 | ||
PCT/US2013/022997 WO2013112741A1 (en) | 2012-01-27 | 2013-01-24 | Apoptosis signal-regulating kinase inhibitor |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2015508749A JP2015508749A (ja) | 2015-03-23 |
JP2015508749A5 true JP2015508749A5 (ja) | 2015-06-18 |
JP5770950B2 JP5770950B2 (ja) | 2015-08-26 |
Family
ID=47684038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014554828A Active JP5770950B2 (ja) | 2012-01-27 | 2013-01-24 | アポトーシスシグナル調節キナーゼ阻害剤 |
Country Status (40)
Country | Link |
---|---|
US (7) | US8742126B2 (ja) |
EP (1) | EP2807151B1 (ja) |
JP (1) | JP5770950B2 (ja) |
KR (5) | KR101582065B1 (ja) |
CN (2) | CN104080771B (ja) |
AP (1) | AP2014007836A0 (ja) |
AR (2) | AR089818A1 (ja) |
AU (1) | AU2013201586C1 (ja) |
BR (1) | BR112014018355B1 (ja) |
CA (3) | CA3026700C (ja) |
CL (1) | CL2014001988A1 (ja) |
CO (1) | CO7061073A2 (ja) |
CR (1) | CR20140405A (ja) |
CY (1) | CY1117201T1 (ja) |
DK (1) | DK2807151T3 (ja) |
EA (1) | EA024746B1 (ja) |
ES (1) | ES2558203T3 (ja) |
HK (1) | HK1204324A1 (ja) |
HR (1) | HRP20151399T1 (ja) |
HU (1) | HUE028641T2 (ja) |
IL (3) | IL233598A (ja) |
IN (1) | IN2014DN06174A (ja) |
MA (1) | MA35861B1 (ja) |
MD (1) | MD4601B1 (ja) |
ME (1) | ME02322B (ja) |
MX (3) | MX2014009075A (ja) |
NZ (1) | NZ739339A (ja) |
PE (1) | PE20141822A1 (ja) |
PH (1) | PH12014501697A1 (ja) |
PL (1) | PL2807151T3 (ja) |
PT (1) | PT2807151E (ja) |
RS (1) | RS54492B1 (ja) |
SG (1) | SG11201404348UA (ja) |
SI (1) | SI2807151T1 (ja) |
SM (1) | SMT201600047B (ja) |
TW (4) | TWI561514B (ja) |
UA (1) | UA112098C2 (ja) |
UY (1) | UY34573A (ja) |
WO (1) | WO2013112741A1 (ja) |
ZA (1) | ZA201405260B (ja) |
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