JPS4995971A
(ja)
*
|
1973-01-27 |
1974-09-11 |
|
|
DE2448869A1
(de)
|
1973-10-19 |
1975-09-04 |
Mcneilab Inc |
4-oxo-2-imidazolidinylidenharnstoffe, verfahren zu ihrer herstellung und arzneimittel
|
US4025517A
(en)
*
|
1975-06-23 |
1977-05-24 |
Mcneil Laboratories, Incorporated |
4-Oxo-2-hexahydropyrimidinylidene ureas
|
JPS554305A
(en)
*
|
1978-06-13 |
1980-01-12 |
Nippon Zoki Pharmaceut Co Ltd |
Remedy for disease caused by stress and its preparation
|
US5070100A
(en)
|
1983-09-14 |
1991-12-03 |
Alcon Laboratories, Inc. |
Spiro-tricyclicaromatic succinimide derivatives
|
US4864028A
(en)
|
1983-09-14 |
1989-09-05 |
Alcon Laboratories, Inc. |
Spiro-tricyclicaromatic succinimide derivatives
|
GB2189699A
(en)
|
1986-04-30 |
1987-11-04 |
Haessle Ab |
Coated acid-labile medicaments
|
GB2189698A
(en)
|
1986-04-30 |
1987-11-04 |
Haessle Ab |
Coated omeprazole tablets
|
CH677886A5
(ja)
|
1989-06-26 |
1991-07-15 |
Hans Georg Prof Dr Weder |
|
EP0647268B1
(en)
|
1990-06-15 |
2004-03-03 |
Scios Inc. |
Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
|
DE69233774D1
(de)
|
1991-01-21 |
2009-12-10 |
Elan Pharm Inc |
Prüfung und Modell für Alzheimers-Krankheit
|
WO1993014200A1
(en)
|
1992-01-07 |
1993-07-22 |
Tsi Corporation |
Transgenic animal models for alzheimer's disease
|
US5604102A
(en)
|
1992-04-15 |
1997-02-18 |
Athena Neurosciences, Inc. |
Methods of screening for β-amyloid peptide production inhibitors
|
ATE198622T1
(de)
|
1993-10-27 |
2001-01-15 |
Elan Pharm Inc |
Transgene tiere, die app allele mit der schwedischen mutation beherbergen
|
US5877399A
(en)
|
1994-01-27 |
1999-03-02 |
Johns Hopkins University |
Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
|
ES2094688B1
(es)
|
1994-08-08 |
1997-08-01 |
Cusi Lab |
Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
|
FR2730932B1
(fr)
|
1995-02-27 |
1997-04-04 |
Oreal |
Nanoemulsion transparente a base de lipides amphiphiles non-ioniques fluides et utilisation en cosmetique ou en dermopharmacie
|
US5744346A
(en)
|
1995-06-07 |
1998-04-28 |
Athena Neurosciences, Inc. |
β-secretase
|
US5942400A
(en)
|
1995-06-07 |
1999-08-24 |
Elan Pharmaceuticals, Inc. |
Assays for detecting β-secretase
|
FR2742676B1
(fr)
|
1995-12-21 |
1998-02-06 |
Oreal |
Nanoemulsion transparente a base de tensioactifs silicones et utilisation en cosmetique ou en dermopharmacie
|
FR2755854B1
(fr)
|
1996-11-15 |
1998-12-24 |
Oreal |
Nanoemulsion a base de lipides amphiphiles non-ioniques et cationiques et utilisations
|
FR2760970B1
(fr)
|
1997-03-18 |
2000-03-10 |
Oreal |
Nanoemulsions a base de lipides amphiphiles non-ioniques et de silicones aminees et utilisations
|
AU5002399A
(en)
|
1998-07-17 |
2000-02-07 |
National Broach And Machine Company |
Full form roll finishing technique
|
ES2318902T3
(es)
|
1998-09-24 |
2009-05-01 |
PHARMACIA & UPJOHN COMPANY LLC |
Secretasa en la enfermedad del alzheimer.
|
FR2787026B1
(fr)
|
1998-12-14 |
2001-01-12 |
Oreal |
Nanoemulsion a base d'esters mixtes d'acide gras ou d'alcool gras, d'acide carboxylique et de glyceryle, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
FR2787027B1
(fr)
|
1998-12-14 |
2001-01-12 |
Oreal |
Nanoemulsion a base d'esters gras de sucre ou d'ethers gras de sucre et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
FR2787325B1
(fr)
|
1998-12-17 |
2001-01-26 |
Oreal |
Nanoemulsion a base d'esters gras de sorbitan oxyethylenes ou non oxyethylenes, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
FR2787326B1
(fr)
|
1998-12-17 |
2001-01-26 |
Oreal |
Nanoemulsion a base d'esters gras de glycerol, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
FR2787728B1
(fr)
|
1998-12-23 |
2001-01-26 |
Oreal |
Nanoemulsion a base d'esters gras d'acide phosphorique, et ses utilisations dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique
|
FR2787703B1
(fr)
|
1998-12-29 |
2001-01-26 |
Oreal |
Nanoemulsion a base d'ethers gras ethoxyles ou d'esters gras ethoxyles, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
FR2788007B1
(fr)
|
1999-01-05 |
2001-02-09 |
Oreal |
Nanoemulsion a base de copolymeres blocs d'oxyde d'ethylene et d'oxyde de propylene, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
FR2788449B1
(fr)
|
1999-01-14 |
2001-02-16 |
Oreal |
Nanoemulsion a base de citrates d'alkylether, et ses utilisations dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique
|
FR2789076B1
(fr)
|
1999-02-02 |
2001-03-02 |
Synthelabo |
Derives de alpha-azacyclomethyl quinoleine, leur preparation et leur application en therapeutique
|
US7161962B1
(en)
|
1999-05-27 |
2007-01-09 |
Nuera Communications, Inc. |
Method and apparatus for coding modem signals for transmission over voice networks
|
FR2811564B1
(fr)
|
2000-07-13 |
2002-12-27 |
Oreal |
Nanoemulsion contenant des polymeres non ioniques, et ses utilisations notamment dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique
|
AU2002241823A1
(en)
|
2001-01-11 |
2002-07-24 |
Eastman Chemical Company |
Cyclodextrin sulfonates, guest inclusion complexes, methods of making the same and related materials
|
FR2819427B1
(fr)
|
2001-01-18 |
2003-04-11 |
Oreal |
Nanoemulsion translucide, son procede de fabrication et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique
|
JP2006512401A
(ja)
|
2001-06-05 |
2006-04-13 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
ナノエマルジョンワクチン
|
US7476393B2
(en)
|
2002-11-29 |
2009-01-13 |
L'oreal |
Process for the preparation of a cationic nanoemulsion, and cosmetic composition
|
JP4472700B2
(ja)
|
2003-08-08 |
2010-06-02 |
シェーリング コーポレイション |
複素環置換基を有する環状アミンbase−1阻害剤
|
ATE424383T1
(de)
|
2003-08-08 |
2009-03-15 |
Schering Corp |
Cyclische amine mit benzamidsubstituent als bace- 1-inhibitoren
|
US7592348B2
(en)
|
2003-12-15 |
2009-09-22 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
US7763609B2
(en)
|
2003-12-15 |
2010-07-27 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
JP5020638B2
(ja)
|
2003-12-15 |
2012-09-05 |
シェーリング コーポレイション |
複素環式アスパルチルプロテアーゼインヒビター
|
US7468402B2
(en)
|
2004-03-17 |
2008-12-23 |
Baker Hughes Incorporated |
Polymeric nanoemulsion as drag reducer for multiphase flow
|
EP1743170A2
(en)
|
2004-04-02 |
2007-01-17 |
Merck & Co., Inc. |
Methods for detecting substances which bind to the amyloid precursor protein or beta amyloid fragments, and binding compounds
|
JP2007533740A
(ja)
|
2004-04-22 |
2007-11-22 |
イーライ リリー アンド カンパニー |
Bace阻害剤としてのアミド
|
IL162288A0
(en)
|
2004-06-01 |
2005-11-20 |
Future Products Man S A |
Compositions and methods for treating neurodegenerative disorders
|
JP2008503460A
(ja)
|
2004-06-16 |
2008-02-07 |
ワイス |
β−セクレターゼのインヒビターとしてのジフェニルイミダゾピリミジンおよびイミダゾールアミン
|
NZ552031A
(en)
|
2004-06-16 |
2009-06-26 |
Wyeth Corp |
Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase
|
MX2007000760A
(es)
|
2004-07-22 |
2007-04-09 |
Schering Corp |
Amida sustituida inhibidora de b secretasa.
|
AR050184A1
(es)
|
2004-07-28 |
2006-10-04 |
Schering Corp |
Inhibidores macrociclicos de beta-secretasa
|
PE20060692A1
(es)
|
2004-09-21 |
2006-07-19 |
Lilly Co Eli |
Inhibidores bace
|
GB0500683D0
(en)
|
2005-01-13 |
2005-02-23 |
Novartis Ag |
Organic compounds
|
WO2006074950A1
(en)
|
2005-01-13 |
2006-07-20 |
Novartis Ag |
Macrocyclic compounds useful as bace inhibitors
|
US8722708B2
(en)
|
2005-06-14 |
2014-05-13 |
Merck Sharp & Dohme Inc. |
Substituted isoindolines as aspartyl protease inhibitors
|
ATE482214T1
(de)
|
2005-06-14 |
2010-10-15 |
Schering Corp |
Aspartylproteasehemmer
|
MX2007016185A
(es)
|
2005-06-14 |
2008-03-07 |
Schering Corp |
Inhibidores de aspartil proteasa heterociclicos macrociclicos.
|
US7759353B2
(en)
|
2005-06-14 |
2010-07-20 |
Schering Corporation |
Substituted spiro iminopyrimidinones as aspartyl protease inhibitors, compositions, and methods of treatment
|
TWI332005B
(en)
|
2005-06-14 |
2010-10-21 |
Schering Corp |
Aspartyl protease inhibitors
|
CA2610829A1
(en)
|
2005-06-14 |
2006-12-28 |
Schering Corporation |
The preparation and use of compounds as aspartyl protease inhibitors
|
MX2007016186A
(es)
|
2005-06-14 |
2008-03-07 |
Schering Corp |
Preparacion y uso de inhibidores de proteasas.
|
WO2007005404A1
(en)
|
2005-06-30 |
2007-01-11 |
Wyeth |
AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION
|
TW200738683A
(en)
|
2005-06-30 |
2007-10-16 |
Wyeth Corp |
Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
|
TW200730523A
(en)
|
2005-07-29 |
2007-08-16 |
Wyeth Corp |
Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
|
BRPI0616757A2
(pt)
|
2005-09-26 |
2011-06-28 |
Wyeth Corp |
composto da fórmula i; processo para o tratamento de uma doença ou de um distúrbio associado com a atividade excessiva de bace; processo para a modulação da atividade de bace; processo para o tratamento da doença de alzheimer; e composição farmacêutica
|
US7763606B2
(en)
|
2005-10-27 |
2010-07-27 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
JP2009513670A
(ja)
|
2005-10-31 |
2009-04-02 |
シェーリング コーポレイション |
アスパルチルプロテアーゼインヒビター
|
JP2009520686A
(ja)
|
2005-11-21 |
2009-05-28 |
アストラゼネカ・アクチエボラーグ |
新規な2−アミノ−イミダゾール−4−オン化合物並びに認知障害、アルツハイマー病、神経変性及び認知症の治療に使用する医薬の製造におけるその使用
|
GB0602951D0
(en)
|
2006-02-14 |
2006-03-29 |
Novartis Ag |
Organic Compounds
|
EP2004630A4
(en)
|
2006-04-05 |
2010-05-19 |
Astrazeneca Ab |
2-AMINOPYRIMIDIN-4-ONES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF PATHOLOGIES RELATED TO PROTEIN A
|
GB0611064D0
(en)
|
2006-06-05 |
2006-07-12 |
Novartis Ag |
Organic compounds
|
US8168641B2
(en)
|
2006-06-12 |
2012-05-01 |
Schering Corporation |
Aspartyl protease inhibitors
|
TW200815443A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds I
|
TW200808796A
(en)
|
2006-06-14 |
2008-02-16 |
Astrazeneca Ab |
New compounds III
|
TW200815449A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds II
|
TW200815447A
(en)
|
2006-06-14 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds IV
|
TW200815349A
(en)
|
2006-06-22 |
2008-04-01 |
Astrazeneca Ab |
New compounds
|
KR20090041387A
(ko)
|
2006-07-20 |
2009-04-28 |
노파르티스 아게 |
마크로시클릭 락탐
|
EP2046761A2
(en)
|
2006-07-20 |
2009-04-15 |
Novartis AG |
Macrocyclic compounds useful as bace inhibitors
|
BRPI0719336A2
(pt)
|
2006-11-23 |
2014-02-04 |
Novartis Ag |
Derivados de 2-hidróxi-1,3-diaminopropano
|
WO2008073365A1
(en)
|
2006-12-12 |
2008-06-19 |
Schering Corporation |
Aspartyl protease inhibitors
|
CA2672295A1
(en)
|
2006-12-12 |
2008-06-19 |
Schering Corporation |
Aspartyl protease inhibitors containing a tricyclic ring system
|
TW200831091A
(en)
*
|
2006-12-20 |
2008-08-01 |
Astrazeneca Ab |
New compounds
|
WO2008112159A2
(en)
*
|
2007-03-12 |
2008-09-18 |
Merck & Co., Inc. |
Monocyclic anilide spirolactam cgrp receptor antagonists
|
PE20090160A1
(es)
*
|
2007-03-20 |
2009-02-11 |
Wyeth Corp |
COMPUESTOS AMINO-5-[4-(DIFLUOROMETOXI)FENIL SUSTITUIDO]-5-FENILIMIDAZOLONA COMO INHIBIDORES DE ß-SECRETASA
|
TW200902499A
(en)
|
2007-05-15 |
2009-01-16 |
Astrazeneca Ab |
New compounds
|
US20090041201A1
(en)
|
2007-08-06 |
2009-02-12 |
Carestream Health, Inc. |
Alignment apparatus for imaging system
|
EA201000340A1
(ru)
|
2007-08-23 |
2010-08-30 |
Новартис Аг |
Аминобензилзамещенные циклические сульфоны, полезные в качестве ингибиторов васе
|
US20090062361A1
(en)
|
2007-08-30 |
2009-03-05 |
Allergan, Inc. |
Therapeutic hydantoins
|
TWI431004B
(zh)
|
2008-05-02 |
2014-03-21 |
Lilly Co Eli |
Bace抑制劑
|
WO2010003976A1
(en)
|
2008-07-10 |
2010-01-14 |
Novartis Ag |
Cyclic sulfones with aminobenzyl substitution useful as bace inhibitors
|
JPWO2010047372A1
(ja)
|
2008-10-22 |
2012-03-22 |
塩野義製薬株式会社 |
Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体
|
AU2008364165B2
(en)
|
2008-11-11 |
2015-01-29 |
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd |
Inclusion complexes of pinocembrin with cyclodextrin or its derivatives
|
AR077277A1
(es)
|
2009-07-09 |
2011-08-17 |
Lilly Co Eli |
Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer
|
US8563543B2
(en)
|
2009-10-08 |
2013-10-22 |
Merck Sharp & Dohme Corp. |
Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
UA108363C2
(uk)
|
2009-10-08 |
2015-04-27 |
|
Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
|
EP2605655B1
(en)
|
2010-08-19 |
2018-10-24 |
Buck Institute for Age Research |
Methods of treating mild cognitive impairment (mci) and related disorders
|
US8415483B2
(en)
|
2010-12-22 |
2013-04-09 |
Astrazeneca Ab |
Compounds and their use as BACE inhibitors
|
US20120165346A1
(en)
|
2010-12-22 |
2012-06-28 |
Astrazeneca Ab |
Compounds and their use as BACE inhibitors
|
US8877744B2
(en)
|
2011-04-04 |
2014-11-04 |
Hoffmann-La Roche Inc. |
1,4-Oxazepines as BACE1 and/or BACE2 inhibitors
|
EP2956443B1
(en)
|
2013-02-12 |
2019-09-25 |
Buck Institute For Research On Aging |
Hydantoins that modulate bace-mediated app processing
|
CA3096896A1
(en)
*
|
2015-08-27 |
2017-03-02 |
Nantneuro, Llc |
5,5'-disubstituted aminohydantoin compounds and compositions useful for inhibition of bace and the treatment of associated diseases
|