JOP20180017A1 - مثبط كيناز منظم لإشارة تلاشي خلايا - Google Patents

مثبط كيناز منظم لإشارة تلاشي خلايا

Info

Publication number
JOP20180017A1
JOP20180017A1 JOP/2018/0017A JOP20180017A JOP20180017A1 JO P20180017 A1 JOP20180017 A1 JO P20180017A1 JO P20180017 A JOP20180017 A JO P20180017A JO P20180017 A1 JOP20180017 A1 JO P20180017A1
Authority
JO
Jordan
Prior art keywords
kinase inhibitor
apoptosis signal
regulating kinase
compound
formula
Prior art date
Application number
JOP/2018/0017A
Other languages
English (en)
Inventor
Kassibla Elodie Dempah
Julie Farand
Gregory Notte
Jennifer Lynne Alleva
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of JOP20180017A1 publication Critical patent/JOP20180017A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بتوفير مركب بالصيغة (I) (I)؛ أو ملح مقبول صيدليًا منه للاستخدام في علاج التهاب الكبد الدهني غير المرتبط بالكحول، التهاب الكبد المرتبط بالكحول، ارتفاع ضغط الدم الشرياني الرئوي، قصور القلب مع الكَسْرُ القَذْفِيّ المحفوظ، وداء الكلى الناتج عن مرض السكر. كذلك يتم توفير صور غير متبلّرة ومتبلّرة من المركب بالصيغة (I) وأملاح، بلورات مشتركة، ذوّابات، ومركبات هيدرات منه.
JOP/2018/0017A 2017-03-14 2017-03-14 مثبط كيناز منظم لإشارة تلاشي خلايا JOP20180017A1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762471300P 2017-03-14 2017-03-14

Publications (1)

Publication Number Publication Date
JOP20180017A1 true JOP20180017A1 (ar) 2019-01-30

Family

ID=61750538

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2018/0017A JOP20180017A1 (ar) 2017-03-14 2017-03-14 مثبط كيناز منظم لإشارة تلاشي خلايا

Country Status (6)

Country Link
AR (1) AR111178A1 (ar)
BR (1) BR102018004862A2 (ar)
JO (1) JOP20180017A1 (ar)
TW (1) TW201840551A (ar)
UY (1) UY37631A (ar)
WO (1) WO2018169742A1 (ar)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI625121B (zh) 2009-07-13 2018-06-01 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
AU2018266911C1 (en) 2017-05-12 2022-10-20 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10597382B2 (en) 2017-08-28 2020-03-24 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2019213239A1 (en) 2018-05-02 2019-11-07 Enanta Pharmaceuticals Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
JP7328254B2 (ja) 2018-05-02 2023-08-16 エナンタ ファーマシューティカルズ インコーポレイテッド アポトーシスシグナル調節キナーゼ１阻害剤を含むテトラゾール及びその使用方法
CN110818683B (zh) * 2018-08-10 2023-04-14 中国科学院上海药物研究所 2-吡啶取代脲结构小分子化合物及其合成和应用
WO2020041417A1 (en) 2018-08-22 2020-02-27 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020106707A1 (en) 2018-11-19 2020-05-28 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020198214A1 (en) 2019-03-25 2020-10-01 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2023125904A1 (zh) * 2021-12-30 2023-07-06 苏州晶云药物科技股份有限公司 氮杂环丁基烟酸类化合物的晶型及其制备方法
CN117503932A (zh) * 2022-07-30 2024-02-06 中国医学科学院阜外医院 Jun抑制剂在制备用于治疗射血分数保留的心衰的药物中的用途
CN117054652B (zh) * 2023-08-04 2024-05-17 南京医科大学 一种用于辅助检测心肌肥厚的生物标志物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI625121B (zh) 2009-07-13 2018-06-01 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
WO2015187499A1 (en) 2014-06-03 2015-12-10 Gilead Sciences, Inc. Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor
TW201618781A (zh) 2014-08-13 2016-06-01 吉李德科學股份有限公司 治療肺高血壓之方法
MA41252A (fr) * 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1

Also Published As

Publication number Publication date
AR111178A1 (es) 2019-06-12
BR102018004862A2 (pt) 2019-01-02
UY37631A (es) 2018-09-28
WO2018169742A1 (en) 2018-09-20
TW201840551A (zh) 2018-11-16

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