AR111178A1 - Inhibidor de la quinasa reguladora de la señal de apoptosis - Google Patents

Inhibidor de la quinasa reguladora de la señal de apoptosis

Info

Publication number
AR111178A1
AR111178A1 ARP180100585A ARP180100585A AR111178A1 AR 111178 A1 AR111178 A1 AR 111178A1 AR P180100585 A ARP180100585 A AR P180100585A AR P180100585 A ARP180100585 A AR P180100585A AR 111178 A1 AR111178 A1 AR 111178A1
Authority
AR
Argentina
Prior art keywords
inhibitor
apoptosis signal
regulatory kinase
compound
formula
Prior art date
Application number
ARP180100585A
Other languages
English (en)
Inventor
Gregory Notte
Julie Farand
Kassibla Eloide Dempah
Jennifer Lynne Alleva
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR111178A1 publication Critical patent/AR111178A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Abstract

Se proporciona un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo para uso en el tratamiento de esteatohepatitis no alcohólica, hepatitis alcohólica, hipertensión arterial pulmonar, insuficiencia cardiaca con fracción de eyección conservada y enfermedad renal diabética. También se proporcionan formas amorfas y cristalinas del compuesto de fórmula (1) y sales, co-cristales, solvatos e hidratos del mismo.
ARP180100585A 2017-03-14 2018-03-14 Inhibidor de la quinasa reguladora de la señal de apoptosis AR111178A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762471300P 2017-03-14 2017-03-14

Publications (1)

Publication Number Publication Date
AR111178A1 true AR111178A1 (es) 2019-06-12

Family

ID=61750538

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180100585A AR111178A1 (es) 2017-03-14 2018-03-14 Inhibidor de la quinasa reguladora de la señal de apoptosis

Country Status (6)

Country Link
AR (1) AR111178A1 (es)
BR (1) BR102018004862A2 (es)
JO (1) JOP20180017A1 (es)
TW (1) TW201840551A (es)
UY (1) UY37631A (es)
WO (1) WO2018169742A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
WO2018209354A1 (en) 2017-05-12 2018-11-15 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2019046186A1 (en) 2017-08-28 2019-03-07 Enanta Pharmaceuticals, Inc. INHIBITORS OF KINASE 1 REGULATING THE APOPTOTIC SIGNAL CONTAINING TETRAZOLES AND METHODS OF USE THEREOF
AU2019262016A1 (en) 2018-05-02 2020-11-19 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US10683289B2 (en) 2018-05-02 2020-06-16 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN110818683B (zh) * 2018-08-10 2023-04-14 中国科学院上海药物研究所 2-吡啶取代脲结构小分子化合物及其合成和应用
WO2020041417A1 (en) 2018-08-22 2020-02-27 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11345699B2 (en) 2018-11-19 2022-05-31 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11466033B2 (en) 2019-03-25 2022-10-11 Enanta Pharmaceuticals, Inc. Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
WO2023125904A1 (zh) * 2021-12-30 2023-07-06 苏州晶云药物科技股份有限公司 氮杂环丁基烟酸类化合物的晶型及其制备方法
CN117503932A (zh) * 2022-07-30 2024-02-06 中国医学科学院阜外医院 Jun抑制剂在制备用于治疗射血分数保留的心衰的药物中的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI598347B (zh) 2009-07-13 2017-09-11 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
WO2015187499A1 (en) 2014-06-03 2015-12-10 Gilead Sciences, Inc. Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor
TW201618781A (zh) 2014-08-13 2016-06-01 吉李德科學股份有限公司 治療肺高血壓之方法
MA41252A (fr) * 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1

Also Published As

Publication number Publication date
UY37631A (es) 2018-09-28
WO2018169742A1 (en) 2018-09-20
BR102018004862A2 (pt) 2019-01-02
JOP20180017A1 (ar) 2019-01-30
TW201840551A (zh) 2018-11-16

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