BR102018004862A2 - composto, forma cristalina, composição farmacêutica, e, métodos para inibir ask1 e para tratar uma condição - Google Patents
composto, forma cristalina, composição farmacêutica, e, métodos para inibir ask1 e para tratar uma condição Download PDFInfo
- Publication number
- BR102018004862A2 BR102018004862A2 BR102018004862A BR102018004862A BR102018004862A2 BR 102018004862 A2 BR102018004862 A2 BR 102018004862A2 BR 102018004862 A BR102018004862 A BR 102018004862A BR 102018004862 A BR102018004862 A BR 102018004862A BR 102018004862 A2 BR102018004862 A2 BR 102018004862A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pyridin
- fluoropropan
- triazol
- distinguished
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762471300P | 2017-03-14 | 2017-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR102018004862A2 true BR102018004862A2 (pt) | 2019-01-02 |
Family
ID=61750538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR102018004862A BR102018004862A2 (pt) | 2017-03-14 | 2018-03-12 | composto, forma cristalina, composição farmacêutica, e, métodos para inibir ask1 e para tratar uma condição |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR111178A1 (es) |
| BR (1) | BR102018004862A2 (es) |
| JO (1) | JOP20180017A1 (es) |
| TW (1) | TW201840551A (es) |
| UY (1) | UY37631A (es) |
| WO (1) | WO2018169742A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
| WO2018209354A1 (en) * | 2017-05-12 | 2018-11-15 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10597382B2 (en) | 2017-08-28 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| AU2019262016A1 (en) | 2018-05-02 | 2020-11-19 | Enanta Pharmaceuticals, Inc. | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US10683289B2 (en) | 2018-05-02 | 2020-06-16 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| CN110818683B (zh) * | 2018-08-10 | 2023-04-14 | 中国科学院上海药物研究所 | 2-吡啶取代脲结构小分子化合物及其合成和应用 |
| WO2020041417A1 (en) | 2018-08-22 | 2020-02-27 | Enanta Pharmaceuticals, Inc. | Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| US11345699B2 (en) | 2018-11-19 | 2022-05-31 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2020198214A1 (en) | 2019-03-25 | 2020-10-01 | Enanta Pharmaceuticals, Inc. | Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| WO2023125904A1 (zh) * | 2021-12-30 | 2023-07-06 | 苏州晶云药物科技股份有限公司 | 氮杂环丁基烟酸类化合物的晶型及其制备方法 |
| CN117503932A (zh) * | 2022-07-30 | 2024-02-06 | 中国医学科学院阜外医院 | Jun抑制剂在制备用于治疗射血分数保留的心衰的药物中的用途 |
| CN117054652B (zh) * | 2023-08-04 | 2024-05-17 | 南京医科大学 | 一种用于辅助检测心肌肥厚的生物标志物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| WO2015187499A1 (en) | 2014-06-03 | 2015-12-10 | Gilead Sciences, Inc. | Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor |
| TW201618781A (zh) | 2014-08-13 | 2016-06-01 | 吉李德科學股份有限公司 | 治療肺高血壓之方法 |
| MA41252A (fr) * | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
-
2017
- 2017-03-14 JO JOP/2018/0017A patent/JOP20180017A1/ar unknown
-
2018
- 2018-03-07 WO PCT/US2018/021334 patent/WO2018169742A1/en active Application Filing
- 2018-03-12 BR BR102018004862A patent/BR102018004862A2/pt not_active Application Discontinuation
- 2018-03-13 TW TW107108465A patent/TW201840551A/zh unknown
- 2018-03-14 AR ARP180100585A patent/AR111178A1/es unknown
- 2018-03-14 UY UY0001037631A patent/UY37631A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JOP20180017A1 (ar) | 2019-01-30 |
| UY37631A (es) | 2018-09-28 |
| TW201840551A (zh) | 2018-11-16 |
| AR111178A1 (es) | 2019-06-12 |
| WO2018169742A1 (en) | 2018-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette] | ||
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |