EA201891780A1 - Производные сульфонамида и содержащие их фармацевтические композиции - Google Patents
Производные сульфонамида и содержащие их фармацевтические композицииInfo
- Publication number
- EA201891780A1 EA201891780A1 EA201891780A EA201891780A EA201891780A1 EA 201891780 A1 EA201891780 A1 EA 201891780A1 EA 201891780 A EA201891780 A EA 201891780A EA 201891780 A EA201891780 A EA 201891780A EA 201891780 A1 EA201891780 A1 EA 201891780A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- sulphonamide
- pharmaceutical compositions
- compounds
- integrin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Предложены соединения, обладающие ингибирующим действием на α4-интегрин. Соединения представляют собой производные сульфонамида следующей формулы (I), либо их фармацевтически приемлемые соли:где R-R, e, f, g, h, D и B означают то, что указано в описании.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016021053 | 2016-02-05 | ||
PCT/JP2017/004278 WO2017135472A1 (ja) | 2016-02-05 | 2017-02-06 | スルホンアミド誘導体及びそれを含有する医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201891780A1 true EA201891780A1 (ru) | 2019-02-28 |
EA036432B1 EA036432B1 (ru) | 2020-11-10 |
Family
ID=59500204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201891780A EA036432B1 (ru) | 2016-02-05 | 2017-02-06 | Производные сульфонамида и содержащие их фармацевтические композиции |
Country Status (16)
Country | Link |
---|---|
US (1) | US10562898B2 (ru) |
EP (1) | EP3412660B9 (ru) |
JP (1) | JP6820282B2 (ru) |
KR (1) | KR20180104758A (ru) |
CN (1) | CN108699008B (ru) |
AU (1) | AU2017214589B2 (ru) |
CA (1) | CA3013433A1 (ru) |
DK (1) | DK3412660T3 (ru) |
EA (1) | EA036432B1 (ru) |
ES (1) | ES2856125T3 (ru) |
HU (1) | HUE053354T2 (ru) |
MX (1) | MX2018009459A (ru) |
PL (1) | PL3412660T3 (ru) |
PT (1) | PT3412660T (ru) |
TW (1) | TWI730042B (ru) |
WO (1) | WO2017135472A1 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000024734A1 (en) | 1998-10-26 | 2000-05-04 | The Research Foundation Of State University Of New York | Lipoic acid derivatives and their use in treatment of disease |
TWI754702B (zh) | 2016-12-28 | 2022-02-11 | 德商Ucb製藥有限公司 | (氮雜)吲哚-和苯並呋喃-3-磺醯胺類 |
WO2019147824A1 (en) | 2018-01-26 | 2019-08-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4β7インテグリンの阻害のための化合物 |
CA3115820A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
JP7192139B2 (ja) | 2018-10-30 | 2022-12-19 | ギリアード サイエンシーズ, インコーポレイテッド | α4β7インテグリン阻害剤としてのキノリン誘導体 |
EP4013499A1 (en) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
WO2021174024A1 (en) | 2020-02-28 | 2021-09-02 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
TW202330490A (zh) | 2021-10-05 | 2023-08-01 | 日商Ea製藥股份有限公司 | 化合物或其藥學上所容許之鹽的製造方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6388084B1 (en) | 1999-12-06 | 2002-05-14 | Hoffmann-La Roche Inc. | 4-pyridinyl-n-acyl-l-phenylalanines |
CA2392566A1 (en) | 1999-12-06 | 2001-06-14 | F. Hoffmann-La Roche Ag | 4-pyridinyl-n-acyl-l-phenylalanines |
AU2001234741A1 (en) | 2000-02-04 | 2001-08-14 | Biogen, Inc. | Integrin antagonists |
PL223152B1 (pl) | 2000-08-18 | 2016-10-31 | Ajinomoto Kk | Pochodne fenyloalaniny, kompozycja farmaceutyczna oraz zastosowanie tych pochodnych |
JP4470219B2 (ja) | 2002-02-20 | 2010-06-02 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
JP4233353B2 (ja) | 2002-02-27 | 2009-03-04 | 田辺三菱製薬株式会社 | 医薬組成物 |
TW200509930A (en) * | 2003-06-25 | 2005-03-16 | Elan Pharm Inc | Methods and compositions for treating rheumatoid arthritis |
JP4743659B2 (ja) | 2003-12-22 | 2011-08-10 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
CN1938283A (zh) | 2004-02-10 | 2007-03-28 | 詹森药业有限公司 | 作为α4整联蛋白拮抗剂的哒嗪酮 |
CA2563432A1 (en) | 2004-04-16 | 2005-12-01 | Genentech, Inc. | Method for augmenting b cell depletion |
BRPI0611285A2 (pt) | 2005-05-20 | 2010-08-31 | Elan Pharm Inc | derivados de imidazolona fenilalanina |
EP2842945B1 (en) * | 2012-04-24 | 2016-10-26 | EA Pharma Co., Ltd. | Sulfonamide derivative and medicinal use thereof |
DE102013206014A1 (de) * | 2013-04-05 | 2014-10-09 | Dürr Systems GmbH | Energiewandler-System und Baugruppen hierfür |
WO2015064580A1 (ja) | 2013-10-29 | 2015-05-07 | 味の素株式会社 | スルホンアミド誘導体及びその医薬用途 |
-
2017
- 2017-02-06 US US16/075,415 patent/US10562898B2/en active Active
- 2017-02-06 CN CN201780009898.0A patent/CN108699008B/zh active Active
- 2017-02-06 PT PT177476223T patent/PT3412660T/pt unknown
- 2017-02-06 WO PCT/JP2017/004278 patent/WO2017135472A1/ja active Application Filing
- 2017-02-06 KR KR1020187025805A patent/KR20180104758A/ko not_active Application Discontinuation
- 2017-02-06 PL PL17747622T patent/PL3412660T3/pl unknown
- 2017-02-06 EA EA201891780A patent/EA036432B1/ru not_active IP Right Cessation
- 2017-02-06 CA CA3013433A patent/CA3013433A1/en active Pending
- 2017-02-06 HU HUE17747622A patent/HUE053354T2/hu unknown
- 2017-02-06 DK DK17747622.3T patent/DK3412660T3/da active
- 2017-02-06 AU AU2017214589A patent/AU2017214589B2/en active Active
- 2017-02-06 ES ES17747622T patent/ES2856125T3/es active Active
- 2017-02-06 EP EP17747622.3A patent/EP3412660B9/en active Active
- 2017-02-06 MX MX2018009459A patent/MX2018009459A/es unknown
- 2017-02-06 JP JP2017565026A patent/JP6820282B2/ja active Active
- 2017-02-06 TW TW106103847A patent/TWI730042B/zh active
Also Published As
Publication number | Publication date |
---|---|
TW201733991A (zh) | 2017-10-01 |
ES2856125T3 (es) | 2021-09-27 |
EP3412660B1 (en) | 2020-11-18 |
PT3412660T (pt) | 2021-01-13 |
PL3412660T3 (pl) | 2021-04-19 |
JP6820282B2 (ja) | 2021-01-27 |
CN108699008A (zh) | 2018-10-23 |
EA036432B1 (ru) | 2020-11-10 |
DK3412660T3 (da) | 2020-11-30 |
CA3013433A1 (en) | 2017-08-10 |
EP3412660A4 (en) | 2019-07-10 |
MX2018009459A (es) | 2018-09-21 |
AU2017214589B2 (en) | 2020-09-03 |
AU2017214589A1 (en) | 2018-08-16 |
TWI730042B (zh) | 2021-06-11 |
JPWO2017135472A1 (ja) | 2018-11-29 |
KR20180104758A (ko) | 2018-09-21 |
HUE053354T2 (hu) | 2021-06-28 |
CN108699008B (zh) | 2021-10-08 |
WO2017135472A1 (ja) | 2017-08-10 |
EP3412660A1 (en) | 2018-12-12 |
US20190040059A1 (en) | 2019-02-07 |
BR112018015855A2 (pt) | 2018-12-26 |
EP3412660B9 (en) | 2021-04-14 |
US10562898B2 (en) | 2020-02-18 |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG TJ TM |