AR124688A2 - Una pirimidina sulfonamida o un tautómero del mismo, o una sal farmacéuticamente aceptable del mismo - Google Patents
Una pirimidina sulfonamida o un tautómero del mismo, o una sal farmacéuticamente aceptable del mismoInfo
- Publication number
- AR124688A2 AR124688A2 ARP220100128A ARP220100128A AR124688A2 AR 124688 A2 AR124688 A2 AR 124688A2 AR P220100128 A ARP220100128 A AR P220100128A AR P220100128 A ARP220100128 A AR P220100128A AR 124688 A2 AR124688 A2 AR 124688A2
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- tautomer
- pharmaceutically acceptable
- acceptable salt
- pyrimidine sulfonamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/78—Benzoic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/12—Radicals substituted by oxygen atoms
Abstract
Se proporciona un compuesto que es (a) una pirimidina sulfonamida de fórmula (1) o un tautómero del mismo, o (b) una sal farmacéuticamente aceptable del mismo, formas cristalinas del compuesto, procesos para obtener el compuesto, intermediarios farmacéuticos utilizados en la fabricación del compuesto y composiciones farmacéuticas que contienen el compuesto. El compuesto es útil en el tratamiento de una enfermedad / afección en la cual resulta beneficiosa la modulación de la actividad del receptor de quimioquina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161506737P | 2011-07-12 | 2011-07-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR124688A2 true AR124688A2 (es) | 2023-04-26 |
Family
ID=46513787
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120102531A AR087168A1 (es) | 2011-07-12 | 2012-07-12 | Compuesto derivado de pirimidina sulfonamida |
ARP220100128A AR124688A2 (es) | 2011-07-12 | 2022-01-21 | Una pirimidina sulfonamida o un tautómero del mismo, o una sal farmacéuticamente aceptable del mismo |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120102531A AR087168A1 (es) | 2011-07-12 | 2012-07-12 | Compuesto derivado de pirimidina sulfonamida |
Country Status (37)
Country | Link |
---|---|
US (3) | US8735413B2 (es) |
EP (2) | EP2731945A1 (es) |
JP (2) | JP6006308B2 (es) |
KR (1) | KR101946664B1 (es) |
CN (1) | CN103781781B (es) |
AR (2) | AR087168A1 (es) |
AU (2) | AU2012282316B2 (es) |
BR (1) | BR112014000636B1 (es) |
CA (1) | CA2841859C (es) |
CL (1) | CL2014000079A1 (es) |
CO (1) | CO6852072A2 (es) |
CR (1) | CR20140007A (es) |
CU (2) | CU24292B1 (es) |
CY (1) | CY1124329T1 (es) |
DK (1) | DK3255043T3 (es) |
DO (1) | DOP2013000308A (es) |
EA (1) | EA027821B1 (es) |
EC (1) | ECSP14013130A (es) |
ES (1) | ES2861927T3 (es) |
HK (1) | HK1245779A1 (es) |
HR (1) | HRP20210413T1 (es) |
HU (1) | HUE053703T2 (es) |
IL (1) | IL230398A (es) |
LT (1) | LT3255043T (es) |
MX (2) | MX342874B (es) |
MY (1) | MY180039A (es) |
NI (1) | NI201400002A (es) |
PE (2) | PE20181069A1 (es) |
PL (1) | PL3255043T3 (es) |
PT (1) | PT3255043T (es) |
RS (1) | RS61608B1 (es) |
SG (1) | SG10201605619XA (es) |
SI (1) | SI3255043T1 (es) |
TW (2) | TWI633098B (es) |
UY (1) | UY34191A (es) |
WO (1) | WO2013008002A1 (es) |
ZA (1) | ZA201401059B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI496773B (zh) | 2010-07-13 | 2015-08-21 | Astrazeneca Ab | N-[2-[[(2,3-二氟苯基)甲基]硫基]-6-{[(1r,2s)-2,3-二羥基-1-甲基丙基]氧基}-4-嘧啶基]-1-三亞甲亞胺磺醯胺之新穎結晶型 |
SG10201605619XA (en) * | 2011-07-12 | 2016-08-30 | Astrazeneca Ab | N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator |
EP3141235A1 (en) * | 2012-12-06 | 2017-03-15 | IP Gesellschaft für Management mbH | N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3-methylazetidine-l -sulfonamide |
CA3017345A1 (en) * | 2016-03-11 | 2017-09-14 | Ardea Biosciences, Inc. | Cxcr-2 inhibitors for treating crystal arthropathy disorders |
AU2018334152A1 (en) * | 2017-09-12 | 2020-04-23 | Ardea Biosciences, Inc. | CXCR-2 inhibitors for treating disorders |
EP3983340B1 (en) * | 2019-06-12 | 2023-08-02 | Nouryon Chemicals International B.V. | Method for isolating carboxylic acid from an aqueous side stream |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3457278A (en) * | 1964-10-15 | 1969-07-22 | Geigy Chem Corp | Cyclopropyl-4-sulfanilamido-pyrimidines |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
TR199801530T2 (xx) | 1996-02-13 | 1998-11-23 | Zeneca Limited | VEGF �nhibit�rleri olarak kinazolin t�revleri. |
JP4464466B2 (ja) | 1996-03-05 | 2010-05-19 | アストラゼネカ・ユーケイ・リミテッド | 4―アニリノキナゾリン誘導体 |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
FI981521A0 (fi) * | 1998-07-01 | 1998-07-01 | Orion Corp | Substituoidut beta-diketonit ja niiden käyttö |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
WO2001092224A1 (en) | 2000-05-31 | 2001-12-06 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
BR0112225A (pt) | 2000-07-07 | 2003-05-06 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto |
IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
GB0419235D0 (en) * | 2004-08-28 | 2004-09-29 | Astrazeneca Ab | Compounds |
BRPI0514735B8 (pt) * | 2004-08-28 | 2021-05-25 | Astrazeneca Ab | derivados de pirimidino sulfonamida como moduladores do receptor de quimiocina. |
JP5237115B2 (ja) * | 2006-01-19 | 2013-07-17 | オーキッド リサーチ ラボラトリーズ リミテッド | 新規複素環類 |
WO2008157273A1 (en) * | 2007-06-14 | 2008-12-24 | Smithkline Beecham Corporation | Chemical compounds |
TW201006824A (en) * | 2008-07-16 | 2010-02-16 | Astrazeneca Ab | Novel compound 395 |
EP2310354A2 (de) | 2008-07-25 | 2011-04-20 | Basf Se | 3-aminomethyl-1-cyclohexylamin und ein verfahren zu dessen herstellung |
TWI496773B (zh) * | 2010-07-13 | 2015-08-21 | Astrazeneca Ab | N-[2-[[(2,3-二氟苯基)甲基]硫基]-6-{[(1r,2s)-2,3-二羥基-1-甲基丙基]氧基}-4-嘧啶基]-1-三亞甲亞胺磺醯胺之新穎結晶型 |
SG10201605619XA (en) * | 2011-07-12 | 2016-08-30 | Astrazeneca Ab | N- (6- ( (2r,3s) -3,4-dihydroxybutan-2-yloxy) -2- (4 - fluorobenzylthio) pyrimidin- 4 - yl) -3- methylazetidine- 1 - sulfonamide as chemokine receptor modulator |
-
2012
- 2012-07-10 SG SG10201605619XA patent/SG10201605619XA/en unknown
- 2012-07-10 CN CN201280044385.0A patent/CN103781781B/zh active Active
- 2012-07-10 KR KR1020147000487A patent/KR101946664B1/ko active IP Right Grant
- 2012-07-10 LT LTEP16202983.9T patent/LT3255043T/lt unknown
- 2012-07-10 CA CA2841859A patent/CA2841859C/en active Active
- 2012-07-10 RS RS20210370A patent/RS61608B1/sr unknown
- 2012-07-10 ES ES16202983T patent/ES2861927T3/es active Active
- 2012-07-10 AU AU2012282316A patent/AU2012282316B2/en not_active Ceased
- 2012-07-10 BR BR112014000636-9A patent/BR112014000636B1/pt active IP Right Grant
- 2012-07-10 CU CUP2014000004A patent/CU24292B1/es unknown
- 2012-07-10 SI SI201231899T patent/SI3255043T1/sl unknown
- 2012-07-10 MY MYPI2014700061A patent/MY180039A/en unknown
- 2012-07-10 MX MX2013015085A patent/MX342874B/es active IP Right Grant
- 2012-07-10 PE PE2018000520A patent/PE20181069A1/es unknown
- 2012-07-10 DK DK16202983.9T patent/DK3255043T3/da active
- 2012-07-10 EP EP12735323.3A patent/EP2731945A1/en not_active Withdrawn
- 2012-07-10 MX MX2016000277A patent/MX353334B/es unknown
- 2012-07-10 EA EA201490077A patent/EA027821B1/ru not_active IP Right Cessation
- 2012-07-10 EP EP16202983.9A patent/EP3255043B1/en active Active
- 2012-07-10 JP JP2014519625A patent/JP6006308B2/ja active Active
- 2012-07-10 HU HUE16202983A patent/HUE053703T2/hu unknown
- 2012-07-10 PE PE2014000009A patent/PE20141944A1/es active IP Right Grant
- 2012-07-10 PL PL16202983T patent/PL3255043T3/pl unknown
- 2012-07-10 WO PCT/GB2012/051620 patent/WO2013008002A1/en active Application Filing
- 2012-07-10 PT PT162029839T patent/PT3255043T/pt unknown
- 2012-07-11 US US13/546,444 patent/US8735413B2/en active Active
- 2012-07-11 UY UY0001034191A patent/UY34191A/es not_active Application Discontinuation
- 2012-07-11 TW TW101124908A patent/TWI633098B/zh active
- 2012-07-11 TW TW106135796A patent/TWI659026B/zh not_active IP Right Cessation
- 2012-07-12 AR ARP120102531A patent/AR087168A1/es not_active Application Discontinuation
-
2013
- 2013-12-17 DO DO2013000308A patent/DOP2013000308A/es unknown
-
2014
- 2014-01-09 NI NI201400002A patent/NI201400002A/es unknown
- 2014-01-09 IL IL230398A patent/IL230398A/en active IP Right Grant
- 2014-01-09 CR CR20140007A patent/CR20140007A/es unknown
- 2014-01-10 CO CO14004182A patent/CO6852072A2/es active IP Right Grant
- 2014-01-10 EC ECSP14013130 patent/ECSP14013130A/es unknown
- 2014-01-10 CL CL2014000079A patent/CL2014000079A1/es unknown
- 2014-02-11 ZA ZA2014/01059A patent/ZA201401059B/en unknown
- 2014-04-15 US US14/253,288 patent/US9221782B2/en not_active Expired - Fee Related
- 2014-11-03 HK HK18105226.5A patent/HK1245779A1/zh unknown
-
2015
- 2015-12-28 US US14/980,754 patent/US9975881B2/en active Active
-
2016
- 2016-06-10 CU CUP2016000083A patent/CU20160083A7/es unknown
- 2016-07-01 JP JP2016131785A patent/JP6261666B2/ja active Active
- 2016-10-12 AU AU2016244246A patent/AU2016244246B2/en not_active Ceased
-
2021
- 2021-03-12 HR HRP20210413TT patent/HRP20210413T1/hr unknown
- 2021-04-07 CY CY20211100296T patent/CY1124329T1/el unknown
-
2022
- 2022-01-21 AR ARP220100128A patent/AR124688A2/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR124688A2 (es) | Una pirimidina sulfonamida o un tautómero del mismo, o una sal farmacéuticamente aceptable del mismo | |
MX2014000536A (es) | Compuestos de 4-piperidinilo para usarse como inhibidores de tanquirasa. | |
CR20160191A (es) | Compuestos derivados de piridilo bicíclicos fusionados a anillo como inhibidores de fgfr4 | |
CR20130560A (es) | Compuestos de bezotiazol y su uso farmacéutico | |
CO6531458A2 (es) | Nuevos compuestos de espiropiperidina | |
DOP2006000170A (es) | Nuevos derivados de espirocromanona | |
UY37028A (es) | Compuestos inhibidores de prostaglandina d sintasa ematopoyética (h-pgds | |
CO6382125A2 (es) | Inhibidores de proteína quinasa | |
GT201400111A (es) | Triazolopiridinas sustituidas | |
CR20150050A (es) | Sales y formas solidas de (s)-3-(4-((4-(morfolinometil) bencil) oxi)-1-oxoisoindolin-2-il) piperidin-2, 6-diona y composiciones que comprenden y métodos para utilizar las mismas | |
DOP2012000139A (es) | Nuevos compuestos de espiropiperidina | |
ECSP099775A (es) | Terapia de combinación con un compuesto actuando como un inhibidor del receptor adp plaquetario | |
AR079134A1 (es) | Procedimiento para la preparacion de (4,6-diamino -2-(1-(2- fluorobencil )-1h- pirazolo (3,4-b) piridin-3-il) pirimidin -5-il) metil carbamato de metilo y su purificacion para su uso como principio activo farmaceutico | |
CO6741217A2 (es) | Modulares de receptor de glucagón | |
EA201270216A1 (ru) | Фармацевтический состав | |
CU20140072A7 (es) | Derivados de dihidro-oxazina y dihidro-pirido-oxazina | |
PH12016502103A1 (en) | Novel disubstituted 1,2, 4-triazine compound | |
EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
EA201300250A1 (ru) | Оксадиазольные ингибиторы продуцирования лейкотриена | |
EA201590562A1 (ru) | Бензамиды | |
CL2019002900A1 (es) | Análogos de benzoazepina como agentes inhibidores de la tirosina cinasa de bruton. | |
MX349254B (es) | Compuestos para el tratamiento del sindrome metabolico. | |
UY31824A (es) | Nuevos compuestos | |
AR083755A1 (es) | Formas solidas del acido (s)-2-amino-3-(4-(-2-amino-6-((r)-1-(4-cloro-2-(3-metil-1h-pirazol-1-il)fenil)-2,2,2-trifluoroetoxi)pirimidin-4-il)fenil)propanoico | |
CL2011001829A1 (es) | 3'-n-desmetil-4''-o-(2-dietilaminoetanoil)-6-o-metil-9a-aza-9a-homoeritromicina a, sus sales y formas cristalinas 1, 2 y 3; proceso de preparacion; uso para tratar enfermedades inflamatorias; composicion farmaceutica; y composicion que ademas comprende otro compuesto activo. |