JP2015502979A5 - - Google Patents

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JP2015502979A5
JP2015502979A5 JP2014548785A JP2014548785A JP2015502979A5 JP 2015502979 A5 JP2015502979 A5 JP 2015502979A5 JP 2014548785 A JP2014548785 A JP 2014548785A JP 2014548785 A JP2014548785 A JP 2014548785A JP 2015502979 A5 JP2015502979 A5 JP 2015502979A5
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alkyl
hydrogen
substituted
tautomer
salt
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JP2015502979A (ja
JP6113185B2 (ja
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Priority claimed from PCT/US2012/000586 external-priority patent/WO2013095684A1/en
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JP2014548785A 2011-12-22 2012-12-21 テロメラーゼ基質およびテロメア長作用因子としてのグアニンアナログ Active JP6113185B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579575P 2011-12-22 2011-12-22
US61/579,575 2011-12-22
PCT/US2012/000586 WO2013095684A1 (en) 2011-12-22 2012-12-21 Guanine analogs as telomerase substrates and telomere length affectors

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JP2016251548A Division JP2017081961A (ja) 2011-12-22 2016-12-26 テロメラーゼ基質およびテロメア長作用因子としてのグアニンアナログ

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JP2015502979A JP2015502979A (ja) 2015-01-29
JP2015502979A5 true JP2015502979A5 (enExample) 2016-02-18
JP6113185B2 JP6113185B2 (ja) 2017-04-12

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JP2014548785A Active JP6113185B2 (ja) 2011-12-22 2012-12-21 テロメラーゼ基質およびテロメア長作用因子としてのグアニンアナログ
JP2016251548A Pending JP2017081961A (ja) 2011-12-22 2016-12-26 テロメラーゼ基質およびテロメア長作用因子としてのグアニンアナログ

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US (5) US9593137B2 (enExample)
EP (2) EP2794624B1 (enExample)
JP (2) JP6113185B2 (enExample)
CA (1) CA2857490C (enExample)
DK (2) DK2794624T3 (enExample)
ES (2) ES2734495T3 (enExample)
WO (1) WO2013095684A1 (enExample)

Families Citing this family (14)

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CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
AR105643A1 (es) 2015-08-10 2017-10-25 Merck Sharp & Dohme COMPUESTOS ANTIVIRALES DE FOSFODIAMIDA DE ÉSTER DE b-AMINOÁCIDO
WO2017100108A1 (en) 2015-12-10 2017-06-15 Merck Sharp & Dohme Corp. Antiviral phosphodiamide prodrugs of tenofovir
EP3390413B1 (en) 2015-12-15 2020-08-19 Merck Sharp & Dohme Corp. Antiviral oxime phosphoramide compounds
US10736908B2 (en) 2016-10-26 2020-08-11 Merck Sharp & Dohme Corp. Antiviral aryl-amide phosphodiamide compounds
KR20190100249A (ko) 2016-12-22 2019-08-28 머크 샤프 앤드 돔 코포레이션 항바이러스 벤질-아민 포스포디아미드 화합물
TWI820984B (zh) 2017-01-31 2023-11-01 美商基利科學股份有限公司 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型
JP7316261B2 (ja) 2017-07-28 2023-07-27 ジェロン・コーポレーション 骨髄異形成症候群の治療方法
EP3823629B1 (en) 2018-07-19 2024-12-25 Merck Sharp & Dohme LLC Phosphinic amide prodrugs of tenofovir
EP3887537A4 (en) 2018-11-29 2023-04-12 Geron Corporation METHODS OF TREATING MYELODYSPLASTIC SYNDROME
CN111205326B (zh) * 2020-02-13 2020-09-22 南京道尔医药科技有限公司 一种绿色环保的泰诺福韦制备方法
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