PL1716162T3 - Fosfoniany, manofosfonamidy i bisfosfonamidy do leczenia chorób wirusowych - Google Patents
Fosfoniany, manofosfonamidy i bisfosfonamidy do leczenia chorób wirusowychInfo
- Publication number
- PL1716162T3 PL1716162T3 PL04815956T PL04815956T PL1716162T3 PL 1716162 T3 PL1716162 T3 PL 1716162T3 PL 04815956 T PL04815956 T PL 04815956T PL 04815956 T PL04815956 T PL 04815956T PL 1716162 T3 PL1716162 T3 PL 1716162T3
- Authority
- PL
- Poland
- Prior art keywords
- monophosphonamidates
- bisphosphonamidates
- phosphonates
- treatment
- viral diseases
- Prior art date
Links
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53374503P | 2003-12-30 | 2003-12-30 | |
US59098704P | 2004-07-26 | 2004-07-26 | |
US60659504P | 2004-09-01 | 2004-09-01 | |
EP04815956A EP1716162B1 (en) | 2003-12-30 | 2004-12-29 | Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases |
PCT/US2004/043969 WO2005066189A1 (en) | 2003-12-30 | 2004-12-29 | Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1716162T3 true PL1716162T3 (pl) | 2011-02-28 |
Family
ID=34753695
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL10158740T PL2204374T3 (pl) | 2003-12-30 | 2004-12-29 | Fosfoniany nukleozydów i ich analogi do leczenia zakażeń HPV |
PL380828A PL212403B1 (pl) | 2003-12-30 | 2004-12-29 | Pochodna fosfonianowa, kompozycja farmaceutyczna zawierajaca ten zwiazek oraz jego zastosowanie w leczeniu guzów |
PL04815956T PL1716162T3 (pl) | 2003-12-30 | 2004-12-29 | Fosfoniany, manofosfonamidy i bisfosfonamidy do leczenia chorób wirusowych |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL10158740T PL2204374T3 (pl) | 2003-12-30 | 2004-12-29 | Fosfoniany nukleozydów i ich analogi do leczenia zakażeń HPV |
PL380828A PL212403B1 (pl) | 2003-12-30 | 2004-12-29 | Pochodna fosfonianowa, kompozycja farmaceutyczna zawierajaca ten zwiazek oraz jego zastosowanie w leczeniu guzów |
Country Status (28)
Country | Link |
---|---|
US (5) | US7553825B2 (pl) |
EP (2) | EP2204374B1 (pl) |
JP (2) | JP4949852B2 (pl) |
KR (2) | KR20120080240A (pl) |
CN (2) | CN1950383B (pl) |
AP (1) | AP2212A (pl) |
AT (1) | ATE478082T1 (pl) |
AU (2) | AU2004312546B2 (pl) |
BR (1) | BRPI0418251C1 (pl) |
CA (1) | CA2550222C (pl) |
CY (2) | CY1111050T1 (pl) |
DE (1) | DE602004028763D1 (pl) |
DK (2) | DK1716162T3 (pl) |
EA (1) | EA011304B1 (pl) |
ES (2) | ES2350983T3 (pl) |
HK (2) | HK1097276A1 (pl) |
HR (3) | HRP20060254A2 (pl) |
IL (1) | IL176407A (pl) |
IS (1) | IS2994B (pl) |
NO (2) | NO338001B1 (pl) |
NZ (1) | NZ548771A (pl) |
PL (3) | PL2204374T3 (pl) |
PT (2) | PT1716162E (pl) |
RS (2) | RS51476B (pl) |
SG (1) | SG149075A1 (pl) |
SI (2) | SI2204374T1 (pl) |
WO (1) | WO2005066189A1 (pl) |
ZA (1) | ZA200606049B (pl) |
Families Citing this family (68)
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US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
AU2003299492B2 (en) * | 2002-05-13 | 2010-06-10 | Metabasis Therapeutics, Inc. | Cyclic prodrugs of PMEA one of its analogues |
EP1504014B1 (en) | 2002-05-13 | 2015-12-02 | Metabasis Therapeutics, Inc. | Process for preparation of cyclic prodrugs of pmea and pmpa |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
KR101108439B1 (ko) | 2002-10-25 | 2012-01-31 | 포믹스 리미티드 | 화장료 및 약제용 거품제 |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
AU2004312546B2 (en) | 2003-12-30 | 2010-10-14 | Gilead Sciences, Inc. | Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases |
KR20070029196A (ko) * | 2004-06-08 | 2007-03-13 | 메타베이시스 테라퓨틱스, 인크. | 고리 에스테르의 루이스 산 매개 합성 |
WO2007002912A2 (en) * | 2005-06-29 | 2007-01-04 | Gilead Sciences, Inc. | Anti-proliferative compounds, compositions, and methods of use thereof |
WO2007002808A1 (en) * | 2005-06-29 | 2007-01-04 | Gilead Sciences, Inc. | Anti-nonmelanoma carcinoma compounds, compositions, and methods of use thereof |
KR101424832B1 (ko) * | 2006-05-16 | 2014-08-06 | 길리애드 사이언시즈, 인코포레이티드 | 악성 혈액 종양 치료 방법 및 악성 혈액 종양 치료용 조성물 |
WO2007137196A2 (en) * | 2006-05-19 | 2007-11-29 | Threshold Pharmaceuticals, Inc. | Tubulin binding anti cancer compounds and prodrugs thereof |
US8338593B2 (en) * | 2006-07-07 | 2012-12-25 | Gilead Sciences, Inc. | Modulators of toll-like receptor 7 |
EP2046121B1 (en) | 2006-07-14 | 2012-08-22 | Stiefel Research Australia Pty Ltd | Fatty acid pharmaceutical foam |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
CA2712120A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
TWI444384B (zh) | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
CA2760186C (en) | 2009-04-28 | 2019-10-29 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
EP2482788B1 (en) | 2009-10-02 | 2022-12-14 | Journey Medical Corporation | Topical tetracycline compositions |
CN102309984B (zh) * | 2011-07-22 | 2013-05-01 | 华东师范大学 | 一种磷酸酰胺类双功能催化剂及其合成方法 |
EP3578563B1 (en) | 2011-12-22 | 2021-04-14 | Geron Corporation | Guanine analogs as telomerase substrates and telomere length affectors |
CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
SG10201800188SA (en) | 2013-03-15 | 2018-02-27 | Univ California | Acyclic nucleoside phosphonate diesters |
CN104804042B (zh) * | 2014-01-24 | 2018-01-19 | 齐鲁制药有限公司 | 核苷酸膦酸酯类化合物、其药物组合物、制备方法及用途 |
EP3105238A4 (en) | 2014-02-13 | 2017-11-08 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
CN105518011B (zh) * | 2014-04-21 | 2018-07-27 | 四川海思科制药有限公司 | 氨基磷酸酯类衍生物制备方法及其中间体和中间体的制备方法 |
EP3164136A4 (en) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
ES2915381T3 (es) * | 2014-09-15 | 2022-06-22 | Univ California | Análogos de nucleótidos |
HRP20211456T1 (hr) | 2014-12-26 | 2021-12-24 | Emory University | Protuvirusni derivati n4-hidroksicitidina |
WO2016174081A1 (en) * | 2015-04-28 | 2016-11-03 | Ku Leuven Research & Development | Novel antiviral compounds, a process for their preparation, and their use for treating viral infections |
WO2017007701A1 (en) * | 2015-07-07 | 2017-01-12 | Merck Sharp & Dohme Corp. | Antiviral phosphodiamide compounds |
TWI620754B (zh) * | 2015-08-26 | 2018-04-11 | Method for preparing amino phosphate derivative and preparation method thereof | |
EP3350191B9 (en) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nucleotide analogs |
US10745428B2 (en) | 2015-12-10 | 2020-08-18 | Idenix Pharmaceuticals Llc | Antiviral phosphodiamide prodrugs of tenofovir |
WO2017106069A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Antiviral oxime phosphoramide compounds |
WO2017124896A1 (zh) * | 2016-01-19 | 2017-07-27 | 四川海思科制药有限公司 | 一种核苷类似物的磷酰胺酯前药及其应用 |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
WO2018055071A1 (en) * | 2016-09-23 | 2018-03-29 | Katholieke Universiteit Leuven | Prodrugs of fluorinated acyclic nucleoside phosphonates |
EP3532069A4 (en) | 2016-10-26 | 2020-05-13 | Merck Sharp & Dohme Corp. | ARYL-AMIDE PHOSPHODIAMIDE COMPOUNDS ANTIVIRALS |
WO2018119013A1 (en) | 2016-12-22 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antiviral aliphatic ester prodrugs of tenofovir |
BR112019012511A2 (pt) * | 2016-12-22 | 2019-11-19 | Idenix Pharmaceuticals Llc | compostos antivirais de benzil-amina fosfodiamida, composição farmacêutica e uso do composto |
CN108276444A (zh) * | 2017-01-06 | 2018-07-13 | 米文君 | 一类新的化合物及其用途 |
US20190374557A1 (en) * | 2017-02-28 | 2019-12-12 | Alexandre Vasilievich Ivachtchenko | Cyclobutyl (S)-2-[[[(R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphoryl]amino]-propanoates, and production process and application thereof |
KR102248165B1 (ko) | 2017-12-07 | 2021-05-06 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
WO2020018399A1 (en) | 2018-07-19 | 2020-01-23 | Merck Sharp & Dohme Corp. | Phosphinic amide prodrugs of tenofovir |
WO2021202669A2 (en) | 2020-04-01 | 2021-10-07 | Reyoung Corporation | Nucleoside and nucleotide conjugate compounds and uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2528490C2 (de) * | 1975-06-26 | 1983-04-28 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung saurer Protease |
US4816570A (en) * | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
ES2083580T3 (es) | 1990-06-13 | 1996-04-16 | Arnold Glazier | Profarmacos de fosforo. |
ES2118069T3 (es) * | 1990-09-14 | 1998-09-16 | Acad Of Science Czech Republic | Profarmacos de fosfonatos. |
US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
US6312662B1 (en) * | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
US20030072814A1 (en) * | 1999-12-16 | 2003-04-17 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of warts |
DE60118521T2 (de) | 2000-01-07 | 2006-10-12 | Universitaire Instelling Antwerpen | Purin derivate, ihre herstellung und verwendung |
DK2682397T3 (da) * | 2000-07-21 | 2017-06-19 | Gilead Sciences Inc | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
DE10236294A1 (de) * | 2001-08-17 | 2003-02-27 | Alstom Switzerland Ltd | Gasversorgungskontrolleinrichtung einer Gasspeicherkraftanlage |
CN1168449C (zh) * | 2002-12-23 | 2004-09-29 | 梁有国 | 抗人乳头瘤病毒感染的药物 |
AU2004312546B2 (en) | 2003-12-30 | 2010-10-14 | Gilead Sciences, Inc. | Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases |
-
2004
- 2004-12-29 AU AU2004312546A patent/AU2004312546B2/en active Active
- 2004-12-29 ES ES04815956T patent/ES2350983T3/es active Active
- 2004-12-29 AP AP2006003675A patent/AP2212A/xx active
- 2004-12-29 CN CN2004800394690A patent/CN1950383B/zh active Active
- 2004-12-29 PT PT04815956T patent/PT1716162E/pt unknown
- 2004-12-29 DK DK04815956.0T patent/DK1716162T3/da active
- 2004-12-29 DE DE602004028763T patent/DE602004028763D1/de active Active
- 2004-12-29 BR BRPI0418251A patent/BRPI0418251C1/pt active Search and Examination
- 2004-12-29 PL PL10158740T patent/PL2204374T3/pl unknown
- 2004-12-29 PT PT10158740T patent/PT2204374E/pt unknown
- 2004-12-29 PL PL380828A patent/PL212403B1/pl unknown
- 2004-12-29 RS RSP-2010/0490A patent/RS51476B/en unknown
- 2004-12-29 KR KR1020127013492A patent/KR20120080240A/ko not_active Application Discontinuation
- 2004-12-29 WO PCT/US2004/043969 patent/WO2005066189A1/en active Application Filing
- 2004-12-29 SI SI200431910T patent/SI2204374T1/sl unknown
- 2004-12-29 RS RS20120389A patent/RS52433B/en unknown
- 2004-12-29 EA EA200601263A patent/EA011304B1/ru not_active IP Right Cessation
- 2004-12-29 CN CN2010101456719A patent/CN101816664B/zh active Active
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- 2004-12-29 CA CA2550222A patent/CA2550222C/en active Active
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2005
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2006
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- 2006-07-31 KR KR1020067015535A patent/KR101214257B1/ko active IP Right Grant
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2007
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2009
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2011
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2015
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