HRP20120699T1 - Nukleozid-fosfonati i njihovi analozi za liječenje hpv infekcija - Google Patents
Nukleozid-fosfonati i njihovi analozi za liječenje hpv infekcija Download PDFInfo
- Publication number
- HRP20120699T1 HRP20120699T1 HRP20120699TT HRP20120699T HRP20120699T1 HR P20120699 T1 HRP20120699 T1 HR P20120699T1 HR P20120699T T HRP20120699T T HR P20120699TT HR P20120699 T HRP20120699 T HR P20120699T HR P20120699 T1 HRP20120699 T1 HR P20120699T1
- Authority
- HR
- Croatia
- Prior art keywords
- methyl
- butyl
- image
- pentyl
- carbon atoms
- Prior art date
Links
- -1 Nucleoside phosphonates Chemical class 0.000 title claims 6
- 208000009608 Papillomavirus Infections Diseases 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 3
- 241001631646 Papillomaviridae Species 0.000 claims abstract 2
- 208000015181 infectious disease Diseases 0.000 claims abstract 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 125000004398 2-methyl-2-butyl group Chemical group CC(C)(CC)* 0.000 claims 1
- 125000004918 2-methyl-2-pentyl group Chemical group CC(C)(CCC)* 0.000 claims 1
- 125000004922 2-methyl-3-pentyl group Chemical group CC(C)C(CC)* 0.000 claims 1
- 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims 1
- 125000004917 3-methyl-2-butyl group Chemical group CC(C(C)*)C 0.000 claims 1
- 125000004919 3-methyl-2-pentyl group Chemical group CC(C(C)*)CC 0.000 claims 1
- 125000004921 3-methyl-3-pentyl group Chemical group CC(CC)(CC)* 0.000 claims 1
- 125000004920 4-methyl-2-pentyl group Chemical group CC(CC(C)*)C 0.000 claims 1
- 125000006043 5-hexenyl group Chemical group 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- 229920002554 vinyl polymer Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Spoj Formule IA ili njegova farmaceutski prihvatljiva sol za uporabu u liječenju infekcija izazvanih papiloma virusom (HPV), naznačen time, ®toY1A i Y1B su -NH(Rx);RX je nezavisno R2;R2 je (a) etil supstituiran sa C(=O)OR4, gdje je R4 metil, etil, n-propil, i-propil, i-butil, s-butil, t-butil, 1-pentil,
Claims (5)
1. Spoj Formule IA ili njegova farmaceutski prihvatljiva sol za uporabu u liječenju infekcija izazvanih papiloma virusom (HPV),
[image]
naznačen time, što
Y1A i Y1B su -NH(Rx);
RX je nezavisno R2;
R2 je
(a) etil supstituiran sa C(=O)OR4, gdje je R4 metil, etil, n-propil, i-propil, i-butil, s-butil, t-butil, 1-pentil, 2-pentil, 3-pentil, 2-metil-2-butil, 3-metil-2-butil, 3-metil-1-butil, 2-metil-1-butil, 1-heksil, 2-heksil, 3-heksil, 2-metil-2-pentil, 3-metil-2-pentil, 4-metil-2-pentil, 3-metil-3-pentil, 2-metil-3-pentil, 2,3-dimetil-2-butil, 3,3-dimetil-2-butil, vinil, alil, ciklopentenil, 5-heksenil, etinil ili propargil;
(b) propil supstituiran sa C(=O)OR4, gdje je R4 alkil sa 1 do 18 ugljikovih atoma, alkenil sa 2 do 18 ugljikovih atoma, ili alkinil sa 2 do 18 ugljikovih atoma; ili
(c) metil supstituiran sa dva R3 gdje je jedan R3 -R5W3 a drugi R3 je C(=O)OR4; R4 je alkil sa 1 do 18 ugljikovih atoma, alkenil sa 2 do 18 ugljikovih atoma ili alkinil sa 2 do 18 ugljikovih atoma, gdje "alkil" sadrži normalne, sekundarne, tercijarne ili ciklične ugljikove atome, "alkenil" sadrži normalne, sekundarne, tercijarne ili ciklične atome sa najmanje jednim mjestom nezasićenja, "alkinil" sadrži normalne, sekundarne, tercijarne ili ciklične ugljikove atome sa najmanje jednim mjestom nezasićenja; R5 je metilen; i W3 je fenil.
2. Spoj za uporabu u skladu sa zahtjevom 1, naznačen time, što se bira od:
[image]
[image]
[image]
[image]
[image]
[image]
[image]
3. Spoj za uporabu u skladu sa zahtjevom 1, naznačen time, što ima formulu
[image]
4. Spoj za uporabu u skladu sa zahtjevom 1, naznačen time, što ima formulu
[image]
5. Spoj za uporabu, iz bilo kojeg od zahtjeva 1 do 4, naznačen time, što dalje podrazumijeva korištenje najmanje jednog drugog antivirusnog sredstva.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53374503P | 2003-12-30 | 2003-12-30 | |
| US59098704P | 2004-07-26 | 2004-07-26 | |
| US60659504P | 2004-09-01 | 2004-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120699T1 true HRP20120699T1 (hr) | 2012-09-30 |
Family
ID=34753695
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20060254A HRP20060254A2 (en) | 2003-12-30 | 2006-07-19 | Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases |
| HR20100626T HRP20100626T1 (hr) | 2003-12-30 | 2010-11-18 | Fosfonati, monofosfonamidati, bisfosfonamidati za liječenje virusnih bolesti |
| HRP20120699TT HRP20120699T1 (hr) | 2003-12-30 | 2012-09-04 | Nukleozid-fosfonati i njihovi analozi za liječenje hpv infekcija |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20060254A HRP20060254A2 (en) | 2003-12-30 | 2006-07-19 | Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases |
| HR20100626T HRP20100626T1 (hr) | 2003-12-30 | 2010-11-18 | Fosfonati, monofosfonamidati, bisfosfonamidati za liječenje virusnih bolesti |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US7553825B2 (hr) |
| EP (2) | EP2204374B1 (hr) |
| JP (2) | JP4949852B2 (hr) |
| KR (2) | KR20120080240A (hr) |
| CN (2) | CN1950383B (hr) |
| AP (1) | AP2212A (hr) |
| AT (1) | ATE478082T1 (hr) |
| AU (2) | AU2004312546B2 (hr) |
| BR (1) | BRPI0418251C1 (hr) |
| CA (1) | CA2550222C (hr) |
| CY (2) | CY1111050T1 (hr) |
| DE (1) | DE602004028763D1 (hr) |
| DK (2) | DK2204374T3 (hr) |
| EA (1) | EA011304B1 (hr) |
| ES (2) | ES2389602T3 (hr) |
| HK (2) | HK1097276A1 (hr) |
| HR (3) | HRP20060254A2 (hr) |
| IL (1) | IL176407A (hr) |
| IS (1) | IS2994B (hr) |
| NO (2) | NO338001B1 (hr) |
| NZ (1) | NZ548771A (hr) |
| PL (3) | PL212403B1 (hr) |
| PT (2) | PT1716162E (hr) |
| RS (2) | RS51476B (hr) |
| SG (1) | SG149075A1 (hr) |
| SI (2) | SI2204374T1 (hr) |
| WO (1) | WO2005066189A1 (hr) |
| ZA (1) | ZA200606049B (hr) |
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| DE2528490C2 (de) * | 1975-06-26 | 1983-04-28 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung saurer Protease |
| US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| DK0533833T3 (da) | 1990-06-13 | 1996-04-22 | Arnold Glazier | Phosphorprolægemidler |
| ATE167679T1 (de) * | 1990-09-14 | 1998-07-15 | Acad Of Science Czech Republic | Wirkstoffvorläufer von phosphonaten |
| US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
| US6312662B1 (en) * | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| US20030072814A1 (en) * | 1999-12-16 | 2003-04-17 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of warts |
| US20030187261A1 (en) * | 2000-01-07 | 2003-10-02 | Libor Havlicek | Purine derivatives, process for their preparation and use thereof |
| HRP20160074B1 (hr) * | 2000-07-21 | 2021-09-03 | Gilead Sciences, Inc. | Prolijekovi koji su fosfonatni analozi nukleotida i metode njihovog odabira te njihova priprava |
| DE10236294A1 (de) * | 2001-08-17 | 2003-02-27 | Alstom Switzerland Ltd | Gasversorgungskontrolleinrichtung einer Gasspeicherkraftanlage |
| CN1168449C (zh) * | 2002-12-23 | 2004-09-29 | 梁有国 | 抗人乳头瘤病毒感染的药物 |
| CN1950383B (zh) | 2003-12-30 | 2010-06-09 | 吉里德科学公司 | 用于治疗病毒性疾病的膦酸酯、单膦酸酰胺化物、双膦酸酰胺化物 |
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