AP2212A - Phosphonates, Monophosphonamidates, Bisphosphonamidates for the treatment of viral diseases. - Google Patents
Phosphonates, Monophosphonamidates, Bisphosphonamidates for the treatment of viral diseases.Info
- Publication number
- AP2212A AP2212A AP2006003675A AP2006003675A AP2212A AP 2212 A AP2212 A AP 2212A AP 2006003675 A AP2006003675 A AP 2006003675A AP 2006003675 A AP2006003675 A AP 2006003675A AP 2212 A AP2212 A AP 2212A
- Authority
- AP
- ARIPO
- Prior art keywords
- monophosphonamidates
- bisphosphonamidates
- phosphonates
- treatment
- viral diseases
- Prior art date
Links
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53374503P | 2003-12-30 | 2003-12-30 | |
| US59098704P | 2004-07-26 | 2004-07-26 | |
| US60659504P | 2004-09-01 | 2004-09-01 | |
| PCT/US2004/043969 WO2005066189A1 (en) | 2003-12-30 | 2004-12-29 | Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2006003675A0 AP2006003675A0 (en) | 2006-08-31 |
| AP2212A true AP2212A (en) | 2011-03-01 |
Family
ID=34753695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2006003675A AP2212A (en) | 2003-12-30 | 2004-12-29 | Phosphonates, Monophosphonamidates, Bisphosphonamidates for the treatment of viral diseases. |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US7553825B2 (hr) |
| EP (2) | EP2204374B1 (hr) |
| JP (2) | JP4949852B2 (hr) |
| KR (2) | KR20120080240A (hr) |
| CN (2) | CN1950383B (hr) |
| AP (1) | AP2212A (hr) |
| AT (1) | ATE478082T1 (hr) |
| AU (2) | AU2004312546B2 (hr) |
| BR (1) | BRPI0418251C1 (hr) |
| CA (1) | CA2550222C (hr) |
| CY (2) | CY1111050T1 (hr) |
| DE (1) | DE602004028763D1 (hr) |
| DK (2) | DK2204374T3 (hr) |
| EA (1) | EA011304B1 (hr) |
| ES (2) | ES2350983T3 (hr) |
| HK (2) | HK1097276A1 (hr) |
| HR (3) | HRP20060254A2 (hr) |
| IL (1) | IL176407A (hr) |
| IS (1) | IS2994B (hr) |
| NO (2) | NO338001B1 (hr) |
| NZ (1) | NZ548771A (hr) |
| PL (3) | PL1716162T3 (hr) |
| PT (2) | PT1716162E (hr) |
| RS (2) | RS51476B (hr) |
| SG (1) | SG149075A1 (hr) |
| SI (2) | SI1716162T1 (hr) |
| WO (1) | WO2005066189A1 (hr) |
| ZA (1) | ZA200606049B (hr) |
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| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| CA2485702C (en) * | 2002-05-13 | 2011-07-19 | Metabasis Therapeutics, Inc. | Novel phosphonic acid based prodrugs of pmea and its analogues |
| US7193081B2 (en) | 2002-05-13 | 2007-03-20 | Metabasis Therapeutics, Inc. | Process for preparation of cyclic prodrugs of PMEA and PMPA |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| KR101108439B1 (ko) | 2002-10-25 | 2012-01-31 | 포믹스 리미티드 | 화장료 및 약제용 거품제 |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| ES2350983T3 (es) | 2003-12-30 | 2011-01-28 | Gilead Sciences, Inc. | Fosfonatos, monofosfonamidatos, bisfosfonamidatos para el tratamiento de enfermedades víricas. |
| US7582758B2 (en) * | 2004-06-08 | 2009-09-01 | Metabasis Therapeutics, Inc. | Lewis acid mediated synthesis of cyclic esters |
| WO2007002912A2 (en) * | 2005-06-29 | 2007-01-04 | Gilead Sciences, Inc. | Anti-proliferative compounds, compositions, and methods of use thereof |
| WO2007002808A1 (en) * | 2005-06-29 | 2007-01-04 | Gilead Sciences, Inc. | Anti-nonmelanoma carcinoma compounds, compositions, and methods of use thereof |
| PT2020996E (pt) * | 2006-05-16 | 2012-02-20 | Gilead Sciences Inc | Método e composições para tratar neoplasias malignas hematológicas |
| WO2007137196A2 (en) * | 2006-05-19 | 2007-11-29 | Threshold Pharmaceuticals, Inc. | Tubulin binding anti cancer compounds and prodrugs thereof |
| TWI399377B (zh) * | 2006-07-07 | 2013-06-21 | Gilead Sciences Inc | 類鐸受體７之調節劑 |
| CA2659095C (en) | 2006-07-14 | 2015-04-28 | Stiefel Research Australia Pty Ltd | Fatty acid pharmaceutical foam |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| WO2009090495A2 (en) | 2007-12-07 | 2009-07-23 | Foamix Ltd. | Oil and liquid silicone foamable carriers and formulations |
| CA2712120A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| TWI444384B (zh) * | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
| CA2760186C (en) | 2009-04-28 | 2019-10-29 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| MX359879B (es) | 2009-10-02 | 2018-10-12 | Foamix Pharmaceuticals Ltd | Composiciones tópicas de tetraciclina. |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| CN102309984B (zh) * | 2011-07-22 | 2013-05-01 | 华东师范大学 | 一种磷酸酰胺类双功能催化剂及其合成方法 |
| EP2794624B1 (en) | 2011-12-22 | 2019-05-15 | Geron Corporation | Guanine analogs as telomerase substrates and telomere length affectors |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| EA201892769A3 (ru) | 2013-03-15 | 2019-08-30 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Сложные диэфиры ациклических нуклеозидфосфонатов |
| CN104804042B (zh) * | 2014-01-24 | 2018-01-19 | 齐鲁制药有限公司 | 核苷酸膦酸酯类化合物、其药物组合物、制备方法及用途 |
| US10449210B2 (en) | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
| WO2015161785A1 (zh) * | 2014-04-21 | 2015-10-29 | 四川海思科制药有限公司 | 氨基磷酸酯类衍生物制备方法及其中间体和中间体的制备方法 |
| US9994600B2 (en) | 2014-07-02 | 2018-06-12 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
| AU2015317972B2 (en) | 2014-09-15 | 2019-10-17 | The Regents Of The University Of California | Nucleotide analogs |
| SG11201705069YA (en) | 2014-12-26 | 2017-07-28 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| CN107820499B (zh) * | 2015-04-28 | 2022-11-11 | 鲁汶大学研究与开发部 | 抗病毒化合物、其制备工艺、以及其用于治疗病毒感染的用途 |
| WO2017007701A1 (en) * | 2015-07-07 | 2017-01-12 | Merck Sharp & Dohme Corp. | Antiviral phosphodiamide compounds |
| TWI620754B (zh) * | 2015-08-26 | 2018-04-11 | Method for preparing amino phosphate derivative and preparation method thereof | |
| EP3350191B9 (en) | 2015-09-15 | 2021-12-22 | The Regents of the University of California | Nucleotide analogs |
| US10745428B2 (en) | 2015-12-10 | 2020-08-18 | Idenix Pharmaceuticals Llc | Antiviral phosphodiamide prodrugs of tenofovir |
| WO2017106069A1 (en) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Antiviral oxime phosphoramide compounds |
| CN107849075A (zh) * | 2016-01-19 | 2018-03-27 | 四川海思科制药有限公司 | 一种核苷类似物的磷酰胺酯前药及其应用 |
| US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
| CN108137630A (zh) * | 2016-09-23 | 2018-06-08 | 鲁汶天主教大学 | 氟化无环核苷膦酸酯的前药 |
| US10736908B2 (en) | 2016-10-26 | 2020-08-11 | Merck Sharp & Dohme Corp. | Antiviral aryl-amide phosphodiamide compounds |
| BR112019013017A2 (pt) | 2016-12-22 | 2020-01-14 | Idenix Pharmaceuticals Llc | compostos de éster alifático antiviral de tenofovir ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica e uso dos mesmos |
| EP3558322B1 (en) | 2016-12-22 | 2021-09-29 | Merck Sharp & Dohme Corp. | Antiviral benzyl-amine phosphodiamide compounds |
| CN108276444A (zh) * | 2017-01-06 | 2018-07-13 | 米文君 | 一类新的化合物及其用途 |
| US20190374557A1 (en) * | 2017-02-28 | 2019-12-12 | Alexandre Vasilievich Ivachtchenko | Cyclobutyl (S)-2-[[[(R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphoryl]amino]-propanoates, and production process and application thereof |
| GB2590198B (en) | 2017-12-07 | 2022-02-23 | Univ Emory | N4-hydroxycytidine derivatives and anti-viral uses related thereto |
| RU2020126177A (ru) | 2018-01-09 | 2022-02-10 | Лиганд Фармасьютикалз, Инк. | Ацетальные соединения и их терапевтическое применение |
| WO2020018399A1 (en) | 2018-07-19 | 2020-01-23 | Merck Sharp & Dohme Corp. | Phosphinic amide prodrugs of tenofovir |
| WO2021202669A2 (en) | 2020-04-01 | 2021-10-07 | Reyoung Corporation | Nucleoside and nucleotide conjugate compounds and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030072814A1 (en) * | 1999-12-16 | 2003-04-17 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of warts |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2528490C2 (de) * | 1975-06-26 | 1983-04-28 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung saurer Protease |
| US4816570A (en) * | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| CA2083386C (en) | 1990-06-13 | 1999-02-16 | Arnold Glazier | Phosphorous prodrugs |
| DE10399025I2 (de) | 1990-09-14 | 2007-11-08 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
| US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
| US6312662B1 (en) * | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| AU3540101A (en) | 2000-01-07 | 2001-07-16 | Universitaire Instelling Antwerpen | Purine derivatives, process for their preparation and use thereof |
| PL213214B1 (pl) * | 2000-07-21 | 2013-01-31 | Gilead Sciences | Diastereoizomerycznie wzbogacone proleki fosfonianowych analogów nukleotydowych oraz kompozycje zawierajace takie zwiazki |
| DE10236294A1 (de) * | 2001-08-17 | 2003-02-27 | Alstom Switzerland Ltd | Gasversorgungskontrolleinrichtung einer Gasspeicherkraftanlage |
| CN1168449C (zh) * | 2002-12-23 | 2004-09-29 | 梁有国 | 抗人乳头瘤病毒感染的药物 |
| ES2350983T3 (es) | 2003-12-30 | 2011-01-28 | Gilead Sciences, Inc. | Fosfonatos, monofosfonamidatos, bisfosfonamidatos para el tratamiento de enfermedades víricas. |
-
2004
- 2004-12-29 ES ES04815956T patent/ES2350983T3/es active Active
- 2004-12-29 SI SI200431534T patent/SI1716162T1/sl unknown
- 2004-12-29 EP EP10158740A patent/EP2204374B1/en active Active
- 2004-12-29 RS RSP-2010/0490A patent/RS51476B/en unknown
- 2004-12-29 PT PT04815956T patent/PT1716162E/pt unknown
- 2004-12-29 JP JP2006547579A patent/JP4949852B2/ja active Active
- 2004-12-29 PL PL04815956T patent/PL1716162T3/pl unknown
- 2004-12-29 PL PL380828A patent/PL212403B1/pl unknown
- 2004-12-29 DE DE602004028763T patent/DE602004028763D1/de active Active
- 2004-12-29 SI SI200431910T patent/SI2204374T1/sl unknown
- 2004-12-29 AT AT04815956T patent/ATE478082T1/de active
- 2004-12-29 RS RS20120389A patent/RS52433B/en unknown
- 2004-12-29 DK DK10158740.0T patent/DK2204374T3/da active
- 2004-12-29 DK DK04815956.0T patent/DK1716162T3/da active
- 2004-12-29 BR BRPI0418251A patent/BRPI0418251C1/pt active Search and Examination
- 2004-12-29 ES ES10158740T patent/ES2389602T3/es active Active
- 2004-12-29 NZ NZ548771A patent/NZ548771A/en unknown
- 2004-12-29 PL PL10158740T patent/PL2204374T3/pl unknown
- 2004-12-29 KR KR1020127013492A patent/KR20120080240A/ko not_active Application Discontinuation
- 2004-12-29 CN CN2004800394690A patent/CN1950383B/zh active Active
- 2004-12-29 WO PCT/US2004/043969 patent/WO2005066189A1/en active Application Filing
- 2004-12-29 EA EA200601263A patent/EA011304B1/ru not_active IP Right Cessation
- 2004-12-29 AU AU2004312546A patent/AU2004312546B2/en active Active
- 2004-12-29 SG SG200809660-4A patent/SG149075A1/en unknown
- 2004-12-29 CN CN2010101456719A patent/CN101816664B/zh active Active
- 2004-12-29 CA CA2550222A patent/CA2550222C/en active Active
- 2004-12-29 US US11/026,303 patent/US7553825B2/en active Active
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2006
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- 2006-07-21 ZA ZA2006/06049A patent/ZA200606049B/en unknown
- 2006-07-28 NO NO20063479A patent/NO338001B1/no unknown
- 2006-07-31 KR KR1020067015535A patent/KR101214257B1/ko active IP Right Grant
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2007
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2009
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2011
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030072814A1 (en) * | 1999-12-16 | 2003-04-17 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of warts |
Non-Patent Citations (3)
| Title |
|---|
| CHRISTENSEN ET AL.: "In vivo anti-papilomavirus activity of nucleoside analogues inciudinh cidofovir on CRPV-induced rabbit papillomas" ANTIVIRAL RESEARCH, vol. 48, 2000, pages 131-142 * |
| KEITH ET AL.: "Evaluation of Nucleoside Phosphonates and Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication" ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 47, no. 7, July 2003 (2003-07), pages 2193-2198 * |
| SNOECK ET AL.: "Antivaccinia Activities of Acyclic Nucleoside Phosphonate Derivatives in Epithelial Cells and Organotypic Cultures" ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 46, no. 11, November 2002 (2002-11), pages 3356-3361 * |
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