|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4421865A
(en)
|
1981-06-08 |
1983-12-20 |
Standard Oil Company (Sohio) |
Selective hydrogen-deuterium interchange using ion exchange resins
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5149820A
(en)
|
1987-03-11 |
1992-09-22 |
Norsk Hydro A.S. |
Deuterated compounds
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
KR0166088B1
(ko)
|
1990-01-23 |
1999-01-15 |
. |
수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
WO1995003009A1
(en)
|
1993-07-22 |
1995-02-02 |
Oculex Pharmaceuticals, Inc. |
Method of treatment of macular degeneration
|
|
US5770589A
(en)
|
1993-07-27 |
1998-06-23 |
The University Of Sydney |
Treatment of macular degeneration
|
|
CN1087725C
(zh)
|
1994-03-25 |
2002-07-17 |
同位素技术有限公司 |
用氘代方法增强药物效果
|
|
US6334997B1
(en)
|
1994-03-25 |
2002-01-01 |
Isotechnika, Inc. |
Method of using deuterated calcium channel blockers
|
|
US6221335B1
(en)
|
1994-03-25 |
2001-04-24 |
Isotechnika, Inc. |
Method of using deuterated calcium channel blockers
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
IT1274549B
(it)
|
1995-05-23 |
1997-07-17 |
Indena Spa |
Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
|
|
US5800819A
(en)
|
1996-01-25 |
1998-09-01 |
National Institute For Pharmaceutical Research And Development Federal Ministry Of Science And Technology |
Piper guineense, pterocarpus osun, eugenia caryophyllata, and sorghum bicolor extracts for treating sickle cell disease
|
|
HU228769B1
(en)
|
1996-07-24 |
2013-05-28 |
Celgene Corp |
Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
|
|
US6281230B1
(en)
|
1996-07-24 |
2001-08-28 |
Celgene Corporation |
Isoindolines, method of use, and pharmaceutical compositions
|
|
PT2177517E
(pt)
|
1996-07-24 |
2011-11-10 |
Celgene Corp |
2-(2,6-dioxopiperidin-3-il)-ftalimida amino-substituída para redução dos níveis de tnf-alfa
|
|
US5635517B1
(en)
|
1996-07-24 |
1999-06-29 |
Celgene Corp |
Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
|
|
US5955476A
(en)
|
1997-11-18 |
1999-09-21 |
Celgene Corporation |
Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
|
|
US20010006973A1
(en)
|
1998-03-16 |
2001-07-05 |
Hon-Wah Man |
1-oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels
|
|
US6015803A
(en)
|
1998-05-04 |
2000-01-18 |
Wirostko; Emil |
Antibiotic treatment of age-related macular degeneration
|
|
US6225348B1
(en)
|
1998-08-20 |
2001-05-01 |
Alfred W. Paulsen |
Method of treating macular degeneration with a prostaglandin derivative
|
|
US6001368A
(en)
|
1998-09-03 |
1999-12-14 |
Protein Technologies International, Inc. |
Method for inhibiting or reducing the risk of macular degeneration
|
|
US6440710B1
(en)
|
1998-12-10 |
2002-08-27 |
The Scripps Research Institute |
Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
|
|
DK1104760T3
(da)
|
1999-12-03 |
2003-06-30 |
Pfizer Prod Inc |
Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
|
|
AR026748A1
(es)
|
1999-12-08 |
2003-02-26 |
Vertex Pharma |
Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
|
|
US7182953B2
(en)
|
1999-12-15 |
2007-02-27 |
Celgene Corporation |
Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders
|
|
US6458810B1
(en)
|
2000-11-14 |
2002-10-01 |
George Muller |
Pharmaceutically active isoindoline derivatives
|
|
US7091353B2
(en)
|
2000-12-27 |
2006-08-15 |
Celgene Corporation |
Isoindole-imide compounds, compositions, and uses thereof
|
|
US20030045552A1
(en)
|
2000-12-27 |
2003-03-06 |
Robarge Michael J. |
Isoindole-imide compounds, compositions, and uses thereof
|
|
AU2002343220A1
(en)
|
2001-11-09 |
2003-05-19 |
Matsushita Electric Industrial Co., Ltd. |
Moving picture coding method and apparatus
|
|
US7968569B2
(en)
|
2002-05-17 |
2011-06-28 |
Celgene Corporation |
Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
|
US7323479B2
(en)
|
2002-05-17 |
2008-01-29 |
Celgene Corporation |
Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
|
|
US7393862B2
(en)
|
2002-05-17 |
2008-07-01 |
Celgene Corporation |
Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
|
|
US9415102B2
(en)
|
2002-09-06 |
2016-08-16 |
Alexion Pharmaceuticals, Inc. |
High concentration formulations of anti-C5 antibodies
|
|
US7189740B2
(en)
|
2002-10-15 |
2007-03-13 |
Celgene Corporation |
Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
|
|
US20050203142A1
(en)
|
2002-10-24 |
2005-09-15 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
|
|
US20040091455A1
(en)
|
2002-10-31 |
2004-05-13 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration
|
|
US7563810B2
(en)
|
2002-11-06 |
2009-07-21 |
Celgene Corporation |
Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
|
|
TW200413273A
(en)
|
2002-11-15 |
2004-08-01 |
Wako Pure Chem Ind Ltd |
Heavy hydrogenation method of heterocyclic rings
|
|
UA83504C2
(en)
|
2003-09-04 |
2008-07-25 |
Селджин Корпорейшн |
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
|
|
US20050100529A1
(en)
|
2003-11-06 |
2005-05-12 |
Zeldis Jerome B. |
Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders
|
|
NZ548049A
(en)
|
2003-12-02 |
2009-01-31 |
Celgene Corp |
Methods and compositions for the treatment and management of hemoglobinopathy and anemia
|
|
US20050143344A1
(en)
|
2003-12-30 |
2005-06-30 |
Zeldis Jerome B. |
Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
|
|
MXPA06010699A
(es)
|
2004-03-22 |
2006-12-15 |
Celgene Corp |
Metodos de usos y composiciones que contienen compuestos inmunomoduladores para el tratamiento y manejo de enfermedades o alteraciones de la piel.
|
|
US20050222209A1
(en)
|
2004-04-01 |
2005-10-06 |
Zeldis Jerome B |
Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
|
|
CN1968695A
(zh)
|
2004-04-14 |
2007-05-23 |
细胞基因公司 |
含有用于治疗和控制骨髓发育不良综合征的免疫调节化合物的组合物和使用方法
|
|
JP2007533761A
(ja)
|
2004-04-23 |
2007-11-22 |
セルジーン・コーポレーション |
肺高血圧症を治療し管理するための、免疫調節性化合物の使用方法及び免疫調節性化合物を含む組成物
|
|
ZA200704784B
(en)
|
2004-11-12 |
2008-10-29 |
Celgene Corp |
Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
|
|
CA2588597A1
(en)
|
2004-11-23 |
2006-06-01 |
Celgene Corporation |
Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury
|
|
CN101111234A
(zh)
|
2004-12-01 |
2008-01-23 |
细胞基因公司 |
包含免疫调节化合物的组合物及其治疗免疫缺陷疾病的用途
|
|
US20060270707A1
(en)
|
2005-05-24 |
2006-11-30 |
Zeldis Jerome B |
Methods and compositions using 4-[(cyclopropanecarbonylamino)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione for the treatment or prevention of cutaneous lupus
|
|
JP5366544B2
(ja)
|
2005-06-30 |
2013-12-11 |
セルジーン コーポレイション |
4−アミノ−2−(2,6−ジオキソピペリジン−3−イル)イソインドリン−1,3−ジオン化合物を調製するための方法
|
|
ES2434946T3
(es)
|
2005-08-31 |
2013-12-18 |
Celgene Corporation |
Compuestos de isoindol imida y composiciones que los comprenden y métodos para usarlo
|
|
JP2009507030A
(ja)
|
2005-09-01 |
2009-02-19 |
セルジーン・コーポレーション |
ワクチン及び抗感染症療法のための免疫調節性化合物の免疫学的使用
|
|
US20070066512A1
(en)
|
2005-09-12 |
2007-03-22 |
Dominique Verhelle |
Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels
|
|
US7598273B2
(en)
|
2005-10-06 |
2009-10-06 |
Auspex Pharmaceuticals, Inc |
Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties
|
|
US7750168B2
(en)
|
2006-02-10 |
2010-07-06 |
Sigma-Aldrich Co. |
Stabilized deuteroborane-tetrahydrofuran complex
|
|
US20080064876A1
(en)
|
2006-05-16 |
2008-03-13 |
Muller George W |
Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
|
|
US8877780B2
(en)
|
2006-08-30 |
2014-11-04 |
Celgene Corporation |
5-substituted isoindoline compounds
|
|
NZ575061A
(en)
|
2006-08-30 |
2011-10-28 |
Celgene Corp |
5-substituted isoindoline compounds
|
|
WO2008033567A1
(en)
|
2006-09-15 |
2008-03-20 |
Celgene Corporation |
N-methylaminomethyl isoindole compounds and compositions comprising and methods of using the same
|
|
LT2420498T
(lt)
*
|
2006-09-26 |
2017-10-25 |
Celgene Corporation |
5-pakeistieji chinazolinono dariniai, kaip priešvėžiniai agentai
|
|
AU2008229383B2
(en)
|
2007-03-20 |
2013-09-05 |
Celgene Corporation |
4'-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
|
|
US20090022706A1
(en)
|
2007-07-20 |
2009-01-22 |
Auspex Pharmaceuticals, Inc. |
Substituted cyclohexenes
|
|
KR100879636B1
(ko)
|
2007-08-22 |
2009-01-21 |
한국과학기술연구원 |
세로토닌 5―ht₃a 길항적 효과를 갖는 퀴나졸린유도체 함유 약제 조성물
|
|
US8288414B2
(en)
|
2007-09-12 |
2012-10-16 |
Deuteria Pharmaceuticals, Inc. |
Deuterium-enriched lenalidomide
|
|
US8354417B2
(en)
|
2007-09-26 |
2013-01-15 |
Celgene Corporation |
Solid forms comprising 3-(2,5-dimethyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the same, and methods of using the same
|
|
ES2523925T3
(es)
|
2007-09-26 |
2014-12-02 |
Celgene Corporation |
Derivados de quinazolinona sustituidos en posición 6, 7 u 8 y composiciones que los contienen y métodos de uso de los mismos
|
|
US9422234B2
(en)
|
2007-11-30 |
2016-08-23 |
The Johns Hopkins University |
Prostate specific membrane antigen (PSMA) targeted nanoparticles for therapy of prostate cancer
|
|
US7964354B2
(en)
|
2007-12-20 |
2011-06-21 |
Celgene Corporation |
Use of micro-RNA as a biomarker of immunomodulatory drug activity
|
|
WO2009097120A1
(en)
|
2008-01-29 |
2009-08-06 |
Celgene Corporation |
Methods using immunomodulatory compounds for modulating level of cd59
|
|
US20090232796A1
(en)
|
2008-02-20 |
2009-09-17 |
Corral Laura G |
Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand
|
|
US20090298882A1
(en)
|
2008-05-13 |
2009-12-03 |
Muller George W |
Thioxoisoindoline compounds and compositions comprising and methods of using the same
|
|
EP2358697B1
(en)
|
2008-10-29 |
2015-10-21 |
Celgene Corporation |
Isoindoline compounds for use in the treatment of cancer.
|
|
ES2444433T3
(es)
*
|
2008-11-14 |
2014-02-25 |
Concert Pharmaceuticals, Inc. |
Derivados de dioxopiperidinil-ftalimida sustituidos
|
|
US9045453B2
(en)
|
2008-11-14 |
2015-06-02 |
Concert Pharmaceuticals, Inc. |
Substituted dioxopiperidinyl phthalimide derivatives
|
|
US20120053159A1
(en)
|
2009-02-11 |
2012-03-01 |
Muller George W |
Isotopologues of lenalidomide
|
|
WO2010093605A1
(en)
|
2009-02-11 |
2010-08-19 |
Celgene Corporation |
Isotopologues of thalidomide
|
|
WO2011066544A2
(en)
|
2009-11-30 |
2011-06-03 |
Pharmatrophix, Inc. |
Deuterated compounds useful for treating neurodegenerative diseases
|
|
RU2012131164A
(ru)
|
2009-12-22 |
2014-01-27 |
Селджин Корпорейшн |
(метилсульфонил)этил-бензол-изоиндолиновые производные и их терапевтическое применение
|
|
SG10201501062SA
(en)
|
2010-02-11 |
2015-04-29 |
Celgene Corp |
Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
|
|
WO2012027065A2
(en)
|
2010-08-27 |
2012-03-01 |
Celgene Corporation |
Combination therapy for treatment of disease
|
|
AU2011329619A1
(en)
|
2010-11-18 |
2013-05-02 |
Deuteria Pharmaceuticals, Inc. |
3-deutero-pomalidomide
|
|
WO2012079022A1
(en)
|
2010-12-10 |
2012-06-14 |
Concert Pharmaceuticals, Inc. |
Substituted dioxopiperidinyl phthalimide derivatives
|
|
EP2683383B1
(en)
|
2011-03-11 |
2017-11-29 |
Celgene Corporation |
Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2-6-dione in treatment of immune-related and inflammatory diseases
|
|
RS56770B1
(sr)
|
2011-03-11 |
2018-04-30 |
Celgene Corp |
Čvrste forme 3-(5-amino-2-metil-4-okso-4h-hinazolin-3-il)-piperidin-2,6-diona i njihove farmaceutske smeše i upotrebe
|
|
AU2012236655B2
(en)
|
2011-03-28 |
2016-09-22 |
Deuterx, Llc, |
2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
|
|
EP3096142A3
(en)
|
2011-04-29 |
2017-03-08 |
Celgene Corporation |
Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
|
|
CA2877736C
(en)
|
2012-06-29 |
2021-12-07 |
Celgene Corporation |
Methods for determining drug efficacy using cereblon-associated proteins
|
|
CA3108974C
(en)
|
2012-08-09 |
2023-04-04 |
Celgene Corporation |
Processes for the preparation of (s)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable forms thereof
|
|
CN114939119A
(zh)
|
2012-08-09 |
2022-08-26 |
细胞基因公司 |
免疫相关和炎性疾病的治疗
|
|
TR201904785T4
(tr)
|
2012-08-09 |
2019-05-21 |
Celgene Corp |
(S)-3-(4-((4-MORFOLINOMETİL)BENZİL)OKSİ)-1-OKSOİZOİNDOLİN-2-il)PİPERİDİN-2,6-DİON HİDROKLORİDİN BİR KATI FORMU.
|
|
CN104755472A
(zh)
*
|
2012-09-04 |
2015-07-01 |
细胞基因公司 |
3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4h)-基)哌啶-2,6-二酮的同位素体及其制备方法
|
|
US9694015B2
(en)
|
2012-09-10 |
2017-07-04 |
Celgene Corporation |
Methods for the treatment of locally advanced breast cancer
|
|
CA2935495C
(en)
|
2013-01-14 |
2021-04-20 |
Deuterx, Llc |
3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
|
|
US9695145B2
(en)
|
2013-01-22 |
2017-07-04 |
Celgene Corporation |
Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
|
|
US9290475B2
(en)
|
2013-03-14 |
2016-03-22 |
Deuterx, Llc |
3-(substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same
|