ES2734495T3 - Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros - Google Patents

Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros Download PDF

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Publication number
ES2734495T3
ES2734495T3 ES12859248T ES12859248T ES2734495T3 ES 2734495 T3 ES2734495 T3 ES 2734495T3 ES 12859248 T ES12859248 T ES 12859248T ES 12859248 T ES12859248 T ES 12859248T ES 2734495 T3 ES2734495 T3 ES 2734495T3
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alkyl
substituted
compound
cancer
compounds
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English (en)
Spanish (es)
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Sergei Gryaznov
Ronald Pruzan
Krisztina Pongracz
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Geron Corp
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Geron Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES12859248T 2011-12-22 2012-12-21 Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros Active ES2734495T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579575P 2011-12-22 2011-12-22
PCT/US2012/000586 WO2013095684A1 (en) 2011-12-22 2012-12-21 Guanine analogs as telomerase substrates and telomere length affectors

Publications (1)

Publication Number Publication Date
ES2734495T3 true ES2734495T3 (es) 2019-12-10

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Family Applications (2)

Application Number Title Priority Date Filing Date
ES12859248T Active ES2734495T3 (es) 2011-12-22 2012-12-21 Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
ES19173147T Active ES2874774T3 (es) 2011-12-22 2012-12-21 Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros

Family Applications After (1)

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ES19173147T Active ES2874774T3 (es) 2011-12-22 2012-12-21 Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros

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Country Link
US (5) US9593137B2 (enExample)
EP (2) EP2794624B1 (enExample)
JP (2) JP6113185B2 (enExample)
CA (1) CA2857490C (enExample)
DK (2) DK2794624T3 (enExample)
ES (2) ES2734495T3 (enExample)
WO (1) WO2013095684A1 (enExample)

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WO2013095684A1 (en) * 2011-12-22 2013-06-27 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
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US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
AR105643A1 (es) 2015-08-10 2017-10-25 Merck Sharp & Dohme COMPUESTOS ANTIVIRALES DE FOSFODIAMIDA DE ÉSTER DE b-AMINOÁCIDO
WO2017100108A1 (en) 2015-12-10 2017-06-15 Merck Sharp & Dohme Corp. Antiviral phosphodiamide prodrugs of tenofovir
EP3390413B1 (en) 2015-12-15 2020-08-19 Merck Sharp & Dohme Corp. Antiviral oxime phosphoramide compounds
US10736908B2 (en) 2016-10-26 2020-08-11 Merck Sharp & Dohme Corp. Antiviral aryl-amide phosphodiamide compounds
KR20190100249A (ko) 2016-12-22 2019-08-28 머크 샤프 앤드 돔 코포레이션 항바이러스 벤질-아민 포스포디아미드 화합물
TWI820984B (zh) 2017-01-31 2023-11-01 美商基利科學股份有限公司 替諾福韋埃拉酚胺(tenofovir alafenamide)之晶型
JP7316261B2 (ja) 2017-07-28 2023-07-27 ジェロン・コーポレーション 骨髄異形成症候群の治療方法
EP3823629B1 (en) 2018-07-19 2024-12-25 Merck Sharp & Dohme LLC Phosphinic amide prodrugs of tenofovir
EP3887537A4 (en) 2018-11-29 2023-04-12 Geron Corporation METHODS OF TREATING MYELODYSPLASTIC SYNDROME
CN111205326B (zh) * 2020-02-13 2020-09-22 南京道尔医药科技有限公司 一种绿色环保的泰诺福韦制备方法
EP4463151A4 (en) 2022-01-19 2025-10-01 Univ Northwestern Agents Targeting Telomerase Reverse Transcriptase (TERT) to Treat Cancer and Sensitize Cancer Cells to Genotoxic Therapy

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US11279720B2 (en) 2022-03-22
US20190106447A1 (en) 2019-04-11
DK2794624T3 (da) 2019-07-22
EP2794624A1 (en) 2014-10-29
JP2015502979A (ja) 2015-01-29
US9593137B2 (en) 2017-03-14
US20150299232A1 (en) 2015-10-22
US12398162B2 (en) 2025-08-26
EP3578563B1 (en) 2021-04-14
US10035814B2 (en) 2018-07-31
US10562926B2 (en) 2020-02-18
JP6113185B2 (ja) 2017-04-12
EP2794624A4 (en) 2015-04-29
CA2857490A1 (en) 2013-06-27
WO2013095684A1 (en) 2013-06-27
EP2794624B1 (en) 2019-05-15
ES2874774T3 (es) 2021-11-05
HK1205515A1 (en) 2015-12-18
US20170233419A1 (en) 2017-08-17
US20200283461A1 (en) 2020-09-10
JP2017081961A (ja) 2017-05-18
US20220306660A1 (en) 2022-09-29
CA2857490C (en) 2020-03-31
EP3578563A1 (en) 2019-12-11
DK3578563T3 (da) 2021-05-31

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