JP2014534218A5 - - Google Patents
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- Publication number
- JP2014534218A5 JP2014534218A5 JP2014538927A JP2014538927A JP2014534218A5 JP 2014534218 A5 JP2014534218 A5 JP 2014534218A5 JP 2014538927 A JP2014538927 A JP 2014538927A JP 2014538927 A JP2014538927 A JP 2014538927A JP 2014534218 A5 JP2014534218 A5 JP 2014534218A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- tnf
- fragment
- seq
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550587P | 2011-10-24 | 2011-10-24 | |
| US61/550,587 | 2011-10-24 | ||
| PCT/US2012/061690 WO2013063114A1 (en) | 2011-10-24 | 2012-10-24 | Immunobinders directed against tnf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014534218A JP2014534218A (ja) | 2014-12-18 |
| JP2014534218A5 true JP2014534218A5 (https=) | 2015-12-17 |
Family
ID=47144149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014538927A Pending JP2014534218A (ja) | 2011-10-24 | 2012-10-24 | Ｔｎｆを標的とする免疫結合剤 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9803009B2 (https=) |
| EP (1) | EP2771362A1 (https=) |
| JP (1) | JP2014534218A (https=) |
| KR (1) | KR20140084253A (https=) |
| CN (1) | CN104093739A (https=) |
| AR (1) | AR088512A1 (https=) |
| AU (1) | AU2012328921B2 (https=) |
| BR (1) | BR112014009799A2 (https=) |
| CA (1) | CA2853357A1 (https=) |
| CL (1) | CL2014001054A1 (https=) |
| CO (1) | CO7020873A2 (https=) |
| CR (1) | CR20140225A (https=) |
| DO (1) | DOP2014000083A (https=) |
| EC (1) | ECSP14001249A (https=) |
| HK (1) | HK1200464A1 (https=) |
| IL (1) | IL232129A0 (https=) |
| IN (1) | IN2014CN03936A (https=) |
| MX (1) | MX2014004981A (https=) |
| PE (1) | PE20141545A1 (https=) |
| PH (1) | PH12014500866A1 (https=) |
| RS (1) | RS20140203A1 (https=) |
| RU (1) | RU2014120755A (https=) |
| SG (1) | SG11201401774VA (https=) |
| TW (1) | TW201326207A (https=) |
| UY (1) | UY34409A (https=) |
| WO (1) | WO2013063114A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011025964A2 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| BR112012021941A2 (pt) | 2010-03-02 | 2022-02-01 | Abbvie Inc | Proteínas terapêuticas de ligação a dll4 |
| US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
| AR084210A1 (es) | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| JP2014533659A (ja) | 2011-10-24 | 2014-12-15 | アッヴィ・インコーポレイテッド | スクレロスチンに対するイムノバインダー |
| WO2013063114A1 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Immunobinders directed against tnf |
| AU2012328917B2 (en) | 2011-10-24 | 2017-05-25 | Abbvie Inc. | Bispecific immunobinders directed against TNF and IL-17 |
| KR20180008921A (ko) | 2012-11-01 | 2018-01-24 | 애브비 인코포레이티드 | 항-ｖｅｇｆ／ｄｌｌ4 이원 가변 도메인 면역글로불린 및 이의 용도 |
| US9458244B2 (en) | 2012-12-28 | 2016-10-04 | Abbvie Inc. | Single chain multivalent binding protein compositions and methods |
| EP2938637A2 (en) | 2012-12-28 | 2015-11-04 | AbbVie Inc. | Multivalent binding protein compositions |
| WO2015057910A1 (en) | 2013-10-16 | 2015-04-23 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| WO2015191760A2 (en) | 2014-06-10 | 2015-12-17 | Abbvie, Inc. | Compositions and methods for treating rheumatoid arthritis |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| EP3247718B1 (en) | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| AR104847A1 (es) | 2015-06-17 | 2017-08-16 | Lilly Co Eli | Formulación de anticuerpo anti-cgrp |
| CN108350063A (zh) * | 2015-09-14 | 2018-07-31 | 星系生物科技责任有限公司 | 针对血管生成因子的高度有效的单克隆抗体 |
| WO2017083525A1 (en) | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| CN109563161A (zh) | 2016-02-03 | 2019-04-02 | 安口生物公司 | 用于提高抗体稳定性的缓冲制剂 |
| MY194619A (en) | 2016-06-02 | 2022-12-07 | Abbvie Inc | Glucocorticoid receptor agonist and immunoconjugates thereof |
| CN110114072A (zh) * | 2016-11-02 | 2019-08-09 | 纳米珀特伊根公司 | 聚合物纳米颗粒 |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN107903323B (zh) * | 2017-11-15 | 2020-04-17 | 中国药科大学 | 抗hTNF-α全人源抗体及其用途 |
| AU2018374634A1 (en) | 2017-12-01 | 2020-05-28 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
| KR20250006910A (ko) * | 2022-04-20 | 2025-01-13 | 센티 바이오사이언시스, 인코포레이티드 | 항원 결합 도메인 및 이의 사용 방법 |
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| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3631229A1 (de) * | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
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| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
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| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
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| EP1690934A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
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| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
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| CA2110799A1 (en) | 1991-06-14 | 1992-12-23 | Arnold H. Horwitz | Microbially-produced antibody fragments and their conjugates |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| NZ255101A (en) | 1992-07-24 | 1997-08-22 | Cell Genesys Inc | A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor |
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| EP0826034A4 (en) | 1995-04-21 | 2002-06-19 | Cell Genesys Inc | PRODUCTION OF LARGE GENOMIC DNA DELETIONS |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| DK0929578T3 (da) * | 1996-02-09 | 2003-08-25 | Abbott Lab Bermuda Ltd | Humane antistoffer, der binder human TNFalfa |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| DK1712623T3 (da) | 1997-01-21 | 2012-02-06 | Gen Hospital Corp | Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| AU2978899A (en) | 1998-03-03 | 1999-09-20 | Abgenix, Inc. | Cd147 binding molecules as therapeutics |
| US20020029391A1 (en) | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
| EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| DK1141028T3 (da) | 1998-12-23 | 2010-05-25 | Pfizer | Humane monoklonale antistoffer til CTLA-4 |
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| EP2322644A1 (en) | 2000-06-28 | 2011-05-18 | GlycoFi, Inc. | Methods for producing modified glycoproteins |
| NZ526720A (en) | 2000-12-28 | 2007-11-30 | Altus Pharmaceuticals Inc | Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies |
| DK1438400T3 (da) | 2001-10-01 | 2009-10-05 | Dyax Corp | Flerkædede eukaryote display-vektorer og anvendelser deraf |
| DE60333228D1 (de) | 2002-12-02 | 2010-08-12 | Amgen Fremont Inc | Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen |
| JP2007525409A (ja) * | 2003-01-08 | 2007-09-06 | アプライド モレキュラー エボリューション，インコーポレイテッド | ＴＮＦ−α結合分子 |
| EP1636270B1 (en) | 2003-06-16 | 2016-07-20 | UCB Pharma S.A. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
| CA2573259A1 (en) * | 2004-07-06 | 2006-02-09 | Bioren Inc. | High affinity anti-tnf-alpha antibodies and method |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2008133722A2 (en) | 2006-11-10 | 2008-11-06 | Ucb Pharma S.A. | Anti human sclerostin antibodies |
| US20100036091A1 (en) | 2006-11-10 | 2010-02-11 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
| NZ578870A (en) | 2007-03-20 | 2012-01-12 | Lilly Co Eli | Anti-sclerostin antibodies |
| TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法 |
| US8187836B2 (en) | 2008-01-15 | 2012-05-29 | Abbott Laboratories | Mammalian expression vectors and uses thereof |
| PE20100092A1 (es) | 2008-06-03 | 2010-03-12 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
| EP2403531A4 (en) | 2009-03-05 | 2013-02-27 | Abbott Lab | IL-17 BINDING PROTEINS |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| WO2011127141A1 (en) | 2010-04-07 | 2011-10-13 | Abbott Laboratories | TNF-α BINDING PROTEINS |
| US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| AR084210A1 (es) * | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| JP2014533659A (ja) | 2011-10-24 | 2014-12-15 | アッヴィ・インコーポレイテッド | スクレロスチンに対するイムノバインダー |
| WO2013063114A1 (en) | 2011-10-24 | 2013-05-02 | Abbvie Inc. | Immunobinders directed against tnf |
| AU2012328917B2 (en) | 2011-10-24 | 2017-05-25 | Abbvie Inc. | Bispecific immunobinders directed against TNF and IL-17 |
| TW201446800A (zh) | 2013-03-15 | 2014-12-16 | Abbvie Inc | 針對ＴＮＦα之雙特異性結合蛋白 |
-
2012
- 2012-10-24 WO PCT/US2012/061690 patent/WO2013063114A1/en not_active Ceased
- 2012-10-24 CA CA2853357A patent/CA2853357A1/en not_active Abandoned
- 2012-10-24 RU RU2014120755/10A patent/RU2014120755A/ru not_active Application Discontinuation
- 2012-10-24 CN CN201280064311.3A patent/CN104093739A/zh active Pending
- 2012-10-24 RS RS20140203A patent/RS20140203A1/sr unknown
- 2012-10-24 SG SG11201401774VA patent/SG11201401774VA/en unknown
- 2012-10-24 BR BR112014009799A patent/BR112014009799A2/pt unknown
- 2012-10-24 AR ARP120103977A patent/AR088512A1/es unknown
- 2012-10-24 KR KR1020147013794A patent/KR20140084253A/ko not_active Withdrawn
- 2012-10-24 PE PE2014000587A patent/PE20141545A1/es not_active Application Discontinuation
- 2012-10-24 US US13/659,658 patent/US9803009B2/en not_active Expired - Fee Related
- 2012-10-24 UY UY0001034409A patent/UY34409A/es not_active Application Discontinuation
- 2012-10-24 HK HK15100709.5A patent/HK1200464A1/xx unknown
- 2012-10-24 AU AU2012328921A patent/AU2012328921B2/en not_active Ceased
- 2012-10-24 IN IN3936CHN2014 patent/IN2014CN03936A/en unknown
- 2012-10-24 JP JP2014538927A patent/JP2014534218A/ja active Pending
- 2012-10-24 PH PH1/2014/500866A patent/PH12014500866A1/en unknown
- 2012-10-24 EP EP12783475.2A patent/EP2771362A1/en not_active Withdrawn
- 2012-10-24 TW TW101139327A patent/TW201326207A/zh unknown
- 2012-10-24 MX MX2014004981A patent/MX2014004981A/es unknown
-
2013
- 2013-11-06 US US14/073,479 patent/US20140170152A1/en not_active Abandoned
-
2014
- 2014-04-13 IL IL232129A patent/IL232129A0/en unknown
- 2014-04-24 DO DO2014000083A patent/DOP2014000083A/es unknown
- 2014-04-24 CL CL2014001054A patent/CL2014001054A1/es unknown
- 2014-05-14 CR CR20140225A patent/CR20140225A/es unknown
- 2014-05-19 EC ECIEPI20141249A patent/ECSP14001249A/es unknown
- 2014-05-22 CO CO14110749A patent/CO7020873A2/es unknown
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