JP2014533181A - インサイチュー架橋性ポリマー組成物およびその方法 - Google Patents

インサイチュー架橋性ポリマー組成物およびその方法 Download PDF

Info

Publication number
JP2014533181A
JP2014533181A JP2014541368A JP2014541368A JP2014533181A JP 2014533181 A JP2014533181 A JP 2014533181A JP 2014541368 A JP2014541368 A JP 2014541368A JP 2014541368 A JP2014541368 A JP 2014541368A JP 2014533181 A JP2014533181 A JP 2014533181A
Authority
JP
Japan
Prior art keywords
polymer composition
polymer
biocompatible polymer
weight
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014541368A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014533181A5 (https=
Inventor
ランドリナ、ジョセフ・エー．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cresilon Inc
Original Assignee
Cresilon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cresilon Inc filed Critical Cresilon Inc
Publication of JP2014533181A publication Critical patent/JP2014533181A/ja
Publication of JP2014533181A5 publication Critical patent/JP2014533181A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Dental Preparations (AREA)
JP2014541368A 2011-11-13 2012-11-12 インサイチュー架橋性ポリマー組成物およびその方法 Pending JP2014533181A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559110P 2011-11-13 2011-11-13
US61/559,110 2011-11-13
PCT/US2012/064670 WO2013071235A1 (en) 2011-11-13 2012-11-12 In-situ cross-linkable polymeric compositions and methods thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018120864A Division JP7013336B2 (ja) 2011-11-13 2018-06-26 インサイチュー架橋性ポリマー組成物およびその方法

Publications (2)

Publication Number Publication Date
JP2014533181A true JP2014533181A (ja) 2014-12-11
JP2014533181A5 JP2014533181A5 (https=) 2016-01-07

Family

ID=48290658

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014541368A Pending JP2014533181A (ja) 2011-11-13 2012-11-12 インサイチュー架橋性ポリマー組成物およびその方法
JP2018120864A Active JP7013336B2 (ja) 2011-11-13 2018-06-26 インサイチュー架橋性ポリマー組成物およびその方法
JP2020153716A Withdrawn JP2021007754A (ja) 2011-11-13 2020-09-14 インサイチュー架橋性ポリマー組成物およびその方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018120864A Active JP7013336B2 (ja) 2011-11-13 2018-06-26 インサイチュー架橋性ポリマー組成物およびその方法
JP2020153716A Withdrawn JP2021007754A (ja) 2011-11-13 2020-09-14 インサイチュー架橋性ポリマー組成物およびその方法

Country Status (16)

Country Link
US (4) US20140287061A1 (https=)
EP (1) EP2776068A4 (https=)
JP (3) JP2014533181A (https=)
KR (1) KR20140090670A (https=)
CN (2) CN109602944A (https=)
AU (2) AU2012334982A1 (https=)
BR (1) BR112014011442A8 (https=)
CA (1) CA2855347C (https=)
HK (1) HK1201734A1 (https=)
IL (1) IL232330B (https=)
IN (1) IN2014CN03524A (https=)
MX (2) MX366366B (https=)
RU (2) RU2017144044A (https=)
SG (2) SG11201402279SA (https=)
WO (1) WO2013071235A1 (https=)
ZA (1) ZA201403166B (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180053636A (ko) * 2015-06-22 2018-05-23 크레실론, 인코퍼레이티드 고효율 지혈용 접착제 조성물 스캐폴드
JP2018162440A (ja) * 2017-03-27 2018-10-18 Jsr株式会社 組成物およびその用途
JP2020502241A (ja) * 2016-12-22 2020-01-23 オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． アニオン交換体及びカルシウム塩を含む止血用組成物
JP2020078729A (ja) * 2015-06-22 2020-05-28 クレシロン， インコーポレイテッド 高度に有用な止血用接着性ポリマー足場
JP2022527348A (ja) * 2019-04-03 2022-06-01 ドテク－ソシエテ ア リスポンサビリタ リミタータ 皮膚病変の治療的処置のための二成分系組成物およびその生成方法
JP2023092390A (ja) * 2021-12-21 2023-07-03 富士フイルム株式会社 止血材組成物

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
WO2009094060A1 (en) 2008-01-24 2009-07-30 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
WO2011149907A1 (en) 2010-05-24 2011-12-01 University Of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
EP2637708A2 (en) 2010-11-12 2013-09-18 University of Utah Research Foundation Simple adhesive coacervates and methods of making and using thereof
CA2855347C (en) 2011-11-13 2019-03-05 Suneris Inc. In-situ cross-linkable polymeric compositions and methods thereof
WO2014123665A1 (en) 2013-02-06 2014-08-14 Kci Licensing, Inc. Polymers, preparation and use thereof
ITTO20130375A1 (it) * 2013-05-10 2014-11-11 Marco Benzi Prodotto per l'uso per il trattamento terapeutico di parodontopatie e perimplantiti
CN103611180B (zh) * 2013-11-21 2015-02-18 无锡中科光远生物材料有限公司 一种自粘止血防粘连纤维体的制备方法
EP3166550B1 (en) 2014-07-11 2023-12-13 The United States of America, as represented by the Secretary, Department of Health and Human Services Surgical tool for ocular tissue transplantation
EP3169374B1 (en) 2014-07-14 2022-01-05 University of Utah Research Foundation In situ solidifying complex coacervates and methods of making and using thereof
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CN105030815B (zh) * 2015-08-10 2019-03-15 贵州扬生医用器材有限公司 一种手术冲洗液及其制法
US11065337B2 (en) 2015-12-14 2021-07-20 University of Pittsburgh—of the Commonwealth System of Higher Education Complex coacervate for controlled release and related methods
KR101666792B1 (ko) 2016-02-05 2016-10-17 주식회사 파마리서치프로덕트 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물
WO2017152039A1 (en) 2016-03-04 2017-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Protection and delivery of multiple therapeutic proteins
CN105860107B (zh) * 2016-04-26 2018-02-09 中南大学 一种过氧化氢响应及具有电化学活性的壳聚糖水凝胶的制备方法
KR101916193B1 (ko) * 2016-08-25 2018-11-07 주식회사 파마리서치프로덕트 핵산 및 키토산을 포함하는 관절강 주사용 조성물
WO2018128704A2 (en) 2016-11-07 2018-07-12 3M Innovative Properties Company Medical composition containing guanidinyl-containing polymer(s) and carrageenane(s)
WO2018119320A1 (en) * 2016-12-21 2018-06-28 Cresilon, Inc. Hemostatic compositions with antifibrinolytic agents
IL249725A0 (en) 2016-12-22 2017-03-30 Omrix Biopharmaceuticals Ltd A hemostatic preparation containing an anion exchanger and a calcium salt
CN108926490B (zh) * 2017-05-25 2021-01-26 南方医科大学南方医院 一种抗凝胃管的制作方法
KR102218427B1 (ko) * 2017-09-20 2021-02-22 차의과학대학교 산학협력단 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제
CA3089480C (en) 2018-01-26 2025-05-27 Fluidx Medical Technology, Inc. APPARATUS AND METHOD FOR USING COMPLEX COACERVATES WITH IN SITU SOLIDIFICATION FOR VASCULAR OCLUSION
EP3743125A4 (en) * 2018-01-26 2022-03-02 Polarityte, Inc. BIOMATERIAL ACCELERATING SUBSTRATE WITH COMPOSITE INTERFACE
RU2675631C1 (ru) * 2018-10-02 2018-12-21 Общество с ограниченной ответственностью "Новые Биомедицинские Решения" Местное гемостатическое средство с повышенной антимикробной активностью
CN110157010B (zh) * 2019-05-05 2021-04-02 上海交通大学 一种基于多糖/聚肽的聚电解质复合物水凝胶止血剂
CN111303453B (zh) * 2020-03-09 2021-06-04 中国海洋大学 一种多重敏感型水凝胶聚合物的制备方法和应用
EP3925636A1 (en) 2020-06-17 2021-12-22 Centre Of Experimental Medicine Slovak Academy Of Sciences Institute Of Experimental Pharmacology Composite membranes containing a smart-released cytoprotectant targeting the inflamed tissue and use thereof
CN115887738B (zh) * 2022-12-16 2024-05-10 湖南师范大学 一种聚丙烯酰胺-壳聚糖/高岭土多孔材料及其制备方法
US12516199B2 (en) 2023-02-15 2026-01-06 Nano And Advanced Materials Institute Limited Transparent, water resistant, antimicrobial and antiviral waterborne coating composition and applications thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06319517A (ja) * 1992-10-22 1994-11-22 Gunze Ltd キトサンの溶解方法
JPH07188424A (ja) * 1993-10-30 1995-07-25 Merck Patent Gmbh 水性のキトサン溶液および水性のキトサンゲルの製造方法
JPH11318407A (ja) * 1998-05-19 1999-11-24 Lion Corp 加工食品
JP2000186048A (ja) * 1998-12-22 2000-07-04 Kuraray Co Ltd 止血材
JP2008507362A (ja) * 2004-07-22 2008-03-13 ヘモ ナノサイエンス リミテッド ライアビリティ カンパニー 過剰な出血を処置するための組成物および方法
CN101463144A (zh) * 2009-01-12 2009-06-24 武汉理工大学 羟丙基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料
CN101463145A (zh) * 2009-01-12 2009-06-24 武汉理工大学 羧甲基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料
JP2009537268A (ja) * 2006-05-22 2009-10-29 ユニヴァーシタ デグリ ステュディ デイ トリエステ 組織工学用で活性化合物のキャリアとしての、多糖類混合物のハイドロゲル
WO2011011658A1 (en) * 2009-07-23 2011-01-27 University Of Utah Research Fundation Adhesive complex coacervates and methods of making and using thereof
JP2011218165A (ja) * 2010-04-08 2011-11-04 Tyco Healthcare Group Lp コーティングされたループ付き縫合糸

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58206751A (ja) 1982-05-26 1983-12-02 日石三菱株式会社 創傷被覆材
JPS59139310A (ja) 1983-01-31 1984-08-10 Shiseido Co Ltd 乳化組成物
JPH0612993B2 (ja) 1987-08-10 1994-02-23 株式会社クラレ 球状の微生物固定化成形物の製造法
US4956350A (en) * 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
FI95207C (fi) 1992-09-14 1996-01-10 Novasso Oy Haavansuojaside
US5670169A (en) 1993-12-20 1997-09-23 E.R. Squibb & Sons, Inc. Wound hydrating gel with novel preservative system and low cytotoxicity
US20020032488A1 (en) 1994-05-13 2002-03-14 Brekke John H. Device for regeneration of articular cartilage and other tissue
US6150581A (en) * 1995-06-07 2000-11-21 United States Surgical Corporation Chitosan/alginate anti-adhesion barrier
US5836970A (en) * 1996-08-02 1998-11-17 The Kendall Company Hemostatic wound dressing
GB2328443B (en) * 1997-08-21 2001-09-05 Reckitt & Colmann Prod Ltd In situ formation of pharmaceutically acceptable polymeric material
CA2317582C (en) 1998-01-06 2009-03-31 Nicholas A. Sceusa A drug dosage form based on the teorell-meyer gradient
JP4241985B2 (ja) 1998-04-24 2009-03-18 株式会社クラレ 医療用接着材
US6200595B1 (en) 1998-04-24 2001-03-13 Kuraray Co., Ltd. Medical adhesive
WO2000012144A1 (en) 1998-08-31 2000-03-09 Coloplast A/S A composition capable of absorbing fluid
JP4267106B2 (ja) * 1998-10-15 2009-05-27 株式会社クラレ 癒着防止用材料
JP4149098B2 (ja) 1999-09-13 2008-09-10 株式会社クラレ 水膨潤性医療用高分子ゲルの製造法及び水膨潤性医療用高分子ゲル
US20030206958A1 (en) 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
WO2003072157A1 (en) * 2002-02-21 2003-09-04 Encelle, Inc. Immobilized bioactive hydrogel matrices as surface coatings
US7217426B1 (en) * 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
JP2004041586A (ja) 2002-07-15 2004-02-12 Fujimori Kogyo Co Ltd 生体適合性材料およびその製造方法
US7112713B2 (en) 2003-03-12 2006-09-26 Gelsus Research And Consulting, Inc. Dressing based on the Teorell-Meyer gradient
US8383158B2 (en) 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8703176B2 (en) * 2004-02-23 2014-04-22 Loma Linda University Medical Center Hemostatic agent for topical and internal use
US20050203058A1 (en) 2004-03-11 2005-09-15 Johnson Edwin L. Compositions of alpha- and beta-chitosan and methods of preparing them
AU2005262070B2 (en) * 2004-07-09 2011-01-27 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
CN101563116A (zh) * 2005-07-21 2009-10-21 Fmc生物聚合物联合股份有限公司 涂覆有快速溶解的生物相容性涂层的医疗装置
WO2007055950A2 (en) * 2005-11-02 2007-05-18 Aeris Therapeutics, Inc. Polycation-polyanion complexes, compositions and methods of use thereof
CN100411690C (zh) * 2006-01-17 2008-08-20 武汉理工大学 一种抑菌聚电解质多孔材料的制备方法
WO2007112446A2 (en) 2006-03-28 2007-10-04 University Of Washington Alginate-based nanofibers and related scaffolds
US20070237811A1 (en) * 2006-04-10 2007-10-11 Scherr George H Chitosan wound dressing
CN1883721A (zh) * 2006-06-21 2006-12-27 哈尔滨工业大学 共价交联凝胶改性人工植入体的方法
US7935363B2 (en) * 2006-12-12 2011-05-03 Synthasome, Inc. Composite material for tissue repair
US8871247B2 (en) 2007-02-19 2014-10-28 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
JP4997650B2 (ja) 2007-06-11 2012-08-08 国立大学法人京都工芸繊維大学 植物の加工方法
US20090041858A1 (en) 2007-08-06 2009-02-12 Cao Group, Inc. Haemostatic Compositions Thickened by Polymers Containing Nitrogen Moieties
US20100291055A1 (en) * 2007-08-28 2010-11-18 Theodore Athanasiadis Surgical hydrogel
US20090123509A1 (en) 2007-11-08 2009-05-14 Cory Berkland Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds
EP2296637B1 (en) * 2008-04-24 2014-04-02 Medtronic, Inc Chitosan-containing protective composition
US8697771B2 (en) * 2008-08-19 2014-04-15 The Regents Of The University Of Michigan Biocompatible coatings, and methods of making and using the same
WO2010117266A1 (en) 2009-04-06 2010-10-14 Broockeville Corporation N.V. In situ gelling alginate systems
KR101103423B1 (ko) * 2009-09-04 2012-01-06 아주대학교산학협력단 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도
CN102844053B (zh) 2009-11-25 2015-08-05 洛马林达大学医学中心 基于壳聚糖的止血织物
EP2512588A4 (en) * 2009-12-16 2014-06-04 Univ Columbia METHODS, DEVICES AND SYSTEMS FOR ULTRASOUND-RELEASED ON-DEMAND AGGREGATE FREEZING
US8389498B2 (en) 2010-03-26 2013-03-05 Taiwan Textile Research Institute Spinning solution and method for manufacturing biomaterial fibers
WO2011149907A1 (en) * 2010-05-24 2011-12-01 University Of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
DK2600910T3 (en) * 2010-08-05 2016-04-04 Lifebond Ltd Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS
CN102475691B (zh) 2010-11-30 2014-04-16 中国科学院大连化学物理研究所 海藻酸盐-壳聚糖酰基衍生物微胶囊及其制备和应用
US8911695B2 (en) 2011-03-17 2014-12-16 Perma-Fix Environmental Services, Inc. Preparation of chitosan-based microporous composite material and its applications
WO2012130031A1 (zh) 2011-04-01 2012-10-04 广州奥托沙医药科技有限公司 一种医用可吸收骨创面止血材料及其制备方法
GB2499359B (en) 2011-10-05 2016-12-28 Univ Of Bolton Polysaccharide fibres for wound dressings
CA2855347C (en) * 2011-11-13 2019-03-05 Suneris Inc. In-situ cross-linkable polymeric compositions and methods thereof
EP2788038A1 (en) 2011-12-09 2014-10-15 Acell, Inc. Hemostatic device
EP3459522B1 (en) 2012-12-10 2021-02-17 Regenics AS Use of egg cellular extracts for wound treatment
EP2983718A4 (en) 2013-04-11 2016-12-07 Univ Of Vermont And State Agricultural College Decellularization and recellularization of whole organs
MX2017016865A (es) 2015-06-22 2018-09-06 Cresilon Inc Andamio de polimero adhesivo hermostatico altamente eficaz.

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06319517A (ja) * 1992-10-22 1994-11-22 Gunze Ltd キトサンの溶解方法
JPH07188424A (ja) * 1993-10-30 1995-07-25 Merck Patent Gmbh 水性のキトサン溶液および水性のキトサンゲルの製造方法
JPH11318407A (ja) * 1998-05-19 1999-11-24 Lion Corp 加工食品
JP2000186048A (ja) * 1998-12-22 2000-07-04 Kuraray Co Ltd 止血材
JP2008507362A (ja) * 2004-07-22 2008-03-13 ヘモ ナノサイエンス リミテッド ライアビリティ カンパニー 過剰な出血を処置するための組成物および方法
JP2009537268A (ja) * 2006-05-22 2009-10-29 ユニヴァーシタ デグリ ステュディ デイ トリエステ 組織工学用で活性化合物のキャリアとしての、多糖類混合物のハイドロゲル
CN101463144A (zh) * 2009-01-12 2009-06-24 武汉理工大学 羟丙基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料
CN101463145A (zh) * 2009-01-12 2009-06-24 武汉理工大学 羧甲基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料
WO2011011658A1 (en) * 2009-07-23 2011-01-27 University Of Utah Research Fundation Adhesive complex coacervates and methods of making and using thereof
JP2011218165A (ja) * 2010-04-08 2011-11-04 Tyco Healthcare Group Lp コーティングされたループ付き縫合糸

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOMATERIALS, 2008, VOL.29, PP.4831-4837, JPN6017028264, ISSN: 0003746941 *
BIOMATERIALS, 2008, VOL.29, PP.4831-4837, JPN7018000525, ISSN: 0003746939 *
第４８回高分子学会予稿集, 1999, VOL.48, NO.10, PP.2431-2432, JPN6017028261, ISSN: 0003746940 *
第４８回高分子学会予稿集, 1999, VOL.48, NO.10, PP.2431-2432, JPN7018000524, ISSN: 0003746938 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180053636A (ko) * 2015-06-22 2018-05-23 크레실론, 인코퍼레이티드 고효율 지혈용 접착제 조성물 스캐폴드
JP2018522101A (ja) * 2015-06-22 2018-08-09 クレシロン， インコーポレイテッド 高度に有用な止血用接着性ポリマー足場
JP2020078729A (ja) * 2015-06-22 2020-05-28 クレシロン， インコーポレイテッド 高度に有用な止血用接着性ポリマー足場
KR102518121B1 (ko) 2015-06-22 2023-04-05 크레실론, 인코퍼레이티드 고효율 지혈용 접착제 조성물 스캐폴드
JP7493961B2 (ja) 2015-06-22 2024-06-03 クレシロン， インコーポレイテッド 高度に有用な止血用接着性ポリマー足場
JP2020502241A (ja) * 2016-12-22 2020-01-23 オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． アニオン交換体及びカルシウム塩を含む止血用組成物
JP2018162440A (ja) * 2017-03-27 2018-10-18 Jsr株式会社 組成物およびその用途
JP2022527348A (ja) * 2019-04-03 2022-06-01 ドテク－ソシエテ ア リスポンサビリタ リミタータ 皮膚病変の治療的処置のための二成分系組成物およびその生成方法
JP2023092390A (ja) * 2021-12-21 2023-07-03 富士フイルム株式会社 止血材組成物
JP7818395B2 (ja) 2021-12-21 2026-02-20 富士フイルム株式会社 止血材組成物

Also Published As

Publication number Publication date
CA2855347A1 (en) 2013-05-16
MX366366B (es) 2019-07-05
EP2776068A4 (en) 2015-05-20
US9687584B1 (en) 2017-06-27
SG11201402279SA (en) 2014-06-27
HK1201734A1 (en) 2015-09-11
BR112014011442A2 (pt) 2017-05-16
IL232330A0 (en) 2014-06-30
JP2018183611A (ja) 2018-11-22
IN2014CN03524A (https=) 2015-10-09
EP2776068A1 (en) 2014-09-17
AU2017219007A1 (en) 2017-09-07
SG10201610469QA (en) 2017-02-27
WO2013071235A1 (en) 2013-05-16
RU2014124157A (ru) 2015-12-27
AU2012334982A1 (en) 2014-05-22
KR20140090670A (ko) 2014-07-17
CN109602944A (zh) 2019-04-12
ZA201403166B (en) 2015-11-25
JP7013336B2 (ja) 2022-01-31
US20210290817A1 (en) 2021-09-23
CN103930133A (zh) 2014-07-16
US10850003B2 (en) 2020-12-01
WO2013071235A9 (en) 2013-07-18
JP2021007754A (ja) 2021-01-28
US20170266339A1 (en) 2017-09-21
IL232330B (en) 2019-06-30
US20170157286A1 (en) 2017-06-08
BR112014011442A8 (pt) 2018-01-09
CA2855347C (en) 2019-03-05
MX2019008051A (es) 2019-09-09
US20140287061A1 (en) 2014-09-25
MX2014005738A (es) 2014-07-09
RU2017144044A (ru) 2019-02-15
RU2640084C2 (ru) 2017-12-26
US11383005B2 (en) 2022-07-12

Similar Documents

Publication Publication Date Title
US11383005B2 (en) In-situ cross-linkable polymeric compositions and methods thereof
Sheokand et al. Natural polymers used in the dressing materials for wound healing: Past, present and future
Shi et al. Recent progresses of collagen dressings for chronic skin wound healing
Mecwan et al. Recent advances in biopolymer-based hemostatic materials
Sezer et al. Biopolymers as wound healing materials: challenges and new strategies
US9950091B2 (en) Composition and method for stopping hemorrhage, infection, and accelerating healing in various types of wound or burns
JP5087628B2 (ja) 治療用組成物を塗布するための塗布器システム
JP2003517997A (ja) 急速な血液凝集及び止血に有用な止血ポリマー
Mercy et al. Chitosan-derivatives as hemostatic agents: Their role in tissue regeneration
Gupta et al. Current status of hemostatic agents, their mechanism of action, and future directions
HK40007228A (en) In-situ cross-linkable polymeric compositions and methods thereof
Khalid et al. Polysaccharide composites as a wound-healing sponge
NZ723969A (en) In-situ cross-linkable polymeric compositions and methods thereof
RU2827960C1 (ru) Гемостатический раствор, гемостатическое изделие и способ его изготовления
NZ723969B2 (en) In-situ cross-linkable polymeric compositions and methods thereof
Perdigão Collagen as a wound healing material
Wahid Polysaccharide Composites as a Wound-Healing Sponge
Grimaldi et al. Biotechnological Approaches to Hemostasis and Molecular Mechanisms of Wound Healing
Catanzano HELPING WOUND HEALING PROCESS THROUGH DRUG DELIVERY SISTEMS
HK1135609B (en) Formation of medically useful gels comprising microporous particles and methods of use

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151111

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151111

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160830

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161130

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170130

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170228

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170801

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171101

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171222

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180227