MX366366B - Composiciones polimericas reticulables in-situ y metodos de las mismas. - Google Patents

Composiciones polimericas reticulables in-situ y metodos de las mismas.

Info

Publication number
MX366366B
MX366366B MX2014005738A MX2014005738A MX366366B MX 366366 B MX366366 B MX 366366B MX 2014005738 A MX2014005738 A MX 2014005738A MX 2014005738 A MX2014005738 A MX 2014005738A MX 366366 B MX366366 B MX 366366B
Authority
MX
Mexico
Prior art keywords
cross
methods
polymeric composition
wound
linking
Prior art date
Application number
MX2014005738A
Other languages
English (en)
Other versions
MX2014005738A (es
Inventor
A Landolina Joseph
Original Assignee
Cresilon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cresilon Inc filed Critical Cresilon Inc
Publication of MX2014005738A publication Critical patent/MX2014005738A/es
Publication of MX366366B publication Critical patent/MX366366B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Dental Preparations (AREA)

Abstract

La presente invención se refiere a una composición polimérica para reticulada in situ en una herida que comprende 1) uno o más polímeros polianiónicos como los alginatos o hialuronatos capaces de ser reticuladas en la superficie de una herida y 2) uno o más polímeros policatiónicos como el quitosán o Dextrano-DEAE que ayuda en el proceso de solidificación y acelera la hemostasis sin necesidad de ejercer presión. La composición polimérica biocompatible puede comprender un agente reticulante como el cloruro de calcio acuoso. La invención abarca una composición polimérica inicial, la matriz solidificada reticulada e integrada a la zona de la herida, incluyendo los métodos de uso, aplicación y reticulación de la composición.
MX2014005738A 2011-11-13 2012-11-12 Composiciones polimericas reticulables in-situ y metodos de las mismas. MX366366B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161559110P 2011-11-13 2011-11-13
PCT/US2012/064670 WO2013071235A1 (en) 2011-11-13 2012-11-12 In-situ cross-linkable polymeric compositions and methods thereof

Publications (2)

Publication Number Publication Date
MX2014005738A MX2014005738A (es) 2014-07-09
MX366366B true MX366366B (es) 2019-07-05

Family

ID=48290658

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014005738A MX366366B (es) 2011-11-13 2012-11-12 Composiciones polimericas reticulables in-situ y metodos de las mismas.
MX2019008051A MX2019008051A (es) 2011-11-13 2014-05-12 Composiciones polimericas reticulables in-situ y metodos de las mismas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019008051A MX2019008051A (es) 2011-11-13 2014-05-12 Composiciones polimericas reticulables in-situ y metodos de las mismas.

Country Status (16)

Country Link
US (4) US20140287061A1 (es)
EP (1) EP2776068A4 (es)
JP (3) JP2014533181A (es)
KR (1) KR20140090670A (es)
CN (2) CN103930133A (es)
AU (2) AU2012334982A1 (es)
BR (1) BR112014011442A8 (es)
CA (1) CA2855347C (es)
HK (1) HK1201734A1 (es)
IL (1) IL232330B (es)
IN (1) IN2014CN03524A (es)
MX (2) MX366366B (es)
RU (2) RU2640084C2 (es)
SG (2) SG10201610469QA (es)
WO (1) WO2013071235A1 (es)
ZA (1) ZA201403166B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009094060A1 (en) 2008-01-24 2009-07-30 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
JP2013526393A (ja) 2010-05-24 2013-06-24 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 強化された接着複合コアセルベートならびにその作製方法および使用方法
JP2014502296A (ja) 2010-11-12 2014-01-30 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 単純接着剤コアセルベートならびにその製造方法および使用
EP2776068A4 (en) * 2011-11-13 2015-05-20 Suneris Inc IN-SITU NETWORKABLE POLYMERIC COMPOSITION AND METHOD THEREFOR
WO2014123665A1 (en) 2013-02-06 2014-08-14 Kci Licensing, Inc. Polymers, preparation and use thereof
ITTO20130375A1 (it) * 2013-05-10 2014-11-11 Marco Benzi Prodotto per l'uso per il trattamento terapeutico di parodontopatie e perimplantiti
CN103611180B (zh) * 2013-11-21 2015-02-18 无锡中科光远生物材料有限公司 一种自粘止血防粘连纤维体的制备方法
DK3166550T3 (da) * 2014-07-11 2024-01-29 Us Health Kirurgisk værktøj til okular vævstransplantation
EP3169374B1 (en) 2014-07-14 2022-01-05 University of Utah Research Foundation In situ solidifying complex coacervates and methods of making and using thereof
US20180185543A1 (en) * 2015-06-22 2018-07-05 Cresilon, Inc. Highly efficacious hemostatic adhesive polymer scaffold
JP7493961B2 (ja) * 2015-06-22 2024-06-03 クレシロン， インコーポレイテッド 高度に有用な止血用接着性ポリマー足場
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CN105030815B (zh) * 2015-08-10 2019-03-15 贵州扬生医用器材有限公司 一种手术冲洗液及其制法
US11065337B2 (en) 2015-12-14 2021-07-20 University of Pittsburgh—of the Commonwealth System of Higher Education Complex coacervate for controlled release and related methods
KR101666792B1 (ko) * 2016-02-05 2016-10-17 주식회사 파마리서치프로덕트 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물
US11298423B2 (en) 2016-03-04 2022-04-12 University of Pittsburgh—of the Commonwealth System of Higher Education Protection and delivery of multiple therapeutic proteins
CN105860107B (zh) * 2016-04-26 2018-02-09 中南大学 一种过氧化氢响应及具有电化学活性的壳聚糖水凝胶的制备方法
KR101916193B1 (ko) * 2016-08-25 2018-11-07 주식회사 파마리서치프로덕트 핵산 및 키토산을 포함하는 관절강 주사용 조성물
WO2018128704A2 (en) 2016-11-07 2018-07-12 3M Innovative Properties Company Medical composition containing guanidinyl-containing polymer(s) and carrageenane(s)
WO2018119320A1 (en) * 2016-12-21 2018-06-28 Cresilon, Inc. Hemostatic compositions with antifibrinolytic agents
IL249725A0 (en) 2016-12-22 2017-03-30 Omrix Biopharmaceuticals Ltd A hemostatic preparation containing an anion exchanger and a calcium salt
IL267432B2 (en) * 2016-12-22 2024-07-01 Omrix Biopharmaceuticals Ltd A hemostatic preparation containing an anion exchanger and a calcium salt
JP6939607B2 (ja) * 2017-03-27 2021-09-22 Jsr株式会社 組成物およびその用途
CN108926490B (zh) * 2017-05-25 2021-01-26 南方医科大学南方医院 一种抗凝胃管的制作方法
KR102218427B1 (ko) 2017-09-20 2021-02-22 차의과학대학교 산학협력단 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제
CN111629765A (zh) * 2018-01-26 2020-09-04 两极组织工程公司 复合界面生物材料促进剂基质
JP7410876B2 (ja) 2018-01-26 2024-01-10 フルイデックス メディカル テクノロジー，リミティッド ライアビリティ カンパニー 血管閉塞のためにその場凝固複合コアセルベートを使用する装置及び方法
RU2675631C1 (ru) * 2018-10-02 2018-12-21 Общество с ограниченной ответственностью "Новые Биомедицинские Решения" Местное гемостатическое средство с повышенной антимикробной активностью
US20220211902A1 (en) * 2019-04-03 2022-07-07 Dtech - Società A Responsabilità Limitata Two-component system for the therapeutic treatment of skin lesions and production method thereof
CN110157010B (zh) * 2019-05-05 2021-04-02 上海交通大学 一种基于多糖/聚肽的聚电解质复合物水凝胶止血剂
CN111303453B (zh) * 2020-03-09 2021-06-04 中国海洋大学 一种多重敏感型水凝胶聚合物的制备方法和应用
EP3925636A1 (en) 2020-06-17 2021-12-22 Centre Of Experimental Medicine Slovak Academy Of Sciences Institute Of Experimental Pharmacology Composite membranes containing a smart-released cytoprotectant targeting the inflamed tissue and use thereof
JP7818395B2 (ja) * 2021-12-21 2026-02-20 富士フイルム株式会社 止血材組成物
CN115887738B (zh) * 2022-12-16 2024-05-10 湖南师范大学 一种聚丙烯酰胺-壳聚糖/高岭土多孔材料及其制备方法
US12516199B2 (en) 2023-02-15 2026-01-06 Nano And Advanced Materials Institute Limited Transparent, water resistant, antimicrobial and antiviral waterborne coating composition and applications thereof

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58206751A (ja) 1982-05-26 1983-12-02 日石三菱株式会社 創傷被覆材
JPS59139310A (ja) 1983-01-31 1984-08-10 Shiseido Co Ltd 乳化組成物
JPH0612993B2 (ja) 1987-08-10 1994-02-23 株式会社クラレ 球状の微生物固定化成形物の製造法
US4956350A (en) * 1988-08-18 1990-09-11 Minnesota Mining And Manufacturing Company Wound filling compositions
FI95207C (fi) 1992-09-14 1996-01-10 Novasso Oy Haavansuojaside
JP3411602B2 (ja) * 1992-10-22 2003-06-03 グンゼ株式会社 キトサンの溶解方法
DE4337152A1 (de) * 1993-10-30 1995-05-04 Merck Patent Gmbh Verfahren zur Herstellung von wäßrigen Chitosan-Lösungen und -Gelen
US5670169A (en) 1993-12-20 1997-09-23 E.R. Squibb & Sons, Inc. Wound hydrating gel with novel preservative system and low cytotoxicity
US20020032488A1 (en) 1994-05-13 2002-03-14 Brekke John H. Device for regeneration of articular cartilage and other tissue
US6150581A (en) * 1995-06-07 2000-11-21 United States Surgical Corporation Chitosan/alginate anti-adhesion barrier
US5836970A (en) * 1996-08-02 1998-11-17 The Kendall Company Hemostatic wound dressing
GB2328443B (en) * 1997-08-21 2001-09-05 Reckitt & Colmann Prod Ltd In situ formation of pharmaceutically acceptable polymeric material
JP2002500169A (ja) 1998-01-06 2002-01-08 セウサ，ニコラス・エイ テオレル−マイヤー勾配に基づく薬投与形
JP4241985B2 (ja) * 1998-04-24 2009-03-18 株式会社クラレ 医療用接着材
US6200595B1 (en) 1998-04-24 2001-03-13 Kuraray Co., Ltd. Medical adhesive
JPH11318407A (ja) * 1998-05-19 1999-11-24 Lion Corp 加工食品
AU5279299A (en) 1998-08-31 2000-03-21 Coloplast A/S A composition capable of absorbing fluid
JP4267106B2 (ja) * 1998-10-15 2009-05-27 株式会社クラレ 癒着防止用材料
JP4159682B2 (ja) * 1998-12-22 2008-10-01 株式会社クラレ 止血材
JP4149098B2 (ja) 1999-09-13 2008-09-10 株式会社クラレ 水膨潤性医療用高分子ゲルの製造法及び水膨潤性医療用高分子ゲル
US20030206958A1 (en) 2000-12-22 2003-11-06 Cattaneo Maurizio V. Chitosan biopolymer for the topical delivery of active agents
CA2476656C (en) * 2002-02-21 2008-11-25 Encelle, Inc. Immobilized bioactive hydrogel matrices as surface coatings
US7217426B1 (en) * 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
JP2004041586A (ja) 2002-07-15 2004-02-12 Fujimori Kogyo Co Ltd 生体適合性材料およびその製造方法
US7112713B2 (en) 2003-03-12 2006-09-26 Gelsus Research And Consulting, Inc. Dressing based on the Teorell-Meyer gradient
US7641643B2 (en) 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
WO2005081866A2 (en) * 2004-02-23 2005-09-09 Loma Linda University Medical Center Hemostatic agent for topical and internal use
AU2005221699A1 (en) 2004-03-11 2005-09-22 Medtrade Products Limited Compositions of alpha and beta chitosan and methods of preparing them
RU2369408C2 (ru) * 2004-07-09 2009-10-10 Ферросан А/С Гемостатическая композиция, включающая гиалуроновую кислоту
CA2574773A1 (en) 2004-07-22 2006-02-02 Allan D. Pronovost Compositions and methods for treating excessive bleeding
JP2009513182A (ja) * 2005-07-21 2009-04-02 エフエムシー バイオポリマー エイエス 急速溶解する生体適合性被覆物で被覆した医療用部材
JP2009514860A (ja) * 2005-11-02 2009-04-09 エアリス セラピューティクス，インコーポレイテッド ポリカチオン−ポリアニオンの複合体、組成物およびその使用方法
CN100411690C (zh) * 2006-01-17 2008-08-20 武汉理工大学 一种抑菌聚电解质多孔材料的制备方法
WO2007112446A2 (en) 2006-03-28 2007-10-04 University Of Washington Alginate-based nanofibers and related scaffolds
US20070237811A1 (en) * 2006-04-10 2007-10-11 Scherr George H Chitosan wound dressing
ITPD20060203A1 (it) 2006-05-22 2007-11-23 Univ Degli Studi Trieste Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi
CN1883721A (zh) * 2006-06-21 2006-12-27 哈尔滨工业大学 共价交联凝胶改性人工植入体的方法
US7935363B2 (en) * 2006-12-12 2011-05-03 Synthasome, Inc. Composite material for tissue repair
EP3000487B8 (en) 2007-02-19 2022-06-15 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
JP4997650B2 (ja) 2007-06-11 2012-08-08 国立大学法人京都工芸繊維大学 植物の加工方法
US20090041858A1 (en) 2007-08-06 2009-02-12 Cao Group, Inc. Haemostatic Compositions Thickened by Polymers Containing Nitrogen Moieties
NZ583819A (en) * 2007-08-28 2012-08-31 Medtronic Xomed Inc Polymer comprising a dicarboxy-derivatised chitosan polymer cross-linked to an aldehyde-derivatised dextran polymer useful for preventing tissue adhesion and for promoting wound healing
US20090123509A1 (en) 2007-11-08 2009-05-14 Cory Berkland Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds
US8283384B2 (en) * 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
CN102883715B (zh) * 2008-04-24 2014-11-12 麦德托尼克公司 包含壳聚糖的保护性组合物
US8697771B2 (en) * 2008-08-19 2014-04-15 The Regents Of The University Of Michigan Biocompatible coatings, and methods of making and using the same
CN101463144B (zh) * 2009-01-12 2010-12-29 武汉理工大学 羟丙基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料的制备方法
CN101463145A (zh) * 2009-01-12 2009-06-24 武汉理工大学 羧甲基壳聚糖/氧化海藻酸钠自交联抗菌水凝胶材料
WO2010117266A1 (en) 2009-04-06 2010-10-14 Broockeville Corporation N.V. In situ gelling alginate systems
KR101103423B1 (ko) * 2009-09-04 2012-01-06 아주대학교산학협력단 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도
CN102844053B (zh) 2009-11-25 2015-08-05 洛马林达大学医学中心 基于壳聚糖的止血织物
WO2011075557A1 (en) * 2009-12-16 2011-06-23 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for on-demand ultrasound-triggered drug delivery
US8389498B2 (en) 2010-03-26 2013-03-05 Taiwan Textile Research Institute Spinning solution and method for manufacturing biomaterial fibers
US8968362B2 (en) 2010-04-08 2015-03-03 Covidien Lp Coated looped suture
JP2013526393A (ja) * 2010-05-24 2013-06-24 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 強化された接着複合コアセルベートならびにその作製方法および使用方法
DK2600910T3 (en) * 2010-08-05 2016-04-04 Lifebond Ltd Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS
CN102475691B (zh) 2010-11-30 2014-04-16 中国科学院大连化学物理研究所 海藻酸盐-壳聚糖酰基衍生物微胶囊及其制备和应用
KR101967005B1 (ko) 2011-03-17 2019-04-08 퍼마-픽스 인바이런멘틀 서비시스, 인크. 키토산계 미세다공성 복합물질의 제조 및 이의 응용
CA2817405C (en) 2011-04-01 2016-02-23 Guangzhou Ortus Pharmaceutical Technology Co., Lt Medical absorbable hemostatic material for bone wounds and preparation method therefor
GB2499359B (en) 2011-10-05 2016-12-28 Univ Of Bolton Polysaccharide fibres for wound dressings
EP2776068A4 (en) * 2011-11-13 2015-05-20 Suneris Inc IN-SITU NETWORKABLE POLYMERIC COMPOSITION AND METHOD THEREFOR
JP5902827B2 (ja) 2011-12-09 2016-04-13 アセル，インコーポレイテッド 止血装置
EP3459522B1 (en) 2012-12-10 2021-02-17 Regenics AS Use of egg cellular extracts for wound treatment
US10918765B2 (en) 2013-04-11 2021-02-16 University Of Vermont And State Agricultural College Decellularization and recellularization of whole organs
US20180185543A1 (en) 2015-06-22 2018-07-05 Cresilon, Inc. Highly efficacious hemostatic adhesive polymer scaffold

Also Published As

Publication number Publication date
JP2021007754A (ja) 2021-01-28
JP2014533181A (ja) 2014-12-11
JP2018183611A (ja) 2018-11-22
CA2855347A1 (en) 2013-05-16
SG11201402279SA (en) 2014-06-27
US11383005B2 (en) 2022-07-12
AU2012334982A1 (en) 2014-05-22
JP7013336B2 (ja) 2022-01-31
KR20140090670A (ko) 2014-07-17
ZA201403166B (en) 2015-11-25
CA2855347C (en) 2019-03-05
MX2014005738A (es) 2014-07-09
RU2017144044A (ru) 2019-02-15
SG10201610469QA (en) 2017-02-27
WO2013071235A1 (en) 2013-05-16
US20210290817A1 (en) 2021-09-23
MX2019008051A (es) 2019-09-09
RU2014124157A (ru) 2015-12-27
RU2640084C2 (ru) 2017-12-26
IN2014CN03524A (es) 2015-10-09
IL232330A0 (en) 2014-06-30
WO2013071235A9 (en) 2013-07-18
IL232330B (en) 2019-06-30
HK1201734A1 (en) 2015-09-11
US20170157286A1 (en) 2017-06-08
CN103930133A (zh) 2014-07-16
US20170266339A1 (en) 2017-09-21
BR112014011442A8 (pt) 2018-01-09
CN109602944A (zh) 2019-04-12
EP2776068A1 (en) 2014-09-17
BR112014011442A2 (pt) 2017-05-16
AU2017219007A1 (en) 2017-09-07
US10850003B2 (en) 2020-12-01
EP2776068A4 (en) 2015-05-20
US20140287061A1 (en) 2014-09-25
US9687584B1 (en) 2017-06-27

Similar Documents

Publication Publication Date Title
MX2019008051A (es) Composiciones polimericas reticulables in-situ y metodos de las mismas.
WO2011110894A3 (en) A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition
WO2013061309A3 (en) New a-prp medical device & tissue engineering composition, manufacturing machines and process
WO2019075263A3 (en) Methods and compositions for topical delivery
WO2012008722A3 (ko) 조직 증강용 충전 조성물
WO2009015255A3 (en) Composition and method for improving retention and drainage in papermaking processes by activating microparticles with a promoter-flocculant system
WO2015091885A3 (en) Microcapsules with polymeric coating comprising a lipid and an active agent
WO2011126839A3 (en) Compositions and methods for improved retention of a pharmaceutical composition at a local administration site
MX2015017334A (es) Uso de un polímero de acrilato de 2-octilo como agente de enlace en una composición de recubrimiento.
CA2861995C (en) Oral product comprising a mouth-stable polymer matrix and fibers
EP2488023A4 (en) ANTIMICROBIAL COMPOSITION
WO2014093489A3 (en) Hydrogel membrane for adhesion prevention
PH12016500706A1 (en) Smoking article with liquid delivery material
WO2018056937A3 (en) Nanofibrous adhesion barrier
BRPI1011188A2 (pt) composições de liberação dérmica compreendendo complexos de partículas de agente ativo-fosfato de cálcio e métodos para usar as mesmas.
EP2395048A3 (en) Polymers compositions including an antioxidant
NZ603479A (en) Chitosan composition
WO2007144644A3 (en) Extracellular matrix composition
EP2868670A4 (en) MODIFIED CONJUGATE DIENPOLYMER, METHOD FOR THE PRODUCTION OF THE MODIFIED CONJUGATED DIENPOLYME AND RUBBER COMPOSITION WITH THE MODIFIED CONJUGATED DIENPOLYMER
WO2012050879A3 (en) Methods for processing microspheres, microspheres processed thereby, and uses thereof
BR112013025495A2 (pt) massa óssea
WO2012142328A3 (en) Polymer microsphere compositions for localized delivery of therapeutic agents
WO2015130602A3 (en) Sustained release composition using biobased biodegradable hyperbranched polyesters
MX2017014464A (es) Composicion reticulante que incluye silicato sintetico en capas.
MX2017016865A (es) Andamio de polimero adhesivo hermostatico altamente eficaz.

Legal Events

Date Code Title Description
HC Change of company name or juridical status

Owner name: NOXELL CORPORATION

FG Grant or registration