JP2014533181A5 - - Google Patents
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- JP2014533181A5 JP2014533181A5 JP2014541368A JP2014541368A JP2014533181A5 JP 2014533181 A5 JP2014533181 A5 JP 2014533181A5 JP 2014541368 A JP2014541368 A JP 2014541368A JP 2014541368 A JP2014541368 A JP 2014541368A JP 2014533181 A5 JP2014533181 A5 JP 2014533181A5
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- JP
- Japan
- Prior art keywords
- biocompatible polymer
- gel composition
- polymer gel
- composition according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 42
- 229920000249 biocompatible polymer Polymers 0.000 claims description 37
- 229920000447 polyanionic polymer Polymers 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 20
- 239000002904 solvent Substances 0.000 claims description 14
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 229920002851 polycationic polymer Polymers 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 11
- 229920001661 Chitosan Polymers 0.000 claims description 10
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 8
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 8
- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- 208000032843 Hemorrhage Diseases 0.000 claims description 6
- 229940072049 amyl acetate Drugs 0.000 claims description 6
- PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 230000000740 bleeding effect Effects 0.000 claims description 6
- MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 150000001768 cations Chemical class 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 claims description 5
- 229920000936 Agarose Polymers 0.000 claims description 4
- 229920002101 Chitin Polymers 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 229920000615 alginic acid Chemical group 0.000 claims description 4
- 238000011065 in-situ storage Methods 0.000 claims description 4
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- 206010060964 Arterial haemorrhage Diseases 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 206010065441 Venous haemorrhage Diseases 0.000 claims description 3
- 238000005299 abrasion Methods 0.000 claims description 3
- 208000034158 bleeding Diseases 0.000 claims description 3
- 210000005252 bulbus oculi Anatomy 0.000 claims description 3
- 230000002496 gastric effect Effects 0.000 claims description 3
- 230000023597 hemostasis Effects 0.000 claims description 3
- 229920000193 polymethacrylate Polymers 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 230000000451 tissue damage Effects 0.000 claims description 3
- 231100000827 tissue damage Toxicity 0.000 claims description 3
- JVIPLYCGEZUBIO-UHFFFAOYSA-N 2-(4-fluorophenyl)-1,3-dioxoisoindole-5-carboxylic acid Chemical compound O=C1C2=CC(C(=O)O)=CC=C2C(=O)N1C1=CC=C(F)C=C1 JVIPLYCGEZUBIO-UHFFFAOYSA-N 0.000 claims description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 229920001425 Diethylaminoethyl cellulose Polymers 0.000 claims description 2
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 claims description 2
- 229920002148 Gellan gum Polymers 0.000 claims description 2
- 229920000388 Polyphosphate Polymers 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000000679 carrageenan Substances 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- 229940113118 carrageenan Drugs 0.000 claims description 2
- -1 diethylaminoethyl groups Chemical group 0.000 claims description 2
- 235000010492 gellan gum Nutrition 0.000 claims description 2
- 239000000216 gellan gum Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 239000001205 polyphosphate Substances 0.000 claims description 2
- 235000011176 polyphosphates Nutrition 0.000 claims description 2
- 229960002796 polystyrene sulfonate Drugs 0.000 claims description 2
- 239000011970 polystyrene sulfonate Substances 0.000 claims description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 2
- 235000019830 sodium polyphosphate Nutrition 0.000 claims description 2
- 229940006186 sodium polystyrene sulfonate Drugs 0.000 claims description 2
- 239000000230 xanthan gum Substances 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 235000010493 xanthan gum Nutrition 0.000 claims description 2
- 229940082509 xanthan gum Drugs 0.000 claims description 2
- 229920006317 cationic polymer Polymers 0.000 claims 4
- 241000251468 Actinopterygii Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 241000283153 Cetacea Species 0.000 claims 2
- 241001481833 Coryphaena hippurus Species 0.000 claims 2
- 241000283073 Equus caballus Species 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 241000270322 Lepidosauria Species 0.000 claims 2
- 241001233242 Lontra Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 241000009328 Perro Species 0.000 claims 2
- 241000283216 Phocidae Species 0.000 claims 2
- 241000282898 Sus scrofa Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229920001600 hydrophobic polymer Polymers 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 108091033319 polynucleotide Chemical group 0.000 description 1
- 239000002157 polynucleotide Chemical group 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- SONHXMAHPHADTF-UHFFFAOYSA-M sodium;2-methylprop-2-enoate Chemical compound [Na+].CC(=C)C([O-])=O SONHXMAHPHADTF-UHFFFAOYSA-M 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559110P | 2011-11-13 | 2011-11-13 | |
| US61/559,110 | 2011-11-13 | ||
| PCT/US2012/064670 WO2013071235A1 (en) | 2011-11-13 | 2012-11-12 | In-situ cross-linkable polymeric compositions and methods thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018120864A Division JP7013336B2 (ja) | 2011-11-13 | 2018-06-26 | インサイチュー架橋性ポリマー組成物およびその方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014533181A JP2014533181A (ja) | 2014-12-11 |
| JP2014533181A5 true JP2014533181A5 (https=) | 2016-01-07 |
Family
ID=48290658
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541368A Pending JP2014533181A (ja) | 2011-11-13 | 2012-11-12 | インサイチュー架橋性ポリマー組成物およびその方法 |
| JP2018120864A Active JP7013336B2 (ja) | 2011-11-13 | 2018-06-26 | インサイチュー架橋性ポリマー組成物およびその方法 |
| JP2020153716A Withdrawn JP2021007754A (ja) | 2011-11-13 | 2020-09-14 | インサイチュー架橋性ポリマー組成物およびその方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018120864A Active JP7013336B2 (ja) | 2011-11-13 | 2018-06-26 | インサイチュー架橋性ポリマー組成物およびその方法 |
| JP2020153716A Withdrawn JP2021007754A (ja) | 2011-11-13 | 2020-09-14 | インサイチュー架橋性ポリマー組成物およびその方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20140287061A1 (https=) |
| EP (1) | EP2776068A4 (https=) |
| JP (3) | JP2014533181A (https=) |
| KR (1) | KR20140090670A (https=) |
| CN (2) | CN109602944A (https=) |
| AU (2) | AU2012334982A1 (https=) |
| BR (1) | BR112014011442A8 (https=) |
| CA (1) | CA2855347C (https=) |
| HK (1) | HK1201734A1 (https=) |
| IL (1) | IL232330B (https=) |
| IN (1) | IN2014CN03524A (https=) |
| MX (2) | MX366366B (https=) |
| RU (2) | RU2017144044A (https=) |
| SG (2) | SG11201402279SA (https=) |
| WO (1) | WO2013071235A1 (https=) |
| ZA (1) | ZA201403166B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8283384B2 (en) | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| WO2009094060A1 (en) | 2008-01-24 | 2009-07-30 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| WO2011149907A1 (en) | 2010-05-24 | 2011-12-01 | University Of Utah Research Foundation | Reinforced adhesive complex coacervates and methods of making and using thereof |
| EP2637708A2 (en) | 2010-11-12 | 2013-09-18 | University of Utah Research Foundation | Simple adhesive coacervates and methods of making and using thereof |
| CA2855347C (en) | 2011-11-13 | 2019-03-05 | Suneris Inc. | In-situ cross-linkable polymeric compositions and methods thereof |
| WO2014123665A1 (en) | 2013-02-06 | 2014-08-14 | Kci Licensing, Inc. | Polymers, preparation and use thereof |
| ITTO20130375A1 (it) * | 2013-05-10 | 2014-11-11 | Marco Benzi | Prodotto per l'uso per il trattamento terapeutico di parodontopatie e perimplantiti |
| CN103611180B (zh) * | 2013-11-21 | 2015-02-18 | 无锡中科光远生物材料有限公司 | 一种自粘止血防粘连纤维体的制备方法 |
| EP3166550B1 (en) | 2014-07-11 | 2023-12-13 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Surgical tool for ocular tissue transplantation |
| EP3169374B1 (en) | 2014-07-14 | 2022-01-05 | University of Utah Research Foundation | In situ solidifying complex coacervates and methods of making and using thereof |
| MX2017016865A (es) * | 2015-06-22 | 2018-09-06 | Cresilon Inc | Andamio de polimero adhesivo hermostatico altamente eficaz. |
| JP7493961B2 (ja) * | 2015-06-22 | 2024-06-03 | クレシロン， インコーポレイテッド | 高度に有用な止血用接着性ポリマー足場 |
| US10751444B2 (en) | 2015-08-07 | 2020-08-25 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
| US10660945B2 (en) | 2015-08-07 | 2020-05-26 | Victor Matthew Phillips | Flowable hemostatic gel composition and its methods of use |
| CN105030815B (zh) * | 2015-08-10 | 2019-03-15 | 贵州扬生医用器材有限公司 | 一种手术冲洗液及其制法 |
| US11065337B2 (en) | 2015-12-14 | 2021-07-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Complex coacervate for controlled release and related methods |
| KR101666792B1 (ko) | 2016-02-05 | 2016-10-17 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물 |
| WO2017152039A1 (en) | 2016-03-04 | 2017-09-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Protection and delivery of multiple therapeutic proteins |
| CN105860107B (zh) * | 2016-04-26 | 2018-02-09 | 中南大学 | 一种过氧化氢响应及具有电化学活性的壳聚糖水凝胶的制备方法 |
| KR101916193B1 (ko) * | 2016-08-25 | 2018-11-07 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 관절강 주사용 조성물 |
| WO2018128704A2 (en) | 2016-11-07 | 2018-07-12 | 3M Innovative Properties Company | Medical composition containing guanidinyl-containing polymer(s) and carrageenane(s) |
| WO2018119320A1 (en) * | 2016-12-21 | 2018-06-28 | Cresilon, Inc. | Hemostatic compositions with antifibrinolytic agents |
| BR112019012531A2 (pt) * | 2016-12-22 | 2019-11-19 | Omrix Biopharmaceuticals Ltd | composição hemostática compreendendo um trocador de ânions e um sal de cálcio |
| IL249725A0 (en) | 2016-12-22 | 2017-03-30 | Omrix Biopharmaceuticals Ltd | A hemostatic preparation containing an anion exchanger and a calcium salt |
| JP6939607B2 (ja) * | 2017-03-27 | 2021-09-22 | Jsr株式会社 | 組成物およびその用途 |
| CN108926490B (zh) * | 2017-05-25 | 2021-01-26 | 南方医科大学南方医院 | 一种抗凝胃管的制作方法 |
| KR102218427B1 (ko) * | 2017-09-20 | 2021-02-22 | 차의과학대학교 산학협력단 | 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제 |
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