JP2014531436A5 - - Google Patents
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- Publication number
- JP2014531436A5 JP2014531436A5 JP2014529985A JP2014529985A JP2014531436A5 JP 2014531436 A5 JP2014531436 A5 JP 2014531436A5 JP 2014529985 A JP2014529985 A JP 2014529985A JP 2014529985 A JP2014529985 A JP 2014529985A JP 2014531436 A5 JP2014531436 A5 JP 2014531436A5
- Authority
- JP
- Japan
- Prior art keywords
- atoms
- cancer
- hal
- group
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C=C)=C(*)C(N)=NC=* Chemical compound *C(C=C)=C(*)C(N)=NC=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161533601P | 2011-09-12 | 2011-09-12 | |
| US61/533,601 | 2011-09-12 | ||
| PCT/US2012/054900 WO2013040059A1 (en) | 2011-09-12 | 2012-09-12 | Novel imidazole amines as modulators of kinase activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531436A JP2014531436A (ja) | 2014-11-27 |
| JP2014531436A5 true JP2014531436A5 (enExample) | 2016-06-09 |
| JP5964974B2 JP5964974B2 (ja) | 2016-08-03 |
Family
ID=46881179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529985A Expired - Fee Related JP5964974B2 (ja) | 2011-09-12 | 2012-09-12 | キナーゼ活性のモジュレーターとしての新規イミダゾールアミン |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9145392B2 (enExample) |
| EP (1) | EP2755965B1 (enExample) |
| JP (1) | JP5964974B2 (enExample) |
| KR (1) | KR101995605B1 (enExample) |
| CN (1) | CN104080782B (enExample) |
| AU (1) | AU2012308696B2 (enExample) |
| BR (1) | BR112014005554A2 (enExample) |
| CA (1) | CA2844830C (enExample) |
| DK (1) | DK2755965T3 (enExample) |
| EA (1) | EA025098B1 (enExample) |
| ES (1) | ES2644536T3 (enExample) |
| HR (1) | HRP20171554T1 (enExample) |
| HU (1) | HUE035019T2 (enExample) |
| IL (1) | IL231383A (enExample) |
| LT (1) | LT2755965T (enExample) |
| MX (1) | MX346095B (enExample) |
| NO (1) | NO2791461T3 (enExample) |
| PL (1) | PL2755965T3 (enExample) |
| PT (1) | PT2755965T (enExample) |
| RS (1) | RS56534B1 (enExample) |
| SG (2) | SG10201606301YA (enExample) |
| SI (1) | SI2755965T1 (enExample) |
| WO (1) | WO2013040059A1 (enExample) |
| ZA (1) | ZA201401013B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2646759T3 (es) * | 2011-09-12 | 2017-12-15 | Merck Patent Gmbh | Derivados de aminopirimidina para uso como moduladores de la actividad de la quinasa |
| GEP201706623B (en) | 2012-10-16 | 2017-02-10 | Almirall Sa | Pyrrolotriazinone derivatives as pi3k inhibitors |
| AR093511A1 (es) | 2012-11-16 | 2015-06-10 | Merck Patent Gmbh | Derivados de imidazol-piperidinilo como moduladores de la actividad de cinasas |
| MX370448B (es) * | 2013-03-11 | 2019-12-13 | Merck Patent Gmbh | Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa. |
| JP6560243B2 (ja) * | 2014-02-11 | 2019-08-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | キナーゼ活性のモジュレーターとしてのピリミジンイミダゾールアミン |
| WO2015159938A1 (ja) | 2014-04-18 | 2015-10-22 | 武田薬品工業株式会社 | 複素環化合物 |
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| KR20200093159A (ko) | 2019-01-28 | 2020-08-05 | 주식회사 링크모션 | 스마트 팜 모듈 구조물 |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| US11866421B2 (en) | 2021-05-31 | 2024-01-09 | Epigen Biosciences, Inc. | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
| CN117567435A (zh) * | 2022-01-30 | 2024-02-20 | 上海市第十人民医院 | 谷氨酰胺环化酶抑制剂及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| US7547794B2 (en) | 2003-04-03 | 2009-06-16 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| US7189729B2 (en) | 2003-09-30 | 2007-03-13 | Irm Llc | Methods and compositions as protein kinase inhibitors |
| US7816353B2 (en) | 2003-10-24 | 2010-10-19 | Exelixis, Inc. | P70S6 kinase modulators and method of use |
| RU2006121646A (ru) | 2003-11-21 | 2008-01-10 | Новартис АГ (CH) | Производные 1h-имидазохинолина в качестве ингибиторов протеинкиназы |
| BRPI0417498A (pt) | 2003-12-09 | 2007-05-29 | Us Gov Health & Human Serv | método para suprimir uma resposta imune em um indivìduo; método de inibição da proliferação de um célula; método de tratamento de um distúrbio proliferativo em um indivìduo; método para selecionar um agente imunossupressor ou anti-proliferativo; composição farmacêutica e estente vascular |
| WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| AU2005322085B2 (en) | 2004-12-28 | 2012-07-19 | Exelixis, Inc. | [1H-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70S6K, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| EP1838703A2 (en) * | 2005-01-19 | 2007-10-03 | Neurogen Corporation | Heteroaryl substituted piperazinyl-pyridine analogues |
| GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| US8343953B2 (en) | 2005-06-22 | 2013-01-01 | Astex Therapeutics Limited | Pharmaceutical compounds |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| KR101699991B1 (ko) | 2009-02-11 | 2017-01-26 | 메르크 파텐트 게엠베하 | 신규의 아미노 아자헤테로시클릭 카르복사미드 |
| UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| US9586938B2 (en) | 2010-07-29 | 2017-03-07 | Merck Patent Gmbh | Cyclic amine azaheterocyclic carboxamides |
| EA023821B1 (ru) | 2010-11-24 | 2016-07-29 | Мерк Патент Гмбх | Хиназолинкарбоксамидазетидины, их применение в лечении гиперпролиферативных заболеваний и содержащие их композиции |
-
2012
- 2012-09-12 HR HRP20171554TT patent/HRP20171554T1/hr unknown
- 2012-09-12 RS RS20171075A patent/RS56534B1/sr unknown
- 2012-09-12 MX MX2014002832A patent/MX346095B/es active IP Right Grant
- 2012-09-12 AU AU2012308696A patent/AU2012308696B2/en not_active Ceased
- 2012-09-12 EP EP12761865.0A patent/EP2755965B1/en active Active
- 2012-09-12 DK DK12761865.0T patent/DK2755965T3/en active
- 2012-09-12 LT LTEP12761865.0T patent/LT2755965T/lt unknown
- 2012-09-12 SG SG10201606301YA patent/SG10201606301YA/en unknown
- 2012-09-12 CA CA2844830A patent/CA2844830C/en not_active Expired - Fee Related
- 2012-09-12 ES ES12761865.0T patent/ES2644536T3/es active Active
- 2012-09-12 US US14/237,075 patent/US9145392B2/en not_active Expired - Fee Related
- 2012-09-12 BR BR112014005554A patent/BR112014005554A2/pt not_active IP Right Cessation
- 2012-09-12 CN CN201280054930.4A patent/CN104080782B/zh not_active Expired - Fee Related
- 2012-09-12 EA EA201400339A patent/EA025098B1/ru not_active IP Right Cessation
- 2012-09-12 PT PT127618650T patent/PT2755965T/pt unknown
- 2012-09-12 HU HUE12761865A patent/HUE035019T2/en unknown
- 2012-09-12 KR KR1020147006807A patent/KR101995605B1/ko not_active Expired - Fee Related
- 2012-09-12 WO PCT/US2012/054900 patent/WO2013040059A1/en not_active Ceased
- 2012-09-12 JP JP2014529985A patent/JP5964974B2/ja not_active Expired - Fee Related
- 2012-09-12 SG SG2014009278A patent/SG2014009278A/en unknown
- 2012-09-12 PL PL12761865T patent/PL2755965T3/pl unknown
- 2012-09-12 SI SI201231104T patent/SI2755965T1/sl unknown
- 2012-12-11 NO NO12858293A patent/NO2791461T3/no unknown
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2014
- 2014-02-10 ZA ZA2014/01013A patent/ZA201401013B/en unknown
- 2014-03-06 IL IL231383A patent/IL231383A/en active IP Right Grant
-
2015
- 2015-09-14 US US14/852,851 patent/US20160000785A1/en not_active Abandoned