AU2012308696B2 - Novel imidazole amines as modulators of kinase activity - Google Patents
Novel imidazole amines as modulators of kinase activity Download PDFInfo
- Publication number
- AU2012308696B2 AU2012308696B2 AU2012308696A AU2012308696A AU2012308696B2 AU 2012308696 B2 AU2012308696 B2 AU 2012308696B2 AU 2012308696 A AU2012308696 A AU 2012308696A AU 2012308696 A AU2012308696 A AU 2012308696A AU 2012308696 B2 AU2012308696 B2 AU 2012308696B2
- Authority
- AU
- Australia
- Prior art keywords
- imidazol
- piperidin
- ethyl
- fluoro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161533601P | 2011-09-12 | 2011-09-12 | |
| US61/533,601 | 2011-09-12 | ||
| PCT/US2012/054900 WO2013040059A1 (en) | 2011-09-12 | 2012-09-12 | Novel imidazole amines as modulators of kinase activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012308696A1 AU2012308696A1 (en) | 2014-02-27 |
| AU2012308696B2 true AU2012308696B2 (en) | 2017-04-27 |
Family
ID=46881179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012308696A Ceased AU2012308696B2 (en) | 2011-09-12 | 2012-09-12 | Novel imidazole amines as modulators of kinase activity |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9145392B2 (enExample) |
| EP (1) | EP2755965B1 (enExample) |
| JP (1) | JP5964974B2 (enExample) |
| KR (1) | KR101995605B1 (enExample) |
| CN (1) | CN104080782B (enExample) |
| AU (1) | AU2012308696B2 (enExample) |
| BR (1) | BR112014005554A2 (enExample) |
| CA (1) | CA2844830C (enExample) |
| DK (1) | DK2755965T3 (enExample) |
| EA (1) | EA025098B1 (enExample) |
| ES (1) | ES2644536T3 (enExample) |
| HR (1) | HRP20171554T1 (enExample) |
| HU (1) | HUE035019T2 (enExample) |
| IL (1) | IL231383A (enExample) |
| LT (1) | LT2755965T (enExample) |
| MX (1) | MX346095B (enExample) |
| NO (1) | NO2791461T3 (enExample) |
| PL (1) | PL2755965T3 (enExample) |
| PT (1) | PT2755965T (enExample) |
| RS (1) | RS56534B1 (enExample) |
| SG (2) | SG2014009278A (enExample) |
| SI (1) | SI2755965T1 (enExample) |
| WO (1) | WO2013040059A1 (enExample) |
| ZA (1) | ZA201401013B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG2014009260A (en) | 2011-09-12 | 2014-09-26 | Merck Patent Gmbh | Aminopyrimidine derivatives for use as modulators of kinase activity |
| EA027277B1 (ru) | 2012-10-16 | 2017-07-31 | Альмираль, С.А. | Производные пирроллотриазинона в качестве ингибиторов pi3k |
| ES2807539T3 (es) | 2012-11-16 | 2021-02-23 | Merck Patent Gmbh | Derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa |
| SG11201505999VA (en) * | 2013-03-11 | 2015-08-28 | Merck Patent Gmbh | 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity |
| CN105980375A (zh) * | 2014-02-11 | 2016-09-28 | 默克专利有限公司 | 用作激酶活性调节剂的嘧啶咪唑胺 |
| EP3205645B1 (en) | 2014-04-18 | 2019-10-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| KR20200093159A (ko) | 2019-01-28 | 2020-08-05 | 주식회사 링크모션 | 스마트 팜 모듈 구조물 |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| US11866421B2 (en) | 2021-05-31 | 2024-01-09 | Epigen Biosciences, Inc. | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment |
| CN117794920A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂 |
| CN117567435A (zh) * | 2022-01-30 | 2024-02-20 | 上海市第十人民医院 | 谷氨酰胺环化酶抑制剂及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008140947A1 (en) * | 2007-05-11 | 2008-11-20 | Eli Lilly And Company | P70 s6 kinase inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| WO2004092154A1 (en) | 2003-04-03 | 2004-10-28 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| CN100412066C (zh) | 2003-09-30 | 2008-08-20 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
| JP4800216B2 (ja) | 2003-10-24 | 2011-10-26 | エグゼリクシス， インコーポレイテッド | ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法 |
| JP2007511575A (ja) | 2003-11-21 | 2007-05-10 | ノバルティス アクチエンゲゼルシャフト | タンパク質キナーゼ阻害剤としての１ｈ−イミダゾキノリン誘導体 |
| TR200808208T1 (tr) | 2003-12-09 | 2008-12-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bir immün tepkinin bastırılması veya proliferatif bir hastalığın tedavisi |
| WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| US7994172B2 (en) | 2004-12-28 | 2011-08-09 | Exelixis, Inc. | [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| CA2595205A1 (en) * | 2005-01-19 | 2006-07-27 | Neurogen Corporation | Heteroaryl substituted piperazinyl-pyridine analogues |
| GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| EP1902032A1 (en) | 2005-06-22 | 2008-03-26 | Astex Therapeutics Limited | Pharmaceutical compounds |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| AR074072A1 (es) * | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| BRPI1008325A2 (pt) | 2009-02-11 | 2020-08-25 | Merck Patent Gmbh | carboxamidas azaeterocíclicas de amino |
| BR112013002212A2 (pt) | 2010-07-29 | 2017-09-26 | Merck Patent Gmbh | carboxamidas aza-heterocíclicas de aminas cíclicas |
| UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| WO2012069146A1 (en) | 2010-11-24 | 2012-05-31 | Merck Patent Gmbh | Quinazoline carboxamide azetidines |
-
2012
- 2012-09-12 SI SI201231104T patent/SI2755965T1/sl unknown
- 2012-09-12 PL PL12761865T patent/PL2755965T3/pl unknown
- 2012-09-12 AU AU2012308696A patent/AU2012308696B2/en not_active Ceased
- 2012-09-12 LT LTEP12761865.0T patent/LT2755965T/lt unknown
- 2012-09-12 SG SG2014009278A patent/SG2014009278A/en unknown
- 2012-09-12 SG SG10201606301YA patent/SG10201606301YA/en unknown
- 2012-09-12 HR HRP20171554TT patent/HRP20171554T1/hr unknown
- 2012-09-12 WO PCT/US2012/054900 patent/WO2013040059A1/en not_active Ceased
- 2012-09-12 JP JP2014529985A patent/JP5964974B2/ja not_active Expired - Fee Related
- 2012-09-12 HU HUE12761865A patent/HUE035019T2/en unknown
- 2012-09-12 EP EP12761865.0A patent/EP2755965B1/en active Active
- 2012-09-12 US US14/237,075 patent/US9145392B2/en not_active Expired - Fee Related
- 2012-09-12 CN CN201280054930.4A patent/CN104080782B/zh not_active Expired - Fee Related
- 2012-09-12 ES ES12761865.0T patent/ES2644536T3/es active Active
- 2012-09-12 DK DK12761865.0T patent/DK2755965T3/en active
- 2012-09-12 RS RS20171075A patent/RS56534B1/sr unknown
- 2012-09-12 MX MX2014002832A patent/MX346095B/es active IP Right Grant
- 2012-09-12 CA CA2844830A patent/CA2844830C/en not_active Expired - Fee Related
- 2012-09-12 PT PT127618650T patent/PT2755965T/pt unknown
- 2012-09-12 EA EA201400339A patent/EA025098B1/ru not_active IP Right Cessation
- 2012-09-12 KR KR1020147006807A patent/KR101995605B1/ko not_active Expired - Fee Related
- 2012-09-12 BR BR112014005554A patent/BR112014005554A2/pt not_active IP Right Cessation
- 2012-12-11 NO NO12858293A patent/NO2791461T3/no unknown
-
2014
- 2014-02-10 ZA ZA2014/01013A patent/ZA201401013B/en unknown
- 2014-03-06 IL IL231383A patent/IL231383A/en active IP Right Grant
-
2015
- 2015-09-14 US US14/852,851 patent/US20160000785A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008140947A1 (en) * | 2007-05-11 | 2008-11-20 | Eli Lilly And Company | P70 s6 kinase inhibitors |
Also Published As
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| Publication | Publication Date | Title |
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| DK2755965T3 (en) | PRESENT UNKNOWN IMIDAZOLAMINES AS MODULATORS OF KINASE ACTIVITY | |
| AU2017245469B2 (en) | Aminopyrimidine derivatives for use as modulators of kinase activity | |
| EP2970201A1 (en) | 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity | |
| US9434714B2 (en) | Pyrimidine imidazole amines as modulators of kinase activity | |
| HK1201825B (en) | Imidazole amines as modulators of kinase activity | |
| HK1228893A1 (en) | Pyrimidine imidazole amines as modulators of kinase activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |