RS56534B1 - Novi imidazol akmini kao modulatori aktivnosti kinaza - Google Patents
Novi imidazol akmini kao modulatori aktivnosti kinazaInfo
- Publication number
- RS56534B1 RS56534B1 RS20171075A RSP20171075A RS56534B1 RS 56534 B1 RS56534 B1 RS 56534B1 RS 20171075 A RS20171075 A RS 20171075A RS P20171075 A RSP20171075 A RS P20171075A RS 56534 B1 RS56534 B1 RS 56534B1
- Authority
- RS
- Serbia
- Prior art keywords
- imidazol
- phenyl
- fluoro
- piperidin
- trifluoromethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161533601P | 2011-09-12 | 2011-09-12 | |
| PCT/US2012/054900 WO2013040059A1 (en) | 2011-09-12 | 2012-09-12 | Novel imidazole amines as modulators of kinase activity |
| EP12761865.0A EP2755965B1 (en) | 2011-09-12 | 2012-09-12 | Novel imidazole amines as modulators of kinase activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS56534B1 true RS56534B1 (sr) | 2018-02-28 |
Family
ID=46881179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20171075A RS56534B1 (sr) | 2011-09-12 | 2012-09-12 | Novi imidazol akmini kao modulatori aktivnosti kinaza |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9145392B2 (enExample) |
| EP (1) | EP2755965B1 (enExample) |
| JP (1) | JP5964974B2 (enExample) |
| KR (1) | KR101995605B1 (enExample) |
| CN (1) | CN104080782B (enExample) |
| AU (1) | AU2012308696B2 (enExample) |
| BR (1) | BR112014005554A2 (enExample) |
| CA (1) | CA2844830C (enExample) |
| DK (1) | DK2755965T3 (enExample) |
| EA (1) | EA025098B1 (enExample) |
| ES (1) | ES2644536T3 (enExample) |
| HR (1) | HRP20171554T1 (enExample) |
| HU (1) | HUE035019T2 (enExample) |
| IL (1) | IL231383A (enExample) |
| LT (1) | LT2755965T (enExample) |
| MX (1) | MX346095B (enExample) |
| NO (1) | NO2791461T3 (enExample) |
| PL (1) | PL2755965T3 (enExample) |
| PT (1) | PT2755965T (enExample) |
| RS (1) | RS56534B1 (enExample) |
| SG (2) | SG10201606301YA (enExample) |
| SI (1) | SI2755965T1 (enExample) |
| WO (1) | WO2013040059A1 (enExample) |
| ZA (1) | ZA201401013B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2646759T3 (es) * | 2011-09-12 | 2017-12-15 | Merck Patent Gmbh | Derivados de aminopirimidina para uso como moduladores de la actividad de la quinasa |
| GEP201706623B (en) | 2012-10-16 | 2017-02-10 | Almirall Sa | Pyrrolotriazinone derivatives as pi3k inhibitors |
| AR093511A1 (es) | 2012-11-16 | 2015-06-10 | Merck Patent Gmbh | Derivados de imidazol-piperidinilo como moduladores de la actividad de cinasas |
| MX370448B (es) * | 2013-03-11 | 2019-12-13 | Merck Patent Gmbh | Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa. |
| JP6560243B2 (ja) * | 2014-02-11 | 2019-08-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | キナーゼ活性のモジュレーターとしてのピリミジンイミダゾールアミン |
| WO2015159938A1 (ja) | 2014-04-18 | 2015-10-22 | 武田薬品工業株式会社 | 複素環化合物 |
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药（上海）有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| KR20200093159A (ko) | 2019-01-28 | 2020-08-05 | 주식회사 링크모션 | 스마트 팜 모듈 구조물 |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| US11866421B2 (en) | 2021-05-31 | 2024-01-09 | Epigen Biosciences, Inc. | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
| CN117567435A (zh) * | 2022-01-30 | 2024-02-20 | 上海市第十人民医院 | 谷氨酰胺环化酶抑制剂及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| US7547794B2 (en) | 2003-04-03 | 2009-06-16 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| US7189729B2 (en) | 2003-09-30 | 2007-03-13 | Irm Llc | Methods and compositions as protein kinase inhibitors |
| US7816353B2 (en) | 2003-10-24 | 2010-10-19 | Exelixis, Inc. | P70S6 kinase modulators and method of use |
| RU2006121646A (ru) | 2003-11-21 | 2008-01-10 | Новартис АГ (CH) | Производные 1h-имидазохинолина в качестве ингибиторов протеинкиназы |
| BRPI0417498A (pt) | 2003-12-09 | 2007-05-29 | Us Gov Health & Human Serv | método para suprimir uma resposta imune em um indivìduo; método de inibição da proliferação de um célula; método de tratamento de um distúrbio proliferativo em um indivìduo; método para selecionar um agente imunossupressor ou anti-proliferativo; composição farmacêutica e estente vascular |
| WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| AU2005322085B2 (en) | 2004-12-28 | 2012-07-19 | Exelixis, Inc. | [1H-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70S6K, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| EP1838703A2 (en) * | 2005-01-19 | 2007-10-03 | Neurogen Corporation | Heteroaryl substituted piperazinyl-pyridine analogues |
| GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| US8343953B2 (en) | 2005-06-22 | 2013-01-01 | Astex Therapeutics Limited | Pharmaceutical compounds |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
| AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| KR101699991B1 (ko) | 2009-02-11 | 2017-01-26 | 메르크 파텐트 게엠베하 | 신규의 아미노 아자헤테로시클릭 카르복사미드 |
| UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
| US9586938B2 (en) | 2010-07-29 | 2017-03-07 | Merck Patent Gmbh | Cyclic amine azaheterocyclic carboxamides |
| EA023821B1 (ru) | 2010-11-24 | 2016-07-29 | Мерк Патент Гмбх | Хиназолинкарбоксамидазетидины, их применение в лечении гиперпролиферативных заболеваний и содержащие их композиции |
-
2012
- 2012-09-12 HR HRP20171554TT patent/HRP20171554T1/hr unknown
- 2012-09-12 RS RS20171075A patent/RS56534B1/sr unknown
- 2012-09-12 MX MX2014002832A patent/MX346095B/es active IP Right Grant
- 2012-09-12 AU AU2012308696A patent/AU2012308696B2/en not_active Ceased
- 2012-09-12 EP EP12761865.0A patent/EP2755965B1/en active Active
- 2012-09-12 DK DK12761865.0T patent/DK2755965T3/en active
- 2012-09-12 LT LTEP12761865.0T patent/LT2755965T/lt unknown
- 2012-09-12 SG SG10201606301YA patent/SG10201606301YA/en unknown
- 2012-09-12 CA CA2844830A patent/CA2844830C/en not_active Expired - Fee Related
- 2012-09-12 ES ES12761865.0T patent/ES2644536T3/es active Active
- 2012-09-12 US US14/237,075 patent/US9145392B2/en not_active Expired - Fee Related
- 2012-09-12 BR BR112014005554A patent/BR112014005554A2/pt not_active IP Right Cessation
- 2012-09-12 CN CN201280054930.4A patent/CN104080782B/zh not_active Expired - Fee Related
- 2012-09-12 EA EA201400339A patent/EA025098B1/ru not_active IP Right Cessation
- 2012-09-12 PT PT127618650T patent/PT2755965T/pt unknown
- 2012-09-12 HU HUE12761865A patent/HUE035019T2/en unknown
- 2012-09-12 KR KR1020147006807A patent/KR101995605B1/ko not_active Expired - Fee Related
- 2012-09-12 WO PCT/US2012/054900 patent/WO2013040059A1/en not_active Ceased
- 2012-09-12 JP JP2014529985A patent/JP5964974B2/ja not_active Expired - Fee Related
- 2012-09-12 SG SG2014009278A patent/SG2014009278A/en unknown
- 2012-09-12 PL PL12761865T patent/PL2755965T3/pl unknown
- 2012-09-12 SI SI201231104T patent/SI2755965T1/sl unknown
- 2012-12-11 NO NO12858293A patent/NO2791461T3/no unknown
-
2014
- 2014-02-10 ZA ZA2014/01013A patent/ZA201401013B/en unknown
- 2014-03-06 IL IL231383A patent/IL231383A/en active IP Right Grant
-
2015
- 2015-09-14 US US14/852,851 patent/US20160000785A1/en not_active Abandoned
Also Published As
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