JP2019526616A5 - - Google Patents
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- Publication number
- JP2019526616A5 JP2019526616A5 JP2019513958A JP2019513958A JP2019526616A5 JP 2019526616 A5 JP2019526616 A5 JP 2019526616A5 JP 2019513958 A JP2019513958 A JP 2019513958A JP 2019513958 A JP2019513958 A JP 2019513958A JP 2019526616 A5 JP2019526616 A5 JP 2019526616A5
- Authority
- JP
- Japan
- Prior art keywords
- diazepine
- thieno
- triazolo
- chlorophenyl
- ethynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*NC1=**=C2*1C(NC(C1NC)=C)=C1C(c1ccccc1)=*C2 Chemical compound C*NC1=**=C2*1C(NC(C1NC)=C)=C1C(c1ccccc1)=*C2 0.000 description 2
- BEIYFCCFKMAEDF-UHFFFAOYSA-N CC1C=CC(C)(C)CC1 Chemical compound CC1C=CC(C)(C)CC1 BEIYFCCFKMAEDF-UHFFFAOYSA-N 0.000 description 1
- CBRVMHNCKYHAOV-UHFFFAOYSA-N CCC1=CN=C(C)CC=C1 Chemical compound CCC1=CN=C(C)CC=C1 CBRVMHNCKYHAOV-UHFFFAOYSA-N 0.000 description 1
- RHOOLJLEYYXKTK-UHFFFAOYSA-N Cc1cnc(C)nc1 Chemical compound Cc1cnc(C)nc1 RHOOLJLEYYXKTK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662393923P | 2016-09-13 | 2016-09-13 | |
| US62/393,923 | 2016-09-13 | ||
| PCT/US2017/051286 WO2018052949A1 (en) | 2016-09-13 | 2017-09-13 | Fused 1,4-diazepines as bet protein degraders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526616A JP2019526616A (ja) | 2019-09-19 |
| JP2019526616A5 true JP2019526616A5 (enExample) | 2020-10-22 |
| JP7035027B2 JP7035027B2 (ja) | 2022-03-14 |
Family
ID=60002003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019513958A Expired - Fee Related JP7035027B2 (ja) | 2016-09-13 | 2017-09-13 | Ｂｅｔタンパク質分解物質としての縮合１，４－ジアゼピン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10975093B2 (enExample) |
| EP (2) | EP3512853B1 (enExample) |
| JP (1) | JP7035027B2 (enExample) |
| CN (1) | CN110072866A (enExample) |
| AU (1) | AU2017326175B2 (enExample) |
| CA (1) | CA3036841A1 (enExample) |
| ES (1) | ES2857743T3 (enExample) |
| WO (1) | WO2018052949A1 (enExample) |
Families Citing this family (47)
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| CN110407854B (zh) * | 2018-08-17 | 2020-09-15 | 北京加科思新药研发有限公司 | 新的四环化合物 |
| JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解 |
| US11969472B2 (en) | 2018-08-22 | 2024-04-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
| IL280984B2 (en) | 2018-08-22 | 2025-02-01 | Cullgen Shanghai Inc | Tropomyosin receptor kinase (TRK) inhibitor compounds and methods of use |
| AU2019381688A1 (en) * | 2018-11-13 | 2021-06-03 | Biotheryx, Inc. | Substituted isoindolinones |
| CN120698983A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| WO2020181232A1 (en) | 2019-03-06 | 2020-09-10 | C4 Therapeutics, Inc. | Heterocyclic compounds for medical treatment |
| CN114867727B (zh) | 2019-07-17 | 2025-02-21 | 阿尔维纳斯运营股份有限公司 | Tau蛋白靶向化合物及相关使用方法 |
| CN112321566B (zh) | 2019-08-05 | 2022-06-10 | 上海科技大学 | Egfr蛋白降解剂及其抗肿瘤应用 |
| CN119019369A (zh) | 2019-10-17 | 2024-11-26 | 阿尔维纳斯运营股份有限公司 | 含有与bcl6靶向部分连接的e3泛素连接酶结合部分的双官能分子 |
| EP4076530A4 (en) * | 2019-12-17 | 2024-04-10 | Orionis Biosciences, Inc. | BIFUNCTIONAL AGENTS FOR RECRUITMENT AND/OR DEGRADATION OF PROTEINS |
| WO2023205701A1 (en) | 2022-04-20 | 2023-10-26 | Kumquat Biosciences Inc. | Macrocyclic heterocycles and uses thereof |
| EP4110772A4 (en) | 2020-02-26 | 2024-04-03 | Cullgen (Shanghai), Inc. | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE |
| MX2022010952A (es) | 2020-03-05 | 2022-10-07 | C4 Therapeutics Inc | Compuestos para la degradacion dirigida de brd9. |
| US12180193B2 (en) | 2020-08-28 | 2024-12-31 | Arvinas Operations, Inc. | Accelerating fibrosarcoma protein degrading compounds and associated methods of use |
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| US20240299557A1 (en) * | 2021-01-22 | 2024-09-12 | Taibidi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Compound for degrading deoxyribonucleic acid (dna) polymerase, and use thereof |
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| CN115611881B (zh) * | 2021-07-13 | 2024-09-20 | 复旦大学 | 一种合成新型vhl配体4-f-vh032的方法 |
| WO2023074780A1 (ja) * | 2021-10-27 | 2023-05-04 | 国立大学法人愛媛大学 | 治療薬組成物 |
| EP4584258A1 (en) | 2022-09-07 | 2025-07-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
| CN116585322B (zh) * | 2023-01-16 | 2023-10-13 | 中山大学中山眼科中心 | Bet蛋白降解剂在预防和治疗视网膜退行性改变相关疾病中的应用 |
| TW202500126A (zh) | 2023-05-24 | 2025-01-01 | 美商金橘生物科技公司 | 雜環化合物及其用途 |
| WO2025007000A1 (en) | 2023-06-30 | 2025-01-02 | Kumquat Biosciences Inc. | Substituted condensed tricyclic amine compounds and uses thereof as ras inhibitors |
| WO2025011624A1 (en) * | 2023-07-11 | 2025-01-16 | Etern Biopharma (Shanghai) Co., Ltd. | Bifunctional compounds for androgen receptor degradation and methods of use |
| TW202523291A (zh) | 2023-11-02 | 2025-06-16 | 美商金橘生物科技公司 | 降解劑及其用途 |
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| WO1982001011A1 (en) | 1980-09-24 | 1982-04-01 | Corp Cetus | Diagnostic method and probe |
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| DK2421533T3 (en) | 2009-04-22 | 2019-01-07 | Resverlogix Corp | Hitherto unknown anti-inflammatory agents |
| DE102009051823A1 (de) | 2009-11-04 | 2011-05-05 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Einkristallines Schweißen von direktional verfestigten Werkstoffen |
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-
2017
- 2017-09-13 US US16/332,544 patent/US10975093B2/en active Active
- 2017-09-13 WO PCT/US2017/051286 patent/WO2018052949A1/en not_active Ceased
- 2017-09-13 EP EP17778012.9A patent/EP3512853B1/en not_active Not-in-force
- 2017-09-13 CN CN201780069335.0A patent/CN110072866A/zh active Pending
- 2017-09-13 JP JP2019513958A patent/JP7035027B2/ja not_active Expired - Fee Related
- 2017-09-13 AU AU2017326175A patent/AU2017326175B2/en not_active Ceased
- 2017-09-13 EP EP20216642.7A patent/EP3858837A1/en not_active Withdrawn
- 2017-09-13 CA CA3036841A patent/CA3036841A1/en active Pending
- 2017-09-13 ES ES17778012T patent/ES2857743T3/es active Active
-
2021
- 2021-04-12 US US17/227,641 patent/US20220356192A1/en not_active Abandoned