CA3036841A1 - Fused 1,4-diazepines as bet protein degraders - Google Patents

Fused 1,4-diazepines as bet protein degraders Download PDF

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Publication number
CA3036841A1
CA3036841A1 CA3036841A CA3036841A CA3036841A1 CA 3036841 A1 CA3036841 A1 CA 3036841A1 CA 3036841 A CA3036841 A CA 3036841A CA 3036841 A CA3036841 A CA 3036841A CA 3036841 A1 CA3036841 A1 CA 3036841A1
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CA
Canada
Prior art keywords
compound
pharmaceutically acceptable
group
acceptable salt
cancer
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Pending
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CA3036841A
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English (en)
French (fr)
Inventor
Shaomeng Wang
Yang Hu
Chong QIN
Fuming XU
Jiantao HU
Weiguo XIANG
Bing Zhou
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University of Michigan System
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University of Michigan System
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Application filed by University of Michigan System filed Critical University of Michigan System
Publication of CA3036841A1 publication Critical patent/CA3036841A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CA3036841A 2016-09-13 2017-09-13 Fused 1,4-diazepines as bet protein degraders Pending CA3036841A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662393923P 2016-09-13 2016-09-13
US62/393,923 2016-09-13
PCT/US2017/051286 WO2018052949A1 (en) 2016-09-13 2017-09-13 Fused 1,4-diazepines as bet protein degraders

Publications (1)

Publication Number Publication Date
CA3036841A1 true CA3036841A1 (en) 2018-03-22

Family

ID=60002003

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3036841A Pending CA3036841A1 (en) 2016-09-13 2017-09-13 Fused 1,4-diazepines as bet protein degraders

Country Status (8)

Country Link
US (2) US10975093B2 (enExample)
EP (2) EP3858837A1 (enExample)
JP (1) JP7035027B2 (enExample)
CN (1) CN110072866A (enExample)
AU (1) AU2017326175B2 (enExample)
CA (1) CA3036841A1 (enExample)
ES (1) ES2857743T3 (enExample)
WO (1) WO2018052949A1 (enExample)

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Also Published As

Publication number Publication date
US20220356192A1 (en) 2022-11-10
EP3512853A1 (en) 2019-07-24
AU2017326175B2 (en) 2022-01-27
CN110072866A (zh) 2019-07-30
US10975093B2 (en) 2021-04-13
JP7035027B2 (ja) 2022-03-14
ES2857743T3 (es) 2021-09-29
EP3512853B1 (en) 2020-12-23
WO2018052949A1 (en) 2018-03-22
AU2017326175A1 (en) 2019-04-04
EP3858837A1 (en) 2021-08-04
JP2019526616A (ja) 2019-09-19
US20190263827A1 (en) 2019-08-29

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