AU2017326175B2 - Fused 1,4-diazepines as BET protein degraders - Google Patents

Fused 1,4-diazepines as BET protein degraders Download PDF

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Publication number
AU2017326175B2
AU2017326175B2 AU2017326175A AU2017326175A AU2017326175B2 AU 2017326175 B2 AU2017326175 B2 AU 2017326175B2 AU 2017326175 A AU2017326175 A AU 2017326175A AU 2017326175 A AU2017326175 A AU 2017326175A AU 2017326175 B2 AU2017326175 B2 AU 2017326175B2
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AU
Australia
Prior art keywords
ethynyl
chlorophenyl
diazepin
triazolo
dione
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Ceased
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AU2017326175A
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AU2017326175A1 (en
Inventor
Jiantao HU
Yang Hu
Chong QIN
Shaomeng Wang
Weiguo XIANG
Fuming XU
Bing Zhou
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University of Michigan (System)
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University of Michigan (System)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2017326175A 2016-09-13 2017-09-13 Fused 1,4-diazepines as BET protein degraders Ceased AU2017326175B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662393923P 2016-09-13 2016-09-13
US62/393,923 2016-09-13
PCT/US2017/051286 WO2018052949A1 (en) 2016-09-13 2017-09-13 Fused 1,4-diazepines as bet protein degraders

Publications (2)

Publication Number Publication Date
AU2017326175A1 AU2017326175A1 (en) 2019-04-04
AU2017326175B2 true AU2017326175B2 (en) 2022-01-27

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Family Applications (1)

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AU2017326175A Ceased AU2017326175B2 (en) 2016-09-13 2017-09-13 Fused 1,4-diazepines as BET protein degraders

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US (2) US10975093B2 (enExample)
EP (2) EP3512853B1 (enExample)
JP (1) JP7035027B2 (enExample)
CN (1) CN110072866A (enExample)
AU (1) AU2017326175B2 (enExample)
CA (1) CA3036841A1 (enExample)
ES (1) ES2857743T3 (enExample)
WO (1) WO2018052949A1 (enExample)

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CN115611881B (zh) * 2021-07-13 2024-09-20 复旦大学 一种合成新型vhl配体4-f-vh032的方法
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Also Published As

Publication number Publication date
US10975093B2 (en) 2021-04-13
JP2019526616A (ja) 2019-09-19
ES2857743T3 (es) 2021-09-29
US20190263827A1 (en) 2019-08-29
EP3858837A1 (en) 2021-08-04
US20220356192A1 (en) 2022-11-10
WO2018052949A1 (en) 2018-03-22
CA3036841A1 (en) 2018-03-22
JP7035027B2 (ja) 2022-03-14
EP3512853A1 (en) 2019-07-24
CN110072866A (zh) 2019-07-30
EP3512853B1 (en) 2020-12-23
AU2017326175A1 (en) 2019-04-04

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