JP2014510727A5 - - Google Patents
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- JP2014510727A5 JP2014510727A5 JP2013557870A JP2013557870A JP2014510727A5 JP 2014510727 A5 JP2014510727 A5 JP 2014510727A5 JP 2013557870 A JP2013557870 A JP 2013557870A JP 2013557870 A JP2013557870 A JP 2013557870A JP 2014510727 A5 JP2014510727 A5 JP 2014510727A5
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- JP
- Japan
- Prior art keywords
- cancer
- composition
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- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 112
- 125000000217 alkyl group Chemical group 0.000 claims description 75
- 229910052736 halogen Inorganic materials 0.000 claims description 46
- 150000002367 halogens Chemical class 0.000 claims description 46
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 30
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 29
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 201000011510 cancer Diseases 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 17
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 16
- 239000001301 oxygen Substances 0.000 claims description 16
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 15
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 11
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 11
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims description 10
- -1 R 22 is H Chemical compound 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- 208000036142 Viral infection Diseases 0.000 claims description 7
- 230000009385 viral infection Effects 0.000 claims description 7
- 125000001188 haloalkyl group Chemical group 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 4
- 102000015303 Fatty Acid Synthases Human genes 0.000 claims description 4
- 108010039731 Fatty Acid Synthases Proteins 0.000 claims description 4
- 230000008482 dysregulation Effects 0.000 claims description 4
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 4
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 4
- 208000005176 Hepatitis C Diseases 0.000 claims description 3
- 239000001257 hydrogen Substances 0.000 claims description 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000010710 hepatitis C virus infection Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 21
- 210000001672 ovary Anatomy 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 claims 1
- 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000001508 eye Anatomy 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 201000010453 lymph node cancer Diseases 0.000 claims 1
- 210000001989 nasopharynx Anatomy 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 210000003300 oropharynx Anatomy 0.000 claims 1
- 201000006958 oropharynx cancer Diseases 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 210000003079 salivary gland Anatomy 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000000626 ureter Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
- 238000011282 treatment Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 0 *C(CC1)(CCN1C(c1cc(C2=*I=C(*)N2)c(*)cc1*)=O)c1cc(*)c(*)c(*)c1 Chemical compound *C(CC1)(CCN1C(c1cc(C2=*I=C(*)N2)c(*)cc1*)=O)c1cc(*)c(*)c(*)c1 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450561P | 2011-03-08 | 2011-03-08 | |
| US201161450482P | 2011-03-08 | 2011-03-08 | |
| US61/450,561 | 2011-03-08 | ||
| US61/450,482 | 2011-03-08 | ||
| US201161508611P | 2011-07-16 | 2011-07-16 | |
| US61/508,611 | 2011-07-16 | ||
| US201261585642P | 2012-01-11 | 2012-01-11 | |
| US61/585,642 | 2012-01-11 | ||
| PCT/US2012/028309 WO2012122391A1 (en) | 2011-03-08 | 2012-03-08 | Heterocyclic modulators of lipid synthesis |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016018610A Division JP6061437B2 (ja) | 2011-03-08 | 2016-02-03 | 脂質合成の複素環式モジュレーター |
| JP2016018611A Division JP2016074742A (ja) | 2011-03-08 | 2016-02-03 | 脂質合成の複素環式モジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510727A JP2014510727A (ja) | 2014-05-01 |
| JP2014510727A5 true JP2014510727A5 (enExample) | 2015-04-30 |
| JP5973473B2 JP5973473B2 (ja) | 2016-08-23 |
Family
ID=48221725
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557870A Active JP5973473B2 (ja) | 2011-03-08 | 2012-03-08 | 脂質合成の複素環式モジュレーター |
| JP2016018611A Pending JP2016074742A (ja) | 2011-03-08 | 2016-02-03 | 脂質合成の複素環式モジュレーター |
| JP2016018610A Active JP6061437B2 (ja) | 2011-03-08 | 2016-02-03 | 脂質合成の複素環式モジュレーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016018611A Pending JP2016074742A (ja) | 2011-03-08 | 2016-02-03 | 脂質合成の複素環式モジュレーター |
| JP2016018610A Active JP6061437B2 (ja) | 2011-03-08 | 2016-02-03 | 脂質合成の複素環式モジュレーター |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP3190108B1 (enExample) |
| JP (3) | JP5973473B2 (enExample) |
| KR (2) | KR101930106B1 (enExample) |
| CN (2) | CN103561576B (enExample) |
| AU (1) | AU2012225390B2 (enExample) |
| BR (3) | BR122015005121B1 (enExample) |
| CA (1) | CA2829082C (enExample) |
| DK (1) | DK2683244T3 (enExample) |
| EA (1) | EA031193B1 (enExample) |
| ES (2) | ES2883274T3 (enExample) |
| HK (1) | HK1216310A1 (enExample) |
| HR (1) | HRP20170500T1 (enExample) |
| HU (1) | HUE032459T2 (enExample) |
| IL (2) | IL228276A (enExample) |
| LT (1) | LT2683244T (enExample) |
| MX (2) | MX369388B (enExample) |
| PL (1) | PL2683244T3 (enExample) |
| PT (1) | PT2683244T (enExample) |
| SI (1) | SI2683244T1 (enExample) |
| WO (1) | WO2012122391A1 (enExample) |
| ZA (1) | ZA201306655B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8871790B2 (en) | 2011-03-08 | 2014-10-28 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| US9624173B2 (en) | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| JP6109934B2 (ja) | 2012-07-03 | 2017-04-05 | ３−ブイ・バイオサイエンシーズ・インコーポレイテッド３−Ｖ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | 脂質合成の複素環モジュレーター |
| AR092211A1 (es) * | 2012-09-24 | 2015-04-08 | Merck Patent Ges Mit Beschränkter Haftung | Derivados de hidropirrolopirrol |
| EP2938338A4 (en) * | 2012-12-27 | 2016-11-23 | Univ Drexel | NOVEL ANTIVIRAL AGENTS AGAINST HBV INFECTION |
| CN104995170A (zh) * | 2013-02-14 | 2015-10-21 | 盖尔德马研究及发展公司 | 合成4-哌啶-4-基-苯-1,3-二醇及其盐以及新型化合物4-(2,4-二羟基-苯基)-4-羟基-哌啶-1-甲酸叔丁酯的方法 |
| JP6163214B2 (ja) * | 2013-03-06 | 2017-07-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ウイルス化合物 |
| CN112521369A (zh) | 2013-03-13 | 2021-03-19 | 福马治疗股份有限公司 | 用于抑制fasn的化合物及组合物 |
| ES2841137T3 (es) | 2013-12-20 | 2021-07-07 | Sagimet Biosciences Inc | Moduladores heterocíclicos de la síntesis de lípidos y combinaciones de los mismos |
| SG11201605422TA (en) * | 2014-01-07 | 2016-07-28 | 3 V Biosciences Inc | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections |
| CN104774204A (zh) * | 2014-01-15 | 2015-07-15 | 鲁南贝特制药有限公司 | 一种制备奈韦拉平及其中间体的方法 |
| WO2015199206A1 (ja) * | 2014-06-27 | 2015-12-30 | 塩野義製薬株式会社 | Ｔｒｐｖ４阻害活性を有する６員環誘導体 |
| JP6691909B2 (ja) * | 2014-08-15 | 2020-05-13 | サギメット バイオサイエンシーズ インコーポレイテッド | 薬物耐性癌の治療で用いるための脂肪酸シンターゼ阻害剤 |
| CA2979696A1 (en) * | 2015-03-19 | 2016-09-22 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| CN105175277B (zh) * | 2015-05-18 | 2018-04-03 | 中山大学肿瘤防治中心 | 一种3‑磷酸甘油醛脱氢酶的抑制剂及其制备方法和应用 |
| EP3310773B1 (en) | 2015-06-18 | 2020-12-02 | 89Bio Ltd. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| CN107847765B (zh) | 2015-06-18 | 2021-05-04 | 89生物有限公司 | 1,4-取代的哌啶衍生物 |
| US10912785B2 (en) * | 2015-09-04 | 2021-02-09 | Poli Md S.R.L. | Composition and medical device comprising acetylsalicylic acid for the treatment of human papilloma virus skin infections |
| CA3043308A1 (en) * | 2016-11-11 | 2018-05-17 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| CN107043347B (zh) * | 2016-11-18 | 2019-07-02 | 泰州禾益新材料科技有限公司 | 一种阿加曲班中间体(2r，4r)-4-甲基哌啶-2-甲酸乙酯的合成方法 |
| CN109212056B (zh) * | 2018-08-19 | 2021-05-07 | 丁立平 | 一种测定水源水中三种痕量单卤代甲基苯甲酸的气相色谱-质谱联用法 |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| WO2020092395A1 (en) | 2018-10-29 | 2020-05-07 | Forma Therapeutics, Inc. | SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE |
| AU2021271330A1 (en) * | 2020-05-14 | 2022-12-15 | Palani Llc | A fatty acid based composition for treatment and/or prevention of enveloped-virus related infections |
| CN114469945A (zh) * | 2020-10-28 | 2022-05-13 | 歌礼生物科技（杭州）有限公司 | 脂肪酸合酶抑制剂的用途和药物组合物 |
| CN113584044A (zh) * | 2021-08-28 | 2021-11-02 | 青岛农业大学 | 一种牙鲆socs3基因及其真核表达载体、表达系统和异源表达方法 |
| IL319179A (en) * | 2022-10-01 | 2025-04-01 | Assia Chem Ind Ltd | Solid forms of Dinipenstat |
| WO2024240108A1 (zh) * | 2023-05-19 | 2024-11-28 | 上海海和药物研究开发股份有限公司 | 一种芳基脲类parp1抑制剂、其制备方法及用途 |
| CN119080742A (zh) * | 2023-06-05 | 2024-12-06 | 甘莱制药有限公司 | 脂质合成的杂环调节剂的工业化制备 |
| WO2025020955A1 (zh) * | 2023-07-21 | 2025-01-30 | 歌礼生物科技（杭州）有限公司 | 一种包含杂环化合物的药物组合物 |
| WO2025086054A1 (zh) * | 2023-10-23 | 2025-05-01 | 歌礼生物科技（杭州）有限公司 | 一种包含苯甲腈衍生物的药物组合物 |
| WO2025120168A1 (en) | 2023-12-07 | 2025-06-12 | Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement (Inrae) | Sulfonamide derivatives and use thereof in the treatment of cryptosporidium infections |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| US4789734A (en) | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| CH671155A5 (enExample) | 1986-08-18 | 1989-08-15 | Clinical Technologies Ass | |
| US5811128A (en) | 1986-10-24 | 1998-09-22 | Southern Research Institute | Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5776434A (en) | 1988-12-06 | 1998-07-07 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5190029A (en) | 1991-02-14 | 1993-03-02 | Virginia Commonwealth University | Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content |
| US5376359A (en) | 1992-07-07 | 1994-12-27 | Glaxo, Inc. | Method of stabilizing aerosol formulations |
| JPH08505625A (ja) | 1993-01-11 | 1996-06-18 | ダナ−ファーバー キャンサー インスティチュート | 細胞毒性ｔリンパ球応答の誘導 |
| US8569352B2 (en) * | 2005-06-27 | 2013-10-29 | Exelixis Patent Company Llc | Imidazole based LXR modulators |
| AU2006319247B2 (en) * | 2005-12-01 | 2010-03-11 | F. Hoffmann-La Roche Ag | Heteroaryl substituted piperidine derivatives as L-CPT1 inhibitors |
| JP2010502731A (ja) * | 2006-09-05 | 2010-01-28 | バイパー サイエンシズ，インコーポレイティド | Ｐａｒｐ阻害剤による脂肪酸合成の阻害、及びその治療方法 |
| WO2008059214A1 (en) * | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
| TW200833663A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
| WO2008075077A1 (en) * | 2006-12-21 | 2008-06-26 | Astrazeneca Ab | Piperidine derivatives for the treatment of obesity |
| TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
-
2012
- 2012-03-08 HU HUE12754969A patent/HUE032459T2/en unknown
- 2012-03-08 CN CN201280020832.9A patent/CN103561576B/zh active Active
- 2012-03-08 HR HRP20170500TT patent/HRP20170500T1/hr unknown
- 2012-03-08 EA EA201391290A patent/EA031193B1/ru unknown
- 2012-03-08 AU AU2012225390A patent/AU2012225390B2/en active Active
- 2012-03-08 MX MX2016009579A patent/MX369388B/es unknown
- 2012-03-08 BR BR122015005121-5A patent/BR122015005121B1/pt active IP Right Grant
- 2012-03-08 DK DK12754969.9T patent/DK2683244T3/en active
- 2012-03-08 JP JP2013557870A patent/JP5973473B2/ja active Active
- 2012-03-08 LT LTEP12754969.9T patent/LT2683244T/lt unknown
- 2012-03-08 EP EP17153778.0A patent/EP3190108B1/en active Active
- 2012-03-08 BR BR112013022761A patent/BR112013022761B8/pt active IP Right Grant
- 2012-03-08 ES ES17153778T patent/ES2883274T3/es active Active
- 2012-03-08 KR KR1020137026499A patent/KR101930106B1/ko active Active
- 2012-03-08 WO PCT/US2012/028309 patent/WO2012122391A1/en not_active Ceased
- 2012-03-08 PL PL12754969T patent/PL2683244T3/pl unknown
- 2012-03-08 CA CA2829082A patent/CA2829082C/en active Active
- 2012-03-08 CN CN201510354353.6A patent/CN105001225B/zh active Active
- 2012-03-08 KR KR1020187017297A patent/KR101968058B1/ko active Active
- 2012-03-08 EP EP12754969.9A patent/EP2683244B1/en active Active
- 2012-03-08 PT PT127549699T patent/PT2683244T/pt unknown
- 2012-03-08 SI SI201230912A patent/SI2683244T1/sl unknown
- 2012-03-08 MX MX2013010170A patent/MX342287B/es active IP Right Grant
- 2012-03-08 BR BR122015005122-3A patent/BR122015005122B1/pt active IP Right Grant
- 2012-03-08 ES ES12754969.9T patent/ES2624131T3/es active Active
-
2013
- 2013-09-03 IL IL228276A patent/IL228276A/en active IP Right Grant
- 2013-09-04 ZA ZA2013/06655A patent/ZA201306655B/en unknown
-
2016
- 2016-02-03 JP JP2016018611A patent/JP2016074742A/ja active Pending
- 2016-02-03 JP JP2016018610A patent/JP6061437B2/ja active Active
- 2016-04-11 HK HK16104111.8A patent/HK1216310A1/zh unknown
- 2016-09-13 IL IL247804A patent/IL247804B/en active IP Right Grant
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