SI2683244T1 - Heterociklični modulatorji sinteze lipidov - Google Patents
Heterociklični modulatorji sinteze lipidovInfo
- Publication number
- SI2683244T1 SI2683244T1 SI201230912A SI201230912A SI2683244T1 SI 2683244 T1 SI2683244 T1 SI 2683244T1 SI 201230912 A SI201230912 A SI 201230912A SI 201230912 A SI201230912 A SI 201230912A SI 2683244 T1 SI2683244 T1 SI 2683244T1
- Authority
- SI
- Slovenia
- Prior art keywords
- lipid synthesis
- heterocyclic modulators
- modulators
- heterocyclic
- lipid
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| PCT/US2012/028309 WO2012122391A1 (en) | 2011-03-08 | 2012-03-08 | Heterocyclic modulators of lipid synthesis |
| EP12754969.9A EP2683244B1 (en) | 2011-03-08 | 2012-03-08 | Heterocyclic modulators of lipid synthesis |
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| US20170119786A1 (en) | 2011-03-08 | 2017-05-04 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| US9624173B2 (en) | 2011-03-08 | 2017-04-18 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| TWI522348B (zh) | 2011-03-08 | 2016-02-21 | 3 V生物科技公司 | 脂質合成之雜環調節劑 |
| CA2877999C (en) | 2012-07-03 | 2021-02-23 | 3-V Biosciences, Inc. | Heterocyclic modulators of lipid synthesis |
| AR092211A1 (es) * | 2012-09-24 | 2015-04-08 | Merck Patent Ges Mit Beschränkter Haftung | Derivados de hidropirrolopirrol |
| US9938236B2 (en) * | 2012-12-27 | 2018-04-10 | Drexel University | Antiviral agents against HBV infection |
| US9650337B2 (en) | 2013-02-14 | 2017-05-16 | Galderma Research & Development | Method of synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate |
| BR112015020952A2 (pt) * | 2013-03-06 | 2017-07-18 | Hoffmann La Roche | compostos antivirais |
| KR102194745B1 (ko) | 2013-03-13 | 2020-12-24 | 포르마 세라퓨틱스 인크. | Fasn 억제용 신규 화합물 및 조성물 |
| EP3083583B1 (en) | 2013-12-20 | 2020-11-18 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis and combinations thereof |
| EP3092232B1 (en) | 2014-01-07 | 2022-03-09 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis for use against cancer and viral infections |
| CN104774204A (zh) * | 2014-01-15 | 2015-07-15 | 鲁南贝特制药有限公司 | 一种制备奈韦拉平及其中间体的方法 |
| WO2015199206A1 (ja) * | 2014-06-27 | 2015-12-30 | 塩野義製薬株式会社 | Trpv4阻害活性を有する6員環誘導体 |
| JP6691909B2 (ja) * | 2014-08-15 | 2020-05-13 | サギメット バイオサイエンシーズ インコーポレイテッド | 薬物耐性癌の治療で用いるための脂肪酸シンターゼ阻害剤 |
| EP3277675B1 (en) | 2015-03-19 | 2022-01-19 | Sagimet Biosciences Inc. | Heterocyclic modulators of lipid synthesis |
| CN105175277B (zh) * | 2015-05-18 | 2018-04-03 | 中山大学肿瘤防治中心 | 一种3‑磷酸甘油醛脱氢酶的抑制剂及其制备方法和应用 |
| ES2821049T3 (es) | 2015-06-18 | 2021-04-23 | 89Bio Ltd | Derivados de piperidina 1,4 sustituidos |
| MX379846B (es) | 2015-06-18 | 2025-03-11 | 89Bio Ltd | Derivados de 4-bencil y 4-benzoil piperidina sustituidos. |
| AU2016314621B2 (en) * | 2015-09-04 | 2021-05-13 | Poli Md S.R.L. | Composition and medical device comprising acetylsalicylic acid for the treatment of human papilloma virus skin infections |
| JP7668509B2 (ja) * | 2016-11-11 | 2025-04-25 | サギメット バイオサイエンシーズ インコーポレイテッド | 脂質合成の複素環式モジュレーター |
| CN107043347B (zh) * | 2016-11-18 | 2019-07-02 | 泰州禾益新材料科技有限公司 | 一种阿加曲班中间体(2r,4r)-4-甲基哌啶-2-甲酸乙酯的合成方法 |
| CN109212056B (zh) * | 2018-08-19 | 2021-05-07 | 丁立平 | 一种测定水源水中三种痕量单卤代甲基苯甲酸的气相色谱-质谱联用法 |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| EP3873214A4 (en) | 2018-10-29 | 2022-07-13 | Forma Therapeutics, Inc. | Solid forms of (4-(2-fluoro-4-(1-methyl-1 h-benzo[d]imidazol-5-yl)benzoyl) piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
| US20230218557A1 (en) * | 2020-05-14 | 2023-07-13 | Palani Llc | A fatty acid based composition for treatment and/or prevention of enveloped-virus related infections |
| CN114469945A (zh) * | 2020-10-28 | 2022-05-13 | 歌礼生物科技(杭州)有限公司 | 脂肪酸合酶抑制剂的用途和药物组合物 |
| CN113584044A (zh) * | 2021-08-28 | 2021-11-02 | 青岛农业大学 | 一种牙鲆socs3基因及其真核表达载体、表达系统和异源表达方法 |
| EP4594313A1 (en) * | 2022-10-01 | 2025-08-06 | Assia Chemical Industries Ltd. | Solid state forms of denifanstat |
| WO2024240108A1 (zh) * | 2023-05-19 | 2024-11-28 | 上海海和药物研究开发股份有限公司 | 一种芳基脲类parp1抑制剂、其制备方法及用途 |
| CN119080742A (zh) * | 2023-06-05 | 2024-12-06 | 甘莱制药有限公司 | 脂质合成的杂环调节剂的工业化制备 |
| WO2025020955A1 (zh) * | 2023-07-21 | 2025-01-30 | 歌礼生物科技(杭州)有限公司 | 一种包含杂环化合物的药物组合物 |
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| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
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| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
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| US6024983A (en) | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
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| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| US5766573A (en) | 1988-12-06 | 1998-06-16 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
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