JP2014505663A5 - - Google Patents
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- Publication number
- JP2014505663A5 JP2014505663A5 JP2013539932A JP2013539932A JP2014505663A5 JP 2014505663 A5 JP2014505663 A5 JP 2014505663A5 JP 2013539932 A JP2013539932 A JP 2013539932A JP 2013539932 A JP2013539932 A JP 2013539932A JP 2014505663 A5 JP2014505663 A5 JP 2014505663A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound according
- acceptable salt
- ylsulfanyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- -1 methylcarbonylamino, hydroxymethylcarbonylamino, methoxycarbonylamino, imidazol-2-ylsulfanyl Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- WNOZOUHFGZKGNT-ANYOLZDRSA-N (1s,2r,3s,4s,5r,6r)-2-amino-3-[(3,4-dichlorophenyl)methoxy]-4-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid Chemical compound O([C@@H]1[C@@H](O)[C@@H]2[C@@H]([C@H]2C(O)=O)[C@]1(N)C(O)=O)CC1=CC=C(Cl)C(Cl)=C1 WNOZOUHFGZKGNT-ANYOLZDRSA-N 0.000 claims 1
- YRHRLQYHSGSFIQ-UHFFFAOYSA-N 1-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid Chemical compound C1CC(C(O)=O)C2(O)C(C(=O)O)C21 YRHRLQYHSGSFIQ-UHFFFAOYSA-N 0.000 claims 1
- 125000006512 3,4-dichlorobenzyl group Chemical group [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C([H])([H])* 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 CC([C@]1[C@](*)[C@]2OCc3ccccc3)([C@]1C(O*)=O)[C@]2(*)C(C)=O Chemical compound CC([C@]1[C@](*)[C@]2OCc3ccccc3)([C@]1C(O*)=O)[C@]2(*)C(C)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41511310P | 2010-11-18 | 2010-11-18 | |
| US61/415,113 | 2010-11-18 | ||
| PCT/US2011/060686 WO2012068041A1 (en) | 2010-11-18 | 2011-11-15 | 4-SUBSTITUTED-3-BENZYLOXY-BICYCLO[3.1.0]HEXANE COMPOUNDS AS mGluR 2/3 ANTAGONISTS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505663A JP2014505663A (ja) | 2014-03-06 |
| JP2014505663A5 true JP2014505663A5 (enExample) | 2014-11-20 |
| JP5870111B2 JP5870111B2 (ja) | 2016-02-24 |
Family
ID=45217666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539932A Active JP5870111B2 (ja) | 2010-11-18 | 2011-11-15 | ｍＧｌｕＲ２／３アンタゴニストとしての４−置換−３−ベンジルオキシ−ビシクロ［３．１．０］ヘキサン化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9056844B2 (enExample) |
| EP (1) | EP2640687B1 (enExample) |
| JP (1) | JP5870111B2 (enExample) |
| KR (1) | KR101554793B1 (enExample) |
| CN (1) | CN103209954B (enExample) |
| AU (1) | AU2011329136B2 (enExample) |
| BR (1) | BR112013012384A2 (enExample) |
| CA (1) | CA2818118C (enExample) |
| EA (1) | EA022196B1 (enExample) |
| ES (1) | ES2682959T3 (enExample) |
| MX (1) | MX2013005623A (enExample) |
| WO (1) | WO2012068041A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2978B1 (en) * | 2009-12-21 | 2016-03-15 | ايلي ليلي اند كومباني | MGLU2 aids |
| EP3000814A1 (en) | 2014-09-26 | 2016-03-30 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
| MY195208A (en) * | 2016-04-18 | 2023-01-11 | Taisho Pharmaceutical Co Ltd | Prodrug of Amino Acid Derivative |
| KR102549584B1 (ko) * | 2018-03-27 | 2023-06-30 | 삼성전자주식회사 | 메모리 모듈을 포함하는 메모리 시스템, 메모리 모듈, 그리고 메모리 모듈의 동작 방법 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0669928B2 (ja) | 1987-10-06 | 1994-09-07 | 宇部興産株式会社 | 光重合性歯科材料 |
| JP2589812B2 (ja) | 1989-07-05 | 1997-03-12 | 松下電器産業株式会社 | スチームアイロン |
| ZA969485B (en) | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
| WO1997017950A1 (en) * | 1995-11-16 | 1997-05-22 | Eli Lilly And Company | Shoulder prosthesis |
| ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| IL138342A0 (en) | 1998-03-17 | 2001-10-31 | Pfizer Prod Inc | Bicyclo[2.2.1] heptanes and related compounds |
| GB9815542D0 (en) | 1998-07-17 | 1998-09-16 | Lilly Co Eli | Bicyclohexane derivatives |
| CH694053A5 (de) | 1998-09-03 | 2004-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten. |
| WO2002068380A1 (en) * | 2001-02-22 | 2002-09-06 | Eli Lilly And Company | Synthetic excitatory amino acids |
| PL208123B1 (pl) | 2001-12-27 | 2011-03-31 | Taisho Pharmaceutical Co Ltd | Pochodna kwasu 2-amino-3-alkoksy-6-fluorobicyklo [3.1.0] heksano-2, 6-dikarboksylowego, zawierająca ją kompozycja farmaceutyczna i lek, oraz jej zastosowanie |
| HRP20041179B1 (hr) * | 2002-06-11 | 2012-11-30 | Eli Lilly And Company | Prekursorski oblici lijekova za aminokiseline s pobuđivačkom aktivnosti |
| EP2123630B1 (en) | 2003-06-26 | 2012-07-25 | Taisho Pharmaceutical Co., Ltd | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative |
| JP2007063129A (ja) * | 2003-06-26 | 2007-03-15 | Taisho Pharmaceut Co Ltd | ２−アミノ−３−アルコキシビシクロ［３．１．０］ヘキサン誘導体 |
| CN100582087C (zh) * | 2003-06-26 | 2010-01-20 | 大正制药株式会社 | 2-氨基-双环[3.1.0]己烷-2,6-二甲酸酯衍生物 |
| US7381746B2 (en) | 2003-06-26 | 2008-06-03 | Taisho Pharmaceutical Co., Ltd. | 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative |
| JP5485492B2 (ja) * | 2004-12-15 | 2014-05-07 | 大正製薬株式会社 | うつ病の予防・治療薬 |
| JO2978B1 (en) * | 2009-12-21 | 2016-03-15 | ايلي ليلي اند كومباني | MGLU2 aids |
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2011
- 2011-11-15 CN CN201180055254.8A patent/CN103209954B/zh active Active
- 2011-11-15 US US13/883,788 patent/US9056844B2/en active Active
- 2011-11-15 BR BR112013012384A patent/BR112013012384A2/pt not_active IP Right Cessation
- 2011-11-15 JP JP2013539932A patent/JP5870111B2/ja active Active
- 2011-11-15 AU AU2011329136A patent/AU2011329136B2/en not_active Ceased
- 2011-11-15 EA EA201390568A patent/EA022196B1/ru not_active IP Right Cessation
- 2011-11-15 CA CA2818118A patent/CA2818118C/en active Active
- 2011-11-15 WO PCT/US2011/060686 patent/WO2012068041A1/en not_active Ceased
- 2011-11-15 ES ES11793573.4T patent/ES2682959T3/es active Active
- 2011-11-15 KR KR1020137012692A patent/KR101554793B1/ko not_active Expired - Fee Related
- 2011-11-15 MX MX2013005623A patent/MX2013005623A/es unknown
- 2011-11-15 EP EP11793573.4A patent/EP2640687B1/en active Active