JP2013519683A5 - - Google Patents
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- JP2013519683A5 JP2013519683A5 JP2012553046A JP2012553046A JP2013519683A5 JP 2013519683 A5 JP2013519683 A5 JP 2013519683A5 JP 2012553046 A JP2012553046 A JP 2012553046A JP 2012553046 A JP2012553046 A JP 2012553046A JP 2013519683 A5 JP2013519683 A5 JP 2013519683A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- treatment
- pharmaceutically acceptable
- composition according
- compound according
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30347210P | 2010-02-11 | 2010-02-11 | |
| US61/303,472 | 2010-02-11 | ||
| PCT/US2011/024583 WO2011100585A1 (en) | 2010-02-11 | 2011-02-11 | Secondary structure stabilized nmda receptor modulators and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016080043A Division JP6328169B2 (ja) | 2010-02-11 | 2016-04-13 | Ｎｍｄａ受容体モジュレータを安定化させる化合物及びそれを含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519683A JP2013519683A (ja) | 2013-05-30 |
| JP2013519683A5 true JP2013519683A5 (enExample) | 2014-03-27 |
| JP5928828B2 JP5928828B2 (ja) | 2016-06-01 |
Family
ID=44368160
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553046A Active JP5928828B2 (ja) | 2010-02-11 | 2011-02-11 | Ｎｍｄａ受容体モジュレータを安定化させる二次構造及びその使用 |
| JP2016080043A Expired - Fee Related JP6328169B2 (ja) | 2010-02-11 | 2016-04-13 | Ｎｍｄａ受容体モジュレータを安定化させる化合物及びそれを含む医薬組成物 |
| JP2018079295A Withdrawn JP2018119004A (ja) | 2010-02-11 | 2018-04-17 | Ｎｍｄａ受容体モジュレータを安定化させる化合物及びそれを含む医薬組成物 |
| JP2020046041A Pending JP2020117510A (ja) | 2010-02-11 | 2020-03-17 | Ｎｍｄａ受容体モジュレータを安定化させる化合物及びそれを含む医薬組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016080043A Expired - Fee Related JP6328169B2 (ja) | 2010-02-11 | 2016-04-13 | Ｎｍｄａ受容体モジュレータを安定化させる化合物及びそれを含む医薬組成物 |
| JP2018079295A Withdrawn JP2018119004A (ja) | 2010-02-11 | 2018-04-17 | Ｎｍｄａ受容体モジュレータを安定化させる化合物及びそれを含む医薬組成物 |
| JP2020046041A Pending JP2020117510A (ja) | 2010-02-11 | 2020-03-17 | Ｎｍｄａ受容体モジュレータを安定化させる化合物及びそれを含む医薬組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9101612B2 (enExample) |
| EP (1) | EP2542254B1 (enExample) |
| JP (4) | JP5928828B2 (enExample) |
| CN (2) | CN102933226A (enExample) |
| AU (1) | AU2011215704B2 (enExample) |
| BR (1) | BR112012020142A2 (enExample) |
| CA (1) | CA2789331C (enExample) |
| ES (1) | ES2706063T3 (enExample) |
| IL (1) | IL221400A (enExample) |
| MX (1) | MX2012009388A (enExample) |
| RU (1) | RU2566821C2 (enExample) |
| SG (3) | SG183265A1 (enExample) |
| WO (1) | WO2011100585A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0918868B8 (pt) | 2008-09-18 | 2021-05-25 | Naurex Inc | compostos moduladores do receptor de nmda e composições compreendendo os mesmos |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| WO2011100585A1 (en) | 2010-02-11 | 2011-08-18 | Joseph Moskal | Secondary structure stabilized nmda receptor modulators and uses thereof |
| KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| US9758525B2 (en) * | 2013-01-29 | 2017-09-12 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| JP2016506962A (ja) | 2013-01-29 | 2016-03-07 | ノーレックス, インコーポレイテッドNaurex, Inc. | スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用 |
| KR102410989B1 (ko) | 2013-01-29 | 2022-06-17 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| PE20151416A1 (es) | 2013-01-29 | 2015-10-10 | Naurex Inc | Moduladores de receptores nmda de espiro-lactama y sus usos |
| EP2951186B1 (en) * | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| US9745342B2 (en) * | 2013-10-28 | 2017-08-29 | Naurex, Inc. | NMDA receptor modulators and prodrugs, salts, and uses thereof |
| JP6702883B2 (ja) * | 2014-04-25 | 2020-06-03 | ノーレックス インコーポレイテッド | 向神経活性ペプチドの安定な組成物 |
| AU2015280108B2 (en) * | 2014-06-23 | 2019-11-28 | Naurex, Inc. | Methods of treating or ameliorating migraine |
| EP3171941B1 (en) * | 2014-07-24 | 2021-03-24 | Naurex Inc. | N-methyl-d-aspartate receptor modulators and methods of making and using same |
| KR20180063306A (ko) | 2015-10-14 | 2018-06-11 | 브리스톨-마이어스 스큅 컴퍼니 | 선택적 nr2b 길항제 |
| BR112018007181A2 (pt) * | 2015-10-14 | 2018-10-16 | Bristol-Myers Squibb Company | antagonistas de nr2b seletivos |
| CN108601814A (zh) * | 2015-10-16 | 2018-09-28 | 西北大学 | 用于治疗精神分裂症、双相障碍、认知损害和重度抑郁障碍的非典型抗精神病药和nmda调节剂的药物组合 |
| CA3013329A1 (en) * | 2016-02-01 | 2017-08-10 | M. Amin Khan | Processes for synthesis of dipyrrolidine peptide compounds |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| PE20190174A1 (es) | 2016-05-19 | 2019-02-01 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos |
| WO2018026798A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda modulators and methods of using same |
| AU2017306158B2 (en) | 2016-08-01 | 2021-10-14 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
| JP7036792B2 (ja) | 2016-08-01 | 2022-03-15 | アプティニックス インコーポレイテッド | スピロ－ラクタムｎｍｄａ受容体修飾因子およびその使用 |
| KR102465758B1 (ko) | 2016-08-01 | 2022-11-09 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
| IL286107B2 (en) | 2016-08-01 | 2024-09-01 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and usesthereof |
| PE20211455A1 (es) * | 2018-01-31 | 2021-08-05 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| CN110003309B (zh) * | 2019-04-09 | 2021-09-10 | 北京广为医药科技有限公司 | 调节nmda受体活性的化合物、其药物组合物及用途 |
| WO2021021996A1 (en) * | 2019-08-01 | 2021-02-04 | Aptinyx Inc. | Methods of treating disorders associated with elevated levels of antibodies that interact with the nmda receptor |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
| CN114957445B (zh) * | 2022-05-31 | 2023-09-19 | 陕西脉元生物科技有限公司 | 一种nmdar nr1亚基、nmdar的突变体及其构建方法和应用 |
| CN114957444B (zh) * | 2022-05-31 | 2023-09-19 | 陕西脉元生物科技有限公司 | 一种nmdar的nr1亚基缺失突变体、突变体细胞及构建方法和应用 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683221A (en) | 1986-01-09 | 1987-07-28 | Scripps Clinic And Research Foundation | Lymphocyte-activating polypeptides |
| CA1305177C (en) | 1987-06-30 | 1992-07-14 | Yasufumi Ohfune | Carboxycyclopropylglycine and process for producing the same |
| US4904681A (en) | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
| EP0360390A1 (en) | 1988-07-25 | 1990-03-28 | Glaxo Group Limited | Spirolactam derivatives |
| US5061721A (en) | 1989-03-15 | 1991-10-29 | G. D. Searle & Co. | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
| US5086072A (en) | 1990-06-18 | 1992-02-04 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex |
| US5350769A (en) | 1990-10-30 | 1994-09-27 | Ss Pharmaceutical Co., Ltd. | Antiinflammatory gel preparation |
| JP3318622B2 (ja) | 1992-05-27 | 2002-08-26 | 独立行政法人産業技術総合研究所 | プロリルエンドペプチダーゼ阻害剤 |
| FR2692268B1 (fr) | 1992-06-15 | 1994-08-19 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides ayant une activité de récepteur NMDA, acides nucléiques codant pour ces polypeptides et utilisations. |
| SE9301667D0 (sv) | 1993-05-14 | 1993-05-14 | Kabi Pharmacia Ab | New use |
| US5523323A (en) | 1993-09-14 | 1996-06-04 | Maccecchini; Maria-Luisa | Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence |
| US5605911A (en) | 1995-01-31 | 1997-02-25 | Washington University | Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH) |
| US5741778A (en) | 1996-03-19 | 1998-04-21 | Amgen Inc. | Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product |
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| TR199802537T2 (xx) | 1996-06-07 | 1999-03-22 | Zeneca Limited | Peptit t�revleri. |
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| US5902815A (en) | 1996-09-03 | 1999-05-11 | Washington University | Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction |
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| WO1999002733A1 (en) | 1997-07-07 | 1999-01-21 | Florida State University | Identification of molecular targets |
| US6897028B1 (en) | 1997-07-07 | 2005-05-24 | Florida State University | Identification of molecular targets |
| AU1585999A (en) | 1997-11-12 | 1999-05-31 | Neurotherapeutics | Methods for the detection and treatment of disease using a glycosyltransferase |
| US5952389A (en) | 1998-01-13 | 1999-09-14 | Synchroneuron | Methods of treating tardive dyskinesia and other movement disorders |
| US6007841A (en) | 1998-03-13 | 1999-12-28 | Algos Pharmaceutical Corporation | Analgesic composition and method for treating pain |
| US6274314B1 (en) | 1998-04-02 | 2001-08-14 | Nyxis Neurotherapies, Inc. | Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine |
| US6197820B1 (en) | 1998-04-06 | 2001-03-06 | Uab Research Foundation | Use of phenylglycine derivatives to decrease neuronal death caused by brain tumors and brain lesions |
| US6025471A (en) | 1998-06-03 | 2000-02-15 | Deghenghi; Romano | Diazaspiro, azepino and azabicyclo therapeutic peptides |
| US6902886B1 (en) | 1998-11-06 | 2005-06-07 | The Research Foundation Of State University Of New York | Genetic assay for protein nuclear transport |
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| US20030064921A1 (en) | 1999-10-27 | 2003-04-03 | The Regents Of The University Of California | Methods and compounds for modulating melanocortin receptor ligand binding and activity |
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| US20020142287A1 (en) | 2000-12-14 | 2002-10-03 | Hirotaka Yamamoto | High throughput assay to detect inhibitors of the map kinase pathway |
| AU2002248553A1 (en) | 2001-03-07 | 2002-09-24 | Cognetix, Inc | Linear y-carboxyglutamate rich conotoxins |
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| US7662856B2 (en) | 2003-08-29 | 2010-02-16 | The University Of Houston System | Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxlyamine |
| US20050096311A1 (en) | 2003-10-30 | 2005-05-05 | Cns Response | Compositions and methods for treatment of nervous system disorders |
| AU2006282942B2 (en) | 2005-08-26 | 2012-07-26 | Wisconsin Alumni Research Foundation | Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same |
| US8507439B2 (en) * | 2005-08-29 | 2013-08-13 | Angela Shashoua | Neuroprotective and neurorestorative method and compositions |
| WO2007103719A2 (en) | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| CA2663502A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives and methods of use thereof |
| CN101066945B (zh) | 2007-05-25 | 2010-05-19 | 中国科学院上海有机化学研究所 | 一种合成3-位取代内酰胺类化合物的方法 |
| CN101125817B (zh) | 2007-08-03 | 2011-09-14 | 中国科学院上海有机化学研究所 | 一种合成高对映选择性醛基取代小环胺类化合物和光学活性3-位取代内酰胺类化合物的方法 |
| WO2009039390A2 (en) | 2007-09-20 | 2009-03-26 | Naurex Inc. | The development of glycobiology-based therapeutics for the treatment of brain tumors |
| KR101647520B1 (ko) | 2008-08-07 | 2016-08-10 | 에프. 호프만-라 로슈 아게 | 거대환식 화합물의 제조 방법 |
| BRPI0918868B8 (pt) | 2008-09-18 | 2021-05-25 | Naurex Inc | compostos moduladores do receptor de nmda e composições compreendendo os mesmos |
| WO2010065709A2 (en) | 2008-12-03 | 2010-06-10 | Amin Khan | Hydroxamic acid derivatives, preparation and therapeutic uses thereof |
| WO2010071132A1 (ja) | 2008-12-15 | 2010-06-24 | カルピス株式会社 | 皮膚老化抑制ペプチド |
| WO2011003064A2 (en) | 2009-07-02 | 2011-01-06 | Naurex, Inc. | Methods of treating neuropathic pain |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| WO2011044089A2 (en) | 2009-10-05 | 2011-04-14 | Joseph Moskal | Methods of treating depression and other related diseases |
| PT2512243E (pt) * | 2009-12-17 | 2016-06-08 | Merck Sharp & Dohme | Moduladores alostéricos positivos de recetor de quinolina amida m1 |
| KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도 |
| WO2011100585A1 (en) | 2010-02-11 | 2011-08-18 | Joseph Moskal | Secondary structure stabilized nmda receptor modulators and uses thereof |
| CA2834286A1 (en) | 2011-04-27 | 2012-11-01 | Northwestern University | Methods of treating alzheimer's disease, huntington's disease, autism, and other disorders |
| US8795919B2 (en) | 2011-11-29 | 2014-08-05 | Societe BIC & Sanyo Electric Co., Ltd. | Fuel cell layer |
-
2011
- 2011-02-11 WO PCT/US2011/024583 patent/WO2011100585A1/en not_active Ceased
- 2011-02-11 JP JP2012553046A patent/JP5928828B2/ja active Active
- 2011-02-11 BR BR112012020142-5A patent/BR112012020142A2/pt not_active Application Discontinuation
- 2011-02-11 CN CN2011800146633A patent/CN102933226A/zh active Pending
- 2011-02-11 AU AU2011215704A patent/AU2011215704B2/en active Active
- 2011-02-11 SG SG2012059358A patent/SG183265A1/en unknown
- 2011-02-11 SG SG10201811584RA patent/SG10201811584RA/en unknown
- 2011-02-11 ES ES11761468T patent/ES2706063T3/es active Active
- 2011-02-11 EP EP11761468.5A patent/EP2542254B1/en active Active
- 2011-02-11 CN CN201510222007.2A patent/CN105037492A/zh active Pending
- 2011-02-11 MX MX2012009388A patent/MX2012009388A/es active IP Right Grant
- 2011-02-11 CA CA2789331A patent/CA2789331C/en active Active
- 2011-02-11 RU RU2012138710/04A patent/RU2566821C2/ru active
- 2011-02-11 US US13/578,189 patent/US9101612B2/en active Active
- 2011-02-11 SG SG10201501050RA patent/SG10201501050RA/en unknown
-
2012
- 2012-08-09 IL IL221400A patent/IL221400A/en active IP Right Grant
-
2015
- 2015-05-14 US US14/712,481 patent/US9593145B2/en active Active
-
2016
- 2016-04-13 JP JP2016080043A patent/JP6328169B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-17 JP JP2018079295A patent/JP2018119004A/ja not_active Withdrawn
-
2020
- 2020-03-17 JP JP2020046041A patent/JP2020117510A/ja active Pending
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