ES2706063T3 - Agonistas del receptor de NMDA y usos del mismo - Google Patents

Agonistas del receptor de NMDA y usos del mismo Download PDF

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Publication number
ES2706063T3
ES2706063T3 ES11761468T ES11761468T ES2706063T3 ES 2706063 T3 ES2706063 T3 ES 2706063T3 ES 11761468 T ES11761468 T ES 11761468T ES 11761468 T ES11761468 T ES 11761468T ES 2706063 T3 ES2706063 T3 ES 2706063T3
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Prior art keywords
compounds
compound
nmda
alkyl
disclosed
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ES11761468T
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English (en)
Spanish (es)
Inventor
Joseph Moskal
Amin Khan
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Northwestern University
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Northwestern University
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0815Tripeptides with the first amino acid being basic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES11761468T 2010-02-11 2011-02-11 Agonistas del receptor de NMDA y usos del mismo Active ES2706063T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347210P 2010-02-11 2010-02-11
PCT/US2011/024583 WO2011100585A1 (en) 2010-02-11 2011-02-11 Secondary structure stabilized nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
ES2706063T3 true ES2706063T3 (es) 2019-03-27

Family

ID=44368160

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11761468T Active ES2706063T3 (es) 2010-02-11 2011-02-11 Agonistas del receptor de NMDA y usos del mismo

Country Status (13)

Country Link
US (2) US9101612B2 (enExample)
EP (1) EP2542254B1 (enExample)
JP (4) JP5928828B2 (enExample)
CN (2) CN102933226A (enExample)
AU (1) AU2011215704B2 (enExample)
BR (1) BR112012020142A2 (enExample)
CA (1) CA2789331C (enExample)
ES (1) ES2706063T3 (enExample)
IL (1) IL221400A (enExample)
MX (1) MX2012009388A (enExample)
RU (1) RU2566821C2 (enExample)
SG (3) SG10201811584RA (enExample)
WO (1) WO2011100585A1 (enExample)

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US9828384B2 (en) * 2013-01-29 2017-11-28 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
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BR112020015666A2 (pt) * 2018-01-31 2021-02-23 Aptinyx Inc. moduladores de espiro-lactamas de receptores nmda e usos dos mesmos
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JP2022543772A (ja) * 2019-08-01 2022-10-14 アプティニックス インコーポレイテッド Nmda受容体と相互作用する抗体のレベル上昇に関連する障害を治療する方法
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Also Published As

Publication number Publication date
IL221400A (en) 2016-07-31
CN102933226A (zh) 2013-02-13
RU2566821C2 (ru) 2015-10-27
IL221400A0 (en) 2012-10-31
US9593145B2 (en) 2017-03-14
MX2012009388A (es) 2012-10-01
RU2012138710A (ru) 2014-03-20
JP2020117510A (ja) 2020-08-06
SG183265A1 (en) 2012-09-27
CA2789331C (en) 2017-11-07
JP6328169B2 (ja) 2018-05-23
SG10201501050RA (en) 2015-04-29
JP5928828B2 (ja) 2016-06-01
EP2542254A4 (en) 2013-07-10
JP2018119004A (ja) 2018-08-02
EP2542254B1 (en) 2018-09-26
US20160115197A1 (en) 2016-04-28
EP2542254A1 (en) 2013-01-09
US20130053325A1 (en) 2013-02-28
JP2013519683A (ja) 2013-05-30
CA2789331A1 (en) 2011-08-18
WO2011100585A1 (en) 2011-08-18
CN105037492A (zh) 2015-11-11
US9101612B2 (en) 2015-08-11
SG10201811584RA (en) 2019-01-30
BR112012020142A2 (pt) 2020-08-18
AU2011215704A1 (en) 2012-08-30
JP2016185948A (ja) 2016-10-27
AU2011215704B2 (en) 2015-07-23

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