KR101554793B1 - mGluR 2／3 길항제로서의 4-치환된-3-벤질옥시-비시클로［3.1.0］헥산 화합물 - Google Patents

mGluR 2／3 길항제로서의 4-치환된-3-벤질옥시-비시클로［3.1.0］헥산 화합물 Download PDF

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KR101554793B1
KR101554793B1 KR1020137012692A KR20137012692A KR101554793B1 KR 101554793 B1 KR101554793 B1 KR 101554793B1 KR 1020137012692 A KR1020137012692 A KR 1020137012692A KR 20137012692 A KR20137012692 A KR 20137012692A KR 101554793 B1 KR101554793 B1 KR 101554793B1
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compound
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hexane
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KR20130080858A (ko
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브루스 앤쏘니 드레스맨
마크 도날드 차펠
아담 마이클 피부쉬
찰스 하워드 미치
폴 레슬리 오른스타인
에릭 조지 트로믹자크
타티아나 나탈리 베트맨
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일라이 릴리 앤드 캄파니
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
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    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/425—Thiazoles
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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KR1020137012692A 2010-11-18 2011-11-15 mGluR 2／3 길항제로서의 4-치환된-3-벤질옥시-비시클로［3.1.0］헥산 화합물 Expired - Fee Related KR101554793B1 (ko)

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Application Number Priority Date Filing Date Title
US41511310P 2010-11-18 2010-11-18
US61/415,113 2010-11-18
PCT/US2011/060686 WO2012068041A1 (en) 2010-11-18 2011-11-15 4-SUBSTITUTED-3-BENZYLOXY-BICYCLO[3.1.0]HEXANE COMPOUNDS AS mGluR 2/3 ANTAGONISTS

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KR20130080858A KR20130080858A (ko) 2013-07-15
KR101554793B1 true KR101554793B1 (ko) 2015-09-21

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EP (1) EP2640687B1 (enExample)
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CN (1) CN103209954B (enExample)
AU (1) AU2011329136B2 (enExample)
BR (1) BR112013012384A2 (enExample)
CA (1) CA2818118C (enExample)
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AR079343A1 (es) * 2009-12-21 2012-01-18 Lilly Co Eli Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
AU2017254266B2 (en) * 2016-04-18 2021-03-11 Taisho Pharmaceutical Co., Ltd. Prodrug of amino acid derivative
KR102549584B1 (ko) * 2018-03-27 2023-06-30 삼성전자주식회사 메모리 모듈을 포함하는 메모리 시스템, 메모리 모듈, 그리고 메모리 모듈의 동작 방법

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RU2315622C2 (ru) 2001-12-27 2008-01-27 Тайсо Фармасьютикал Ко.,Лтд. Производные 6-фторбицикло[3.1.0]гексана
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AR079343A1 (es) * 2009-12-21 2012-01-18 Lilly Co Eli Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico

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JP5870111B2 (ja) 2016-02-24
EP2640687A1 (en) 2013-09-25
ES2682959T3 (es) 2018-09-24
CN103209954B (zh) 2015-09-02
EA022196B1 (ru) 2015-11-30
CA2818118A1 (en) 2012-05-24
CN103209954A (zh) 2013-07-17
WO2012068041A1 (en) 2012-05-24
AU2011329136A1 (en) 2013-05-02
US20130237573A1 (en) 2013-09-12
AU2011329136B2 (en) 2014-11-06
EP2640687B1 (en) 2018-06-27
US9056844B2 (en) 2015-06-16
CA2818118C (en) 2016-03-29
MX2013005623A (es) 2013-07-05
JP2014505663A (ja) 2014-03-06
EA201390568A1 (ru) 2013-09-30
KR20130080858A (ko) 2013-07-15
BR112013012384A2 (pt) 2019-09-24

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